Burre, Jacqueline

Publications

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selected publications

N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine. 2024 GET IT
Disease-linked mutations in Munc18-1 deplete synaptic Doc2. Brain : a journal of neurology. 2024 Academic Article GET IT
Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
α-Synuclein in synaptic function and dysfunction. Trends in neurosciences. 2022 Review GET IT
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models. Nature communications. 2022 Academic Article GET IT
Cellular And Small Animal Models Of Neurodegenerative Diseases. Journal of visualized experiments : JoVE. 2022 Editorial Article GET IT
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins. Cell reports. 2022 Academic Article GET IT
Targeted stabilization of Munc18-1 function via pharmacological chaperones. EMBO molecular medicine. 2020 Academic Article GET IT
STXBP1 encephalopathies: Clinical spectrum, disease mechanisms, and therapeutic strategies. Journal of neurochemistry. 2020 Information Resource GET IT
Times cited: 49
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators. Nature structural & molecular biology. 2020 Academic Article GET IT
Times cited: 12
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones. Nature communications. 2018 Academic Article GET IT
Times cited: 50
Modulating membrane binding of α-synuclein as a therapeutic strategy. Proceedings of the National Academy of Sciences of the United States of America. 2017 Article GET IT
Times cited: 39
Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. PLoS biology. 2015 Academic Article GET IT
Times cited: 59
Definition of a molecular pathway mediating α-synuclein neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Academic Article GET IT
Times cited: 151
The Synaptic Function of α-Synuclein. Journal of Parkinson's disease. 2015 Information Resource GET IT
Times cited: 382
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 347
Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity. Neuron. 2014 Academic Article GET IT
Times cited: 47
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2. eLife. 2013 Academic Article GET IT
Times cited: 252
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 133
Proteasome inhibition alleviates SNARE-dependent neurodegeneration. Science translational medicine. 2012 Academic Article GET IT
Times cited: 42
CSPα knockout causes neurodegeneration by impairing SNAP-25 function. The EMBO journal. 2011 Academic Article GET IT
Times cited: 117
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nature cell biology. 2010 Academic Article GET IT
Times cited: 162
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 1332
Non-classical 2-D electrophoresis. Methods in molecular biology (Clifton, N.J.). 2009 Academic Article GET IT
Times cited: 15
Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter. Journal of neurochemistry. 2007 Academic Article GET IT
Times cited: 22
The synaptic vesicle proteome. Journal of neurochemistry. 2007 Information Resource GET IT
Times cited: 70
Immunoisolation and subfractionation of synaptic vesicle proteins. Analytical biochemistry. 2007 Academic Article GET IT
Times cited: 14
Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques. Proteomics. 2006 Academic Article GET IT
Times cited: 83
Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis. Electrophoresis. 2006 Academic Article GET IT
Times cited: 30
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis. Journal of neurochemistry. 2005 Academic Article GET IT
Times cited: 119

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Research

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Funding awarded

The impact of beta- and gamma-synucleins on alpha-synuclein''s synaptic function awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2025
The impact of synaptic vesicle-binding of alpha-synuclein on neuron function and neuropathology awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2020 - 2025
The impact of beta- and gamma-synucleins on alpha-synuclein''s synaptic function awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2023 - 2024
Synaptic vesicle changes in synucleinopathies awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2024
Molecular Mechanisms of Munc18-1 Linked Infantile Seizure Disorders and Rational Rescue Strategies awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2017 - 2024

Clinical and Translational Science Center - UL1 awarded by National Center for Advancing Translational Sciences Co-Investigator 2022 - 2027

Leveraging the genetics and biochemistry of UNC-13 to uncover mechanisms driving neurotransmitter secretion awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2023 - 2026
Dissecting STXBP1 dysfunction in a novel mouse model of STXBP1 Encephalopathies awarded by Uplifting Athletes Key Personnel 2024 - 2025
Munc18-1 mutations disrupt syntaxin-5 stability and general secretory trafficking awarded by National Institute of Child Health & Human Development Key Personnel 2020 - 2024

The role of VAMP2 in alpha-synuclein function and pathology awarded by National Institute of Neurological Disorders & Stroke Principal Investigator Subaward 2021 - 2026
A novel gene therapy approach to prevent alpha-synuclein misfolding in multiple system atrophy awarded by National Institute of Neurological Disorders & Stroke Principal Investigator Subaward 2023 - 2025

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Background

education and training

Ph.D., Johann Wolfgang Goethe University (Germany) 2006
Diploma, Johann Wolfgang Goethe University (Germany) 2003

Contact

full name

Jacqueline Burre

primary email

jab2058@med.cornell.edu

VIVO Weill Cornell Medical College

Jacqueline Burre Associate Professor of Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email