selected publications
- Quantitative Whole-Body Imaging of I-124-labeled Adeno-Associated Viral Vector Biodistribution in Nonhuman Primates. Human gene therapy. 2020 Academic Article GET IT
- Intrathecal 99mTc-DTPA imaging of molecular passage from lumbar cerebrospinal fluid to brain and periphery in humans. Alzheimer's & dementia (Amsterdam, Netherlands). 2020 Academic Article GET IT
- Neurophysiological Biomarkers of Parkinson's Disease. Journal of Parkinson's disease. 2020 Academic Article GET IT
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Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury.
Brain : a journal of neurology.
2019
Academic Article
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Times cited: 3 -
Statistical Considerations for Planning Clinical Trials with Quantitative Imaging Biomarkers.
Journal of the National Cancer Institute.
2019
Review
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Times cited: 3 -
18F-FPEB PET/CT Shows mGluR5 Upregulation in Parkinson's Disease.
Journal of neuroimaging : official journal of the American Society of Neuroimaging.
2018
Academic Article
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Times cited: 7 -
Noninvasive PK11195-PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease.
Journal of neuroimaging : official journal of the American Society of Neuroimaging.
2018
Academic Article
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Times cited: 9 -
[11 C]arachidonic acid incorporation measurement in human brain: Optimization for clinical use.
Synapse (New York, N.Y.).
2017
Academic Article
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Times cited: 1 -
Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation.
Multiple sclerosis and related disorders.
2017
Academic Article
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Times cited: 13 -
Three-Dimensional Dosimetry for Radiation Safety Estimates from Intrathecal Administration.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2017
Academic Article
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Times cited: 2 -
Automated segmentation of MR imaging to determine normative central nervous system cerebrospinal fluid volumes in healthy volunteers.
Clinical imaging.
2017
Academic Article
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Times cited: 12 - Yttrium-90 microsphere radioembolotherapy in a patient with spontaneously ruptured hepatocellular carcinoma. Clinical imaging. 2015 Academic Article GET IT
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Repeatability of 18F-FDG PET/CT in Advanced Non-Small Cell Lung Cancer: Prospective Assessment in 2 Multicenter Trials.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2015
Academic Article
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Times cited: 61 -
Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2015
Academic Article
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Times cited: 15 -
Variability in assessing treatment response: metastatic colorectal cancer as a paradigm.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014
Academic Article
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Times cited: 9 -
Repeatability of quantitative FDG-PET/CT and contrast-enhanced CT in recurrent ovarian carcinoma: test-retest measurements for tumor FDG uptake, diameter, and volume.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014
Academic Article
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Times cited: 30 -
(11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2013
Academic Article
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Times cited: 14 -
18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: a first-in-human study of radiochemical safety, biokinetics, and radiation dosimetry.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2013
Academic Article
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Times cited: 64 -
Equivalent dynamic human brain NK1-receptor occupancy following single-dose i.v. fosaprepitant vs. oral aprepitant as assessed by PET imaging.
Clinical pharmacology and therapeutics.
2012
Academic Article
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Times cited: 30 - Measurement of tumor volumes improves RECIST-based response assessments in advanced lung cancer. Translational oncology. 2012 Academic Article GET IT
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X-ray computed tomography: semiautomated volumetric analysis of late-stage lung tumors as a basis for response assessments.
International journal of biomedical imaging.
2011
Academic Article
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Times cited: 17 -
Quantitative imaging test approval and biomarker qualification: interrelated but distinct activities.
Radiology.
2011
Academic Article
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Times cited: 54 -
Data sets for the qualification of volumetric CT as a quantitative imaging biomarker in lung cancer.
Optics express.
2010
Academic Article
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Times cited: 14 -
Biodistribution and radiation dosimetry of a positron emission tomographic ligand, 18F-SP203, to image metabotropic glutamate subtype 5 receptors in humans.
European journal of nuclear medicine and molecular imaging.
2010
Academic Article
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Times cited: 24 -
Change in lung tumor volume as a biomarker of treatment response: a critical review of the evidence.
Annals of oncology : official journal of the European Society for Medical Oncology.
2010
Review
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Times cited: 60 -
Alteration of PHYA expression change circadian rhythms and timing of bud set in Populus.
Plant molecular biology.
2010
Academic Article
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Times cited: 40 -
The use of volumetric CT as an imaging biomarker in lung cancer.
Academic radiology.
2010
Academic Article
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Times cited: 37 -
Volumetric CT in lung cancer: an example for the qualification of imaging as a biomarker.
Academic radiology.
2010
Academic Article
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Times cited: 33 -
Development of the 2nd generation neurokinin-1 receptor antagonist LY686017 for social anxiety disorder.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2009
Academic Article
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Times cited: 37 -
Dopamine transporter binding in smokers and nonsmokers.
Clinical nuclear medicine.
2007
Academic Article
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Times cited: 40 -
Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysis.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007
Academic Article
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Times cited: 22 -
Comparison of region-of-interest analysis and human observers in the diagnosis of Parkinson's disease using [99mTc]TRODAT-1 and SPECT.
Physics in medicine and biology.
2006
Academic Article
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Times cited: 25 -
Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates.
Nuclear medicine communications.
2005
Academic Article
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Times cited: 14 -
[99mTc]TRODAT-1 SPECT imaging correlates with odor identification in early Parkinson disease.
Neurology.
2005
Academic Article
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Times cited: 122 -
Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters.
Synapse (New York, N.Y.).
2005
Academic Article
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Times cited: 20 -
Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2005
Academic Article
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Times cited: 59 -
Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's disease.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2005
Academic Article
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Times cited: 170 -
Weaving single photon imaging into new drug development.
Molecular imaging and biology.
2005
Review
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Times cited: 3 -
Pilot study on the effect of estrogen replacement therapy on brain dopamine transporter availability in healthy, postmenopausal women.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
2004
Academic Article
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Times cited: 48 -
Differences in [99mTc]TRODAT-1 SPECT binding to dopamine transporters in patients with multiple system atrophy and Parkinson's disease.
European journal of nuclear medicine and molecular imaging.
2004
Academic Article
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Times cited: 27 -
Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease.
Parkinsonism & related disorders.
2004
Academic Article
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Times cited: 43 -
PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain.
Synapse (New York, N.Y.).
2004
Academic Article
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Times cited: 97 -
Biodistribution and imaging with (123)I-ADAM: a serotonin transporter imaging agent.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2004
Academic Article
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Times cited: 48 -
Greater availability of brain dopamine transporters in major depression shown by [99m Tc]TRODAT-1 SPECT imaging.
The American journal of psychiatry.
2003
Academic Article
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Times cited: 96 -
Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER.
Nuclear medicine and biology.
2003
Academic Article
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Times cited: 66 -
Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society.
2003
Academic Article
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Times cited: 43 - Imaging-based measures of disease progression in clinical trials of disease-modifying drugs for Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2003 Review GET IT
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Evaluation of [3H]LY341495 for labeling group II metabotropic glutamate receptors in vivo.
Nuclear medicine and biology.
2003
Academic Article
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Times cited: 6 -
Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter.
Nuclear medicine and biology.
2003
Academic Article
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Times cited: 79 -
Biomarkers in psychotropic drug development.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
2002
Academic Article
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Times cited: 8 -
Chest tube insertion as a potential source of false-positive FDG-positron emission tomographic results.
Clinical nuclear medicine.
2002
Academic Article
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Times cited: 21 -
Dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2001
Academic Article
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Times cited: 520 -
Striatal dopamine transporters and cognitive functioning in healthy men and women.
The American journal of psychiatry.
2001
Academic Article
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Times cited: 250 -
Horseshoe kidney on FDG positron emission tomographic imaging is easily confused with malignancy.
Clinical nuclear medicine.
2001
Academic Article
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Times cited: 4 -
Evaluation of recurrent squamous cell carcinoma of the head and neck with FDG positron emission tomography.
Clinical nuclear medicine.
2001
Academic Article
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Times cited: 71 - Gallbladder stone shown on a hepatobiliary scan. Clinical nuclear medicine. 2001 Academic Article GET IT
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Ipsilateral and contralateral thalamic hypometabolism as a predictor of outcome after temporal lobectomy for seizures.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2000
Academic Article
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Times cited: 67 -
Simplified quantification of dopamine transporters in humans using [99mTc]TRODAT-1 and single-photon emission tomography.
European journal of nuclear medicine.
2000
Academic Article
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Times cited: 31 -
Regional cerebral glucose metabolism in healthy volunteers determined by fluordeoxyglucose positron emission tomography: appearance and variance in the transaxial, coronal, and sagittal planes.
Clinical nuclear medicine.
2000
Academic Article
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Times cited: 22 -
Regional cerebral distribution of [Tc-99m] hexylmethylpropylene amineoxine in patients with progressive aphasia.
Journal of neuroimaging : official journal of the American Society of Neuroimaging.
2000
Academic Article
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Times cited: 4 - Noninvasive visualization of serotonergically mediated pathophysiology. AJNR. American journal of neuroradiology. 2000 Editorial Article GET IT
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Binding of [99mTc]TRODAT-1 to dopamine transporters in patients with Parkinson's disease and in healthy volunteers.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2000
Academic Article
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Times cited: 158 - Striatal dopamine transporter binding assessed by [I-123]IPT and single photon emission computed tomography in patients with early Parkinson's disease: implications for a preclinical diagnosis. Archives of neurology. 2000 Academic Article GET IT
- Single photon emission tomography imaging in parkinsonian disorders: a review. Behavioural neurology. 2000 Academic Article GET IT
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Effects of a 99mTc-labeled murine immunoglobulin M antibody to CD15 antigens on human granulocyte membranes in healthy volunteers.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1999
Academic Article
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Times cited: 21 -
Effects of age on dopamine transporters in healthy humans.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1999
Academic Article
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Times cited: 99 -
Logistic discriminant parametric mapping: a novel method for the pixel-based differential diagnosis of Parkinson's disease.
European journal of nuclear medicine.
1999
Academic Article
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Times cited: 26 -
A simplified method to determine [99mTc]TRODAT-1 in human plasma.
Nuclear medicine and biology.
1999
Academic Article
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Times cited: 1 -
Simplified reference region model for the kinetic analysis of [99mTc]TRODAT-1 binding to dopamine transporters in nonhuman primates using single-photon emission tomography.
European journal of nuclear medicine.
1999
Academic Article
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Times cited: 63 -
Radiation dosimetry of a 99mTc-labeled IgM murine antibody to CD15 antigens on human granulocytes.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1999
Academic Article
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Times cited: 12 -
Effects of development of host immunity on the biodistribution of xenogeneic MHC non-restricted cytotoxic T cells: implications for adoptive cell therapy of cancer.
International journal of oncology.
1999
Academic Article
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Times cited: 5 -
Kinetic modeling of [99mTc]TRODAT-1: a dopamine transporter imaging agent.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1999
Academic Article
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Times cited: 37 -
Limbic activation during cue-induced cocaine craving.
The American journal of psychiatry.
1999
Academic Article
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Times cited: 1132 -
Biodistribution and dosimetry of TRODAT-1: a technetium-99m tropane for imaging dopamine transporters.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1998
Academic Article
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Times cited: 56 -
Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia.
The American journal of psychiatry.
1998
Academic Article
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Times cited: 371 -
Dopaminergic deficit in amyotrophic lateral sclerosis assessed with [I-123] IPT single photon emission computed tomography.
Journal of neurology, neurosurgery, and psychiatry.
1998
Academic Article
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Times cited: 68 -
Reduced striatal dopaminergic innervation shown by IPT and SPECT in patients under neuroleptic treatment: need for levodopa therapy?.
Psychiatry research.
1998
Academic Article
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Times cited: 19 -
Persistent cognitive and motor deficits following acute hydrogen sulphide poisoning.
Occupational medicine (Oxford, England).
1998
Academic Article
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Times cited: 33 - Neuroimaging of acupuncture in patients with chronic pain. Journal of Alternative and Complementary Medicine. 1997 Article
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Focal acute tubular necrosis in a renal allograft.
Transplantation.
1997
Academic Article
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Times cited: 4 -
Large-scale generation of affinity-purified recombinant phytochrome chromopeptide.
Photochemistry and photobiology.
1997
Academic Article
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Times cited: 36 -
HMPAO SPECT brain imaging in treatment-resistant depression.
Progress in neuro-psychopharmacology & biological psychiatry.
1997
Academic Article
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Times cited: 39 -
Effect of chromophore exchange on the resonance Raman spectra of recombinant phytochromes.
FEBS letters.
1997
Academic Article
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Times cited: 29 -
A proposal for minimum detectable compartment in MIRD dosimetry modelling.
Physics in medicine and biology.
1997
Academic Article
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Times cited: 3 -
Effects of aging on the cerebral distribution of technetium-99m hexamethylpropylene amine oxime in healthy humans.
European journal of nuclear medicine.
1997
Academic Article
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Times cited: 29 -
Lateralized changes in regional cerebral blood flow during performance of verbal and facial recognition tasks: correlations with performance and "effort".
Brain and cognition.
1997
Academic Article
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Times cited: 46 -
PET regional cerebral blood flow change during working and declarative memory: relationship with task performance.
Neuropsychology.
1997
Academic Article
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Times cited: 37 -
Relationship between clinical features of Parkinson's disease and presynaptic dopamine transporter binding assessed with [123I]IPT and single-photon emission tomography.
European journal of nuclear medicine.
1997
Academic Article
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Times cited: 143 -
P-[18F]-MPPF: a potential radioligand for PET studies of 5-HT1A receptors in humans.
Synapse (New York, N.Y.).
1997
Academic Article
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Times cited: 87 -
Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents.
Journal of medicinal chemistry.
1997
Academic Article
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Times cited: 144 -
Iodine-123-IPT SPECT imaging of CNS dopamine transporters: nonlinear effects of normal aging on striatal uptake values.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1996
Academic Article
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Times cited: 60 -
In vivo SPECT imaging of 5-HT1A receptors with [123I]p-MPPI in nonhuman primates.
Synapse (New York, N.Y.).
1996
Academic Article
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Times cited: 30 -
Relationships between verbal memory performance and the cerebral distribution of fluorodeoxyglucose in patients with schizophrenia.
Biological psychiatry.
1996
Academic Article
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Times cited: 21 -
Case report: failure of adrenal scintigraphy to exhibit 131I cholesterol uptake in a CT-demonstrated, surgically proven aldosteronoma.
The American journal of the medical sciences.
1996
Academic Article
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Times cited: 8 -
Neuropsychiatry of 18q- syndrome.
American journal of medical genetics.
1996
Academic Article
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Times cited: 33 -
Cerebral HMPAO SPECT in patients with major depression and healthy volunteers.
Progress in neuro-psychopharmacology & biological psychiatry.
1996
Academic Article
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Times cited: 19 -
Cerebral blood flow changes in limbic regions induced by unsolvable anagram tasks.
The American journal of psychiatry.
1996
Academic Article
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Times cited: 84 -
Stimulating technetium-99m cerebral perfusion studies with a three-dimensional Hoffmann brain phantom: collimator and filter selection in SPECT neuroimaging.
Annals of nuclear medicine.
1996
Academic Article
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Times cited: 18 -
Dosimetry of an iodine-123-labeled tropane to image dopamine transporters.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1996
Academic Article
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Times cited: 45 - I123-Iofetamine (IMP) spect brain imaging in depressed patients: Normalization of temporal lobe asymmetry during clinical recovery. Depression. 1995 Article
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Mood effects on limbic blood flow correlate with emotional self-rating: a PET study with oxygen-15 labeled water.
Psychiatry research.
1995
Academic Article
GET IT
Times cited: 170 -
Function of phytochrome A in potato plants as revealed through the study of transgenic plants.
Plant physiology.
1995
Academic Article
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Times cited: 35 -
Postpartum fever.
American family physician.
1995
Review
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Times cited: 4 -
Resting cerebral glucose metabolism in first-episode and previously treated patients with schizophrenia relates to clinical features.
Archives of general psychiatry.
1995
Academic Article
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Times cited: 131 -
Dosimetry of a D2/D3 dopamine receptor antagonist that can be used with PET or SPECT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1995
Academic Article
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Times cited: 12 -
Regional cerebral function determined by FDG-PET in healthy volunteers: normal patterns and changes with age.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1995
Academic Article
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Times cited: 186 - Normative neuropsychological test performance: effects of age, education, gender and ethnicity. Applied neuropsychology. 1995 Academic Article GET IT
- Cognitive Functioning and Neuroanatomic Volume Measures in Schizophrenia. Neuropsychology. 1995 Article
- Developmental and photobiological factors affecting photoperiodic induction in Arabidopsis thaliana Heynh. landsberg erecta. Journal of Experimental Botany. 1995 Article GET IT
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Sex differences in regional cerebral glucose metabolism during a resting state.
Science (New York, N.Y.).
1995
Academic Article
GET IT
Times cited: 307 -
Direct vesicoureteral scintigraphy: quantifying early outcome predictors in children with primary reflux.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1994
Academic Article
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Times cited: 34 -
The efficacy of iodine-123-MIBG as a screening test for pheochromocytoma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1994
Academic Article
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Times cited: 75 -
Magnetic resonance imaging in schizophrenia: relationship with clinical measures.
Schizophrenia research.
1994
Academic Article
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Times cited: 27 -
Clinical subtypes of schizophrenia: differences in brain and CSF volume.
The American journal of psychiatry.
1994
Academic Article
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Times cited: 117 -
Biodistribution and dosimetry of iodine-123-IBF: a potent radioligand for imaging the D2 dopamine receptor.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1993
Academic Article
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Times cited: 18 -
Cholescintigraphy in the diagnosis of acute cholecystitis: morphine augmentation is superior to delayed imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1993
Academic Article
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Times cited: 36 -
A simplified method for quantitation of iodine-123 iodobenzamide in human plasma: a technical note.
European journal of nuclear medicine.
1993
Academic Article
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Times cited: 2 -
The dosimetry of iodine-123-labeled TISCH: a SPECT imaging agent for the D1 dopamine receptor.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1993
Academic Article
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Times cited: 9 -
Characterization of radioiodinated TISCH: a high-affinity and selective ligand for mapping CNS D1 dopamine receptor.
Journal of neurochemistry.
1992
Academic Article
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Times cited: 18 -
Temporal lobe asymmetry with iofetamine (IMP) SPECT imaging in patients with major depression.
Journal of affective disorders.
1992
Academic Article
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Times cited: 37 -
Deep gray matter hypointensity patterns with aging in healthy adults: MR imaging at 1.5 T.
Radiology.
1991
Academic Article
GET IT
Times cited: 57 -
Volunteers for biomedical research. Recruitment and screening of normal controls.
Archives of general psychiatry.
1991
Academic Article
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Times cited: 162 -
Neuropsychological function in schizophrenia. Selective impairment in memory and learning.
Archives of general psychiatry.
1991
Academic Article
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Times cited: 1023 -
Magnetic resonance imaging in schizophrenia. I. Volumetric analysis of brain and cerebrospinal fluid.
Archives of general psychiatry.
1991
Academic Article
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Times cited: 88 -
Gender differences in age effect on brain atrophy measured by magnetic resonance imaging.
Proceedings of the National Academy of Sciences of the United States of America.
1991
Academic Article
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Times cited: 342 -
Relations among clinical scales in schizophrenia.
The American journal of psychiatry.
1991
Academic Article
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Times cited: 140 -
Analysis of brain and cerebrospinal fluid volumes with MR imaging. Part I. Methods, reliability, and validation.
Radiology.
1991
Academic Article
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Times cited: 242 - Atrophic vaginitis. Medical Aspects of Human Sexuality. 1983 Article
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A light and electron microscopic study of the human ovarian ligament.
Acta anatomica.
1982
Academic Article
GET IT
Times cited: 2 -
Malignant hyperthermia following intravenous iodinated contrast media. Report of a fatal case.
Diagnostic gynecology and obstetrics.
1981
Review
GET IT
Times cited: 4