Funabiki, Hironori

Publications

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selected publications

CDCA7 is an evolutionarily conserved hemimethylated DNA sensor in eukaryotes. Science advances. 2024 Academic Article GET IT
Architecture of native kinetochores revealed by structural studies utilizing a thermophilic yeast. Current biology : CB. 2024 Academic Article GET IT
cGAS meets its demise in the nucleus. Nature immunology. 2024 Academic Article GET IT
Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast. 2024 GET IT
Cryo-EM analysis on magnetic beads for scarce macromolecules in heterogeneous samples. 2024 GET IT
CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS. 2023 GET IT
Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases. eLife. 2023 Academic Article GET IT
Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases. 2023 GET IT
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS. Nature communications. 2023 Academic Article GET IT
Times cited: 12
Visualization of the three-dimensional structure of the human centromere in mitotic chromosomes by superresolution microscopy. Molecular biology of the cell. 2023 Academic Article GET IT
Structural Mechanics of the Alpha-2-Macroglobulin Transformation. Journal of molecular biology. 2021 Academic Article GET IT
Structural features of nucleosomes in interphase and metaphase chromosomes. Molecular cell. 2021 Academic Article GET IT
Times cited: 21
Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization. eLife. 2021 Academic Article GET IT
Times cited: 18
CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 49
Structural basis for the inhibition of cGAS by nucleosomes. Science (New York, N.Y.). 2020 Academic Article GET IT
Times cited: 156
Regulation and Consequences of cGAS Activation by Self-DNA. Trends in cell biology. 2020 Review GET IT
Times cited: 58
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death. Cell. 2019 Academic Article GET IT
Times cited: 279
Author Correction: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. 2019 GET IT
Times cited: 1
Correcting aberrant kinetochore microtubule attachments: a hidden regulation of Aurora B on microtubules. Current opinion in cell biology. 2019 Review GET IT
Times cited: 25
CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 59
Protein Immunodepletion and Complementation in Xenopus laevis Egg Extracts. Cold Spring Harbor protocols. 2018 Academic Article GET IT
Times cited: 6
Nucleosome-Dependent Pathways That Control Mitotic Progression. Cold Spring Harbor symposia on quantitative biology. 2018 Academic Article GET IT
Times cited: 2
HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 76
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. Nature cell biology. 2017 Academic Article GET IT
Times cited: 34
Dual recognition of chromatin and microtubules by INCENP is important for mitotic progression. The Journal of cell biology. 2017 Academic Article GET IT
Times cited: 32
Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 77
Interphase Positioning of Centromeres Sets Up Spindle Assembly. Developmental cell. 2016 Comment GET IT
VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Molecular cell. 2016 Academic Article GET IT
Times cited: 85
Heterogeneous architecture of vertebrate kinetochores revealed by three-dimensional superresolution fluorescence microscopy. Molecular biology of the cell. 2016 Academic Article GET IT
Times cited: 15
Kinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components. The Journal of cell biology. 2015 Academic Article GET IT
Times cited: 53
Nucleosome functions in spindle assembly and nuclear envelope formation. BioEssays : news and reviews in molecular, cellular and developmental biology. 2015 Review GET IT
Times cited: 21
Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion. Nature structural & molecular biology. 2014 Academic Article GET IT
Times cited: 79
Nuclear assembly shaped by microtubule dynamics. Nucleus (Austin, Tex.). 2014 Academic Article GET IT
Times cited: 7
Autoinhibition and Polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase Haspin to mitosis. Molecular cell. 2013 Academic Article GET IT
Times cited: 71
Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly. Developmental cell. 2013 Academic Article GET IT
Times cited: 48
Making an effective switch at the kinetochore by phosphorylation and dephosphorylation. Chromosoma. 2013 Review GET IT
Times cited: 104
An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation. Cell cycle (Georgetown, Tex.). 2013 Academic Article GET IT
Times cited: 49
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nature reviews. Molecular cell biology. 2012 Review GET IT
Times cited: 663
Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex. The EMBO journal. 2012 Academic Article GET IT
Times cited: 30
Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin. Structure (London, England : 1993). 2012 Academic Article GET IT
Times cited: 55
To Cut or NoCut in mitosis. Nature reviews. Molecular cell biology. 2011 Comment GET IT
KNL1/Spc105 recruits PP1 to silence the spindle assembly checkpoint. Current biology : CB. 2011 Academic Article GET IT
Times cited: 171
Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B. Science (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 390
Dual detection of chromosomes and microtubules by the chromosomal passenger complex drives spindle assembly. Developmental cell. 2010 Academic Article GET IT
Times cited: 88
Identification of SMARCAL1 as a component of the DNA damage response. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 98
Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view. Current opinion in cell biology. 2009 Review GET IT
Times cited: 114
Ku80 removal from DNA through double strand break-induced ubiquitylation. The Journal of cell biology. 2008 Academic Article GET IT
Times cited: 121
Efficient identification of phosphorylation by mass spectrometric phosphopeptide fingerprinting. Analytical chemistry. 2008 Academic Article GET IT
Times cited: 13
Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly. Developmental cell. 2007 Academic Article GET IT
Times cited: 178
Dynamic regulation of effector protein binding to histone modifications: the biology of HP1 switching. Cell cycle (Georgetown, Tex.). 2006 Academic Article GET IT
Times cited: 51
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature. 2005 Academic Article GET IT
Times cited: 750
Two birds with one stone--dealing with nuclear transport and spindle assembly. Cell. 2005 Comment GET IT
Times cited: 7
The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell. 2004 Academic Article GET IT
Times cited: 345
The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell. 2000 Academic Article GET IT
Times cited: 265
Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis. Current biology : CB. 1998 Academic Article GET IT
Times cited: 111
Fission yeast Cut2 required for anaphase has two destruction boxes. The EMBO journal. 1997 Academic Article GET IT
Times cited: 69
Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes. The EMBO journal. 1996 Academic Article GET IT
Times cited: 168
Cut2 proteolysis required for sister-chromatid seperation in fission yeast. Nature. 1996 Academic Article GET IT
Times cited: 416
Telomere-led premeiotic chromosome movement in fission yeast. Science (New York, N.Y.). 1994 Academic Article GET IT
Times cited: 403
Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast. The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 447
A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere. Molecular biology of the cell. 1992 Academic Article GET IT
Times cited: 224

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Background

education and training

Ph.D., Kyoto University (Japan) 1995
M.S., Kyoto University (Japan) 1992
B.S., Kyoto University (Japan) 1990

Contact

full name

Hironori Funabiki

primary email

funabih@rockefeller.edu

VIVO Weill Cornell Medical College

Hironori Funabiki Tri-Institutional Professor

Publications

selected publications

Background

education and training

Contact

full name

primary email