Nimigean, Crina

Publications

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selected publications

Calcium-gated potassium channel blockade via membrane-facing fenestrations. Nature chemical biology. 2023 Academic Article GET IT
A pentameric TRPV3 channel with a dilated pore. Nature. 2023 Academic Article GET IT
Times cited: 1
Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel. Nature structural & molecular biology. 2023 Academic Article GET IT
Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nature communications. 2023 Academic Article GET IT
Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nature communications. 2022 Academic Article GET IT
Anionic lipids unlock the gates of select ion channels in the pacemaker family. Nature structural & molecular biology. 2022 Academic Article GET IT
35 years of channelling potassium ions. Nature. 2022 Article GET IT
Ball-and-Chain Inactivation in Potassium Channels. Annual review of biophysics. 2022 Review GET IT
Correlation of membrane protein conformational and functional dynamics. Nature communications. 2021 Academic Article GET IT
Correlating ion channel structure and function. Methods in enzymology. 2021 Article GET IT
Mechanistic insights into volatile anesthetic modulation of K2P channels. eLife. 2020 Academic Article GET IT
Times cited: 10
Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel. Nature communications. 2020 Academic Article GET IT
Times cited: 10
An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2. Cell reports. 2020 Academic Article GET IT
Times cited: 57
Selectivity filter ion binding affinity determines inactivation in a potassium channel. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 23
Time-resolved cryo-EM using Spotiton. Nature methods. 2020 Academic Article GET IT
Times cited: 80
Ball-and-chain inactivation in a calcium-gated potassium channel. Nature. 2020 Academic Article GET IT
Reconstitution of Membrane Proteins into Platforms Suitable for Biophysical and Structural Analyses. Methods in molecular biology (Clifton, N.J.). 2020 Article GET IT
Times cited: 2
Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel. eLife. 2019 Academic Article GET IT
Times cited: 32
Identifying coupled clusters of allostery participants through chemical shift perturbations. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 21
Structural basis of Ca²⁺-dependent activation and lipid transport by a TMEM16 scramblase. eLife. 2019 Academic Article GET IT
Times cited: 75
Fluorescence Titrations to Determine the Binding Affinity of Cyclic Nucleotides to SthK Ion Channels. Bio-protocol. 2018 Academic Article GET IT
An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel. Nature communications. 2018 Academic Article GET IT
Times cited: 40
Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures. eLife. 2018 Academic Article GET IT
Times cited: 38
Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK. The Journal of general physiology. 2018 Academic Article GET IT
Times cited: 23
Stopped-Flow Fluorometric Ion Flux Assay for Ligand-Gated Ion Channel Studies. 2018 GET IT
Times cited: 10
High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer. Structure (London, England : 1993). 2017 Academic Article GET IT
Times cited: 10
Mechanism of activation at the selectivity filter of the KcsA K⁺ channel. eLife. 2017 Academic Article GET IT
Times cited: 35
Identification of a pre-active conformation of a pentameric channel receptor. eLife. 2017 Academic Article GET IT
Times cited: 28
Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels. Nature communications. 2016 Academic Article GET IT
Times cited: 24
Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles. The Journal of general physiology. 2016 Academic Article GET IT
Times cited: 17
Calcium ions open a selectivity filter gate during activation of the MthK potassium channel. Nature communications. 2015 Academic Article GET IT
Times cited: 31
Regulation of ion channel function by the host lipid bilayer examined by a stopped-flow spectrofluorometric assay. Biophysical journal. 2014 Academic Article GET IT
Times cited: 28
A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 12
Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1. Nature communications. 2014 Academic Article GET IT
Times cited: 57
Molecular interactions involved in proton-dependent gating in KcsA potassium channels. The Journal of general physiology. 2013 Academic Article GET IT
Times cited: 21
Preparation of uniformly isotope labeled KcsA for solid state NMR: expression, purification, reconstitution into liposomes and functional assay. Protein expression and purification. 2013 Academic Article GET IT
Times cited: 22
The voltage-dependent gate in MthK potassium channels is located at the selectivity filter. Nature structural & molecular biology. 2012 Academic Article GET IT
Times cited: 57
Structural correlates of selectivity and inactivation in potassium channels. Biochimica et biophysica acta. 2011 Information Resource GET IT
Times cited: 62
Mechanism for selectivity-inactivation coupling in KcsA potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 72
Non-vesicular transfer of membrane proteins from nanoparticles to lipid bilayers. The Journal of general physiology. 2011 Academic Article GET IT
Times cited: 23
Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 55
Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nature structural & molecular biology. 2009 Academic Article GET IT
Times cited: 147
Molecular mechanism of pH sensing in KcsA potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 122
The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution. Structure (London, England : 1993). 2007 Academic Article GET IT
Times cited: 50
Ligand binding and activation in a prokaryotic cyclic nucleotide-modulated channel. Journal of molecular biology. 2007 Academic Article GET IT
Times cited: 19
Calcium-dependent gating of MthK, a prokaryotic potassium channel. The Journal of general physiology. 2006 Academic Article GET IT
Times cited: 47
A radioactive uptake assay to measure ion transport across ion channel-containing liposomes. Nature protocols. 2006 Academic Article GET IT
Times cited: 28
A cyclic nucleotide modulated prokaryotic K+ channel. The Journal of general physiology. 2004 Academic Article GET IT
Times cited: 73
Electrostatic tuning of ion conductance in potassium channels. Biochemistry. 2003 Academic Article GET IT
Times cited: 98
Slo1 tail domains, but not the Ca2+ bowl, are required for the beta 1 subunit to increase the apparent Ca2+ sensitivity of BK channels. The Journal of general physiology. 2002 Academic Article GET IT
Times cited: 40
Na+ block and permeation in a K+ channel of known structure. The Journal of general physiology. 2002 Academic Article GET IT
Times cited: 102
Functional coupling of the beta(1) subunit to the large conductance Ca(2+)-activated K(+) channel in the absence of Ca(2+). Increased Ca(2+) sensitivity from a Ca(2+)-independent mechanism. The Journal of general physiology. 2000 Academic Article GET IT
Times cited: 74
Ca2+-dependent gating mechanisms for dSlo, a large-conductance Ca2+-activated K+ (BK) channel. Biophysical journal. 1999 Academic Article GET IT
Times cited: 11
The beta subunit increases the Ca2+ sensitivity of large conductance Ca2+-activated potassium channels by retaining the gating in the bursting states. The Journal of general physiology. 1999 Academic Article GET IT
Times cited: 114

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Research

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Co-investigator Network

Funding awarded

Uncovering druggable allosteric sites in HCN channels awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2024 - 2029
Structural dynamics in cyclic nucleotide-modulated channels awarded by National Institute of General Medical Sciences Principal Investigator 2021 - 2025
Molecular Mechanisms of Potassium Channel Permeation and Gating awarded by National Institute of General Medical Sciences Principal Investigator 2019 - 2024

Identification of potential drug binding sites within allosteric networks in cyclic nucleotide modulated channels awarded by National Institute of General Medical Sciences Key Personnel 2022 - 2024

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Background

education and training

Ph.D., University of Miami 1999
B.S., University of Bucharest (Romania) 1995
M.S., University of Bucharest (Romania) 1995

Contact

full name

Crina Nimigean

primary email

crn2002@med.cornell.edu

VIVO Weill Cornell Medical College

Crina Nimigean Professor of Physiology and Biophysics in Anesthesiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email