Khelashvili, George

Publications

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selected publications

Mechanistic Understanding of the Modes of Ca²⁺ Ion Binding to the SARS-CoV-1 Fusion Peptide and Their Role in the Dynamics of Host Membrane Penetration. ACS infectious diseases. 2024 Academic Article GET IT
A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. The Journal of biological chemistry. 2024 Academic Article GET IT
A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. 2023 GET IT
Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A. Nature communications. 2023 Academic Article GET IT
Times cited: 2
CD19 CAR antigen engagement mechanisms and affinity tuning. Science immunology. 2023 Academic Article GET IT
BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science (New York, N.Y.). 2023 Academic Article GET IT
Molecular Simulations and NMR Reveal How Lipid Fluctuations Affect Membrane Mechanics. Biophysical journal. 2022 Academic Article GET IT
The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase. Communications biology. 2022 Academic Article GET IT
The permeation of potassium ions through the lipid scrambling path of the membrane protein nhTMEM16. Frontiers in molecular biosciences. 2022 Academic Article GET IT
Cholesterol occupies the lipid translocation pathway to block phospholipid scrambling by a G protein-coupled receptor. Structure (London, England : 1993). 2022 Academic Article GET IT
Phosphatidylinositol Phosphates Modulate Interactions between the StarD4 Sterol Trafficking Protein and Lipid Membranes. The Journal of biological chemistry. 2022 Academic Article GET IT
Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants. Biophysical journal. 2022 Academic Article GET IT
Mechanistic Kinetic Model Reveals How Amyloidogenic Hydrophobic Patches Facilitate the Amyloid-β Fibril Elongation. ACS chemical neuroscience. 2022 Academic Article GET IT
Localization atomic force microscopy. Nature. 2021 Academic Article GET IT
Times cited: 4
Structural basis of omega-3 fatty acid transport across the blood-brain barrier. Nature. 2021 Academic Article GET IT
Reply to Nagle et al.: The universal stiffening effects of cholesterol on lipid membranes. Proceedings of the National Academy of Sciences of the United States of America. 2021 Article GET IT
Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin. Scientific reports. 2021 Academic Article GET IT
Ca²⁺-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide. Biophysical journal. 2021 Academic Article GET IT
Times cited: 38
How cholesterol stiffens unsaturated lipid membranes. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 184
Confinement in Nanodiscs Anisotropically Modifies Lipid Bilayer Elastic Properties. The journal of physical chemistry. B. 2020 Academic Article GET IT
Times cited: 22
GPCRmd uncovers the dynamics of the 3D-GPCRome. Nature methods. 2020 Academic Article GET IT
Times cited: 26
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature communications. 2020 Academic Article GET IT
Times cited: 25
Exchange of water for sterol underlies sterol egress from a StARkin domain. eLife. 2019 Academic Article GET IT
Times cited: 13
Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins. Journal of computational chemistry. 2019 Academic Article GET IT
Times cited: 12
Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca²⁺-bound nhTMEM16. Nature communications. 2019 Academic Article GET IT
Times cited: 18
The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 19
A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs. Molecules (Basel, Switzerland). 2019 Academic Article GET IT
Times cited: 35
A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited. Biophysical journal. 2019 Academic Article GET IT
Times cited: 48
Mesoscale Computational Modeling of Protein-Membrane Interactions Based on Continuum Mean-Field Theory. Methods in molecular biology (Clifton, N.J.). 2019 Article GET IT
Times cited: 1
Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase. Nature communications. 2018 Academic Article GET IT
Times cited: 56
An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1. Cell reports. 2018 Academic Article GET IT
Times cited: 15
Light-independent phospholipid scramblase activity of bacteriorhodopsin from Halobacterium salinarum. Scientific reports. 2018 Academic Article GET IT
Times cited: 18
How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties. BMC biology. 2018 Academic Article GET IT
Times cited: 28
A partially-open inward-facing intermediate conformation of LeuT is associated with Na⁺ release and substrate transport. Nature communications. 2018 Academic Article GET IT
Times cited: 33
Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin. Structure (London, England : 1993). 2017 Academic Article GET IT
Times cited: 41
An engineered opsin monomer scrambles phospholipids. Scientific reports. 2017 Academic Article GET IT
Times cited: 11
Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter. Biophysical journal. 2017 Academic Article GET IT
Times cited: 13
Cholesterol Promotes Protein Binding by Affecting Membrane Electrostatics and Solvation Properties. Biophysical journal. 2017 Academic Article GET IT
Times cited: 30
Ligand modulation of sidechain dynamics in a wild-type human GPCR. eLife. 2017 Academic Article GET IT
Times cited: 67
Determination of bending rigidity and tilt modulus of lipid membranes from real-space fluctuation analysis of molecular dynamics simulations. Physical chemistry chemical physics : PCCP. 2017 Academic Article GET IT
Times cited: 85
A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter. Scientific reports. 2017 Academic Article GET IT
Times cited: 54
Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances - The case of the benzofuran 5-MAPB. Progress in neuro-psychopharmacology & biological psychiatry. 2016 Academic Article GET IT
Times cited: 10
Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 19
Implementation of a methodology for determining elastic properties of lipid assemblies from molecular dynamics simulations. BMC bioinformatics. 2016 Academic Article GET IT
Times cited: 22
Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters. Chemical reviews. 2016 Information Resource GET IT
Times cited: 49
Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles. Biochemistry. 2016 Academic Article GET IT
Times cited: 12
Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus. ACS chemical neuroscience. 2015 Academic Article GET IT
Times cited: 83
Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering. Structure (London, England : 1993). 2015 Academic Article GET IT
Times cited: 32
Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 42
Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops. Biochimica et biophysica acta. 2015 Information Resource GET IT
Times cited: 25
Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes. Proteins. 2015 Academic Article GET IT
Times cited: 40
Cholesterol under oxidative stress-How lipid membranes sense oxidation as cholesterol is being replaced by oxysterols. Free radical biology & medicine. 2015 Academic Article GET IT
Times cited: 36
Transport domain unlocking sets the uptake rate of an aspartate transporter. Nature. 2015 Academic Article GET IT
Times cited: 126
Curvature and Lipid Packing Modulate the Elastic Properties of Lipid Assemblies: Comparing HII and Lamellar Phases. The journal of physical chemistry letters. 2014 Academic Article GET IT
Times cited: 12
A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 65
Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins. Biophysical journal. 2014 Information Resource GET IT
Times cited: 45
PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein. Nature chemical biology. 2014 Academic Article GET IT
Times cited: 96
Protein and lipid interactions driving molecular mechanisms of in meso crystallization. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 17
Molecular origins of bending rigidity in lipids with isolated and conjugated double bonds: the effect of cholesterol. Chemistry and physics of lipids. 2014 Academic Article GET IT
Times cited: 23
Membrane driven spatial organization of GPCRs. Scientific reports. 2013 Academic Article GET IT
Times cited: 95
The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site. Journal of the American Chemical Society. 2013 Academic Article GET IT
Times cited: 29
Calculating the Bending Modulus for Multicomponent Lipid Membranes in Different Thermodynamic Phases. Journal of chemical theory and computation. 2013 Academic Article GET IT
How cholesterol tilt modulates the mechanical properties of saturated and unsaturated lipid membranes. The journal of physical chemistry. B. 2013 Academic Article GET IT
Times cited: 50
The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT. Chemistry and physics of lipids. 2013 Academic Article GET IT
Times cited: 37
Phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure. Biochemistry. 2012 Academic Article GET IT
Times cited: 25
Why GPCRs behave differently in cubic and lamellar lipidic mesophases. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 43
Structural intermediates in a model of the substrate translocation path of the bacterial glutamate transporter homologue GltPh. The journal of physical chemistry. B. 2012 Academic Article GET IT
Times cited: 37
Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties. PLoS computational biology. 2012 Academic Article GET IT
Times cited: 95
Impact of sterol tilt on membrane bending rigidity in cholesterol and 7DHC-containing DMPC membranes. Soft matter. 2011 Academic Article GET IT
Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors. Biophysical journal. 2011 Academic Article GET IT
Times cited: 77
Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors. The journal of physical chemistry. B. 2010 Academic Article GET IT
Times cited: 27
Cholesterol orientation and tilt modulus in DMPC bilayers. The journal of physical chemistry. B. 2010 Academic Article GET IT
Times cited: 78
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (Oxford, England). 2010 Academic Article GET IT
Times cited: 69
Modeling membrane deformations and lipid demixing upon protein-membrane interaction: the BAR dimer adsorption. Biophysical journal. 2009 Academic Article GET IT
Times cited: 60
Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations. Proteins. 2009 Academic Article GET IT
Times cited: 107
Protein diffusion on charged membranes: a dynamic mean-field model describes time evolution and lipid reorganization. Biophysical journal. 2007 Academic Article GET IT
Times cited: 47
Lateral organization in lipid-cholesterol mixed bilayers. Biophysical journal. 2006 Academic Article GET IT
Times cited: 47
Self-consistent mean-field model based on molecular dynamics: application to lipid-cholesterol bilayers. The Journal of chemical physics. 2005 Academic Article GET IT
Times cited: 38
Combined Monte Carlo and molecular dynamics simulation of hydrated 18:0 sphingomyelin-cholesterol lipid bilayers. The Journal of chemical physics. 2004 Academic Article GET IT
Times cited: 70

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Research

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Funding awarded

Structural basis of receptor-mediated cellular vitamin A uptake awarded by National Institute of Mental Health Principal Investigator Subaward 2023 - 2028

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Background

education and training

Ph.D., Illinois Institute of Technology 2005
M.Sc., Tbilisi State University (Georgia) 1999
B.Sc., Tbilisi State University (Georgia) 1997

Contact

full name

George Khelashvili

primary email

gek2009@med.cornell.edu

VIVO Weill Cornell Medical College

George Khelashvili Associate Professor of Physiology and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email