selected publications
- Isotope-reinforced polyunsaturated fatty acids improve Parkinson's disease-like phenotype in rats overexpressing α-synuclein. Acta neuropathologica communications. 2020 Academic Article GET IT
- Changes of Coenzyme A and Acetyl-Coenzyme A Concentrations in Rats after a Single-Dose Intraperitoneal Injection of Hepatotoxic Thioacetamide Are Not Consistent with Rapid Recovery. International journal of molecular sciences. 2020 Academic Article GET IT
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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing.
Nature reviews. Drug discovery.
2020
Review
GET IT
Times cited: 13 - High-dose biotin restores redox balance, energy and lipid homeostasis, and axonal health in a model of adrenoleukodystrophy. Brain pathology (Zurich, Switzerland). 2020 Academic Article GET IT
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Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm.
The European journal of neuroscience.
2020
Academic Article
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Times cited: 3 -
PGC-1α, Sirtuins and PARPs in Huntington's Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All.
Neurochemical research.
2019
Academic Article
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Times cited: 6 -
Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease.
The European journal of neuroscience.
2018
Review
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Times cited: 11 -
Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy.
Human molecular genetics.
2018
Academic Article
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Times cited: 19 -
Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy.
EMBO molecular medicine.
2018
Academic Article
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Times cited: 12 -
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.
Cell metabolism.
2018
Academic Article
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Times cited: 43 -
Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection.
Molecules (Basel, Switzerland).
2017
Academic Article
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Times cited: 21 -
Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease.
Human molecular genetics.
2017
Academic Article
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Times cited: 31 -
A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.
Neurology.
2016
Academic Article
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Times cited: 53 -
Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?.
Journal of neurochemistry.
2016
Academic Article
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Times cited: 8 -
Mitochondrial dysfunction in Parkinson's disease.
Journal of neurochemistry.
2016
Review
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Times cited: 231 -
Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2016
Academic Article
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Times cited: 76 -
Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease.
Human molecular genetics.
2016
Academic Article
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Times cited: 18 -
Simultaneous determination of tricarboxylic acid cycle metabolites by high-performance liquid chromatography with ultraviolet detection.
Analytical biochemistry.
2016
Academic Article
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Times cited: 9 -
Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo.
Human molecular genetics.
2015
Academic Article
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Times cited: 35 -
HPLC determination of α-ketoglutaramate [5-amino-2,5-dioxopentanoate] in biological samples.
Analytical biochemistry.
2015
Academic Article
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Times cited: 2 -
Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.
Neurobiology of aging.
2015
Academic Article
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Times cited: 19 -
Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.
Cell death and differentiation.
2015
Academic Article
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Times cited: 14 -
Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.
Human molecular genetics.
2015
Academic Article
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Times cited: 7 -
The high-affinity D2/D3 agonist D512 protects PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of Parkinson's disease.
Journal of neurochemistry.
2014
Academic Article
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Times cited: 19 -
Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2014
Academic Article
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Times cited: 28 -
A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.
JAMA neurology.
2014
Academic Article
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Times cited: 186 -
Prospects for neuroprotective therapies in prodromal Huntington's disease.
Movement disorders : official journal of the Movement Disorder Society.
2014
Review
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Times cited: 30 -
Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity.
Human molecular genetics.
2014
Academic Article
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Times cited: 80 -
Sex differences in cerebral energy metabolism in Parkinson's disease: a phosphorus magnetic resonance spectroscopic imaging study.
Parkinsonism & related disorders.
2014
Academic Article
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Times cited: 14 -
Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial.
JAMA neurology.
2014
Academic Article
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Times cited: 139 -
PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2014
Academic Article
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Times cited: 35 -
Usefulness of proton and phosphorus MR spectroscopic imaging for early diagnosis of Parkinson's disease.
Journal of neuroimaging : official journal of the American Society of Neuroimaging.
2013
Academic Article
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Times cited: 24 -
Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway.
PLoS genetics.
2013
Academic Article
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Times cited: 12 -
Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy.
Brain : a journal of neurology.
2013
Academic Article
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Times cited: 42 -
A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.
Human molecular genetics.
2013
Academic Article
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Times cited: 69 - PGC-1α, mitochondrial dysfunction, and Huntington's disease. Free radical biology & medicine. 2013 Review GET IT
- Mitochondrial diseases of the brain. Free radical biology & medicine. 2013 Review GET IT
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The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2013
Academic Article
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Times cited: 37 -
Nitration of Hsp90 induces cell death.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 84 -
Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases.
Molecular and cellular neurosciences.
2012
Academic Article
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Times cited: 93 -
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.
The Journal of experimental medicine.
2012
Academic Article
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Times cited: 87 - Somatic mitochondrial DNA mutations and parkinsonism. Annals of neurology. 2012 Letter GET IT
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Dopamine transporter imaging is associated with long-term outcomes in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society.
2012
Academic Article
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Times cited: 82 -
Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice.
Human molecular genetics.
2012
Academic Article
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Times cited: 43 -
Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease.
Antioxidants & redox signaling.
2012
Academic Article
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Times cited: 108 -
Mitochondrial dysfunction in neurodegenerative diseases.
The Journal of pharmacology and experimental therapeutics.
2012
Review
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Times cited: 290 -
Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease.
Annals of neurology.
2012
Academic Article
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Times cited: 65 -
Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease.
Human molecular genetics.
2012
Academic Article
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Times cited: 37 -
Muscling in on PGC-1α for improved quality of life in ALS.
Cell metabolism.
2012
Article
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Times cited: 1 -
Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.
PloS one.
2012
Academic Article
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Times cited: 41 -
Impaired mitochondrial function in psychiatric disorders.
Nature reviews. Neuroscience.
2012
Review
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Times cited: 252 -
NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease.
Antioxidants & redox signaling.
2012
Academic Article
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Times cited: 105 -
Oral repeated-dose toxicity studies of coenzyme Q10 in beagle dogs.
International journal of toxicology.
2012
Academic Article
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Times cited: 4 -
A neuroprotective role of the human uncoupling protein 2 (hUCP2) in a Drosophila Parkinson's disease model.
Neurobiology of disease.
2012
Academic Article
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Times cited: 30 -
Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice.
Journal of Alzheimer's disease : JAD.
2012
Academic Article
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Times cited: 33 -
Huntington's disease.
2012
GET IT
Times cited: 10 -
Antioxidants in Huntington's disease.
Biochimica et biophysica acta.
2011
Review
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Times cited: 92 -
Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease.
Human molecular genetics.
2011
Academic Article
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Times cited: 97 -
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease.
Nature.
2011
Academic Article
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Times cited: 1051 -
Biomarkers of Parkinson's disease and Dementia with Lewy bodies.
Progress in neurobiology.
2011
Review
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Times cited: 24 -
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2011
Academic Article
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Times cited: 59 -
Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease.
Neuro-degenerative diseases.
2011
Academic Article
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Times cited: 29 -
Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease.
Antioxidants & redox signaling.
2011
Academic Article
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Times cited: 35 -
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
PloS one.
2011
Academic Article
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Times cited: 258 -
Molecular insights into Parkinson's disease.
F1000 medicine reports.
2011
Review
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Times cited: 36 -
Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis.
Free radical biology & medicine.
2011
Academic Article
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Times cited: 131 -
Neuroprotective effects of creatine.
Amino acids.
2011
Review
GET IT
Times cited: 110 -
DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death.
Antioxidants & redox signaling.
2011
Academic Article
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Times cited: 19 -
Hugging tight in Huntington's.
Nature medicine.
2011
Academic Article
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Times cited: 16 -
Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death.
The Journal of biological chemistry.
2011
Academic Article
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Times cited: 57 -
Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease.
Neuroscience letters.
2011
Academic Article
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Times cited: 18 - The genes of Parkinson's disease. Scientist. 2011 Article
-
Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD.
2011
Academic Article
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Times cited: 59 -
Determination of neurotransmitter levels in models of Parkinson's disease by HPLC-ECD.
Methods in molecular biology (Clifton, N.J.).
2011
Academic Article
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Times cited: 34 -
MicroRNA-related cofilin abnormality in Alzheimer's disease.
PloS one.
2010
Academic Article
GET IT
Times cited: 79 -
Impaired brain creatine kinase activity in Huntington's disease.
Neuro-degenerative diseases.
2010
Academic Article
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Times cited: 30 -
Neuroprotective strategies involving ROS in Alzheimer disease.
Free radical biology & medicine.
2010
Review
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Times cited: 255 -
Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications.
Trends in neurosciences.
2010
Review
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Times cited: 161 -
Acute and long-term response of dopamine nigrostriatal synapses to a single, low-dose episode of 3-nitropropionic acid-mediated chemical hypoxia.
Synapse (New York, N.Y.).
2010
Academic Article
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Times cited: 6 -
Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects.
Movement disorders : official journal of the Movement Disorder Society.
2010
Academic Article
GET IT
Times cited: 73 -
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.
EMBO molecular medicine.
2010
Academic Article
GET IT
Times cited: 99 -
Parkinson's disease: a model dilemma.
Nature.
2010
Article
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Times cited: 68 -
Hunting-ton for new proteases: MMPs as the new target?.
Neuron.
2010
Article
GET IT
Times cited: 6 -
Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2010
Academic Article
GET IT
Times cited: 118 -
Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease.
Human molecular genetics.
2010
Academic Article
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Times cited: 201 -
Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation.
Human molecular genetics.
2010
Academic Article
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Times cited: 98 -
Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease.
Experimental neurology.
2010
Academic Article
GET IT
Times cited: 102 -
Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease.
Free radical biology & medicine.
2010
Academic Article
GET IT
Times cited: 129 -
Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease.
Journal of Alzheimer's disease : JAD.
2010
Review
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Times cited: 68 -
Mitochondrial therapies for Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society.
2010
Academic Article
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Times cited: 33 -
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.
The Journal of experimental medicine.
2009
Academic Article
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Times cited: 290 -
Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009
Academic Article
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Times cited: 87 -
Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease.
Parkinsonism & related disorders.
2009
Academic Article
GET IT
Times cited: 76 -
Urate as a predictor of the rate of clinical decline in Parkinson disease.
Archives of neurology.
2009
Academic Article
GET IT
Times cited: 239 - Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatric disease and treatment. 2009 Academic Article GET IT
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N-iminoethyl-L-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition.
Neurochemistry international.
2009
Academic Article
GET IT
Times cited: 11 -
Metabolomic profiling in LRRK2-related Parkinson's disease.
PloS one.
2009
Academic Article
GET IT
Times cited: 102 -
Promethazine protects against 3-nitropropionic acid-induced neurotoxicity.
Neurochemistry international.
2009
Academic Article
GET IT
Times cited: 5 -
Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis.
Experimental neurology.
2009
Academic Article
GET IT
Times cited: 60 -
Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.
Antioxidants & redox signaling.
2009
Academic Article
GET IT
Times cited: 110 -
Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease.
BMC neuroscience.
2009
Academic Article
GET IT
Times cited: 102 -
The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death.
Antioxidants & redox signaling.
2009
Academic Article
GET IT
Times cited: 110 -
Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.
Biochimica et biophysica acta.
2009
Review
GET IT
Times cited: 160 -
Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease.
The Journal of biological chemistry.
2009
Academic Article
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Times cited: 82 -
Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.
Neurobiology of disease.
2009
Academic Article
GET IT
Times cited: 16 - Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Molecular neurodegeneration. 2009 Academic Article GET IT
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Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.
Free radical biology & medicine.
2009
Academic Article
GET IT
Times cited: 46 -
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.
Nature neuroscience.
2009
Academic Article
GET IT
Times cited: 369 -
Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.
PloS one.
2009
Academic Article
GET IT
Times cited: 131 -
Impaired PGC-1alpha function in muscle in Huntington's disease.
Human molecular genetics.
2009
Academic Article
GET IT
Times cited: 176 -
Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2009
Academic Article
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Times cited: 169 -
Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases.
Journal of neurochemistry.
2009
Academic Article
GET IT
Times cited: 173 -
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.
PloS one.
2009
Academic Article
GET IT
Times cited: 101 -
Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.
Journal of neurochemistry.
2009
Academic Article
GET IT
Times cited: 86 -
Mitochondria and oxidative stress in neurodegenerative disorders. Preface.
Annals of the New York Academy of Sciences.
2008
Conference Paper
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Times cited: 12 -
Mitochondrial approaches for neuroprotection.
Annals of the New York Academy of Sciences.
2008
Conference Paper
GET IT
Times cited: 201 -
Multinuclear magnetic resonance spectroscopy for in vivo assessment of mitochondrial dysfunction in Parkinson's disease.
Annals of the New York Academy of Sciences.
2008
Conference Paper
GET IT
Times cited: 38 -
Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.
Biochimica et biophysica acta.
2008
Review
GET IT
Times cited: 174 -
Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases.
Neuromolecular medicine.
2008
Review
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Times cited: 108 -
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
Neurochemistry international.
2008
Academic Article
GET IT
Times cited: 335 -
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis.
Nature clinical practice. Neurology.
2008
Review
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Times cited: 502 -
Portal to Alzheimer's disease.
Nature medicine.
2008
Article
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Times cited: 32 -
Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008
Academic Article
GET IT
Times cited: 22 -
A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells.
Journal of neurochemistry.
2008
Academic Article
GET IT
Times cited: 88 -
Oxidative stress biomarkers in sporadic ALS.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.
2008
Academic Article
GET IT
Times cited: 93 -
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery.
Proceedings of the National Academy of Sciences of the United States of America.
2008
Academic Article
GET IT
Times cited: 400 -
Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.
Neurobiology of aging.
2008
Academic Article
GET IT
Times cited: 86 -
PPAR: a therapeutic target in Parkinson's disease.
Journal of neurochemistry.
2008
Review
GET IT
Times cited: 108 -
Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases.
Neuroscience.
2008
Academic Article
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Times cited: 49 -
The urokinase system of plasminogen activator plays a role in amyotrophic lateral sclerosis (ALS) pathogenesis.
Experimental neurology.
2008
Comment
GET IT
Times cited: 1 -
Metabolomic profiling to develop blood biomarkers for Parkinson's disease.
Brain : a journal of neurology.
2008
Academic Article
GET IT
Times cited: 310 -
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease.
Trends in molecular medicine.
2008
Academic Article
GET IT
Times cited: 560 -
Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008
Academic Article
GET IT
Times cited: 121 -
Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007
Academic Article
GET IT
Times cited: 67 -
Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism.
Journal of neurochemistry.
2007
Academic Article
GET IT
Times cited: 101 -
Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007
Academic Article
GET IT
Times cited: 172 -
Parkinson's disease.
Human molecular genetics.
2007
Review
GET IT
Times cited: 616 -
A randomized study of the bioavailability of different formulations of coenzyme Q(10) (ubiquinone).
Journal of clinical pharmacology.
2007
Academic Article
GET IT
Times cited: 19 -
Merging mitochondria for neuronal survival.
Nature medicine.
2007
Article
GET IT
Times cited: 8 -
Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
Proceedings of the National Academy of Sciences of the United States of America.
2007
Academic Article
GET IT
Times cited: 119 -
Profiles of matrix metalloproteinases and their inhibitors in plasma of patients with dementia.
International psychogeriatrics.
2007
Conference Paper
GET IT
Times cited: 41 -
The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry.
2007
Academic Article
GET IT
Times cited: 44 -
Attenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IV.
Experimental neurology.
2007
Academic Article
GET IT
Times cited: 45 -
Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
Free radical biology & medicine.
2007
Academic Article
GET IT
Times cited: 38 -
Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis.
Experimental neurology.
2007
Academic Article
GET IT
Times cited: 78 -
Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders.
Muscle & nerve.
2007
Academic Article
GET IT
Times cited: 193 -
Large stem cell grafts could lead to erroneous interpretations of behavioral results?.
Nature medicine.
2007
Letter
GET IT
Times cited: 13 -
MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity.
Neurobiology of disease.
2007
Academic Article
GET IT
Times cited: 55 -
Excitotoxicity.
Handbook of clinical neurology.
2007
Review
GET IT
Times cited: 2 -
Mitochondria and neurodegeneration.
Novartis Foundation symposium.
2007
Conference Paper
GET IT
Times cited: 69 -
A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2006
Academic Article
GET IT
Times cited: 146 -
PGC-1alpha, a new therapeutic target in Huntington's disease?.
Cell.
2006
Article
GET IT
Times cited: 107 -
Alzheimer's APP mangles mitochondria.
Nature medicine.
2006
Article
GET IT
Times cited: 102 -
Oxidative damage in Huntington's disease pathogenesis.
Antioxidants & redox signaling.
2006
Review
GET IT
Times cited: 232 -
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.
Nature medicine.
2006
Academic Article
GET IT
Times cited: 645 -
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
Nature.
2006
Review
GET IT
Times cited: 3744 -
Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice.
Journal of the neurological sciences.
2006
Academic Article
GET IT
Times cited: 32 -
Common threads in neurodegenerative disorders of aging.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
2006
Review
GET IT
Times cited: 3 -
Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease.
Neurobiology of disease.
2006
Academic Article
GET IT
Times cited: 25 -
Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry.
2006
Academic Article
GET IT
Times cited: 121 -
The proteasomal inhibition model of Parkinson's disease: "Boon or bust"?.
Annals of neurology.
2006
Editorial Article
GET IT
Times cited: 39 -
Neuroprotective agents for clinical trials in ALS: a systematic assessment.
Neurology.
2006
Review
GET IT
Times cited: 164 -
Parkinsonism genes: culprits and clues.
Journal of neurochemistry.
2006
Review
GET IT
Times cited: 87 -
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin.
Proceedings of the National Academy of Sciences of the United States of America.
2006
Academic Article
GET IT
Times cited: 588 -
The role of mitochondria in inherited neurodegenerative diseases.
Journal of neurochemistry.
2006
Review
GET IT
Times cited: 132 -
Mitochondrial dysfunction and amyotrophic lateral sclerosis.
Muscle & nerve.
2006
Review
GET IT
Times cited: 85 -
Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS.
Neurobiology of disease.
2006
Academic Article
GET IT
Times cited: 113 -
The matrix metalloproteinases inhibitor Ro 28-2653 [correction of Ro 26-2853] extends survival in transgenic ALS mice.
Experimental neurology.
2006
Academic Article
GET IT
Times cited: 51 -
Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice.
Journal of neurochemistry.
2006
Academic Article
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Times cited: 167 -
Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006
Academic Article
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Times cited: 140 -
Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.
Neurology.
2006
Academic Article
GET IT
Times cited: 226 -
Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?.
Human genetics.
2006
Academic Article
GET IT
Times cited: 84 -
Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS.
Neurology.
2005
Academic Article
GET IT
Times cited: 132 -
Mice lacking alpha-synuclein are resistant to mitochondrial toxins.
Neurobiology of disease.
2005
Academic Article
GET IT
Times cited: 165 -
Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis.
Neurobiology of disease.
2005
Academic Article
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Times cited: 137 -
Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America.
2005
Comment
GET IT
Times cited: 14 -
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.
The Journal of experimental medicine.
2005
Academic Article
GET IT
Times cited: 156 -
Alterations of striatal neurons in benign hereditary chorea.
Movement disorders : official journal of the Movement Disorder Society.
2005
Academic Article
GET IT
Times cited: 40 -
Mitochondria take center stage in aging and neurodegeneration.
Annals of neurology.
2005
Review
GET IT
Times cited: 718 -
Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.
Neurochemical research.
2005
Academic Article
GET IT
Times cited: 43 -
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling.
Proceedings of the National Academy of Sciences of the United States of America.
2005
Academic Article
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Times cited: 286 -
Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease.
Journal of neurochemistry.
2005
Academic Article
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Times cited: 56 -
Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.
Neurobiology of disease.
2005
Academic Article
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Times cited: 16 -
Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity.
Journal of neurochemistry.
2005
Academic Article
GET IT
Times cited: 144 -
Manganese porphyrin given at symptom onset markedly extends survival of ALS mice.
Annals of neurology.
2005
Academic Article
GET IT
Times cited: 118 -
Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons.
Journal of neurochemistry.
2005
Academic Article
GET IT
Times cited: 51 -
Beta-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients.
Neurobiology of disease.
2005
Academic Article
GET IT
Times cited: 40 -
Less stress, longer life.
Nature medicine.
2005
Article
GET IT
Times cited: 10 -
Oxidative damage as an early marker of Alzheimer's disease and mild cognitive impairment.
Neurobiology of aging.
2005
Comment
GET IT
Times cited: 67 -
Are mitochondria critical in the pathogenesis of Alzheimer's disease?.
Brain research. Brain research reviews.
2005
Review
GET IT
Times cited: 225 -
Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2005
Academic Article
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Times cited: 198 -
Increased oxidative damage to DNA in an animal model of amyotrophic lateral sclerosis.
Free radical research.
2005
Academic Article
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Times cited: 60 -
Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry.
2005
Academic Article
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Times cited: 59 -
Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity.
Journal of neurochemistry.
2005
Academic Article
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Times cited: 84 -
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2005
Academic Article
GET IT
Times cited: 176 -
Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis.
Experimental neurology.
2005
Academic Article
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Times cited: 172 -
Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.
Current drug targets. CNS and neurological disorders.
2005
Review
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Times cited: 140 -
Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2005
Academic Article
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Times cited: 154 -
A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities.
Experimental neurology.
2005
Academic Article
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Times cited: 41 -
Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis.
Neuro-degenerative diseases.
2005
Academic Article
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Times cited: 152 - Metabolomic analysis and signatures in motor neuron disease. Metabolomics : Official journal of the Metabolomic Society. 2005 Academic Article GET IT
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The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration.
Molecular neurobiology.
2005
Conference Paper
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Times cited: 132 -
Somatic mitochondrial DNA mutations in single neurons and glia.
Neurobiology of aging.
2004
Academic Article
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Times cited: 59 -
Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004
Academic Article
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Times cited: 149 -
A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo.
Neurobiology of disease.
2004
Academic Article
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Times cited: 60 -
Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 357 -
Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.
PLoS biology.
2004
Academic Article
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Times cited: 232 -
Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004
Academic Article
GET IT
Times cited: 45 -
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004
Academic Article
GET IT
Times cited: 491 -
Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment.
Journal of bioenergetics and biomembranes.
2004
Conference Paper
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Times cited: 240 -
Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease.
Experimental neurology.
2004
Academic Article
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Times cited: 172 -
Poison and antidote: a novel model to study pathogenesis and therapy of LHON.
Annals of neurology.
2004
Editorial Article
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Times cited: 7 -
The mitochondrial permeability transition as a target for neuroprotection.
Journal of bioenergetics and biomembranes.
2004
Conference Paper
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Times cited: 50 -
Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology.
The Journal of experimental medicine.
2004
Academic Article
GET IT
Times cited: 81 -
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication.
Proceedings of the National Academy of Sciences of the United States of America.
2004
Academic Article
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Times cited: 380 -
Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004
Academic Article
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Times cited: 93 -
3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy.
Journal of neurochemistry.
2004
Academic Article
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Times cited: 26 -
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.
Journal of neurochemistry.
2004
Academic Article
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Times cited: 220 -
Measuring the effects of therapy in Parkinson disease.
JAMA.
2004
Letter
GET IT
Times cited: 7 -
Experimental therapeutics in transgenic mouse models of Huntington's disease.
Nature reviews. Neuroscience.
2004
Review
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Times cited: 191 -
Commentary on "Alpha-synuclein and mitochondria: a tangled skein".
Experimental neurology.
2004
Comment
GET IT
Times cited: 10 -
Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase.
Neurobiology of disease.
2004
Academic Article
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Times cited: 51 -
Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice.
Free radical biology & medicine.
2004
Academic Article
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Times cited: 73 -
Elevated levels of matrix metalloproteinases-9 and -1 and of tissue inhibitors of MMPs, TIMP-1 and TIMP-2 in postmortem brain tissue of progressive supranuclear palsy.
Journal of the neurological sciences.
2004
Academic Article
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Times cited: 22 -
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.
Journal of neurochemistry.
2004
Academic Article
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Times cited: 76 -
The energetics of Huntington's disease.
Neurochemical research.
2004
Review
GET IT
Times cited: 185 -
Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry.
2004
Academic Article
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Times cited: 150 -
Diffusion tensor imaging in the diagnosis of primary lateral sclerosis.
Journal of magnetic resonance imaging : JMRI.
2004
Academic Article
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Times cited: 46 -
Matrix metalloproteinase-9 is elevated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.
Neuromolecular medicine.
2004
Academic Article
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Times cited: 48 -
Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity.
Neuromolecular medicine.
2004
Academic Article
GET IT
Times cited: 9 -
Neuroprotective effects of phenylbutyrate against MPTP neurotoxicity.
Neuromolecular medicine.
2004
Academic Article
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Times cited: 72 -
Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease.
Neurobiology of aging.
2004
Academic Article
GET IT
Times cited: 96 -
Therapeutic effects of coenzyme Q10 in neurodegenerative diseases.
Methods in enzymology.
2004
Academic Article
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Times cited: 49 -
Minocycline enhances MPTP toxicity to dopaminergic neurons.
Journal of neuroscience research.
2003
Academic Article
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Times cited: 130 -
Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice.
Nature biotechnology.
2003
Academic Article
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Times cited: 517 -
Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.
Endocrinology.
2003
Academic Article
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Times cited: 143 -
Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease.
Neurochemistry international.
2003
Academic Article
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Times cited: 154 -
Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease.
Journal of neurochemistry.
2003
Academic Article
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Times cited: 52 -
Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice.
Journal of neurochemistry.
2003
Academic Article
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Times cited: 145 -
Mitochondria, oxidative damage, and inflammation in Parkinson's disease.
Annals of the New York Academy of Sciences.
2003
Conference Paper
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Times cited: 435 -
Dysregulation of the levels of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the early phase of cerebral ischemia.
Stroke.
2003
Comment
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Times cited: 27 -
The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis.
Journal of magnetic resonance imaging : JMRI.
2003
Academic Article
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Times cited: 34 -
Urinary 8-hydroxy-2'-deoxyguanosine, a metabolite of oxidized DNA, is not elevated in HIV patients on combination antiretroviral therapy.
Free radical research.
2003
Academic Article
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Times cited: 2 -
Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis.
Journal of neurochemistry.
2003
Academic Article
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Times cited: 76 -
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease.
Neuron.
2003
Academic Article
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Times cited: 521 -
Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases.
Journal of the neurological sciences.
2003
Conference Paper
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Times cited: 105 -
Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice.
Brain research.
2003
Academic Article
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Times cited: 116 -
Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells.
Experimental neurology.
2003
Academic Article
GET IT
Times cited: 31 -
Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.
Journal of molecular neuroscience : MN.
2003
Academic Article
GET IT
Times cited: 69 -
Bioenergetic approaches for neuroprotection in Parkinson's disease.
Annals of neurology.
2003
Review
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Times cited: 188 -
Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease.
BioFactors (Oxford, England).
2003
Conference Paper
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Times cited: 52 -
Oral dyskinesias and histopathological alterations in substantia nigra after long-term haloperidol treatment of old rats.
Neuroscience.
2003
Academic Article
GET IT
Times cited: 42 -
Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression.
Neurobiology of disease.
2002
Academic Article
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Times cited: 92 -
Expression of MMP-2, MMP-9, and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of Parkinson's disease.
Experimental neurology.
2002
Academic Article
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Times cited: 96 -
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
The American journal of pathology.
2002
Academic Article
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Times cited: 526 -
Therapeutic effects of cystamine in a murine model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002
Academic Article
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Times cited: 285 -
Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline.
Archives of neurology.
2002
Academic Article
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Times cited: 852 -
Stress-induced mitochondrial depolarization and oxidative damage in PSP cybrids.
Brain research.
2002
Academic Article
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Times cited: 24 -
Lipid peroxidation in aging brain and Alzheimer's disease.
Free radical biology & medicine.
2002
Academic Article
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Times cited: 336 - Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid. Experimental neurology. 2002 Academic Article GET IT
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Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.
The Journal of biological chemistry.
2002
Academic Article
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Times cited: 411 - Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Archives of neurology. 2002 Academic Article GET IT
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Mitochondrial dysfunction in progressive supranuclear palsy.
Neurochemistry international.
2002
Academic Article
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Times cited: 34 -
Oxidatively modified proteins in aging and disease.
Free radical biology & medicine.
2002
Academic Article
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Times cited: 644 -
Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice.
Free radical biology & medicine.
2002
Academic Article
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Times cited: 52 -
Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups.
American journal of human genetics.
2002
Academic Article
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Times cited: 427 -
Coenzyme Q10 as a possible treatment for neurodegenerative diseases.
Free radical research.
2002
Academic Article
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Times cited: 123 -
Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice.
Brain research.
2002
Academic Article
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Times cited: 41 -
Expression and activity of antioxidants in the brain in progressive supranuclear palsy.
Brain research.
2002
Academic Article
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Times cited: 28 -
Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002
Academic Article
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Times cited: 337 -
Sequence analysis of the entire mitochondrial genome in Parkinson's disease.
Biochemical and biophysical research communications.
2002
Academic Article
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Times cited: 60 -
Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients.
Journal of neurochemistry.
2002
Academic Article
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Times cited: 227 -
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain.
Human molecular genetics.
2002
Academic Article
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Times cited: 245 -
Cytochrome C and caspase-9 expression in Huntington's disease.
Neuromolecular medicine.
2002
Academic Article
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Times cited: 99 -
Toxin-induced mitochondrial dysfunction.
International review of neurobiology.
2002
Review
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Times cited: 16 -
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2001
Academic Article
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Times cited: 247 -
Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease.
Journal of neurochemistry.
2001
Academic Article
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Times cited: 199 -
Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy.
Journal of neuroscience research.
2001
Conference Paper
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Times cited: 69 -
N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease.
Journal of neurochemistry.
2001
Academic Article
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Times cited: 78 - Lipoic acid improves survival in transgenic mouse models of Huntington's disease. Neuroreport. 2001 Academic Article GET IT
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In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I.
The Journal of biological chemistry.
2001
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Striatal volume loss in HD as measured by MRI and the influence of CAG repeat.
Neurology.
2001
Academic Article
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Times cited: 112 -
Therapeutic efficacy of EGb761 (Gingko biloba extract) in a transgenic mouse model of amyotrophic lateral sclerosis.
Journal of molecular neuroscience : MN.
2001
Academic Article
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Times cited: 49 - Bcl-2 Suppresses Oxidative Phosphorylation Defects Caused by Mitochondrial DNA Mutations. TheScientificWorldJournal. 2001 Academic Article GET IT
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Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.
Annals of neurology.
2001
Academic Article
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Times cited: 60 -
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.
Neurobiology of disease.
2001
Academic Article
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Times cited: 239 -
Metal chelator decreases Alzheimer beta-amyloid plaques.
Neuron.
2001
Review
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Times cited: 30 -
Experimental models of Parkinson's disease.
Nature reviews. Neuroscience.
2001
Review
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Times cited: 472 -
Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders.
Annals of neurology.
2001
Academic Article
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Times cited: 192 -
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2001
Academic Article
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Times cited: 396 - Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice. Experimental neurology. 2001 Academic Article GET IT
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Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.
Journal of neurochemistry.
2001
Academic Article
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Times cited: 93 -
Low mutational burden of individual acquired mitochondrial DNA mutations in brain.
Genomics.
2001
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Times cited: 30 - Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPTP and 3-nitropropionic acid. Experimental neurology. 2001 Academic Article GET IT
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Further evidence for mitochondrial dysfunction in progressive supranuclear palsy.
Experimental neurology.
2001
Academic Article
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Times cited: 56 -
Novel therapies in the search for a cure for Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America.
2001
Comment
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Times cited: 21 -
Age and sex influence on oxidative damage and functional status in human skeletal muscle.
Journal of muscle research and cell motility.
2001
Academic Article
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Times cited: 117 - Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Experimental neurology. 2001 Academic Article GET IT
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Mitochondria and oxidative damage in amyotrophic lateral sclerosis.
Functional neurology.
2001
Conference Paper
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Times cited: 5 -
Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome.
Free radical biology & medicine.
2000
Academic Article
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Times cited: 135 -
Oxidative stress in patients with Friedreich ataxia.
Neurology.
2000
Academic Article
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Times cited: 267 -
No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls.
Annals of neurology.
2000
Letter
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Times cited: 39 -
Increased oxidative damage to DNA in ALS patients.
Free radical biology & medicine.
2000
Academic Article
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Times cited: 235 -
Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Experimental neurology.
2000
Academic Article
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Times cited: 42 -
N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis.
Neuroreport.
2000
Academic Article
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Times cited: 111 -
Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant.
Journal of neurochemistry.
2000
Academic Article
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Times cited: 37 -
Energetics in the pathogenesis of neurodegenerative diseases.
Trends in neurosciences.
2000
Review
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Times cited: 411 -
Mitochondria and the pathogenesis of ALS.
Brain : a journal of neurology.
2000
Editorial Article
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Times cited: 75 -
The role of mitochondria in the pathogenesis of neurodegenerative diseases.
Brain pathology (Zurich, Switzerland).
2000
Conference Paper
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Times cited: 94 -
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2000
Academic Article
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Times cited: 434 -
Limited-time exposure to mitochondrial toxins may lead to chronic progressive neurodegenerative diseases.
Movement disorders : official journal of the Movement Disorder Society.
2000
Editorial Article
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Times cited: 5 -
Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice.
Journal of neurochemistry.
2000
Academic Article
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Times cited: 139 -
Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity.
Neuroreport.
2000
Academic Article
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Times cited: 59 -
Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis.
Annals of neurology.
2000
Academic Article
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Times cited: 68 -
Neuroprotective effects of creatine administration against NMDA and malonate toxicity.
Brain research.
2000
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Times cited: 56 -
Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease.
Neurology.
2000
Academic Article
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Times cited: 91 -
Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment.
Journal of neurochemistry.
2000
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MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons.
Neuroreport.
2000
Academic Article
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Times cited: 205 -
Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2000
Academic Article
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Times cited: 185 -
Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease.
Journal of neural transmission. Supplementum.
2000
Review
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Oxidative metabolism.
Annals of the New York Academy of Sciences.
2000
Conference Paper
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Huntington aggregates may not predict neuronal death in Huntington's disease.
Annals of neurology.
1999
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NOS knockouts and neuroprotection.
Nature medicine.
1999
Article
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Replicating Huntington's disease phenotype in experimental animals.
Progress in neurobiology.
1999
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Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation.
Neurology.
1999
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Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment.
Neuroreport.
1999
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Immunohistochemical detection of the lipid peroxidation product 4-hydroxynonenal after experimental brain injury in the rat.
Neuroscience letters.
1999
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Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex.
Neuroscience letters.
1999
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A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2'-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods.
Free radical biology & medicine.
1999
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Free radical biology & medicine.
1999
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Evidence for oxidative stress in the subthalamic nucleus in progressive supranuclear palsy.
Journal of neurochemistry.
1999
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Serial 1H-NMR spectroscopy study of metabolic impairment in primates chronically treated with the succinate dehydrogenase inhibitor 3-nitropropionic acid.
Neurobiology of disease.
1999
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Times cited: 35 -
Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1999
Academic Article
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Creatine and cyclocreatine attenuate MPTP neurotoxicity.
Experimental neurology.
1999
Academic Article
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NOS inhibitors decrease hypoxia-induced ATP reductions in respiring cerebrocortical slices.
Anesthesiology.
1999
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Novel free radical spin traps protect against malonate and MPTP neurotoxicity.
Experimental neurology.
1999
Academic Article
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Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1999
Review
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Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase.
Brain research.
1999
Academic Article
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Cerebrospinal fluid F2-isoprostanes are elevated in Huntington's disease.
Neurology.
1999
Comment
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Mitochondria in neurodegeneration: bioenergetic function in cell life and death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1999
Review
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Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.
Nature medicine.
1999
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Riluzole therapy in Huntington's disease (HD).
Movement disorders : official journal of the Movement Disorder Society.
1999
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Oxidative stress is attenuated in mice overexpressing BCL-2.
Neuroscience letters.
1999
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Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity.
Neuroreport.
1999
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Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle.
Free radical biology & medicine.
1999
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Increased CSF F2-isoprostane concentration in probable AD.
Neurology.
1999
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The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1999
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Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats.
Neuroscience letters.
1999
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A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease.
BioFactors (Oxford, England).
1999
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An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniques.
Annals of the New York Academy of Sciences.
1999
Conference Paper
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Times cited: 16 -
Bioenergetics in Huntington's disease.
Annals of the New York Academy of Sciences.
1999
Conference Paper
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Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases.
BioFactors (Oxford, England).
1999
Academic Article
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Times cited: 90 -
Estimation of hydroxyl free radical levels in vivo based on liquid chromatography with electrochemical detection.
Methods in enzymology.
1999
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Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.
Neuroscience.
1999
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Mitochondria, NO and neurodegeneration.
Biochemical Society symposium.
1999
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Oxidative stress in Huntington's disease.
Brain pathology (Zurich, Switzerland).
1999
Conference Paper
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Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade.
Neuroscience.
1999
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Journal of neurochemistry.
1998
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Mice deficient in group IV cytosolic phospholipase A2 are resistant to MPTP neurotoxicity.
Journal of neurochemistry.
1998
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Oral Dyskinesias and striatal lesions in rats after long-term co-treatment with haloperidol and 3-nitropropionic acid.
Neuroscience.
1998
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Evidence of oxidative stress in mdx mouse muscle: studies of the pre-necrotic state.
Journal of the neurological sciences.
1998
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1998
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Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia.
Cell death and differentiation.
1998
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Manganese superoxide dismutase overexpression attenuates MPTP toxicity.
Neurobiology of disease.
1998
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Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis.
Journal of neurochemistry.
1998
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Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis.
Annals of neurology.
1998
Conference Paper
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Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke.
Free radical biology & medicine.
1998
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Mitochondrial dysfunction in neurodegenerative diseases.
Biochimica et biophysica acta.
1998
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Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects.
Proceedings of the National Academy of Sciences of the United States of America.
1998
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Azulenyl nitrone spin traps protect against MPTP neurotoxicity.
Experimental neurology.
1998
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Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis.
Journal of neurochemistry.
1998
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Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
1998
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1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers.
Neurology.
1998
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Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients.
Neurology.
1998
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The neurotoxicity of amyloid beta protein in aged primates.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
1998
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Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice.
Brain research.
1998
Academic Article
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Glutamate toxicity in chronic neurodegenerative disease.
Progress in brain research.
1998
Review
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Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1998
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Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis.
Journal of neurochemistry.
1997
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Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis.
Annals of neurology.
1997
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New techniques for investigating mitochondrial DNA in neurodegenerative diseases.
Neurology.
1997
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Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1997
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Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data.
Magnetic resonance in medicine.
1997
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Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation.
Annals of neurology.
1997
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The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases.
Molecular and cellular biochemistry.
1997
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Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects.
Annals of neurology.
1997
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Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant.
Proceedings of the National Academy of Sciences of the United States of America.
1997
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Iodoacetate produces striatal excitotoxic lesions.
Journal of neurochemistry.
1997
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Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1997
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Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain.
Molecular and chemical neuropathology.
1997
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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.
Annals of neurology.
1997
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Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America.
1997
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Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra.
Brain research.
1997
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Cortical peptide changes in Huntington's disease may be independent of striatal degeneration.
Annals of neurology.
1997
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Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques.
The American journal of physiology.
1997
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MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress.
Experimental neurology.
1997
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Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.
Annals of neurology.
1997
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S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity.
Experimental neurology.
1997
Academic Article
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Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases.
Molecular aspects of medicine.
1997
Conference Paper
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Increased levels of plasma cholesteryl ester hydroperoxides in patients with subarachnoid hemorrhage.
Free radical biology & medicine.
1997
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MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice.
Neurobiology of disease.
1997
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NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease.
Neuroreport.
1996
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Mitochondria, free radicals, and neurodegeneration.
Current opinion in neurobiology.
1996
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Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons.
Nature medicine.
1996
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Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity.
Neurochemistry international.
1996
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Oxidative damage in Alzheimer's.
Nature.
1996
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Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.
Journal of neurochemistry.
1996
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Huntington's disease, behavioral disturbances, and kynurenines: preclinical findings and therapeutic perspectives.
Biological psychiatry.
1996
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Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1996
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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury.
Nature genetics.
1996
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Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1996
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Increased 3-nitrotyrosine in brains of Apo E-deficient mice.
Brain research.
1996
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Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases.
Neuroscience.
1996
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Altered mitochondrial membrane fluidity in AD brain.
Neuroscience letters.
1996
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NGF, BDNF and NT-5, but not NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals.
Brain research.
1996
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Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration.
Cell transplantation.
1996
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Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study.
Neurology.
1996
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Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1995
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Metabolic disorders and neurotoxicology.
Current opinion in neurology.
1995
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Role of nitric oxide in neurodegenerative diseases.
Current opinion in neurology.
1995
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Tardive dyskinesia and substrates of energy metabolism in CSF.
The American journal of psychiatry.
1995
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CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain.
Neuron.
1995
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Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1995
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Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients.
Neurology.
1995
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Neuroprotective effects of free radical scavengers and energy repletion in animal models of neurodegenerative disease.
Annals of the New York Academy of Sciences.
1995
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Aging, energy, and oxidative stress in neurodegenerative diseases.
Annals of neurology.
1995
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Excitotoxins, aging, and environmental neurotoxins: implications for understanding human neurodegenerative diseases.
Toxicology and applied pharmacology.
1995
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3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice.
Journal of neurochemistry.
1995
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Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.
Proceedings of the National Academy of Sciences of the United States of America.
1995
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Basic fibroblast growth factor protects against excitotoxicity and chemical hypoxia in both neonatal and adult rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1995
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Involvement of free radicals in excitotoxicity in vivo.
Journal of neurochemistry.
1995
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Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis.
Journal of neurochemistry.
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Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity.
Experimental neurology.
1995
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Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.
Journal of neurochemistry.
1995
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Bioenergetic and oxidative stress in neurodegenerative diseases.
Life sciences.
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Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate.
Annals of neurology.
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Cortical cytochrome oxidase activity is reduced in Alzheimer's disease.
Journal of neurochemistry.
1994
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Neurochemistry and toxin models in Huntington's disease.
Current opinion in neurology.
1994
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3-Acetylpyridine produces age-dependent excitotoxic lesions in rat striatum.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
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Journal of neurochemistry.
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Oxidative damage and mitochondrial dysfunction in neurodegenerative diseases.
Biochemical Society transactions.
1994
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Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease.
Annals of neurology.
1994
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Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism.
Experimental neurology.
1994
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Marked changes in mitochondrial DNA deletion levels in Alzheimer brains.
Genomics.
1994
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Elevation of neuronal MAO-B activity in a transgenic mouse model does not increase sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Brain research.
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Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10.
Neuroscience letters.
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Implanted NGF-producing fibroblasts induce catalase and modify ATP levels but do not affect glutamate receptor binding or NMDA receptor expression in the rat striatum.
Experimental neurology.
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Mitochondrial dysfunction in movement disorders.
Current opinion in neurology.
1994
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Movement disorder following excitotoxin lesions in primates.
Neuroreport.
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A frequent ala 4 to val superoxide dismutase-1 mutation is associated with a rapidly progressive familial amyotrophic lateral sclerosis.
Human molecular genetics.
1994
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Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis.
Human molecular genetics.
1994
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Malonate produces striatal lesions by indirect NMDA receptor activation.
Brain research.
1994
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Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.
Proceedings of the National Academy of Sciences of the United States of America.
1994
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Huntington's disease, energy, and excitotoxicity.
Neurobiology of aging.
1994
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Neurobiology of aging.
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Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy.
Neurology.
1993
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Intrastriatal injections of quinolinic acid or kainic acid: differential patterns of cell survival and the effects of data analysis on outcome.
Experimental neurology.
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Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis.
Journal of neurochemistry.
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Neurochemical aspects of aging in primates.
Neurobiology of aging.
1993
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Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
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Neurochemical substrates of rigidity and chorea in Huntington's disease.
Brain : a journal of neurology.
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Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.
Annals of neurology.
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Journal of neurochemistry.
1993
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Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss.
Neurobiology of aging.
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Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients.
Genomics.
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Age-dependent impairment of mitochondrial function in primate brain.
Journal of neurochemistry.
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Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?.
Trends in neurosciences.
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NMDA antagonists partially protect against MPTP induced neurotoxicity in mice.
Neuroreport.
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Delayed administration of basic fibroblast growth factor protects against N-methyl-D-aspartate neurotoxicity in neonatal rats.
European journal of pharmacology.
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Basic fibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1993
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Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism.
Experimental neurology.
1993
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Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.
Journal of neurochemistry.
1993
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Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization.
Experimental neurology.
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
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Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age.
Nature genetics.
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The effect of peripheral loading with kynurenine and probenecid on extracellular striatal kynurenic acid concentrations.
Neuroscience letters.
1992
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Role of excitotoxicity in human neurological disease.
Current opinion in neurobiology.
1992
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The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex.
Annals of neurology.
1992
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Behavioral and pharmacological effects of centrally administered aminooxyacetic acid in rats.
European journal of pharmacology.
1992
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In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment.
Neurobiology of aging.
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Neurology.
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Developmental changes in brain kynurenic acid concentrations.
Brain research. Developmental brain research.
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Annals of the New York Academy of Sciences.
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1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.
Journal of neurochemistry.
1992
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Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1992
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Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex.
Journal of the neurological sciences.
1992
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Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?.
Annals of neurology.
1992
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Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.
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Effects of aging on quinolinic acid lesions in rat striatum.
Brain research.
1991
Academic Article
GET IT
Times cited: 20 -
Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism.
Journal of neurochemistry.
1991
Academic Article
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Times cited: 104 -
Neurotransmitters in neocortex of aged rhesus monkeys.
Neurobiology of aging.
1991
Academic Article
GET IT
Times cited: 37 -
An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.
Proceedings of the National Academy of Sciences of the United States of America.
1991
Academic Article
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Times cited: 505 -
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1991
Academic Article
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Times cited: 434 -
Comparative behavioral and neurochemical studies with striatal kainic acid- or quinolinic acid-lesioned rats.
Pharmacology, biochemistry, and behavior.
1991
Academic Article
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Times cited: 41 -
2-Chloroadenosine attenuates NMDA, kainate, and quisqualate toxicity.
Neuroscience letters.
1991
Academic Article
GET IT
Times cited: 22 -
Cholecystokinin and somatostatin in Alzheimer's disease postmortem cerebral cortex.
Neurology.
1991
Academic Article
GET IT
Times cited: 37 -
Comparative behavioral and pharmacological studies with centrally administered kynurenine and kynurenic acid in rats.
European journal of pharmacology.
1991
Academic Article
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Times cited: 31 -
Global ischemia induces NMDA receptor-mediated c-fos expression in neurons resistant to injury in gerbil hippocampus.
Brain research.
1991
Academic Article
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Times cited: 93 -
Glutamate-, glutaminase-, and taurine-immunoreactive neurons develop neurofibrillary tangles in Alzheimer's disease.
Annals of neurology.
1991
Academic Article
GET IT
Times cited: 68 -
Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease.
Neuroscience letters.
1991
Academic Article
GET IT
Times cited: 53 -
Neurochemical characterization of excitotoxin lesions in the cerebral cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1991
Academic Article
GET IT
Times cited: 85 -
Intracerebroventricular injection of kynurenic acid, but not kynurenine, induces ataxia and stereotyped behavior in rats.
Brain research bulletin.
1990
Academic Article
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Times cited: 31 -
Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid.
Journal of neurochemistry.
1990
Academic Article
GET IT
Times cited: 251 -
Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1990
Academic Article
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Times cited: 222 -
Influence of kynurenine treatment on open-field activity, elevated plus-maze, avoidance behaviors and seizures in rats.
Pharmacology, biochemistry, and behavior.
1990
Academic Article
GET IT
Times cited: 29 -
Somatostatin in neurodegenerative illnesses.
Metabolism: clinical and experimental.
1990
Academic Article
GET IT
Times cited: 25 -
Galanin immunoreactivity is increased in the nucleus basalis of Meynert in Alzheimer's disease.
Annals of neurology.
1990
Academic Article
GET IT
Times cited: 101 -
Characterization and mechanism of glutamate neurotoxicity in primary striatal cultures.
Brain research.
1990
Academic Article
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Times cited: 67 -
Selective sparing of NADPH-diaphorase-somatostatin-neuropeptide Y neurons in ischemic gerbil striatum.
Annals of neurology.
1990
Academic Article
GET IT
Times cited: 190 -
Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode array detection.
Analytical biochemistry.
1990
Academic Article
GET IT
Times cited: 111 -
Multiple cranial-nerve palsies: a diagnostic challenge.
The New England journal of medicine.
1990
Editorial Article
GET IT
Times cited: 13 -
Homocysteic acid lesions in rat striatum spare somatostatin-neuropeptide Y (NADPH-diaphorase) neurons.
Neuroscience letters.
1990
Academic Article
GET IT
Times cited: 39 -
Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats.
Neuropeptides.
1989
Academic Article
GET IT
Times cited: 36 -
Substance P-like immunoreactivity in brains with pathological features of Parkinson's and Alzheimer's diseases.
Brain research.
1989
Academic Article
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Times cited: 17 -
Galanin-like immunoreactivity is present in human substantia innominata and in senile plaques in Alzheimer's disease.
Neuroscience letters.
1989
Academic Article
GET IT
Times cited: 38 -
Aluminum-induced neurofibrillary degeneration affects a subset of neurons in rabbit cerebral cortex, basal forebrain and upper brainstem.
Neuroscience.
1989
Academic Article
GET IT
Times cited: 84 -
Differential sparing of somatostatin-neuropeptide Y and cholinergic neurons following striatal excitotoxin lesions.
Synapse (New York, N.Y.).
1989
Academic Article
GET IT
Times cited: 169 -
Neurochemical characteristics of aluminum-induced neurofibrillary degeneration in rabbits.
Neuroscience.
1989
Academic Article
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Times cited: 31 -
Cerebral aspergillosis.
New York state journal of medicine.
1988
Academic Article
GET IT
Times cited: 4 - Cortical amino acids in brains with pathological features of Parkinson's and Alzheimer's diseases. Neurochemical Pathology. 1988 Article
-
Galanin-like immunoreactivity is unchanged in Alzheimer's disease and Parkinson's disease dementia cerebral cortex.
Journal of neurochemistry.
1988
Academic Article
GET IT
Times cited: 39 -
Cerebrospinal fluid neurochemistry in the myoclonic subtype of Alzheimer's disease.
Annals of neurology.
1988
Academic Article
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Times cited: 38 -
Developmental changes of neuropeptides and amino acids in baboon cortex.
Brain research. Developmental brain research.
1988
Academic Article
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Times cited: 13 -
Systemic approaches to modifying quinolinic acid striatal lesions in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1988
Academic Article
GET IT
Times cited: 87 -
Age-related disruption of classical conditioning: a model systems approach to memory disorders.
Neurobiology of aging.
1988
Academic Article
GET IT
Times cited: 42 - Response:Model of Huntington's disease. Science (New York, N.Y.). 1988 Academic Article GET IT
-
Distribution of galanin-like immunoreactivity in baboon brain.
Peptides.
1988
Academic Article
GET IT
Times cited: 42 -
Amino acid and neuropeptide neurotransmitters in Huntington's disease cerebellum.
Brain research.
1988
Academic Article
GET IT
Times cited: 10 -
Somatostatin and neuropeptide Y concentrations in pathologically graded cases of Huntington's disease.
Annals of neurology.
1988
Academic Article
GET IT
Times cited: 70 -
Characterization of galanin-like immunoreactivity in the rat brain: effects of neonatal glutamate treatment.
Neuroscience letters.
1988
Academic Article
GET IT
Times cited: 38 -
A detailed examination of substance P in pathologically graded cases of Huntington's disease.
Journal of the neurological sciences.
1988
Academic Article
GET IT
Times cited: 38 -
Cerebrospinal fluid somatostatin and neuropeptide Y. Concentrations in aging and in dementia of the Alzheimer type with and without extrapyramidal signs.
Archives of neurology.
1988
Academic Article
GET IT
Times cited: 67 -
Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: normal anatomy and alterations in Alzheimer's disease.
Annals of neurology.
1988
Academic Article
GET IT
Times cited: 195 -
Neuropathologic, neurochemical and immunocytochemical characteristics of aluminum-induced neurofilamentous degeneration.
Neurotoxicology.
1988
Academic Article
GET IT
Times cited: 14 -
Somatostatin and neuropeptide Y immunoreactivity in Parkinson's disease dementia with Alzheimer's changes.
Synapse (New York, N.Y.).
1988
Academic Article
GET IT
Times cited: 21 -
Amino acid neurotransmitter abnormalities in Huntington's disease and the quinolinic acid animal model of Huntington's disease.
Brain : a journal of neurology.
1987
Academic Article
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Times cited: 94 -
The regional distribution of somatostatin and neuropeptide Y in control and Alzheimer's disease striatum.
Neuroscience letters.
1987
Academic Article
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Times cited: 14 -
EC array sensor concepts and data.
Life sciences.
1987
Academic Article
GET IT
Times cited: 85 -
Phosphoethanolamine and ethanolamine are decreased in Alzheimer's disease and Huntington's disease.
Brain research.
1987
Academic Article
GET IT
Times cited: 80 -
Substance P-like immunoreactivity is reduced in Alzheimer's disease cerebral cortex.
Neurology.
1987
Academic Article
GET IT
Times cited: 80 -
Oxytocin in Alzheimer's disease: postmortem brain levels.
Neurology.
1987
Academic Article
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Times cited: 43 -
Somatostatin and neuropeptide Y are unaltered in the amygdala in schizophrenia.
Neurochemical pathology.
1987
Academic Article
GET IT
Times cited: 16 -
Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease.
Brain research.
1987
Academic Article
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Times cited: 198 -
The effect of amphetamine on the in vivo release of dopamine, somatostatin and neuropeptide Y from rat caudate nucleus.
Brain research.
1987
Academic Article
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Times cited: 55 -
No evidence for preservation of somatostatin-containing neurons after intrastriatal injections of quinolinic acid.
Nature.
1987
Academic Article
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Times cited: 106 -
Amino acid neurotransmitters in postmortem human brain analyzed by high performance liquid chromatography with electrochemical detection.
Journal of neuroscience methods.
1987
Academic Article
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Times cited: 80 -
A comparison of somatostatin and neuropeptide Y distribution in monkey brain.
Brain research.
1987
Academic Article
GET IT
Times cited: 41 -
Neuropeptide Y, somatostatin, and reduced nicotinamide adenine dinucleotide phosphate diaphorase in the human striatum: a combined immunocytochemical and enzyme histochemical study.
Neuroscience.
1987
Academic Article
GET IT
Times cited: 137 -
Idiopathic cranial polyneuropathy. A fifteen-year experience.
Brain : a journal of neurology.
1987
Academic Article
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Times cited: 43 -
Effect of cysteamine on somatostatin and neuropeptide Y in rat striatum and cortical synaptosomes.
Brain research.
1987
Academic Article
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Times cited: 13 -
Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease.
Journal of neuropathology and experimental neurology.
1987
Academic Article
GET IT
Times cited: 245 -
Neuropeptides in Alzheimer's disease.
Journal of neural transmission. Supplementum.
1987
Review
GET IT
Times cited: 23 -
Results of immunocytochemical, neurochemical, and behavioral studies in aluminum-induced neurofilamentous degeneration.
Journal of neural transmission. Supplementum.
1987
Academic Article
GET IT
Times cited: 9 -
Vasopressin in Alzheimer's disease: a study of postmortem brain concentrations.
Annals of neurology.
1986
Academic Article
GET IT
Times cited: 43 -
Somatostatin immunoreactivity is reduced in Parkinson's disease dementia with Alzheimer's changes.
Brain research.
1986
Academic Article
GET IT
Times cited: 19 -
A postmortem study of amino acid neurotransmitters in Alzheimer's disease.
Annals of neurology.
1986
Academic Article
GET IT
Times cited: 107 -
Neuropeptides in Alzheimer's disease. Clinical implications.
Neurologic clinics.
1986
Review
GET IT
Times cited: 5 -
Neuropeptides in neurological disease.
Annals of neurology.
1986
Academic Article
GET IT
Times cited: 135 -
The effect of neuropeptide Y on striatal catecholamines.
Neuroscience letters.
1986
Academic Article
GET IT
Times cited: 50 -
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 39-1986. A 66-year-old woman with fever, fluctuating neurologic signs, and negative blood cultures.
The New England journal of medicine.
1986
Academic Article
GET IT
Times cited: 11 -
Widespread reduction of somatostatin-like immunoreactivity in the cerebral cortex in Alzheimer's disease.
Annals of neurology.
1986
Academic Article
GET IT
Times cited: 76 -
Beta-endorphin and somatostatin concentrations in the ventricular cerebrospinal fluid of patients with affective disorder.
Biological psychiatry.
1986
Academic Article
GET IT
Times cited: 20 -
Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer's disease.
Annals of neurology.
1986
Academic Article
GET IT
Times cited: 129 -
CSF vasopressin concentration is reduced in Alzheimer's disease.
Neurology.
1986
Academic Article
GET IT
Times cited: 37 -
A comparison of regional somatostatin and neuropeptide Y distribution in rat striatum and brain.
Brain research.
1986
Academic Article
GET IT
Times cited: 39 -
Reduced concentrations of arginine vasopressin and MHPG in lumbar CSF of patients with Korsakoff's psychosis.
Life sciences.
1986
Academic Article
GET IT
Times cited: 11 -
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid.
Nature.
1986
Academic Article
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Times cited: 1077 -
Somatostatin-28(1-12)-like immunoreactivity is reduced in Alzheimer's disease cerebral cortex.
Brain research.
1986
Academic Article
GET IT
Times cited: 28 -
An examination of neuropeptide Y postmortem stability in an animal model simulating human autopsy conditions.
Neuroscience letters.
1986
Academic Article
GET IT
Times cited: 48 -
CSF somatostatin-like immunoreactivity in dementia.
Neurology.
1986
Academic Article
GET IT
Times cited: 57 -
Somatostatin binding sites in human and monkey brain: localization and characterization.
Journal of neurochemistry.
1986
Academic Article
GET IT
Times cited: 36 -
CSF cyclic nucleotides and somatostatin in Parkinson's disease.
Neurology.
1986
Academic Article
GET IT
Times cited: 25 -
CSF neurotransmitter markers in Alzheimer's disease.
Progress in neuro-psychopharmacology & biological psychiatry.
1986
Review
GET IT
Times cited: 12 -
Somatostatin: alterations in the central nervous system in neurological diseases.
Research publications - Association for Research in Nervous and Mental Disease.
1986
Review
GET IT
Times cited: 37 -
Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease.
Brain research.
1985
Academic Article
GET IT
Times cited: 28 -
Topographical dopamine and serotonin distribution and turnover in rat striatum.
Brain research.
1985
Academic Article
GET IT
Times cited: 61 -
Human cerebrospinal fluid somatostatin in neurologic disease.
Journal of the neurological sciences.
1985
Academic Article
GET IT
Times cited: 39 -
Selective sparing of a class of striatal neurons in Huntington's disease.
Science (New York, N.Y.).
1985
Academic Article
GET IT
Times cited: 654 -
Topography of nicotinamide adenine dinucleotide phosphate-diaphorase staining neurons in rat striatum.
Neuroscience letters.
1985
Academic Article
GET IT
Times cited: 48 -
Reduced numbers of somatostatin receptors in the cerebral cortex in Alzheimer's disease.
Science (New York, N.Y.).
1985
Academic Article
GET IT
Times cited: 186 -
Immunoreactive somatostatin-28(1-12) is increased in Huntington's disease.
Neuroscience letters.
1985
Academic Article
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Times cited: 13 -
Two types of somatostatin receptors differentiated by cyclic somatostatin analogs.
Science (New York, N.Y.).
1985
Academic Article
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Times cited: 195 -
Effects of lesions in the amygdala and periventricular hypothalamus on striatal somatostatin-like immunoreactivity.
Brain research.
1985
Academic Article
GET IT
Times cited: 15 -
Effects of neuroleptic drugs on brain beta-endorphin immunoreactivity.
Neuroscience letters.
1985
Academic Article
GET IT
Times cited: 6 -
Depletion of striatal somatostatin by local cysteamine injection.
Brain research.
1984
Academic Article
GET IT
Times cited: 23 -
Effects of neuroleptic drugs on brain somatostatin-like-immunoreactivity.
Neuroscience letters.
1984
Academic Article
GET IT
Times cited: 65 -
Somatostatin is increased in the nucleus accumbens in Huntington's disease.
Neurology.
1984
Academic Article
GET IT
Times cited: 65 -
The effect of somatostatin on striatal catecholamines.
Neuroscience letters.
1984
Academic Article
GET IT
Times cited: 61 -
Implications of neuropeptides in neurological diseases.
Peptides.
1984
Academic Article
GET IT
Times cited: 25 -
Regional somatostatin distribution in the rat striatum.
Brain research.
1983
Academic Article
GET IT
Times cited: 54 -
Immunosuppression and plasmapheresis in chronic progressive multiple sclerosis. Design of a clinical trial.
Archives of neurology.
1983
Academic Article
GET IT
Times cited: 15 -
Localized brainstem ischemic damage and Ondine's curse after near-drowning.
Neurology.
1983
Academic Article
GET IT
Times cited: 43 -
Effects of lesions on somatostatin-like immunoreactivity in the rat striatum.
Brain research.
1983
Academic Article
GET IT
Times cited: 57 - Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. The New England journal of medicine. 1983 Academic Article GET IT
-
Amitriptyline ophthalmoplegia.
Neurology.
1982
Letter
GET IT
Times cited: 4 -
Cerebral vein thrombosis and multiple intracranial hemorrhages by computed tomography.
Archives of neurology.
1982
Academic Article
GET IT
Times cited: 13 -
Aspergillosis of the nervous system.
Neurology.
1982
Academic Article
GET IT
Times cited: 107 -
Neoplastic angioendotheliosis.
Journal of the neurological sciences.
1982
Academic Article
GET IT
Times cited: 52 - Controlled randomized trial of high-dose cyclophosphamide, plasmapheresis, and ACTH in progressive multiple sclerosis. Neurology. 1982 Article
-
Computed tomography of intracranial aspergillosis.
Journal of computer assisted tomography.
1981
Academic Article
GET IT
Times cited: 26 -
Gangliocytoma of third ventricle: hyperphagia, somnolence, and dementia.
Neurology.
1981
Academic Article
GET IT
Times cited: 34 -
Primary lateral sclerosis: a case report.
Archives of neurology.
1981
Academic Article
GET IT
Times cited: 68 -
Cholesterol embolism as a cause of transient ischemic attacks and cerebral infarction.
Neurology.
1981
Academic Article
GET IT
Times cited: 100 -
Cerebral atheromatous embolism following carotid sinus pressure.
Archives of neurology.
1981
Academic Article
GET IT
Times cited: 29 - Neoplastic angioendotheliosis. Stroke. 1981 Article
-
Cortical blindness and homonymous hemianopia in the postpartum period.
JAMA.
1980
Academic Article
GET IT
Times cited: 20 -
Catecholamine uptake, accumulation, and release in acute porphyria.
The Journal of clinical investigation.
1977
Academic Article
GET IT
Times cited: 20