Gold, Ben S

Publications

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selected publications

Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase. Science advances. 2024 Academic Article GET IT
Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas. ACS medicinal chemistry letters. 2023 Academic Article GET IT
Times cited: 4
Editorial: Drug-resistant Mycobacterium tuberculosis. Frontiers in cellular and infection microbiology. 2023 Editorial Article GET IT
Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions. ACS infectious diseases. 2022 Academic Article GET IT
In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas. Journal of medicinal chemistry. 2022 Academic Article GET IT
Times cited: 13
Oxidative damage and delayed replication allow viable Mycobacterium tuberculosis to go undetected. Science translational medicine. 2021 Academic Article GET IT
Times cited: 13
Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis. Microbiology spectrum. 2021 Academic Article GET IT
Times cited: 1
A Multistress Model for High Throughput Screening Against Nonreplicating Mycobacterium tuberculosis. Methods in molecular biology (Clifton, N.J.). 2021 Article GET IT
Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases. Frontiers in microbiology. 2020 Academic Article GET IT
Times cited: 12
Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA. mBio. 2019 Academic Article GET IT
Times cited: 7
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis. ACS infectious diseases. 2019 Academic Article GET IT
Times cited: 10
Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma. The Journal of antibiotics. 2019 Academic Article GET IT
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science (New York, N.Y.). 2019 Academic Article GET IT
Times cited: 53
Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis. ACS infectious diseases. 2018 Academic Article GET IT
Times cited: 24
Targeting the Proteostasis Network for Mycobacterial Drug Discovery. ACS infectious diseases. 2018 Review GET IT
Times cited: 53
Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis. ACS infectious diseases. 2018 Academic Article GET IT
Times cited: 17
Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 59
Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria. Journal of visualized experiments : JoVE. 2016 Academic Article GET IT
Times cited: 8
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS pathogens. 2016 Academic Article GET IT
Times cited: 222
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 72
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis. Journal of medicinal chemistry. 2016 Academic Article GET IT
Times cited: 39
Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy. 2015 Academic Article GET IT
Times cited: 35
Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis. ACS infectious diseases. 2015 Academic Article GET IT
Times cited: 27
A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis. Methods in molecular biology (Clifton, N.J.). 2015 Academic Article GET IT
Times cited: 35
Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis. Journal of medicinal chemistry. 2014 Academic Article GET IT
Times cited: 58
Benzimidazole-based compounds kill Mycobacterium tuberculosis. European journal of medicinal chemistry. 2014 Academic Article GET IT
Times cited: 33
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 94
Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite. Molecular microbiology. 2009 Academic Article GET IT
Times cited: 67
Identification of a copper-binding metallothionein in pathogenic mycobacteria. Nature chemical biology. 2008 Academic Article GET IT
Times cited: 174
A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis. Tuberculosis (Edinburgh, Scotland). 2008 Review GET IT
Times cited: 51
The signatures of autozygosity among patients with colorectal cancer. Cancer research. 2008 Academic Article GET IT
Times cited: 43
Selective killing of nonreplicating mycobacteria. Cell host & microbe. 2008 Academic Article GET IT
Times cited: 159
Real-time measurement of in vitro transcription. Nucleic acids research. 2004 Academic Article GET IT
Times cited: 36
Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 231
ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infection and immunity. 2002 Academic Article GET IT
Times cited: 411
The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages. Molecular microbiology. 2001 Academic Article GET IT
Times cited: 194
Transcriptional control of the iron-responsive fxbA gene by the mycobacterial regulator IdeR. Journal of bacteriology. 1999 Academic Article GET IT
Times cited: 86
Identification and characterization of two divergently transcribed iron regulated genes in Mycobacterium tuberculosis. Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 1999 Academic Article GET IT
Times cited: 44
Nucleotide sequence of a preferred maize chloroplast genome template for in vitro DNA synthesis. Proceedings of the National Academy of Sciences of the United States of America. 1987 Academic Article GET IT
Times cited: 41

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Research

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Funding awarded

Identification of NadD and NadE hits and leads for TB awarded by Bill & Melinda Gates Foundation Principal Investigator 2024 - 2025
Screening NadE and NadD awarded by Bill & Melinda Gates Foundation Principal Investigator 2022 - 2024
missing activity Principal Investigator 2021 - 2024

Phosphopantetheinyl transferase (PptT) inhibitors for treatment of TB- INV-040480 awarded by Bill & Melinda Gates Foundation Co-Investigator 2022 - 2023

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Background

education and training

M.A., Indiana University 96
Ph.D., New York University 2001
B.S., Indiana University 1993

Contact

full name

Ben S Gold

primary email

bsg2001@med.cornell.edu

VIVO Weill Cornell Medical College

Ben S Gold Associate Professor of Research in Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email