Cheng, Emily

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selected publications

Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis. Nature communications. 2023 Academic Article GET IT
Author Correction: Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations. 2023 GET IT
Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations. Nature cancer. 2023 Academic Article GET IT
Times cited: 9
SMARCB1 regulates the hypoxic stress response in sickle cell trait. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
Times cited: 6
Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2023 Academic Article GET IT
Times cited: 5
Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy. Clinical and translational medicine. 2023 Academic Article GET IT
Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell death and differentiation. 2023 Review GET IT
Times cited: 126
SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis. JCI insight. 2023 Academic Article GET IT
Times cited: 4
Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity. Cell reports. 2022 Academic Article GET IT
Times cited: 4
SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes. Nature cancer. 2022 Academic Article GET IT
Times cited: 36
Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis. Cancer cell. 2021 Academic Article GET IT
Times cited: 69
Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA. JCI insight. 2021 Academic Article GET IT
Times cited: 3
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis. Nature communications. 2021 Academic Article GET IT
Times cited: 28
RET inhibition in novel patient-derived models of RET-fusion positive lung adenocarcinoma reveals a role for MYC upregulation. Disease models & mechanisms. 2020 Academic Article GET IT
Times cited: 13
Exploiting the circuit breaker cancer evolution model in human clear cell renal cell carcinoma. Cell stress. 2020 Academic Article GET IT
Times cited: 2
Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer cell. 2020 Academic Article GET IT
Times cited: 73
T cell-derived interferon-γ programs stem cell death in immune-mediated intestinal damage. Science immunology. 2019 Academic Article GET IT
Times cited: 86
Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma. eLife. 2019 Academic Article GET IT
Times cited: 37
Upbeat: Augmented Reality-Guided Dancing for Prosthetic Rehabilitation of Upper Limb Amputees. Journal of healthcare engineering. 2019 Academic Article GET IT
Times cited: 25
Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models. Cancer research. 2018 Academic Article GET IT
Times cited: 27
Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan-omics precision. The Journal of pathology. 2018 Information Resource GET IT
Times cited: 55
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell death and differentiation. 2018 Information Resource GET IT
Times cited: 4370
ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival. Cell reports. 2017 Academic Article GET IT
Times cited: 57
Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma. European urology focus. 2017 Academic Article GET IT
Times cited: 28
Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy. Nature communications. 2017 Academic Article GET IT
Times cited: 133
Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma. JCI insight. 2017 Academic Article GET IT
Times cited: 87
Persistent Severe Hyperlactatemia and Metabolic Derangement in Lethal SDHB-Mutated Metastatic Kidney Cancer: Clinical Challenges and Examples of Extreme Warburg Effect. JCO precision oncology. 2017 Comment GET IT
Times cited: 18
The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Cell reports. 2017 Academic Article GET IT
Times cited: 145
BAK regulates catalase release from peroxisomes. Molecular & cellular oncology. 2017 Academic Article GET IT
The VDAC2-BAK axis regulates peroxisomal membrane permeability. The Journal of cell biology. 2017 Academic Article GET IT
Times cited: 60
The panoramic view of clear cell renal cell carcinoma metabolism: values of integrated global cancer metabolomics. Translational andrology and urology. 2016 Article GET IT
Times cited: 6
Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures. Genome biology. 2016 Academic Article GET IT
Times cited: 654
A braided cancer river connects tumor heterogeneity and precision medicine. Clinical and translational medicine. 2016 Academic Article GET IT
Genomic Biomarkers of a Randomized Trial Comparing First-line Everolimus and Sunitinib in Patients with Metastatic Renal Cell Carcinoma. European urology. 2016 Academic Article GET IT
Times cited: 166
Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. Nature communications. 2016 Academic Article GET IT
Times cited: 144
Overcome tumor heterogeneity-imposed therapeutic barriers through convergent genomic biomarker discovery: A braided cancer river model of kidney cancer. Seminars in cell & developmental biology. 2016 Information Resource GET IT
Times cited: 38
Tumor Xenografts of Human Clear Cell Renal Cell Carcinoma But Not Corresponding Cell Lines Recapitulate Clinical Response to Sunitinib: Feasibility of Using Biopsy Samples. European urology focus. 2016 Academic Article GET IT
Times cited: 28
Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore. Scientific reports. 2016 Academic Article GET IT
Times cited: 39
Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin. The Journal of clinical investigation. 2016 Academic Article GET IT
Times cited: 79
An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway. Molecular cell. 2016 Academic Article GET IT
Times cited: 67
An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma. Cancer cell. 2016 Academic Article GET IT
Times cited: 521
An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nature cell biology. 2015 Academic Article GET IT
Times cited: 227
Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. The Journal of clinical investigation. 2015 Academic Article GET IT
Times cited: 22
Taspase 1: A protease with many biological surprises. Molecular & cellular oncology. 2015 Academic Article GET IT
Times cited: 16
Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis. Cell research. 2014 Academic Article GET IT
Times cited: 28
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell death and differentiation. 2014 Information Resource GET IT
Times cited: 777
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Molecular cell. 2014 Academic Article GET IT
Times cited: 319
The impact of genetic heterogeneity on biomarker development in kidney cancer assessed by multiregional sampling. Cancer medicine. 2014 Academic Article GET IT
Times cited: 99
Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4. Cancer cell. 2014 Academic Article GET IT
Times cited: 38
Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency. Diabetes. 2014 Academic Article GET IT
Times cited: 21
Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Academic Article GET IT
Times cited: 178
Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs. Developmental cell. 2013 Academic Article GET IT
Times cited: 30
A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2. Cell reports. 2013 Academic Article GET IT
Times cited: 27
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. eLife. 2013 Academic Article GET IT
Times cited: 207
HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 52
Cancer therapeutics: Pulling the plug on BCL-X(L). Nature chemical biology. 2013 Article GET IT
Times cited: 10
Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Academic Article GET IT
Times cited: 292
PUMA and BIM are required for oncogene inactivation-induced apoptosis. Science signaling. 2013 Academic Article GET IT
Times cited: 106
Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma. European urology. 2012 Academic Article GET IT
Times cited: 181
A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway. PloS one. 2012 Academic Article GET IT
Times cited: 35
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. The EMBO journal. 2012 Academic Article GET IT
Times cited: 99
A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer research. 2011 Academic Article GET IT
Times cited: 37
A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair. The EMBO journal. 2011 Academic Article GET IT
Times cited: 92
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 397
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint. Nature. 2010 Academic Article GET IT
Times cited: 115
Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis. Cancer research. 2010 Academic Article GET IT
Times cited: 34
Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 118
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Molecular cell. 2009 Academic Article GET IT
Times cited: 503
The VDAC2-BAK rheostat controls thymocyte survival. Science signaling. 2009 Academic Article GET IT
Times cited: 49
MLL fusions: pathways to leukemia. Cancer biology & therapy. 2009 Information Resource GET IT
The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 92
BAX activation is initiated at a novel interaction site. Nature. 2008 Academic Article GET IT
Times cited: 589
Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. International journal of radiation oncology, biology, physics. 2008 Academic Article GET IT
Times cited: 51
Biphasic MLL takes helm at cell cycle control: implications in human mixed lineage leukemia. Cell cycle (Georgetown, Tex.). 2007 Information Resource GET IT
Times cited: 25
Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions. Genes & development. 2007 Academic Article GET IT
Times cited: 94
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nature cell biology. 2006 Academic Article GET IT
Times cited: 665
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes & development. 2006 Academic Article GET IT
Times cited: 139
Proapoptotic BAX and BAK control multiple initiator caspases. EMBO reports. 2005 Academic Article GET IT
Times cited: 110
Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell. 2003 Academic Article GET IT
Times cited: 200
VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science (New York, N.Y.). 2003 Academic Article GET IT
Times cited: 632
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science (New York, N.Y.). 2003 Academic Article GET IT
Times cited: 1173
A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast. The Journal of cell biology. 2001 Academic Article GET IT
Times cited: 244
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Molecular cell. 2001 Academic Article GET IT
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (New York, N.Y.). 2001 Academic Article GET IT
Times cited: 3483
Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1. Molecular cell. 2000 Academic Article GET IT
Times cited: 156
Modulation of cell death by Bcl-XL through caspase interaction. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 478
Conversion of Bcl-2 to a Bax-like death effector by caspases. Science (New York, N.Y.). 1997 Academic Article GET IT
Times cited: 974
Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene. Journal of virology. 1997 Academic Article GET IT
Times cited: 122
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 401
Bax-independent inhibition of apoptosis by Bcl-XL. Nature. 1996 Academic Article GET IT
Times cited: 441

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Background

education and training

Ph.D., The Johns Hopkins University 1997
M.D., Taipei Medical College (Taiwan) 1990

Contact

full name

Emily Cheng

primary email

chenge1@mskcc.org

VIVO Weill Cornell Medical College

Emily Cheng Professor of Pathology and Laboratory Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email