selected publications
- Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome. Nature communications. 2024 Academic Article GET IT
- Sudden Unexpected Death in Epilepsy: Respiratory vs. Cardiac Contributions. Cardiovascular research. 2024 Academic Article GET IT
- A Natural History Study of Timothy Syndrome. 2024 GET IT
- Augmented Cardiac Inotropy by Phosphodiesterase Inhibition Requires Phosphorylation of Rad and Increased Calcium Current. Circulation. 2024 Letter GET IT
- Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism. 2024 GET IT
- Mutations of Splicing Regulator RBM20 in Atrial Fibrillation. JACC. Basic to translational science. 2024 Editorial Article GET IT
- A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels. The Journal of clinical investigation. 2024 Academic Article GET IT
- Increased Ca2+ signaling through CaV 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 Academic Article GET IT
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Tumour extracellular vesicles and particles induce liver metabolic dysfunction.
Nature.
2023
Academic Article
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Times cited: 70 - A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nature cell biology. 2023 Academic Article GET IT
- Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response. Nature cardiovascular research. 2022 Academic Article GET IT
- Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 Academic Article GET IT
- A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells. iScience. 2022 Academic Article GET IT
- Proteolytic regulation of calcium channels - avoiding controversy. Faculty reviews. 2022 Comment GET IT
- SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells. Circulation research. 2022 Academic Article GET IT
- JACC: Basic to Translational Science Top Reviewers 2021: With Appreciation. JACC. Basic to translational science. 2022 Editorial Article GET IT
- Increased Ca2+ influx through CaV1.2 drives aortic valve calcification. JCI insight. 2022 Academic Article GET IT
- Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors. JCI insight. 2021 Academic Article GET IT
- Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations. Genetics in medicine : official journal of the American College of Medical Genetics. 2021 Academic Article GET IT
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A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain.
Nature communications.
2021
Academic Article
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Times cited: 95 -
Voltage-Gated Calcium Channels in Nonexcitable Tissues.
Annual review of physiology.
2020
Information Resource
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Times cited: 43 -
Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop.
Circulation research.
2020
Academic Article
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Times cited: 36 -
Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.
JCI insight.
2020
Academic Article
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Times cited: 15 - Cardiac phenotype in ATP1A3-related syndromes: A multicenter cohort study. Neurology. 2020 Academic Article GET IT
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An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF.
The Journal of general physiology.
2020
Academic Article
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Times cited: 18 -
Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics.
Nature.
2020
Academic Article
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Times cited: 151 -
Ca2+/CaM interaction with voltage-gated Na+ channels.
Proceedings of the National Academy of Sciences of the United States of America.
2019
Article
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Times cited: 1 -
Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019
Academic Article
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Times cited: 9 -
The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.
Bone.
2019
Academic Article
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Times cited: 17 -
Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.
The Journal of clinical investigation.
2019
Academic Article
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Times cited: 50 -
An update on the journey towards precision medicine in cardiology.
European heart journal.
2018
Academic Article
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Times cited: 1 -
The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.
The Journal of clinical investigation.
2018
Academic Article
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Times cited: 58 -
Progress in Understanding and Treating SCN2A-Mediated Disorders.
Trends in neurosciences.
2018
Information Resource
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Times cited: 198 -
Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.
JCI insight.
2017
Academic Article
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Times cited: 38 -
Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Academic Article
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Times cited: 36 -
Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Academic Article
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Times cited: 26 -
Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.
Journal of molecular and cellular cardiology.
2017
Academic Article
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Times cited: 30 -
Calmodulin limits pathogenic Na+ channel persistent current.
The Journal of general physiology.
2017
Academic Article
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Times cited: 48 -
FGF14 is a regulator of KCNQ2/3 channels.
Proceedings of the National Academy of Sciences of the United States of America.
2016
Academic Article
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Times cited: 38 -
Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.
Cell stem cell.
2016
Academic Article
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Times cited: 166 -
Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.
Protein science : a publication of the Protein Society.
2016
Information Resource
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Times cited: 39 -
FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.
Channels (Austin, Tex.).
2016
Academic Article
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Times cited: 25 -
α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.
PloS one.
2016
Academic Article
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Times cited: 10 - Long QT Syndrome and Seizures. JACC. Clinical electrophysiology. 2016 Editorial Article GET IT
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STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.
Proceedings of the National Academy of Sciences of the United States of America.
2015
Academic Article
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Times cited: 42 -
SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
Proceedings of the National Academy of Sciences of the United States of America.
2015
Academic Article
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Times cited: 46 -
Calcium Channel Mutations in Cardiac Arrhythmia Syndromes.
Current molecular pharmacology.
2015
Information Resource
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Times cited: 43 -
Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow.
Journal of molecular and cellular cardiology.
2014
Academic Article
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Times cited: 12 -
The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart.
The Journal of biological chemistry.
2014
Academic Article
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Times cited: 10 -
Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
2014
Information Resource
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Times cited: 34 -
FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons.
eLife.
2014
Academic Article
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Times cited: 54 -
Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.
Nature communications.
2014
Academic Article
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Times cited: 85 -
A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis.
PloS one.
2014
Academic Article
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Times cited: 43 -
FGF12 is a candidate Brugada syndrome locus.
Heart rhythm.
2013
Academic Article
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Times cited: 85 -
FGF14 regulates presynaptic Ca2+ channels and synaptic transmission.
Cell reports.
2013
Academic Article
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Times cited: 64 -
Fibroblast growth factor homologous factors modulate cardiac calcium channels.
Circulation research.
2013
Academic Article
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Times cited: 52 -
The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.
The Journal of biological chemistry.
2013
Academic Article
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Times cited: 20 -
Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.
The Journal of clinical investigation.
2013
Academic Article
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Times cited: 58 -
Long-term in vivo imaging of multiple organs at the single cell level.
PloS one.
2013
Academic Article
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Times cited: 5 -
Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.
PLoS genetics.
2012
Academic Article
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Times cited: 44 -
A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.
Cell metabolism.
2012
Academic Article
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Times cited: 73 -
Can polymorphisms predict response to antiarrhythmic drugs in atrial fibrillation?.
Journal of the American College of Cardiology.
2012
Editorial Article
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Times cited: 2 -
Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin.
Structure (London, England : 1993).
2012
Academic Article
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Times cited: 131 -
Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel.
Cell reports.
2012
Academic Article
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Times cited: 169 -
Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.
Trends in cardiovascular medicine.
2011
Information Resource
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Times cited: 17 -
Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.
PloS one.
2011
Academic Article
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Times cited: 11 -
Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.
Circulation research.
2011
Academic Article
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Times cited: 98 -
Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels.
The Journal of biological chemistry.
2011
Academic Article
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Times cited: 70 -
The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction.
Circulation. Cardiovascular genetics.
2011
Academic Article
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Times cited: 41 -
Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation.
Heart rhythm.
2010
Academic Article
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Times cited: 7 - The glitter of gold: biolistic transfection of fresh adult cardiac myocytes. Focus on "normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method". American journal of physiology. Cell physiology. 2010 Editorial Article GET IT
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Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository.
American heart journal.
2009
Academic Article
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Times cited: 6 -
Calcineurin finds a new partner in the L-type Ca2+ channel.
Circulation research.
2009
Editorial Article
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Times cited: 2 -
Accessory subunit KChIP2 modulates the cardiac L-type calcium current.
Circulation research.
2009
Academic Article
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Times cited: 70 -
Solution structure of the NaV1.2 C-terminal EF-hand domain.
The Journal of biological chemistry.
2009
Academic Article
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Times cited: 41 -
Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008
Academic Article
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Times cited: 27 -
Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007
Academic Article
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Times cited: 54 -
Calmodulin and CaMKII as molecular switches for cardiac ion channels.
Cardiovascular research.
2006
Information Resource
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Times cited: 70 -
Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases.
The Journal of general physiology.
2006
Academic Article
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Times cited: 34 -
Remodeled cardiac calcium channels.
Journal of molecular and cellular cardiology.
2006
Information Resource
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Times cited: 42 -
The real estate of cardiac signaling: location, location, location.
Proceedings of the National Academy of Sciences of the United States of America.
2006
Article
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Times cited: 11 -
KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin.
Circulation research.
2006
Academic Article
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Times cited: 117 -
Aldosterone, ion channels, and sudden death: another piece of the circle?.
American journal of physiology. Heart and circulatory physiology.
2006
Editorial Article
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Times cited: 3 -
CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.
The Journal of cell biology.
2005
Academic Article
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Times cited: 283 -
Essential Ca(V)beta modulatory properties are AID-independent.
Nature structural & molecular biology.
2005
Academic Article
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Times cited: 49 -
Calmodulin mediates Ca2+ sensitivity of sodium channels.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 134 -
Calcium channel function regulated by the SH3-GK module in beta subunits.
Neuron.
2004
Academic Article
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Times cited: 63 -
Identification of the components controlling inactivation of voltage-gated Ca2+ channels.
Neuron.
2004
Academic Article
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Times cited: 129 -
Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels.
The Journal of biological chemistry.
2001
Academic Article
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Times cited: 237 -
Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit.
The Journal of biological chemistry.
2000
Academic Article
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Times cited: 149 -
Calmodulin supports both inactivation and facilitation of L-type calcium channels.
Nature.
1999
Academic Article
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Times cited: 700 -
Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.
Developmental biology.
1997
Academic Article
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Times cited: 72 -
Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores.
The Journal of biological chemistry.
1996
Academic Article
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Times cited: 71 -
Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA).
Genes & development.
1993
Academic Article
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Times cited: 77 -
Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.
Molecular biology of the cell.
1992
Academic Article
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Times cited: 53 -
Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C.
Molecular biology of the cell.
1992
Academic Article
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Times cited: 51 -
Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development.
Cell.
1992
Academic Article
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Times cited: 250 -
Mechanisms of excitation and adaptation in Dictyostelium.
Seminars in cell biology.
1990
Information Resource
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Times cited: 5 -
Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America.
1989
Academic Article
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Times cited: 95 - A simple BASIC program allows the rapid entry of DNA nucleotide sequences into personal computers. BioTechniques. 1988 Academic Article GET IT
- Development and characterization of a monoclonal antibody to human embryonal carcinoma. The Journal of urology. 1987 Academic Article GET IT