Kentsis, Alex

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Toward a Unified Theory of Why Young People Develop Cancer. Cold Spring Harbor perspectives in medicine. 2024 Academic Article GET IT
Childhood cancer mutagenesis caused by transposase-derived PGBD5. Science advances. 2024 Academic Article GET IT
Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia. HemaSphere. 2024 Academic Article GET IT
Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy. Cancer discovery. 2024 Academic Article GET IT
Dual-receptor T cell platform with Ab-TCR and costimulatory receptor achieves specificity and potency against AML. Blood. 2023 Academic Article GET IT
Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma. iScience. 2023 Academic Article GET IT
SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3. EMBO reports. 2023 Academic Article GET IT
Integrative Proteogenomics Using ProteomeGenerator2. Journal of proteome research. 2023 Academic Article GET IT
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications. 2023 Academic Article GET IT
Times cited: 1
Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy. 2023 GET IT
Integrative proteogenomics using ProteomeGenerator2. 2023 GET IT
The tumor microenvironment and immune targeting therapy in pediatric renal tumors. Pediatric blood & cancer. 2022 Review GET IT
Quantitative Cell Proteomic Atlas: Pathway-Scale Targeted Mass Spectrometry for High-Resolution Functional Profiling of Cell Signaling. Journal of proteome research. 2022 Academic Article GET IT
Automated Multidimensional Nanoscale Chromatography for Ultrasensitive Targeted Mass Spectrometry. 2022 GET IT
The Menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML. Blood. 2021 Academic Article GET IT
Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 27
Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics. Journal of proteome research. 2021 Academic Article GET IT
Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors. Nature cancer. 2021 Academic Article GET IT
Times cited: 67
Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia. eLife. 2021 Academic Article GET IT
Times cited: 30
The piggyBac-derived protein 5 (PGBD5) transposes both the closely and the distantly related piggyBac-like elements Tcr-pble and Ifp2. Journal of molecular biology. 2021 Academic Article GET IT
The C-terminal Domain of piggyBac Transposase Is Not Required for DNA Transposition. Journal of molecular biology. 2021 Academic Article GET IT
Times cited: 6
Why do young people get cancer?. Pediatric blood & cancer. 2020 Information Resource GET IT
Developmental Mutators and Early Onset Cancer. Frontiers in pediatrics. 2020 Academic Article GET IT
Times cited: 2
11p15.5 epimutations in children with Wilms tumor and hepatoblastoma detected in peripheral blood. Cancer. 2020 Academic Article GET IT
Times cited: 21
Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature. 2019 Academic Article GET IT
Times cited: 76
MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma. Oral oncology. 2019 Academic Article GET IT
Times cited: 18
Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor. JCI insight. 2019 Academic Article GET IT
Times cited: 20
A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis. iScience. 2019 Academic Article GET IT
Times cited: 9
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis. Nature genetics. 2019 Academic Article GET IT
Times cited: 69
Optimized Cross-Linking Mass Spectrometry for in Situ Interaction Proteomics. Journal of proteome research. 2019 Academic Article GET IT
Times cited: 23
HIV Detection via a Carbon Nanotube RNA Sensor. ACS sensors. 2019 Academic Article GET IT
Times cited: 60
A Chemical Strategy for Protease Substrate Profiling. Cell chemical biology. 2019 Academic Article GET IT
Times cited: 49
Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma. JCI insight. 2019 Academic Article GET IT
Times cited: 21
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia. Leukemia. 2019 Academic Article GET IT
Times cited: 69
Targeting the CALR interactome in myeloproliferative neoplasms. JCI insight. 2018 Academic Article GET IT
Times cited: 45
ProteomeGenerator: A Framework for Comprehensive Proteomics Based on de Novo Transcriptome Assembly and High-Accuracy Peptide Mass Spectral Matching. Journal of proteome research. 2018 Academic Article GET IT
Times cited: 21
Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development. JCI insight. 2018 Information Resource GET IT
Times cited: 8
Analytical Validation of Clinical Whole-Genome and Transcriptome Sequencing of Patient-Derived Tumors for Reporting Targetable Variants in Cancer. The Journal of molecular diagnostics : JMD. 2018 Academic Article GET IT
Times cited: 20
Disabling an oncogenic transcription factor by targeting of control kinases. Oncotarget. 2018 Editorial Article GET IT
Times cited: 2
Germline SDHA mutations in children and adults with cancer. Cold Spring Harbor molecular case studies. 2018 Academic Article GET IT
Times cited: 31
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia. Nature medicine. 2018 Academic Article GET IT
Times cited: 232
A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response. Cell. 2018 Academic Article GET IT
Times cited: 71
MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia. Cancer discovery. 2018 Academic Article GET IT
Peptidomimetic blockade of MYB in acute myeloid leukemia. Nature communications. 2018 Academic Article GET IT
Times cited: 62
Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Science translational medicine. 2017 Academic Article GET IT
Times cited: 36
High Sensitivity Quantitative Proteomics Using Automated Multidimensional Nano-flow Chromatography and Accumulated Ion Monitoring on Quadrupole-Orbitrap-Linear Ion Trap Mass Spectrometer. Molecular & cellular proteomics : MCP. 2017 Academic Article GET IT
Times cited: 35
PGBD5 promotes site-specific oncogenic mutations in human tumors. Nature genetics. 2017 Academic Article GET IT
Times cited: 56
ProteoModlR for functional proteomic analysis. BMC bioinformatics. 2017 Academic Article GET IT
Times cited: 3
Towards comprehensive and quantitative proteomics for diagnosis and therapy of human disease. Proteomics. 2016 Information Resource GET IT
Times cited: 67
Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia. British journal of haematology. 2016 Academic Article GET IT
Forward genetic screen of human transposase genomic rearrangements. BMC genomics. 2016 Academic Article GET IT
Times cited: 9
Integrating Genomics Into Clinical Pediatric Oncology Using the Molecular Tumor Board at the Memorial Sloan Kettering Cancer Center. Pediatric blood & cancer. 2016 Academic Article GET IT
Times cited: 32
Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius. Nature communications. 2016 Academic Article GET IT
Times cited: 66
Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization. The Journal of molecular diagnostics : JMD. 2015 Academic Article GET IT
Times cited: 15
Advancing Urinary Protein Biomarker Discovery by Data-Independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer. Journal of proteome research. 2015 Academic Article GET IT
Times cited: 93
High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group. Journal of hematology & oncology. 2015 Academic Article GET IT
Times cited: 31
Genomic DNA transposition induced by human PGBD5. eLife. 2015 Academic Article GET IT
Times cited: 55
MStern Blotting-High Throughput Polyvinylidene Fluoride (PVDF) Membrane-Based Proteomic Sample Preparation for 96-Well Plates. Molecular & cellular proteomics : MCP. 2015 Academic Article GET IT
Times cited: 61
Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice. Leukemia. 2015 Academic Article GET IT
Times cited: 71
A High-Efficiency Cellular Extraction System for Biological Proteomics. Journal of proteome research. 2015 Academic Article GET IT
Times cited: 18
Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia. Frontiers in oncology. 2015 Information Resource GET IT
Times cited: 22
Biological properties of ligand-dependent activation of the MET receptor kinase in acute myeloid leukemia. Leukemia. 2014 Article GET IT
Times cited: 7
Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia. British journal of haematology. 2014 Academic Article GET IT
Times cited: 18
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. The Journal of clinical investigation. 2014 Academic Article GET IT
Times cited: 176
Colorimetric and longitudinal analysis of leukocoria in recreational photographs of children with retinoblastoma. PloS one. 2013 Academic Article GET IT
Times cited: 21
KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. British journal of haematology. 2013 Academic Article GET IT
Times cited: 147
Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease. EMBO molecular medicine. 2012 Academic Article GET IT
Times cited: 62
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia. 2012 Academic Article GET IT
Times cited: 158
Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia. Nature medicine. 2012 Academic Article GET IT
Times cited: 148
Detection and diagnostic value of urine leucine-rich α-2-glycoprotein in children with suspected acute appendicitis. Annals of emergency medicine. 2012 Academic Article GET IT
Times cited: 52
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 2011 Academic Article GET IT
Times cited: 150
Challenges and opportunities for discovery of disease biomarkers using urine proteomics. Pediatrics international : official journal of the Japan Pediatric Society. 2011 Academic Article GET IT
Times cited: 20
Venous thrombosis associated with gene deletion of tissue factor pathway inhibitor. American journal of hematology. 2009 Article GET IT
Times cited: 3
Urine proteomics for profiling of human disease using high accuracy mass spectrometry. Proteomics. Clinical applications. 2009 Academic Article GET IT
Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Annals of emergency medicine. 2009 Academic Article GET IT
Times cited: 72
Calculation of the free energy and cooperativity of protein folding. PloS one. 2007 Academic Article GET IT
Times cited: 23
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. The EMBO journal. 2006 Academic Article GET IT
Times cited: 166
Correspondence patterns: mechanisms and models of human dynamics. Nature. 2006 Article GET IT
Times cited: 9
Origin of the sequence-dependent polyproline II structure in unfolded peptides. Proteins. 2005 Academic Article GET IT
Times cited: 16
Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. Journal of virology. 2005 Academic Article GET IT
Times cited: 93
Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels. Molecular and cellular biology. 2005 Academic Article GET IT
Times cited: 84
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 29
Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 262
Unfolded state of polyalanine is a segmented polyproline II helix. Proteins. 2004 Academic Article GET IT
Times cited: 90
Physical mechanisms and biological significance of supramolecular protein self-assembly. Current protein & peptide science. 2004 Information Resource GET IT
Times cited: 36
Nedd8 on cullin: building an expressway to protein destruction. Oncogene. 2004 Information Resource GET IT
Times cited: 323
MC-PHS: a Monte Carlo implementation of the primary hydration shell for protein folding and design. Biophysical journal. 2003 Academic Article GET IT
Times cited: 20
Control of biochemical reactions through supramolecular RING domain self-assembly. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 100
Self-assembly properties of a model RING domain. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 88
The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. Journal of molecular biology. 2001 Academic Article GET IT
Times cited: 117
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA. The EMBO journal. 2001 Academic Article GET IT
Times cited: 164
Reconstructing the pml nuclear body: pml binds eif4e and lowers its affinity for 5' cap of mrna. Blood. 2000 Article
Construction of macromolecular assemblages in eukaryotic processes and their role in human disease: linking RINGs together. Current protein & peptide science. 2000 Academic Article GET IT
Times cited: 26
D/H amide kinetic isotope effects reveal when hydrogen bonds form during protein folding. Nature structural biology. 2000 Academic Article GET IT
Times cited: 96
Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 107
Rat preputial sebocyte differentiation involves peroxisome proliferator-activated receptors. The Journal of investigative dermatology. 1999 Academic Article GET IT
Times cited: 119
Trifluoroethanol promotes helix formation by destabilizing backbone exposure: desolvation rather than native hydrogen bonding defines the kinetic pathway of dimeric coiled coil folding. Biochemistry. 1998 Academic Article GET IT
Times cited: 145

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Background

education and training

M.D., Mount Sinai School of Medicine 2006
Ph.D., New York University 2004
A.B., University of Chicago 1998
S.M., University of Chicago 1998

Contact

full name

Alex Kentsis

VIVO Weill Cornell Medical College

Alex Kentsis Associate Professor of Pediatrics

Publications

selected publications

Background

education and training

Contact

full name

primary email