Hanash, Alan

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Corticosteroids impair epithelial regeneration in immune-mediated intestinal damage. The Journal of clinical investigation. 2024 Academic Article GET IT
A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury. Nature communications. 2023 Academic Article GET IT
Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse. Science translational medicine. 2023 Academic Article GET IT
Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function. 2023 GET IT
A phase 2 study of interleukin-22 and systemic corticosteroids as initial treatment for acute GVHD of the lower GI tract. Blood. 2023 Academic Article GET IT
Times cited: 22
Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease. Mucosal immunology. 2022 Review GET IT
Times cited: 8
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design. Immunity. 2021 Academic Article GET IT
Times cited: 42
High progression-free survival after intermediate intensity double unit cord blood transplantation in adults. Blood advances. 2020 Academic Article GET IT
Times cited: 33
Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 176
T cell-derived interferon-γ programs stem cell death in immune-mediated intestinal damage. Science immunology. 2019 Academic Article GET IT
Times cited: 86
T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation. Immunity. 2019 Academic Article GET IT
Times cited: 65
BCL6 inhibition: a chronic GVHD twofer. Blood. 2019 Comment GET IT
Times cited: 3
Nrf2 regulates CD4⁺ T cell-induced acute graft-versus-host disease in mice. Blood. 2018 Academic Article GET IT
Times cited: 31
Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. 2018 Academic Article GET IT
Times cited: 94
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Science immunology. 2018 Academic Article GET IT
Times cited: 95
Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury. Nature medicine. 2018 Academic Article GET IT
Times cited: 33
Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft-versus-host disease. Blood. 2017 Academic Article GET IT
Times cited: 51
RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. Science translational medicine. 2017 Academic Article GET IT
Times cited: 107
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity. Nature medicine. 2017 Academic Article GET IT
Times cited: 174
Role of the intestinal mucosa in acute gastrointestinal GVHD. Blood. 2016 Information Resource GET IT
Times cited: 44
Corrigendum: Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease. 2016 GET IT
Times cited: 5
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. Science translational medicine. 2016 Academic Article GET IT
Times cited: 404
Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease. Nature immunology. 2016 Academic Article GET IT
Times cited: 504
Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting. Blood. 2016 Academic Article GET IT
Times cited: 247
Cord blood T cells are "completely different". Blood. 2015 Comment GET IT
Times cited: 5
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature. 2015 Academic Article GET IT
Times cited: 796
Association between Nondominant Unit Total Nucleated Cell Dose and Engraftment in Myeloablative Double-Unit Cord Blood Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 8
Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 551
Intensified Mycophenolate Mofetil Dosing and Higher Mycophenolic Acid Trough Levels Reduce Severe Acute Graft-versus-Host Disease after Double-Unit Cord Blood Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 32
Interleukin-22: immunobiology and pathology. Annual review of immunology. 2015 Information Resource GET IT
Times cited: 684
High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation. Blood. 2014 Academic Article GET IT
Times cited: 91
Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. The Journal of experimental medicine. 2014 Academic Article GET IT
Times cited: 220
PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD. Cancer research. 2013 Academic Article GET IT
Times cited: 10
Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 22
Nrf2 regulates haematopoietic stem cell function. Nature cell biology. 2013 Academic Article GET IT
Times cited: 173
Graft-versus-host disease after double-unit cord blood transplantation has unique features and an association with engrafting unit-to-recipient HLA match. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013 Academic Article GET IT
Times cited: 58
The central nervous system is a target of acute graft versus host disease in mice. Blood. 2013 Academic Article GET IT
Times cited: 47
Extrathymic development of murine T cells after bone marrow transplantation. The Journal of clinical investigation. 2012 Academic Article GET IT
Times cited: 19
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity. 2012 Academic Article GET IT
Times cited: 483
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 515
Interleukin-22 drives endogenous thymic regeneration in mice. Science (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 298
Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood. 2011 Academic Article GET IT
Times cited: 59
Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 129
Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation. Blood. 2004 Academic Article GET IT
Times cited: 134
The contribution of cytotoxic and noncytotoxic function by donor T-cells that support engraftment after allogeneic bone marrow transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2002 Academic Article GET IT
Times cited: 30

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Background

education and training

M.D., University of Miami School of Medicine 2006
Ph.D., University of Miami 2004
B.S., University of Michigan 1998

Contact

full name

Alan Hanash

primary email

hanasha@mskcc.org

VIVO Weill Cornell Medical College

Alan Hanash Associate Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email