selected publications
- The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex. Cell reports. 2024 Academic Article GET IT
- VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates. Nature cell biology. 2024 Academic Article GET IT
- Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis. Movement disorders : official journal of the Movement Disorder Society. 2024 Review GET IT
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Disease-linked mutations in Munc18-1 deplete synaptic Doc2.
Brain : a journal of neurology.
2024
Academic Article
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Times cited: 1 - The Gut-Brain Axis in Parkinson's Disease. Cold Spring Harbor perspectives in medicine. 2024 Academic Article GET IT
- Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins. 2024 GET IT
- N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine. 2024 GET IT
- Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
- α-Synuclein in synaptic function and dysfunction. Trends in neurosciences. 2022 Review GET IT
- Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models. Nature communications. 2022 Academic Article GET IT
- Cellular And Small Animal Models Of Neurodegenerative Diseases. Journal of visualized experiments : JoVE. 2022 Editorial Article GET IT
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Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins.
Cell reports.
2022
Academic Article
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Times cited: 31 -
Targeted stabilization of Munc18-1 function via pharmacological chaperones.
EMBO molecular medicine.
2020
Academic Article
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Times cited: 9 -
STXBP1 encephalopathies: Clinical spectrum, disease mechanisms, and therapeutic strategies.
Journal of neurochemistry.
2020
Information Resource
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Times cited: 56 -
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
Nature structural & molecular biology.
2020
Academic Article
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Times cited: 12 -
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones.
Nature communications.
2018
Academic Article
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Times cited: 59 -
Cell Biology and Pathophysiology of α-Synuclein.
Cold Spring Harbor perspectives in medicine.
2018
Review
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Times cited: 377 -
Modulating membrane binding of α-synuclein as a therapeutic strategy.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Article
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Times cited: 40 -
Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.
PLoS biology.
2015
Academic Article
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Times cited: 60 -
Definition of a molecular pathway mediating α-synuclein neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015
Academic Article
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Times cited: 160 -
The Synaptic Function of α-Synuclein.
Journal of Parkinson's disease.
2015
Information Resource
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Times cited: 409 -
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 369 -
Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity.
Neuron.
2014
Academic Article
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Times cited: 48 -
Properties of native brain α-synuclein.
Nature.
2013
Comment
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Times cited: 273 -
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.
eLife.
2013
Academic Article
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Times cited: 264 -
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012
Academic Article
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Times cited: 139 -
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
Science translational medicine.
2012
Academic Article
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Times cited: 42 -
CSPα knockout causes neurodegeneration by impairing SNAP-25 function.
The EMBO journal.
2011
Academic Article
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Times cited: 119 -
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Nature cell biology.
2010
Academic Article
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Times cited: 162 -
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
Science (New York, N.Y.).
2010
Academic Article
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Times cited: 1398 -
Non-classical 2-D electrophoresis.
Methods in molecular biology (Clifton, N.J.).
2009
Academic Article
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Times cited: 15 -
Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter.
Journal of neurochemistry.
2007
Academic Article
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Times cited: 22 -
The synaptic vesicle proteome.
Journal of neurochemistry.
2007
Information Resource
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Times cited: 70 -
Immunoisolation and subfractionation of synaptic vesicle proteins.
Analytical biochemistry.
2007
Academic Article
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Times cited: 14 -
Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques.
Proteomics.
2006
Academic Article
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Times cited: 83 -
Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis.
Electrophoresis.
2006
Academic Article
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Times cited: 30 -
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Journal of neurochemistry.
2005
Academic Article
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Times cited: 119