Wen, Duancheng

Publications

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selected publications

Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation. 2023 GET IT
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells. Protein & cell. 2023 Academic Article GET IT
Generation of sex-reversed female clonal mice via CRISPR/Cas9-mediated Y chromosome deletion in male embryonic stem cells. 2022 GET IT
Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability. Nature cell biology. 2021 Academic Article GET IT
Times cited: 22
Exogenous insulin-like growth factor 1 accelerates growth and maturation of follicles in human cortical xenografts and increases ovarian output in mice. F&S science. 2021 Academic Article GET IT
Times cited: 5
Breakthrough of interspecific chimerism: blocking apoptosis. Cell regeneration (London, England). 2021 Academic Article GET IT
Generation of Sex-Reversed Female Clonal Mice via CRISPR-Cas9-Mediated Y Chromosome Deletion in Male Embryonic Stem Cells. The CRISPR journal. 2021 Academic Article GET IT
Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest. Stem cells (Dayton, Ohio). 2020 Academic Article GET IT
Times cited: 2
Long noncoding RNAs sustain high expression levels of exogenous octamer-binding protein 4 by sponging regulatory microRNAs during cellular reprogramming. The Journal of biological chemistry. 2019 Academic Article GET IT
Times cited: 10
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity. Nature cell biology. 2018 Academic Article GET IT
Times cited: 40
Histone variant H3.3-mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos. The Journal of biological chemistry. 2018 Academic Article GET IT
Times cited: 40
Activated ovarian endothelial cells promote early follicular development and survival. Journal of ovarian research. 2017 Academic Article GET IT
Times cited: 7
Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells. Nature communications. 2016 Academic Article GET IT
Times cited: 28
Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron. 2015 Academic Article GET IT
Times cited: 227
Genome editing a mouse locus encoding a variant histone, H3.3B, to report on its expression in live animals. Genesis (New York, N.Y. : 2000). 2014 Academic Article GET IT
Times cited: 7
Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs. Cell stem cell. 2014 Academic Article GET IT
Times cited: 44
Histone variant H3.3 is an essential maternal factor for oocyte reprogramming. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 76
Completely ES cell-derived mice produced by tetraploid complementation using inner cell mass (ICM) deficient blastocysts. PloS one. 2014 Academic Article GET IT
Times cited: 22
Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells. Cell. 2013 Academic Article GET IT
Times cited: 212
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 2010 Academic Article GET IT
Times cited: 993
Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse. Developmental dynamics : an official publication of the American Association of Anatomists. 2009 Academic Article GET IT
Times cited: 128
CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells. Stem cells (Dayton, Ohio). 2008 Academic Article GET IT
Times cited: 31
The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation. Development (Cambridge, England). 2007 Academic Article GET IT
Times cited: 173
Non-equivalence of cloned and clonal mice. Current biology : CB. 2005 Article GET IT
Times cited: 19
Hybrid embryos produced by transferring panda or cat somatic nuclei into rabbit MII oocytes can develop to blastocyst in vitro. Journal of experimental zoology. Part A, Comparative experimental biology. 2005 Academic Article GET IT
Times cited: 29
Blastocysts produced by nuclear transfer between chicken blastodermal cells and rabbit oocytes. Molecular reproduction and development. 2004 Academic Article GET IT
Times cited: 30
Comparison of developmental capacity for intra- and interspecies cloned cat (Felis catus) embryos. Molecular reproduction and development. 2003 Academic Article GET IT
Times cited: 38
In vitro development and mitochondrial fate of macaca-rabbit cloned embryos. Molecular reproduction and development. 2003 Academic Article GET IT
Times cited: 62
Asynchronous cytoplast and karyoplast transplantation reveals that the cytoplasm determines the developmental fate of the nucleus in mouse oocytes. Molecular reproduction and development. 2003 Academic Article GET IT
Times cited: 12
Development of mouse embryos derived from oocytes reconstructed by metaphase I spindle transfer. Zygote (Cambridge, England). 2003 Academic Article GET IT
Times cited: 6
Interspecies implantation and mitochondria fate of panda-rabbit cloned embryos. Biology of reproduction. 2002 Academic Article GET IT
Times cited: 115
[Interspecies nuclear transfer using nonquiescent somatic cell]. Shi yan sheng wu xue bao. 2002 Academic Article GET IT
Times cited: 3

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Research

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Funding awarded

Direct generation of complex genetically-modified mouse models via embryonic stem cells awarded by National Institutes of Health, Office of the Director Principal Investigator 2022 - 2025
H3.3-mediated epigenetic regulation of developmental bivalent genes for reprogramming and differentiation awarded by National Institute of General Medical Sciences Principal Investigator 2018 - 2025
Contribution of H3.3-mediated chromatin dynamics to stem cell pluripotency and developmental potential Principal Investigator 2018 - 2021

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Background

education and training

B.A., Hunan Agricultural University (China) 1984
Ph.D., Chinese Academy of Sciences, Beijing (China) 2003
M.S., Chinese Academy of Medical Sciences (China) 1995

Contact

full name

Duancheng Wen

primary email

duw2001@med.cornell.edu

Identity

eRA Commons ID

DUANCHENGWEN

VIVO Weill Cornell Medical College

Duancheng Wen Assistant Professor of Reproductive Medicine Research in Obstetrics and Gynecology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Identity

eRA Commons ID