Frindt, Gustavo

Publications

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selected publications

High dietary K⁺ intake inhibits proximal tubule transport. American journal of physiology. Renal physiology. 2023 Academic Article GET IT
Expression of ENaC subunits in epithelia. The Journal of general physiology. 2022 Academic Article GET IT
Times cited: 4
ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion. The Journal of general physiology. 2021 Academic Article GET IT
Times cited: 32
Cleavage state of γENaC in mouse and rat kidneys. American journal of physiology. Renal physiology. 2021 Academic Article GET IT
Times cited: 16
Aldosterone-dependent and -independent regulation of Na⁺ and K⁺ excretion and ENaC in mouse kidneys. American journal of physiology. Renal physiology. 2020 Academic Article GET IT
Times cited: 18
Ubiquitination of renal ENaC subunits in vivo. American journal of physiology. Renal physiology. 2020 Academic Article GET IT
Times cited: 17
Na restriction activates epithelial Na channels in rat kidney through two mechanisms and decreases distal Na⁺ delivery. The Journal of physiology. 2018 Academic Article GET IT
Times cited: 23
Responses of distal nephron Na⁺ transporters to acute volume depletion and hyperkalemia. American journal of physiology. Renal physiology. 2017 Academic Article GET IT
Times cited: 24
SGK1-dependent ENaC processing and trafficking in mice with high dietary K intake and elevated aldosterone. American journal of physiology. Renal physiology. 2016 Academic Article GET IT
Times cited: 36
Regulation of ENaC trafficking in rat kidney. The Journal of general physiology. 2016 Academic Article GET IT
Times cited: 43
Acute effects of aldosterone on the epithelial Na channel in rat kidney. American journal of physiology. Renal physiology. 2014 Academic Article GET IT
Times cited: 37
mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity. The Journal of clinical investigation. 2014 Academic Article GET IT
Times cited: 65
Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease. American journal of physiology. Renal physiology. 2014 Academic Article GET IT
Times cited: 38
Inhibition of ROMK channels by low extracellular K+ and oxidative stress. American journal of physiology. Renal physiology. 2013 Academic Article GET IT
Times cited: 6
Feedback inhibition of ENaC during acute sodium loading in vivo. American journal of physiology. Renal physiology. 2012 Academic Article GET IT
Times cited: 19
Effects of insulin on Na and K transporters in the rat CCD. American journal of physiology. Renal physiology. 2012 Academic Article GET IT
Times cited: 33
Regulation and dysregulation of epithelial Na+ channels. Clinical and experimental nephrology. 2011 Review GET IT
Times cited: 40
Regulation of epithelial Na+ channels by adrenal steroids: mineralocorticoid and glucocorticoid effects. American journal of physiology. Renal physiology. 2011 Academic Article GET IT
Times cited: 40
Conservation of Na+ vs. K+ by the rat cortical collecting duct. American journal of physiology. Renal physiology. 2011 Academic Article GET IT
Times cited: 33
Magnesium modulates ROMK channel-mediated potassium secretion. Journal of the American Society of Nephrology : JASN. 2010 Academic Article GET IT
Times cited: 52
Effects of dietary K on cell-surface expression of renal ion channels and transporters. American journal of physiology. Renal physiology. 2010 Academic Article GET IT
Times cited: 110
The absence of a clathrin adapter confers unique polarity essential to proximal tubule function. Kidney international. 2010 Academic Article GET IT
Times cited: 41
Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium. American journal of physiology. Renal physiology. 2009 Academic Article GET IT
Times cited: 93
K+ secretion in the rat kidney: Na+ channel-dependent and -independent mechanisms. American journal of physiology. Renal physiology. 2009 Academic Article GET IT
Times cited: 69
Dietary K regulates ROMK channels in connecting tubule and cortical collecting duct of rat kidney. American journal of physiology. Renal physiology. 2008 Academic Article GET IT
Times cited: 48
Surface expression of epithelial Na channel protein in rat kidney. The Journal of general physiology. 2008 Academic Article GET IT
Times cited: 92
Epithelial Na+ channel activation and processing in mice lacking SGK1. American journal of physiology. Renal physiology. 2008 Academic Article GET IT
Times cited: 102
Na+ and K+ transport by the renal connecting tubule. Current opinion in nephrology and hypertension. 2007 Review GET IT
Times cited: 19
Na channel expression and activity in the medullary collecting duct of rat kidney. American journal of physiology. Renal physiology. 2007 Academic Article GET IT
Times cited: 36
High-conductance K channels in intercalated cells of the rat distal nephron. American journal of physiology. Renal physiology. 2006 Academic Article GET IT
Times cited: 58
Cl- channels of the distal nephron. American journal of physiology. Renal physiology. 2006 Academic Article GET IT
Times cited: 25
Regulation of maturation and processing of ENaC subunits in the rat kidney. American journal of physiology. Renal physiology. 2006 Academic Article GET IT
Times cited: 124
Quantification of K+ secretion through apical low-conductance K channels in the CCD. American journal of physiology. Renal physiology. 2005 Academic Article GET IT
Times cited: 36
Basolateral K+ conductance in principal cells of rat CCD. American journal of physiology. Renal physiology. 2004 Academic Article GET IT
Times cited: 34
Apical potassium channels in the rat connecting tubule. American journal of physiology. Renal physiology. 2004 Academic Article GET IT
Times cited: 67
Na channels in the rat connecting tubule. American journal of physiology. Renal physiology. 2003 Academic Article GET IT
Times cited: 78
Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. The Journal of clinical investigation. 2003 Academic Article GET IT
Times cited: 197
Mineralocorticoid regulation of epithelial Na+ channels is maintained in a mouse model of Liddle's syndrome. American journal of physiology. Renal physiology. 2003 Academic Article GET IT
Times cited: 66
Epithelial Na channels and short-term renal response to salt deprivation. American journal of physiology. Renal physiology. 2002 Academic Article GET IT
Times cited: 31
Activation of epithelial Na channels during short-term Na deprivation. American journal of physiology. Renal physiology. 2001 Academic Article GET IT
Times cited: 74
Potassium restriction downregulates ROMK expression in rat kidney. American journal of physiology. Renal physiology. 2000 Academic Article GET IT
Times cited: 35
Aldosterone and potassium secretion by the cortical collecting duct. Kidney international. 2000 Review GET IT
Times cited: 67
Regulation of apical K channels in rat cortical collecting tubule during changes in dietary K intake. The American journal of physiology. 1999 Academic Article GET IT
Times cited: 78
Low-NaCl diet increases H-K-ATPase in intercalated cells from rat cortical collecting duct. The American journal of physiology. 1998 Academic Article GET IT
Times cited: 30
Regulation of Na+ channels by luminal Na+ in rat cortical collecting tubule. The Journal of physiology. 1998 Academic Article GET IT
Times cited: 66
Dissociation of K channel density and ROMK mRNA in rat cortical collecting tubule during K adaptation. The American journal of physiology. 1998 Academic Article GET IT
Times cited: 32
Localization of ROMK channels in the rat kidney. Journal of the American Society of Nephrology : JASN. 1997 Academic Article GET IT
Times cited: 100
Is the secretory K channel in the rat CCT ROMK?. The American journal of physiology. 1997 Academic Article GET IT
Times cited: 100
Regulation of Na channels in the rat cortical collecting tubule: effects of cAMP and methyl donors. The American journal of physiology. 1996 Academic Article GET IT
Times cited: 35
Selectivity of the renal collecting duct water channel aquaporin-3. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 110
Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1996 Review GET IT
Times cited: 167
Feedback regulation of Na channels in rat CCT. IV. Mediation by activation of protein kinase C. The American journal of physiology. 1996 Academic Article GET IT
Times cited: 47
Gating of Na channels in the rat cortical collecting tubule: effects of voltage and membrane stretch. The Journal of general physiology. 1996 Academic Article GET IT
Times cited: 104
Aquaporin-3 water channel localization and regulation in rat kidney. The American journal of physiology. 1995 Academic Article GET IT
Times cited: 379
Feedback regulation of Na channels in rat CCT. III. Response to cAMP. The American journal of physiology. 1995 Academic Article GET IT
Times cited: 44
Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 274
Regulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K. The Journal of general physiology. 1994 Academic Article GET IT
Times cited: 163
Regulation of Na channels of the rat cortical collecting tubule by aldosterone. The Journal of general physiology. 1993 Academic Article GET IT
Times cited: 211
Regulation of the Na-K pump of the rat cortical collecting tubule by aldosterone. The Journal of general physiology. 1993 Academic Article GET IT
Times cited: 60
Expression of multiple water channel activities in Xenopus oocytes injected with mRNA from rat kidney. The Journal of general physiology. 1993 Academic Article GET IT
Times cited: 41
Feedback regulation of Na channels in rat CCT. I. Effects of inhibition of Na pump. The American journal of physiology. 1993 Academic Article GET IT
Times cited: 82
Feedback regulation of Na channels in rat CCT. II. Effects of inhibition of Na entry. The American journal of physiology. 1993 Academic Article GET IT
Times cited: 60
Functional identification of H-K-ATPase in intercalated cells of cortical collecting tubule. The American journal of physiology. 1993 Academic Article GET IT
Times cited: 49
Regulation of apical membrane Na and K channels in rat renal collecting tubules by aldosterone. Seminars in nephrology. 1992 Review GET IT
Times cited: 24
Regulation of principal cell pH by Na/H exchange in rabbit cortical collecting tubule. The Journal of membrane biology. 1992 Academic Article GET IT
Times cited: 21
Apical maxi K channels in intercalated cells of CCT. The American journal of physiology. 1991 Academic Article GET IT
Times cited: 149
Expression of renal Na(+)-Ca2+ exchange activity in Xenopus laevis oocytes. The American journal of physiology. 1991 Academic Article GET IT
Times cited: 11
Ca2(+)-dependent inhibition of sodium transport in rabbit cortical collecting tubules. The American journal of physiology. 1990 Academic Article GET IT
Times cited: 35
Whole-cell currents in rat cortical collecting tubule: low-Na diet increases amiloride-sensitive conductance. The American journal of physiology. 1990 Academic Article GET IT
Times cited: 58
Low-conductance K channels in apical membrane of rat cortical collecting tubule. The American journal of physiology. 1989 Academic Article GET IT
Times cited: 188
Conductance and gating of epithelial Na channels from rat cortical collecting tubule. Effects of luminal Na and Li. The Journal of general physiology. 1988 Academic Article GET IT
Times cited: 107
Effect of peritubular [Ca] or ionomycin on hydrosmotic response of CCTs to ADH or cAMP. The American journal of physiology. 1988 Academic Article GET IT
Times cited: 36
Effects of L-glutamate infusion on the renal utilization of glutamate and glutamine in the dog kidney in vivo during chronic metabolic acidosis or alkalosis. Contributions to nephrology. 1988 Academic Article GET IT
Times cited: 3
Measurements of aiCa, aiNa and membrane potential and patch clamp studies of the effect of changes in aiCa on Na channel activity in renal tubules. Progress in clinical and biological research. 1988 Academic Article GET IT
Potential role of cytoplasmic calcium ions in the regulation of sodium transport in renal tubules. Mineral and electrolyte metabolism. 1988 Review GET IT
Times cited: 15
Effects of cell Ca and pH on Na channels from rat cortical collecting tubule. The American journal of physiology. 1987 Academic Article GET IT
Times cited: 156
Quinidine effect on hydrosmotic response of collecting tubules to vasopressin and cAMP. The American journal of physiology. 1987 Academic Article GET IT
Times cited: 6
Ca-activated K channels in apical membrane of mammalian CCT, and their role in K secretion. The American journal of physiology. 1987 Academic Article GET IT
Times cited: 129
Epithelial sodium channels: characterization by using the patch-clamp technique. Federation proceedings. 1986 Academic Article GET IT
Times cited: 34
Intracellular calcium ions as regulators of renal tubular sodium transport. Klinische Wochenschrift. 1986 Academic Article GET IT
Times cited: 10
Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule. Proceedings of the National Academy of Sciences of the United States of America. 1986 Academic Article GET IT
Times cited: 266
Regulatory role of calcium in sodium transport. Progress in clinical and biological research. 1984 Academic Article GET IT
Times cited: 1
Role of Ca++ as a regulator of Na+ permeability in epithelia. Progress in clinical and biological research. 1984 Academic Article GET IT
Times cited: 2
Hydroosmotic response of collecting tubules to ADH or cAMP at reduced peritubular sodium. The American journal of physiology. 1982 Academic Article GET IT
Times cited: 18
Effects of fluorocitrate on renal ammoniagenesis and glutamine metabolism in the intact dog kidney. Kidney international. 1979 Academic Article GET IT
Times cited: 9
The effect of fluorocitrate on urinary calcium and citrate excretion. Experientia. 1977 Academic Article GET IT
Times cited: 6
Effect of vasopressin on sodium transport in renal cortical collecting tubules. Kidney international. 1972 Academic Article GET IT
Times cited: 73
Primary hyperoxaluria with normal alpha-ketoglutarate: glyoxylate carboligase activity. Treatment with isocarboxazid. Annals of internal medicine. 1972 Academic Article GET IT
Times cited: 12
Effect of chronic alkalosis and acidosis on glutaminase II path in the dog kidney in vivo. The American journal of physiology. 1971 Academic Article GET IT
Times cited: 9
Studies with uraemic serum on the renal transport of hippurates and tetraethylammonium in the rabbit and rat: effects of oral neomycin. Clinical science. 1970 Academic Article GET IT
Times cited: 10
[Use of the glucose disappearance rate in the clinical study of carbohydrate metabolism variations]. Revista medica de Chile. 1968 Academic Article GET IT
Conjugation of p-aminohippuric acid by human kidney and liver slices. Acta physiologica latino americana. 1968 Academic Article GET IT
Times cited: 2
Conjugation of para-aminohippuric acid by human kidney and liver slices. Acta physiologica latino americana. 1968 Academic Article GET IT
Times cited: 1
[Clinical experiences with renal biopsies]. Revista medica de Chile. 1966 Academic Article GET IT
[STUDY OF RENAL FUNCTION WITH PARA-AMINOHIPPURATE AND HIPPURAN I 131]. Revista medica de Chile. 1963 Academic Article GET IT

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Research

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Funding awarded

Regulation of ENaC Trafficking and Activity in the Kidney awarded by National Institute of Diabetes & Digestive & Kidney Diseases Co-Investigator 2022 - 2026

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Background

education and training

M.D., Pontifical Catholic University of Chile Medical School (Chile) 1963
B.Sc., Pontifical Catholic University (Chile) 1959

Contact

full name

Gustavo Frindt

primary email

gfrindt@med.cornell.edu

VIVO Weill Cornell Medical College

Gustavo Frindt Associate Professor of Research in Physiology and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email