Butelman, Eduardo

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Combined single-cell profiling of chromatin-transcriptome and splicing across brain cell types, regions and disease state. Nature biotechnology. 2025 Academic Article GET IT
Quantitative Economon Model of Transactions for Drugs and Other Commodities. 2025 GET IT
Sex and Hormonal Effects on Drug Cue Reactivity and Its Regulation in Human Addiction. Biological psychiatry. 2025 Academic Article GET IT
Peripheral Blood Cytokines as Markers of Longitudinal Change in White Matter Microstructure Following Inpatient Treatment for Opioid Use Disorders. Biological psychiatry global open science. 2025 Academic Article GET IT
Times cited: 1
Sex disparities in outcome of medication-assisted therapy of opioid use disorder: Nationally representative outpatient clinic data. Drug and alcohol dependence. 2025 Academic Article GET IT
Times cited: 3
Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction. 2024 GET IT
Serum cytokines and inflammatory proteins in individuals with heroin use disorder: potential mechanistically based biomarkers for diagnosis. Translational psychiatry. 2024 Academic Article GET IT
Times cited: 2
Sex disparities in outcome of medication-assisted therapy of opioid use disorder: Nationally representative study. 2024 GET IT
Dynamic alterations in gene co-expression networks and gene-transcript associations characterize co-morbidities in cocaine use disorder. 2024 GET IT
Serum cytokine and inflammatory markers in individuals with heroin use disorder: potential biomarkers for diagnosis and disease severity. 2024 GET IT
Impact of the COVID-19 Pandemic on Functions of Nursing Professionals in the Care of Opioid Use Disorder: Systematic Review. Journal of addictions nursing. 2024 Academic Article GET IT
Times cited: 1
Impact of OPRM1 (Mu-opioid Receptor Gene) A112G Polymorphism on Dual Oxycodone and Cocaine Self-administration Behavior in a Mouse Model. Neuroscience. 2024 Academic Article GET IT
Effect of prenatal and early post-natal oxycodone exposure on the reinforcing and antinociceptive effects of oxycodone in adult C57BL/6 J mice. Psychopharmacology. 2023 Academic Article GET IT
Times cited: 1
Neuroimmune Mechanisms of Opioid Use Disorder and Recovery: Translatability to Human Studies, and Future Research Directions. Neuroscience. 2023 Review GET IT
Times cited: 15
The Kappa Opioid Receptor Agonist 16-Bromo Salvinorin A Has Anti-Cocaine Effects without Significant Effects on Locomotion, Food Reward, Learning and Memory, or Anxiety and Depressive-like Behaviors. Molecules (Basel, Switzerland). 2023 Academic Article GET IT
Times cited: 6
Overdose mortality rates for opioids and stimulant drugs are substantially higher in men than in women: state-level analysis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023 Academic Article GET IT
Times cited: 46
Overdose mortality rates for opioids or stimulants are higher in males than females, controlling for rates of drug misuse: State-level data. 2023 GET IT
Times cited: 1
Has the United States Reached a Plateau in Overdoses Caused by Synthetic Opioids After the Onset of the COVID-19 Pandemic? Examination of Centers for Disease Control and Prevention Data to November 2021. Frontiers in psychiatry. 2022 Academic Article GET IT
Times cited: 10
Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold. ACS chemical neuroscience. 2022 Academic Article GET IT
Times cited: 2
Kappa Opioid Receptor Antagonists as Potential Therapeutics for Mood and Substance Use Disorders. Handbook of experimental pharmacology. 2022 Academic Article GET IT
Times cited: 15
Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population. Neuroscience letters. 2021 Academic Article GET IT
Times cited: 10
Rapid-Onset Anti-Stress Effects of a Kappa-Opioid Receptor Antagonist, LY2795050, Against Immobility in an Open Space Swim Paradigm in Male and Female Mice. Frontiers in pharmacology. 2021 Academic Article GET IT
Times cited: 1
Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent. Journal of biomedical science. 2021 Academic Article GET IT
Times cited: 14
Age of onset of heaviest use of cannabis or alcohol in persons with severe opioid or cocaine use disorders. Drug and alcohol dependence. 2021 Academic Article GET IT
Times cited: 2
Profile of a short-acting κ-antagonist, LY2795050, on self-grooming behaviors, forced swim test and locomotor activity: sex comparison in mice. Journal of psychopharmacology (Oxford, England). 2021 Academic Article GET IT
Times cited: 6
Association of Serotonin Transporter (SERT) Polymorphisms with Opioid Dependence and Dimensional Aspects of Cocaine Use in a Caucasian Cohort of Opioid Users. Neuropsychiatric disease and treatment. 2021 Academic Article GET IT
Times cited: 5
Bidirectional influence of heroin and cocaine escalation in persons with dual opioid and cocaine dependence diagnoses. Experimental and clinical psychopharmacology. 2020 Academic Article GET IT
Times cited: 3
Relapse-like behavior in a mouse model of the OPRM1 (mu-opioid receptor) A118G polymorphism: Examination with intravenous oxycodone self-administration. Neuropharmacology. 2020 Academic Article GET IT
Times cited: 6
Neuroendocrine effects of naltrexone versus nalmefene in humans. Human psychopharmacology. 2020 Academic Article GET IT
Times cited: 5
Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat. Psychopharmacology. 2020 Academic Article GET IT
Times cited: 15
Escalation of drug use in persons dually diagnosed with opioid and cocaine dependence: Gender comparison and dimensional predictors. Drug and alcohol dependence. 2019 Academic Article GET IT
Times cited: 14
Are trait impulsivity and exposure to cannabis or alcohol associated with the age of trajectory of cocaine use? A gender-specific dimensional analysis in humans with cocaine dependence diagnosis. Experimental and clinical psychopharmacology. 2019 Academic Article GET IT
Times cited: 9
Impact of Pharmacological Manipulation of the κ-Opioid Receptor System on Self-grooming and Anhedonic-like Behaviors in Male Mice. The Journal of pharmacology and experimental therapeutics. 2019 Academic Article GET IT
Times cited: 29
Association of variants of prodynorphin promoter 68-bp repeats in caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use. Neuroscience letters. 2019 Academic Article GET IT
Times cited: 7
Re-evaluation of the KMSK scales, rapid dimensional measures of self-exposure to specific drugs: Gender-specific features. Drug and alcohol dependence. 2018 Academic Article GET IT
Times cited: 15
Non-medical Cannabis Self-Exposure as a Dimensional Predictor of Opioid Dependence Diagnosis: A Propensity Score Matched Analysis. Frontiers in psychiatry. 2018 Academic Article GET IT
Times cited: 14
Gender-specific association of functional prodynorphin 68 bp repeats with cannabis exposure in an African American cohort. Neuropsychiatric disease and treatment. 2018 Academic Article GET IT
Times cited: 10
Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence. 2018 GET IT
Times cited: 5
Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions. Current topics in behavioral neurosciences. 2018 Review GET IT
Times cited: 5
Medications for substance use disorders (SUD): emerging approaches. Expert opinion on emerging drugs. 2017 Review GET IT
Times cited: 18
Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2017 Academic Article GET IT
Times cited: 51
"Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats". Psychopharmacology. 2017 Academic Article GET IT
Times cited: 44
Adolescent oxycodone self administration alters subsequent oxycodone-induced conditioned place preference and anti-nociceptive effect in C57BL/6J mice in adulthood. Neuropharmacology. 2016 Academic Article GET IT
Times cited: 27
Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence. Drug and alcohol dependence. 2016 Academic Article GET IT
Times cited: 15
Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration. Neuropharmacology. 2016 Academic Article GET IT
Times cited: 26
Corrigendum: Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. 2015 GET IT
Times cited: 3
Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Frontiers in pharmacology. 2015 Review GET IT
Times cited: 67
Mouse model of the OPRM1 (A118G) polymorphism: differential heroin self-administration behavior compared with wild-type mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2015 Academic Article GET IT
Times cited: 51
Genetics of opiate addiction. Current psychiatry reports. 2014 Review GET IT
Times cited: 41
Neurocognitive and neuroinflammatory correlates of PDYN and OPRK1 mRNA expression in the anterior cingulate in postmortem brain of HIV-infected subjects. Journal of neuroinflammation. 2014 Academic Article GET IT
Times cited: 6
LC-MS/MS quantification of salvinorin A from biological fluids. Analytical methods : advancing methods and applications. 2013 Academic Article GET IT
Times cited: 6
Extended access oxycodone self-administration and neurotransmitter receptor gene expression in the dorsal striatum of adult C57BL/6 J mice. Psychopharmacology. 2013 Academic Article GET IT
Times cited: 43
Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice. Neuropharmacology. 2012 Academic Article GET IT
Times cited: 34
Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics. The Journal of clinical investigation. 2012 Review GET IT
Times cited: 190
κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends in neurosciences. 2012 Review GET IT
Times cited: 176
Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice. Neuropharmacology. 2012 Academic Article GET IT
Times cited: 9
Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo. The Journal of pharmacology and experimental therapeutics. 2012 Academic Article GET IT
Times cited: 19
Semisynthetic neoclerodanes as kappa opioid receptor probes. Bioorganic & medicinal chemistry. 2012 Academic Article GET IT
Times cited: 33
Dose preference and dose escalation in extended-access cocaine self-administration in Fischer and Lewis rats. Psychopharmacology. 2010 Academic Article GET IT
Times cited: 36
Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission. Trends in pharmacological sciences. 2010 Academic Article GET IT
Times cited: 96
The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology. 2010 Academic Article GET IT
Times cited: 33
PET imaging of leptin biodistribution and metabolism in rodents and primates. Cell metabolism. 2009 Academic Article GET IT
Times cited: 53
Opiate and cocaine addiction: from bench to clinic and back to the bench. Current opinion in pharmacology. 2009 Review GET IT
Times cited: 47
Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid. The Journal of pharmacology and experimental therapeutics. 2008 Academic Article GET IT
Times cited: 50
Behavioral and neurochemical changes induced by oxycodone differ between adolescent and adult mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2008 Academic Article GET IT
Times cited: 75
The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates. The Journal of pharmacology and experimental therapeutics. 2008 Academic Article GET IT
Times cited: 14
Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates. Psychoneuroendocrinology. 2008 Academic Article GET IT
Times cited: 6
Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958. The Journal of pharmacology and experimental therapeutics. 2007 Academic Article GET IT
Times cited: 27
Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans. The Journal of pharmacology and experimental therapeutics. 2006 Academic Article GET IT
Times cited: 48
Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates. Synapse (New York, N.Y.). 2005 Academic Article GET IT
Times cited: 73
Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature neuroscience. 2005 Review GET IT
Times cited: 859
Biological clock: biological clocks may modulate drug addiction. European journal of human genetics : EJHG. 2005 Article GET IT
Times cited: 32
Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. Journal of medicinal chemistry. 2005 Academic Article GET IT
Times cited: 134
Determination of Salvinorin A in body fluids by high performance liquid chromatography-atmospheric pressure chemical ionization. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Academic Article GET IT
Times cited: 57
11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2005 Academic Article GET IT
Times cited: 68
Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors. Psychopharmacology. 2005 Academic Article GET IT
Times cited: 158
Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates. The Journal of pharmacology and experimental therapeutics. 2004 Academic Article GET IT
Times cited: 33
Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic kappa-opioid agonists in rhesus monkeys. Psychoneuroendocrinology. 2004 Academic Article GET IT
Times cited: 15
Effect of the endogenous kappa opioid agonist dynorphin A(1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology. 2004 Academic Article GET IT
Times cited: 113
Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology. 2004 Academic Article GET IT
Times cited: 59
Evolving perspectives on neurobiological research on the addictions: celebration of the 30th anniversary of NIDA. Neuropharmacology. 2004 Review GET IT
Times cited: 26
The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys. Psychopharmacology. 2003 Academic Article GET IT
Times cited: 90
Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation. The Journal of pharmacology and experimental therapeutics. 2003 Academic Article GET IT
Times cited: 27
Comparison of the discriminative and neuroendocrine effects of centrally penetrating kappa-opioid agonists in rhesus monkeys. Psychopharmacology. 2002 Academic Article GET IT
Times cited: 21

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Background

education and training

M.S., Mercy College 2015
Ph.D., University College, London School of Medicine (United Kingdom) 1990

Contact

full name

Eduardo Butelman

VIVO Weill Cornell Medical College

Eduardo Butelman Adjunct Assistant Professor of Research in Neuroscience

Publications

selected publications

Background

education and training

Contact

full name