Boudker, Olga

Publications

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selected publications

HS-AFM single-molecule structural biology uncovers basis of transporter wanderlust kinetics. Nature structural & molecular biology. 2024 Academic Article GET IT
Ion and lipid orchestration of secondary active transport. Nature. 2024 Review GET IT
Author Correction: Structural basis of pH-dependent activation in a CLC transporter. 2024 GET IT
Structural basis of pH-dependent activation in a CLC transporter. Nature structural & molecular biology. 2024 Academic Article GET IT
Uncoupled substrate binding underlies the evolutionary switch between Na ⁺ and H ⁺ -coupled prokaryotic aspartate transporters. 2023 GET IT
Symport and antiport mechanisms of human glutamate transporters. Nature communications. 2023 Academic Article GET IT
Times cited: 2
Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by ¹⁹F NMR and Cryo-EM. Journal of the American Chemical Society. 2023 Academic Article GET IT
The archaeal glutamate transporter homologue GltPh shows heterogeneous substrate binding. The Journal of general physiology. 2022 Academic Article GET IT
Linking function to global and local dynamics in an elevator-type transporter. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
FRET-based Microscopy Assay to Measure Activity of Membrane Amino Acid Transporters with Single-transporter Resolution. Bio-protocol. 2021 Academic Article GET IT
Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Science advances. 2021 Academic Article GET IT
Times cited: 26
The high-energy transition state of the glutamate transporter homologue GltPh. The EMBO journal. 2020 Academic Article GET IT
Times cited: 15
Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters. eLife. 2020 Academic Article GET IT
Times cited: 29
Millisecond dynamics of an unlabeled amino acid transporter. Nature communications. 2020 Academic Article GET IT
Times cited: 27
Use of paramagnetic ¹⁹F NMR to monitor domain movement in a glutamate transporter homolog. Nature chemical biology. 2020 Academic Article GET IT
Times cited: 25
Single-molecule transport kinetics of a glutamate transporter homolog shows static disorder. Science advances. 2020 Academic Article GET IT
Times cited: 20
Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh. eLife. 2018 Academic Article GET IT
Times cited: 27
A facile approach for the in vitro assembly of multimeric membrane transport proteins. eLife. 2018 Academic Article GET IT
Times cited: 16
Structural basis of sterol binding and transport by a yeast StARkin domain. The Journal of biological chemistry. 2018 Academic Article GET IT
Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5. Nature communications. 2018 Academic Article GET IT
Times cited: 55
Direct visualization of glutamate transporter elevator mechanism by high-speed AFM. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 92
The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters. PloS one. 2015 Academic Article GET IT
Times cited: 12
Isothermal titration calorimetry of ion-coupled membrane transporters. Methods (San Diego, Calif.). 2015 Academic Article GET IT
Times cited: 18
Transport domain unlocking sets the uptake rate of an aspartate transporter. Nature. 2015 Academic Article GET IT
Times cited: 128
Coupled ion binding and structural transitions along the transport cycle of glutamate transporters. eLife. 2014 Academic Article GET IT
Times cited: 85
Transport dynamics in a glutamate transporter homologue. Nature. 2013 Academic Article GET IT
Times cited: 137
Chemical catalysis by the translocator protein (18 kDa). Biochemistry. 2013 Academic Article GET IT
Times cited: 25
Binding thermodynamics of a glutamate transporter homolog. Nature structural & molecular biology. 2013 Academic Article GET IT
Times cited: 72
Conformational ensemble of the sodium-coupled aspartate transporter. Nature structural & molecular biology. 2013 Academic Article GET IT
Times cited: 107
Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog. Nature structural & molecular biology. 2012 Academic Article GET IT
Times cited: 133
Structural perspectives on secondary active transporters. Trends in pharmacological sciences. 2010 Information Resource GET IT
Times cited: 116
Transport mechanism of a bacterial homologue of glutamate transporters. Nature. 2009 Academic Article GET IT
Times cited: 354
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature. 2007 Academic Article GET IT
Times cited: 366
Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus. Biochemistry. 2003 Academic Article GET IT
Times cited: 77
Isolation and characterization of IIAChb, a soluble protein of the enzyme II complex required for the transport/phosphorylation of N, N'-diacetylchitobiose in Escherichia coli. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 17
The structural stability of the co-chaperonin GroES. Journal of molecular biology. 1997 Academic Article GET IT
Times cited: 67
Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 65

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Research

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Funding awarded

Ion coupling, permeation, and regulation in glutamate transporters awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2024 - 2027

Functional dynamics of glutamate transporters probed by high-speed atomic force microscopy with micro- to millisecond time resolution awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2019 - 2024

Molecular Biophysics Training Program awarded by National Institute of General Medical Sciences Co-Principal Investigator 2020 - 2025

The mechanism of allosteric modulation of glutamate transporters awarded by National Institute of Neurological Disorders & Stroke Principal Investigator Subaward 2019 - 2024
The spilt personality of glutamate transporters: the structural basis and physiological role of a dual function transporter/channel awarded by National Health and Medical Research Council Principal Investigator Subaward 2019 - 2021

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Background

education and training

Ph.D., The Johns Hopkins University School of Medicine 1999
M.Sc., Weizmann Institute of Science (Israel) 1993
B.Sc., Novosibirsk State University (Russia) 1990

Contact

full name

Olga Boudker

primary email

olb2003@med.cornell.edu

VIVO Weill Cornell Medical College

Olga Boudker Acting Chair of Physiology and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email