Polyzos, Alexander

Publications

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selected publications

T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response. Nature cell biology. 2025 Academic Article GET IT
Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 via LINE1 regulatory elements. EMBO reports. 2025 Academic Article GET IT
Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm. Developmental cell. 2025 Academic Article GET IT
Times cited: 4
Disruption of TAD hierarchy promotes LTR co-option in cancer. Nature genetics. 2025 Academic Article GET IT
Three-dimensional regulatory hubs support oncogenic programs in glioblastoma. Molecular cell. 2025 Academic Article GET IT
Times cited: 2
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells. Stem cell reports. 2025 Academic Article GET IT
Times cited: 2
Single-cell analysis of bidirectional reprogramming between early embryonic states identify mechanisms of differential lineage plasticities in mice. Developmental cell. 2024 Academic Article GET IT
Times cited: 1
3D chromatin hubs as regulatory units of identity and survival in human acute leukemia. Molecular cell. 2024 Academic Article GET IT
Times cited: 8
Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 through binding to LINE-1 regulatory elements. 2024 GET IT
Three-dimensional regulatory hubs support oncogenic programs in glioblastoma. 2024 GET IT
An Unbiased Approach to Identifying Cellular Reprogramming-Inducible Enhancers. International journal of molecular sciences. 2024 Academic Article GET IT
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naïve pluripotent stem cells. 2024 GET IT
TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer. 2024 GET IT
Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm. 2024 GET IT
3D Enhancer-promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages. Nature structural & molecular biology. 2023 Academic Article GET IT
Times cited: 27
Systematic mapping and modeling of 3D enhancer-promoter interactions in early mouse embryonic lineages reveal regulatory principles that determine the levels and cell-type specificity of gene expression. 2023 GET IT
Combinatorial targeting of a specific EMT/MET network by macroH2A variants safeguards mesenchymal identity. PloS one. 2023 Academic Article GET IT
Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticities. 2023 GET IT
A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2022 Academic Article GET IT
Times cited: 19
Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. 2022 GET IT
Times cited: 1
Assessing Specific Networks of Chromatin Interactions with HiChIP. Methods in molecular biology (Clifton, N.J.). 2022 Academic Article GET IT
Times cited: 2
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization. Molecular cell. 2021 Academic Article GET IT
Times cited: 22
A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus. Developmental cell. 2021 Academic Article GET IT
Times cited: 25
Correction to: A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence. 2021 GET IT
Times cited: 1
H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization. Molecular cell. 2021 Academic Article GET IT
Times cited: 68
Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes. The EMBO journal. 2020 Academic Article GET IT
Times cited: 14
Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency. Stem cell reports. 2020 Academic Article GET IT
Times cited: 8
Transcription factors: building hubs in the 3D space. Cell cycle (Georgetown, Tex.). 2020 Review GET IT
Times cited: 46
A Deep Learning Framework for Predicting Response to Therapy in Cancer. Cell reports. 2019 Academic Article GET IT
Times cited: 107
CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation. Life science alliance. 2019 Academic Article GET IT
Times cited: 9
KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks. Nature cell biology. 2019 Academic Article GET IT
Times cited: 146
Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining. Pharmacology & therapeutics. 2019 Review GET IT
Times cited: 73
The lysine-specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer. EMBO reports. 2019 Academic Article GET IT
Times cited: 120
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion. Cell reports. 2018 Academic Article GET IT
Times cited: 116
RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. Cell reports. 2018 Academic Article GET IT
Times cited: 69
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 98
Hippocampal lipidome and transcriptome profile alterations triggered by acute exposure of mice to GSM 1800 MHz mobile phone radiation: An exploratory study. Brain and behavior. 2018 Academic Article GET IT
Times cited: 26
The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition. Molecular and cellular biology. 2018 Academic Article GET IT
Times cited: 15
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome biology. 2018 Academic Article GET IT
Times cited: 62
Impaired anti-inflammatory activity of PPARγ in the salivary epithelia of Sjögren's syndrome patients imposed by intrinsic NF-κB activation. Journal of autoimmunity. 2017 Academic Article GET IT
Times cited: 24
Erratum to 'Exploring and exploiting the systemic effects of deregulated replication licensing' [Seminars in Cancer Biology 37-38C, (2016) 3-15]. 2017 GET IT
Proteomic Analysis of Normal and Cancer Cervical Cell Lines Reveals Deregulation of Cytoskeleton-associated Proteins. Cancer genomics & proteomics. 2017 Academic Article GET IT
Times cited: 37
Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Fly. 2016 Academic Article GET IT
Times cited: 12
Pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta as regulators of angiogenesis and cancer. Biochimica et biophysica acta. 2016 Review GET IT
Times cited: 44
Exploring and exploiting the systemic effects of deregulated replication licensing. Seminars in cancer biology. 2015 Review GET IT
Times cited: 33
Profiling of Discrete Gynecological Cancers Reveals Novel Transcriptional Modules and Common Features Shared by Other Cancer Types and Embryonic Stem Cells. PloS one. 2015 Academic Article GET IT
Times cited: 64
Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene Expression. Cell reports. 2015 Academic Article GET IT
Times cited: 35
Maternal weight as an alternative determinant of the gestational day of Wistar rats housed in individually-ventilated cages. Laboratory animals. 2014 Academic Article GET IT
Times cited: 7
Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer. Journal of the National Cancer Institute. 2014 Academic Article GET IT
Times cited: 68
A new tumor suppressor role for the Notch pathway in bladder cancer. Nature medicine. 2014 Academic Article GET IT
Times cited: 146
Genomic analysis reveals a novel nuclear factor-κB (NF-κB)-binding site in Alu-repetitive elements. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 53
Endoscopic tests for the diagnosis of Helicobacter pylori infection in children: Validation of rapid urease test. Helicobacter. 2010 Academic Article GET IT
Times cited: 17
Inflammatory bowel disease in children: the role of a positive family history. European journal of gastroenterology & hepatology. 2010 Academic Article GET IT
Times cited: 24
Prolonged disease free survival with aggressive adjuvant chemotherapy in a case of large cell neuroendocrine carcinoma of the uterine cervix. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2009 Letter GET IT
Times cited: 3
Dose escalating clinical study of high dose infusional 5-fluorouracil and leukovorin (AIO regimen) plus alternate weekly administration of oxaliplatin and irinotecan in patients with advanced tumors of the gastrointestinal tract. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2007 Academic Article GET IT
Times cited: 1
Temozolomide in combination with celecoxib in patients with advanced melanoma. A phase II study of the Hellenic Cooperative Oncology Group. Annals of oncology : official journal of the European Society for Medical Oncology. 2006 Academic Article GET IT
Times cited: 25
Sequential gemcitabine and cisplatin followed by docetaxel as first-line treatment of advanced urothelial carcinoma: a multicenter phase II study of the Hellenic Oncology Research Group. Annals of oncology : official journal of the European Society for Medical Oncology. 2006 Academic Article GET IT
Times cited: 10
Temozolomide and cisplatin versus temozolomide in patients with advanced melanoma: a randomized phase II study of the Hellenic Cooperative Oncology Group. Annals of oncology : official journal of the European Society for Medical Oncology. 2005 Academic Article GET IT
Times cited: 49
Dose escalation of docetaxel and ifosfamide in patients with advanced breast cancer failing prior anthracyclines: mature results of a phase I-II study. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2005 Academic Article GET IT
Combination of irinotecan (CPT-11) plus oxaliplatin (L-OHP) as first-line treatment in locally advanced or metastatic gastric cancer: a multicentre phase II trial. Annals of oncology : official journal of the European Society for Medical Oncology. 2004 Academic Article GET IT
Times cited: 50

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Research

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Funding awarded

Transcriptional control by autism associated H3K9 methylation regulators during human neurogenesis awarded by National Institute of Mental Health Co-Investigator 2026 - 2030
Identifying and targeting 3D regulatory nodes that maintain glioblastoma programs. awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2024 - 2029

Organizational principles and functional role of 3D enhancer hubs in cell fate decisions Key Personnel 2020 - 2025

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Background

education and training

Ph.D., University of Athens, Faculty of Medicine (Greece) 2011
M.Sc., University of Athens (Greece) 2006
B.Sc., University of Crete (Greece) 2004

Contact

full name

Alexander Polyzos

primary email

app2006@med.cornell.edu

VIVO Weill Cornell Medical College

Alexander Polyzos Assistant Professor of Molecular Biology Research in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email