selected publications
- Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors. iScience. 2026 Academic Article GET IT
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Effect of TGF-β mediated phenotypic changes on prostate cancer cell anoikis response.
Oncogene.
2025
Academic Article
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Times cited: 1 - HLA-E and NKG2A Mediate Resistance to BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer. bioRxiv : the preprint server for biology. 2025 Article GET IT
- Unlocking the therapeutic potential of rigosertib as a selective therapy for ovarian cancer. Cell reports. Medicine. 2025 Academic Article GET IT
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Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models.
British journal of cancer.
2025
Academic Article
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Times cited: 9 -
Epigenomic analysis identifies DTP subpopulation using HOPX to develop targeted therapy resistance in lung adenocarcinoma.
iScience.
2025
Academic Article
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Times cited: 2 -
The role of biomarkers in the management of HPV-related oropharyngeal cancer.
Current opinion in oncology.
2025
Information Resource
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Times cited: 1 - Functional genomics pipeline identifies CRL4 inhibition for the treatment of ovarian cancer. Clinical and translational medicine. 2025 Academic Article GET IT
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Characteristics, Treatment, and Outcomes of Primary Urethral Cancer: A Multicenter Review Over Two Decades.
Clinical genitourinary cancer.
2024
Article
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Times cited: 2 -
Risk of late radiation necrosis more than 5 years after stereotactic radiosurgery.
Journal of neurosurgery.
2024
Academic Article
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Times cited: 3 -
Hormone Deprivation-Free Survival-Inequities Persist in Research Priorities for Patients With Cancer.
JAMA oncology.
2024
Academic Article
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Times cited: 1 -
Multiscale protein networks systematically identify aberrant protein interactions and oncogenic regulators in seven cancer types.
Journal of hematology & oncology.
2023
Article
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Times cited: 10 -
Epinephrine inhibits PI3Kα via the Hippo kinases.
Cell reports.
2023
Academic Article
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Times cited: 2 - Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma. Nature communications. 2023 Article GET IT
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Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.
Science translational medicine.
2023
Academic Article
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Times cited: 45 -
An atlas of substrate specificities for the human serine/threonine kinome.
Nature.
2023
Academic Article
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Times cited: 448 -
A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.
Nature communications.
2022
Academic Article
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Times cited: 33 -
PI3K drives the de novo synthesis of coenzyme A from vitamin B5.
Nature.
2022
Academic Article
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Times cited: 78 -
PI3King the Environment for Growth: PI3K Activation Drives Transcriptome Changes That Support Oncogenic Growth.
Cancer research.
2022
Editorial Article
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Times cited: 3 -
Circling back to PTEN: Fumarate inhibits canonical tumor suppressor.
Molecular cell.
2022
Article
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Times cited: 2 -
Patient-Derived In Vitro and In Vivo Models of Cancer.
Advances in experimental medicine and biology.
2022
Academic Article
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Times cited: 8 -
A Functional Precision Oncology Approach to Identify Treatment Strategies for Myxofibrosarcoma Patients.
Molecular cancer research : MCR.
2021
Article
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Times cited: 10 -
Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential.
Proceedings of the National Academy of Sciences of the United States of America.
2021
Academic Article
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Times cited: 18 - Targeting Cullin-RING E3 Ubiquitin Ligase 4 by Small Molecule Modulators. Journal of cellular signaling. 2021 Academic Article GET IT
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Precision Targeting of pten-Null Triple-Negative Breast Tumors Guided by Electrophilic Metabolite Sensing.
ACS central science.
2020
Academic Article
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Times cited: 31 -
Obesity-associated Adipose Stromal Cells Promote Breast Cancer Invasion Through Direct Cell Contact and ECM Remodeling.
Advanced functional materials.
2020
Academic Article
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Times cited: 50 -
Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer.
Nature reviews. Endocrinology.
2020
Information Resource
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Times cited: 237 -
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.
Cell reports.
2019
Academic Article
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Times cited: 45 -
Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer.
Cancers.
2019
Academic Article
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Times cited: 54 -
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer.
The New England journal of medicine.
2018
Information Resource
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Times cited: 269 -
Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.
Nature.
2018
Article
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Times cited: 2 -
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.
Nature.
2018
Academic Article
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Times cited: 588 -
Cancer metabolism gets physical.
Science translational medicine.
2018
Information Resource
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Times cited: 36 -
Fenofibrate prevents skeletal muscle loss in mice with lung cancer.
Proceedings of the National Academy of Sciences of the United States of America.
2018
Academic Article
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Times cited: 97 -
Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity.
Immunity.
2017
Academic Article
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Times cited: 54 -
The PI3K Pathway in Human Disease.
Cell.
2017
Information Resource
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Times cited: 2312 -
Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine.
Cancer discovery.
2017
Academic Article
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Times cited: 848 -
Obesity and Cancer Mechanisms: Cancer Metabolism.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2016
Information Resource
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Times cited: 331 -
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.
Science signaling.
2015
Academic Article
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Times cited: 61 -
Analysis of intracellular PTEN signaling and secretion.
Methods (San Diego, Calif.).
2014
Information Resource
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Times cited: 11 -
Metformin and erlotinib synergize to inhibit basal breast cancer.
Oncotarget.
2014
Academic Article
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Times cited: 48 -
Molecular pathways: intercellular PTEN and the potential of PTEN restoration therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014
Information Resource
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Times cited: 43 -
A unified nomenclature and amino acid numbering for human PTEN.
Science signaling.
2014
Academic Article
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Times cited: 59 -
PTEN function: the long and the short of it.
Trends in biochemical sciences.
2014
Information Resource
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Times cited: 275 -
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 58 -
A secreted PTEN phosphatase that enters cells to alter signaling and survival.
Science (New York, N.Y.).
2013
Academic Article
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Times cited: 282 -
Survival factor NFIL3 restricts FOXO-induced gene expression in cancer.
Genes & development.
2013
Academic Article
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Times cited: 45 -
Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells.
Cancer biology & therapy.
2013
Academic Article
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Times cited: 32 -
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription.
Nature communications.
2013
Academic Article
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Times cited: 55 -
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.
Science (New York, N.Y.).
2009
Academic Article
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Times cited: 206 -
3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.
Cancer research.
2009
Academic Article
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Times cited: 128 -
Gab2-mediated signaling promotes melanoma metastasis.
The American journal of pathology.
2009
Academic Article
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Times cited: 74 -
Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina.
American journal of physiology. Heart and circulatory physiology.
2009
Academic Article
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Times cited: 52 -
Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability.
Cancer research.
2008
Academic Article
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Times cited: 102 -
Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro.
Blood.
2006
Academic Article
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Times cited: 144 -
Anti-VEGF antibody in experimental hepatoblastoma: suppression of tumor growth and altered angiogenesis.
Journal of pediatric surgery.
2003
Academic Article
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Times cited: 36