Kafsack, Bjorn F

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scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance. Nature microbiology. 2025 Academic Article GET IT
Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites. Pathogens (Basel, Switzerland). 2024 Academic Article GET IT
Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites. 2024 GET IT
Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome. Cell chemical biology. 2024 Academic Article GET IT
Times cited: 5
Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunity. 2024 GET IT
Sexual differentiation in human malaria parasites is regulated by competition between phospholipid metabolism and histone methylation. Nature microbiology. 2023 Academic Article GET IT
Times cited: 20
The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
Times cited: 14
A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency. Communications biology. 2023 Academic Article GET IT
Times cited: 7
Genome-wide profiling of histone modifications in Plasmodium falciparum using CUT&RUN. Life science alliance. 2022 Academic Article GET IT
Times cited: 4
Safe, Effective, and Inexpensive Clearance of Mycoplasma Contamination from Cultures of Apicomplexan Parasites with Sparfloxacin. Microbiology spectrum. 2022 Academic Article GET IT
Times cited: 2
Publisher Correction: The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites. 2022 GET IT
The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites. Nature microbiology. 2022 Academic Article GET IT
Times cited: 19
There and back again: malaria parasite single-cell transcriptomics comes full circle. Trends in parasitology. 2021 Comment GET IT
Times cited: 6
Activity Comparison of Epigenetic Modulators against the Hemoprotozoan Parasites Babesia divergens and Plasmodium falciparum. ACS infectious diseases. 2021 Academic Article GET IT
Times cited: 1
Telomere length dynamics in response to DNA damage in malaria parasites. iScience. 2021 Academic Article GET IT
Times cited: 7
Metabolic regulation of sexual commitment in Plasmodium falciparum. Current opinion in microbiology. 2020 Review GET IT
Times cited: 19
Activity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages. Antimicrobial agents and chemotherapy. 2020 Academic Article GET IT
Times cited: 25
Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases. ACS infectious diseases. 2020 Academic Article GET IT
Times cited: 21
Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters. Scientific reports. 2019 Academic Article GET IT
Times cited: 19
Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors. Journal of medicinal chemistry. 2019 Academic Article GET IT
Times cited: 33
Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum. Nature microbiology. 2018 Academic Article GET IT
Times cited: 90
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 70
Single-Cell Transcriptome Profiling of Protozoan and Metazoan Parasites. Trends in parasitology. 2018 Review GET IT
Times cited: 4
Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites. Nature. 2017 Academic Article GET IT
Times cited: 155
A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. Cell host & microbe. 2014 Academic Article GET IT
Times cited: 169
A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium. Nature. 2014 Academic Article GET IT
Times cited: 319
A transcriptional switch underlies commitment to sexual development in malaria parasites. Nature. 2014 Academic Article GET IT
Times cited: 376
Stress and sex in malaria parasites: Why does commitment vary?. Evolution, medicine, and public health. 2013 Academic Article GET IT
Whole-genome analysis of Plasmodium spp. Utilizing a new agilent technologies DNA microarray platform. Methods in molecular biology (Clifton, N.J.). 2013 Academic Article GET IT
Times cited: 19
New Agilent platform DNA microarrays for transcriptome analysis of Plasmodium falciparum and Plasmodium berghei for the malaria research community. Malaria journal. 2012 Academic Article GET IT
Times cited: 24
Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites. Cellular microbiology. 2010 Academic Article GET IT
Times cited: 64
Eating at the table of another: metabolomics of host-parasite interactions. Cell host & microbe. 2010 Review GET IT
Times cited: 77
Apicomplexan perforin-like proteins. Communicative & integrative biology. 2010 Academic Article GET IT
Times cited: 10
Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells. Science (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 234
Kinetic modeling of Toxoplasma gondii invasion. Journal of theoretical biology. 2007 Academic Article GET IT
Times cited: 23
The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasion and survival proteins. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 119
Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase. The Biochemical journal. 2004 Academic Article GET IT
Times cited: 48
Synchronous invasion of host cells by Toxoplasma gondii. Molecular and biochemical parasitology. 2004 Academic Article GET IT
Times cited: 56
The novel coccidian micronemal protein MIC11 undergoes proteolytic maturation by sequential cleavage to remove an internal propeptide. International journal for parasitology. 2004 Academic Article GET IT
Times cited: 25
Competition between two MHC binding registers in a single peptide processed from myelin basic protein influences tolerance and susceptibility to autoimmunity. The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 46

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Research

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Funding awarded

Identifying the Target of a Potent and Selective Inhibitor of Babesia Blood Stages. awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2022 - 2025
Regulation of Sexual Differentiation in Malaria Parasites awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2019 - 2025

missing activity Co-Investigator 2018 - 2024

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Background

education and training

M.S., The Johns Hopkins University Bloomberg School of Public Health , Molecular Microbiology & Immunology, Masters of Health Science in Bioinformatics
Ph.D., The Johns Hopkins University 2008
M.H.S., The Johns Hopkins University 2006
B.S., University of Washington 2001

VIVO Weill Cornell Medical College

Bjorn F Kafsack Associate Professor of Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

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