selected publications
- Cep120 is essential for kidney stromal progenitor cell growth and differentiation. EMBO reports. 2023 Academic Article GET IT
- Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease. Development (Cambridge, England). 2023 Academic Article GET IT
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis. PLoS genetics. 2023 Academic Article GET IT
- Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney disease. 2023 GET IT
- Impaired centrosome biogenesis in kidney stromal progenitors reduces abundance of interstitial lineages and accelerates injury-induced fibrosis. 2023 GET IT
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Primary cilia defects causing mitral valve prolapse.
Science translational medicine.
2019
Academic Article
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Times cited: 78 -
Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse.
Journal of cell science.
2018
Academic Article
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Times cited: 19 -
Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse.
Development (Cambridge, England).
2018
Academic Article
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Times cited: 19 -
Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse.
Developmental biology.
2017
Academic Article
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Times cited: 14 -
Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse.
Human molecular genetics.
2017
Academic Article
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Times cited: 23 -
PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant.
Developmental biology.
2017
Academic Article
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Times cited: 22 -
SHH ventralizes the otocyst by maintaining basal PKA activity and regulating GLI3 signaling.
Developmental biology.
2016
Academic Article
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Times cited: 12 -
BMP regulates regional gene expression in the dorsal otocyst through canonical and non-canonical intracellular pathways.
Development (Cambridge, England).
2016
Academic Article
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Times cited: 24 -
Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner.
Molecular pharmacology.
2015
Academic Article
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Times cited: 8 -
ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling.
Cell reports.
2014
Academic Article
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Times cited: 14 -
Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors.
PloS one.
2014
Academic Article
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Times cited: 35 -
Pyrvinium attenuates Hedgehog signaling downstream of smoothened.
Cancer research.
2014
Academic Article
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Times cited: 71 -
Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.
The Journal of biological chemistry.
2013
Academic Article
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Times cited: 41 -
Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants.
Developmental biology.
2013
Academic Article
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Times cited: 23 -
Primary cilia and Gli3 activity regulate cerebral cortical size.
Developmental neurobiology.
2012
Academic Article
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Times cited: 64 -
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
Developmental biology.
2012
Academic Article
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Times cited: 37 -
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
The Journal of biological chemistry.
2012
Academic Article
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Times cited: 24 -
Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo.
Developmental dynamics : an official publication of the American Association of Anatomists.
2011
Academic Article
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Times cited: 16 -
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.
Science signaling.
2011
Academic Article
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Times cited: 86 -
Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome.
Disease models & mechanisms.
2010
Academic Article
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Times cited: 68 -
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.
Development (Cambridge, England).
2010
Academic Article
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Times cited: 174 -
Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors.
Cancer research.
2010
Academic Article
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Times cited: 50 -
Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2.
Molecular and cellular biology.
2008
Academic Article
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Times cited: 48 -
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development.
Developmental biology.
2008
Academic Article
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Times cited: 131 -
Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.
Developmental biology.
2008
Academic Article
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Times cited: 100 -
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.
Proceedings of the National Academy of Sciences of the United States of America.
2008
Academic Article
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Times cited: 254 -
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning.
Developmental biology.
2008
Academic Article
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Times cited: 52 -
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells.
Stem cells (Dayton, Ohio).
2008
Academic Article
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Times cited: 76 -
The molecular basis of Pallister Hall associated polydactyly.
Human molecular genetics.
2007
Academic Article
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Times cited: 28 -
Ftm is a novel basal body protein of cilia involved in Shh signalling.
Development (Cambridge, England).
2007
Academic Article
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Times cited: 148 -
A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype.
Developmental dynamics : an official publication of the American Association of Anatomists.
2007
Academic Article
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Times cited: 23 -
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning.
Developmental biology.
2007
Academic Article
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Times cited: 89 -
A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome.
The Journal of biological chemistry.
2007
Academic Article
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Times cited: 106 -
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.
Molecular and cellular biology.
2006
Academic Article
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Times cited: 441 -
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing.
Proceedings of the National Academy of Sciences of the United States of America.
2005
Academic Article
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Times cited: 222 -
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.
Developmental biology.
2005
Academic Article
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Times cited: 330 -
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors.
Development (Cambridge, England).
2005
Academic Article
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Times cited: 409 -
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.
Molecular cell.
2003
Academic Article
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Times cited: 187 -
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
Nature.
2003
Academic Article
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Times cited: 904 -
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
Nature.
2000
Academic Article
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Times cited: 1065 -
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.
Cell.
2000
Academic Article
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Times cited: 786 -
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched.
Proceedings of the National Academy of Sciences of the United States of America.
1999
Academic Article
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Times cited: 155 -
Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression.
Cell.
1999
Academic Article
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Times cited: 215 -
Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G.
Oncogene.
1998
Academic Article
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Times cited: 70 -
ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks.
The Journal of biological chemistry.
1997
Academic Article
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Times cited: 102 -
Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk.
Oncogene.
1996
Academic Article
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Times cited: 29 -
Subcellular localization of the Arg protein tyrosine kinase.
Oncogene.
1996
Academic Article
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Times cited: 37 -
Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.
Molecular and cellular biology.
1996
Academic Article
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Times cited: 223 -
Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene.
Oncogene.
1996
Academic Article
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Times cited: 30 -
Large-scale preparation of plasmid DNA by microwave lysis.
BioTechniques.
1995
Academic Article
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Times cited: 11 -
Structure, sequence and expression of the mouse Cx43 gene encoding connexin 43.
Gene.
1993
Academic Article
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Times cited: 62