Leschziner, Andres

Publications

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selected publications

Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2. eLife. 2025 Academic Article GET IT
Structural basis of nucleosome recognition by the conserved Dsup and HMGN nucleosome-binding motif. Genes & development. 2025 Academic Article GET IT
Times cited: 1
Cryo-EM captures early intermediate steps in dynein activation by LIS1. Nature communications. 2025 Academic Article GET IT
Times cited: 1
Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2. bioRxiv : the preprint server for biology. 2025 Article GET IT
Structural biology of Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2). The Journal of biological chemistry. 2025 Information Resource GET IT
Times cited: 3
Type II kinase inhibitors that target Parkinson's disease-associated LRRK2. Science advances. 2025 Academic Article GET IT
Times cited: 5
Multiple steps of dynein activation by Lis1 visualized by cryo-EM. Nature structural & molecular biology. 2025 Academic Article GET IT
Times cited: 1
The LOTUS domain of Oskar promotes localisation of both protein and mRNA components of Drosophila germ plasm. bioRxiv : the preprint server for biology. 2025 Article GET IT
Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2. bioRxiv : the preprint server for biology. 2025 Article GET IT
Structural basis of nucleosome recognition by the conserved Dsup and HMGN nucleosome-binding motif. bioRxiv : the preprint server for biology. 2025 Article GET IT
Cryo-EM visualizes multiple steps of dynein's activation pathway. bioRxiv : the preprint server for biology. 2024 Article GET IT
A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2. The Journal of biological chemistry. 2024 Academic Article GET IT
Times cited: 1
Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
Times cited: 15
Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Science advances. 2023 Academic Article GET IT
Times cited: 34
Author Correction: Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nature communications. 2023 Article GET IT
Times cited: 2
Structure of LRRK1 and mechanisms of autoinhibition and activation. Nature structural & molecular biology. 2023 Academic Article GET IT
Times cited: 9
Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. Nature structural & molecular biology. 2023 Academic Article GET IT
Times cited: 16
Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. eLife. 2023 Academic Article GET IT
Times cited: 17
Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules. Nature structural & molecular biology. 2022 Academic Article GET IT
Times cited: 34
Structural basis for cytoplasmic dynein-1 regulation by Lis1. eLife. 2022 Academic Article GET IT
Times cited: 30
Structure Analysis of Proteins and Peptides by Difference Circular Dichroism Spectroscopy. The protein journal. 2021 Academic Article GET IT
Times cited: 9
Structural Biology of LRRK2 and its Interaction with Microtubules. Movement disorders : official journal of the Movement Disorder Society. 2021 Information Resource GET IT
Times cited: 12
Structures and function of the amino acid polymerase cyanophycin synthetase. Nature chemical biology. 2021 Academic Article GET IT
Times cited: 27
Structural insights into assembly and function of the RSC chromatin remodeling complex. Nature structural & molecular biology. 2020 Academic Article GET IT
Times cited: 28
Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 29
Structure of LRRK2 in Parkinson's disease and model for microtubule interaction. Nature. 2020 Academic Article GET IT
Times cited: 173
Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nature communications. 2020 Academic Article GET IT
Times cited: 28
LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes. Nature cell biology. 2020 Academic Article GET IT
Times cited: 85
A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex. eLife. 2019 Academic Article GET IT
Times cited: 16
3.1 Å structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids. Journal of structural biology. 2019 Academic Article GET IT
Times cited: 23
cryoem-cloud-tools: A software platform to deploy and manage cryo-EM jobs in the cloud. Journal of structural biology. 2018 Academic Article GET IT
Times cited: 17
Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase. Communications biology. 2018 Academic Article GET IT
Times cited: 20
Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. 2017 Academic Article GET IT
Times cited: 174
Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 2017 Academic Article GET IT
Times cited: 64
Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. eLife. 2017 Academic Article GET IT
Times cited: 33
Mechanism and regulation of cytoplasmic dynein. Annual review of cell and developmental biology. 2015 Information Resource GET IT
Times cited: 201
Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud. eLife. 2015 Academic Article GET IT
Times cited: 32
Lis1 regulates dynein by sterically blocking its mechanochemical cycle. eLife. 2014 Academic Article GET IT
Times cited: 80
Traffic control: adaptor proteins guide dynein-cargo takeoff. The EMBO journal. 2014 Article GET IT
Times cited: 2
Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1. Cell. 2013 Academic Article GET IT
Times cited: 131
Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 359
Structural basis for microtubule binding and release by dynein. Science (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 136
Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell. 2012 Academic Article GET IT
Times cited: 189
Electron microscopy studies of nucleosome remodelers. Current opinion in structural biology. 2011 Information Resource GET IT
Times cited: 20
Validation of the orthogonal tilt reconstruction method with a biological test sample. Journal of structural biology. 2011 Academic Article GET IT
Times cited: 5
Introduction of customized inserts for s-treamlined assembly and optimization of BioBrick synthetic genetic circuits. Journal of biological engineering. 2010 Academic Article GET IT
Times cited: 28
The orthogonal tilt reconstruction method. Methods in enzymology. 2010 Academic Article GET IT
Times cited: 7
A dimeric structure for archaeal box C/D small ribonucleoproteins. Science (New York, N.Y.). 2009 Academic Article GET IT
Times cited: 49
Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nature structural & molecular biology. 2007 Academic Article GET IT
Times cited: 80
Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 81
Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions. Annual review of biophysics and biomolecular structure. 2007 Information Resource GET IT
Times cited: 69
Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nature structural & molecular biology. 2006 Academic Article GET IT
Times cited: 78
The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles. Journal of structural biology. 2005 Academic Article GET IT
Times cited: 82
Structural studies of the human PBAF chromatin-remodeling complex. Structure (London, England : 1993). 2005 Academic Article GET IT
Times cited: 43
The architecture of the gammadelta resolvase crossover site synaptic complex revealed by using constrained DNA substrates. Molecular cell. 2003 Academic Article GET IT
Times cited: 26
A model for the gamma delta resolvase synaptic complex. Molecular cell. 2001 Academic Article GET IT
Times cited: 70
Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 38
Neural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscle. Journal of neurochemistry. 2000 Academic Article GET IT
Times cited: 52
In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis. Nucleic acids research. 1999 Academic Article GET IT
Times cited: 32
Tn552 transposase catalyzes concerted strand transfer in vitro. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 20
DNA transposition: from a black box to a color monitor. Cell. 1995 Information Resource GET IT
Times cited: 66
The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions. Molecular microbiology. 1995 Academic Article GET IT
Times cited: 28

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Research

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Co-investigator Network

Funding awarded

Mechanism of cytoskeletal transport and transcription-coupled DNA repair awarded by National Institute of General Medical Sciences Principal Investigator 2025 - 2027

Developing inhibitors of LRRK2''s GTPase awarded by Michael J. Fox Foundation for Parkinson''s Research Co-Principal Investigator 2025 - 2026

Developing LRRK2 WD40 binders awarded by Michael J. Fox Foundation for Parkinson''s Research Principal Investigator Subaward 2025 - 2027
Developing LRRK2-specific Type 2 inhibitors awarded by Michael J. Fox Foundation for Parkinson''s Research Principal Investigator Subaward 2025 - 2027

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Background

education and training

Ph.D., Yale University 2000
Bs.C., McGill University (Canada) 1993

Contact

full name

Andres Leschziner

primary email

ale4009@med.cornell.edu

VIVO Weill Cornell Medical College

Andres Leschziner Professor of Biochemistry and Biophysics (Pending Appointment at Rank)

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email