Fagin, James Alexander

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selected publications

Vemurafenib Redifferentiation of BRAF Mutant, RAI-Refractory Thyroid Cancers. The Journal of clinical endocrinology and metabolism. 2019 Academic Article GET IT
Times cited: 168
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness. Thyroid : official journal of the American Thyroid Association. 2018 Academic Article GET IT
Times cited: 17
Radioactive Iodine-Related Clonal Hematopoiesis in Thyroid Cancer Is Common and Associated With Decreased Survival. The Journal of clinical endocrinology and metabolism. 2018 Academic Article GET IT
Times cited: 31
EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC. Cancer discovery. 2018 Academic Article GET IT
Times cited: 64
Hgf/Met activation mediates resistance to BRAF inhibition in murine anaplastic thyroid cancers. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 49
Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers. Cancer research. 2018 Academic Article GET IT
Times cited: 61
Phase 2 study evaluating the combination of sorafenib and temsirolimus in the treatment of radioactive iodine-refractory thyroid cancer. Cancer. 2017 Academic Article GET IT
Times cited: 57
Biologic and Clinical Perspectives on Thyroid Cancer. The New England journal of medicine. 2016 Article GET IT
Times cited: 24
Comparison of Empiric Versus Whole-Body/-Blood Clearance Dosimetry-Based Approach to Radioactive Iodine Treatment in Patients with Metastases from Differentiated Thyroid Cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2016 Academic Article GET IT
Times cited: 34
Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine. The Journal of clinical investigation. 2016 Academic Article GET IT
Times cited: 103
Biologic and Clinical Perspectives on Thyroid Cancer. The New England journal of medicine. 2016 Information Resource GET IT
Times cited: 619
NADPH Oxidase NOX4 Is a Critical Mediator of BRAF^V600E-Induced Downregulation of the Sodium/Iodide Symporter in Papillary Thyroid Carcinomas. Antioxidants & redox signaling. 2016 Academic Article GET IT
Times cited: 68
An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling. Cancer cell. 2016 Academic Article GET IT
Times cited: 126
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers. The Journal of clinical investigation. 2016 Academic Article GET IT
Times cited: 857
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer. Nature. 2015 Academic Article GET IT
Times cited: 186
Response to: Letter to the Editor Regarding the Article "Thyrotropin Suppression Increases the Risk of Osteoporosis Without Decreasing Recurrence in ATA Low- and Intermediate-Risk Patients with Differentiated Thyroid Carcinoma". Thyroid : official journal of the American Thyroid Association. 2015 Article GET IT
NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition. Cancer discovery. 2015 Academic Article GET IT
Times cited: 108
Thyrotropin suppression increases the risk of osteoporosis without decreasing recurrence in ATA low- and intermediate-risk patients with differentiated thyroid carcinoma. Thyroid : official journal of the American Thyroid Association. 2014 Academic Article GET IT
Times cited: 114
Integrated genomic characterization of papillary thyroid carcinoma. Cell. 2014 Academic Article GET IT
Times cited: 2290
Association between BRAF V600E mutation and recurrence of papillary thyroid cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2014 Academic Article GET IT
Times cited: 453
Switch in signaling control of mTORC1 activity after oncoprotein expression in thyroid cancer cell lines. The Journal of clinical endocrinology and metabolism. 2014 Academic Article GET IT
Times cited: 22
External beam radiotherapy with or without concurrent chemotherapy in advanced or recurrent non-anaplastic non-medullary thyroid cancer. Journal of surgical oncology. 2014 Academic Article GET IT
Times cited: 33
Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition. Oncogene. 2013 Academic Article GET IT
Times cited: 41
Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Human molecular genetics. 2013 Academic Article GET IT
Times cited: 35
Targeting mTOR in RET mutant medullary and differentiated thyroid cancer cells. Endocrine-related cancer. 2013 Academic Article GET IT
Times cited: 54
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease. The Journal of clinical endocrinology and metabolism. 2013 Academic Article GET IT
Times cited: 351
Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression. The Journal of clinical endocrinology and metabolism. 2013 Academic Article GET IT
Times cited: 76
Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer. JAMA. 2013 Academic Article GET IT
Times cited: 787
Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroid malignancy. The Journal of clinical endocrinology and metabolism. 2013 Academic Article GET IT
Times cited: 161
Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. The New England journal of medicine. 2013 Academic Article GET IT
Times cited: 651
Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression. PloS one. 2013 Academic Article GET IT
Times cited: 120
Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS. The Journal of clinical endocrinology and metabolism. 2012 Academic Article GET IT
Times cited: 209
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas. Cancer cell. 2012 Academic Article GET IT
Times cited: 437
Genome-wide analysis of Pax8 binding provides new insights into thyroid functions. BMC genomics. 2012 Academic Article GET IT
Times cited: 38
Papillary thyroid carcinomas with cervical lymph node metastases can be stratified into clinically relevant prognostic categories using oncogenic BRAF, the number of nodal metastases, and extra-nodal extension. Thyroid : official journal of the American Thyroid Association. 2012 Academic Article GET IT
Times cited: 98
GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation. Endocrinology. 2012 Academic Article GET IT
Times cited: 95
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 307
Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011 Academic Article GET IT
Times cited: 1213
Absence of common activating mutations of the epidermal growth factor receptor gene in thyroid cancers from American and Japanese patients. International journal of cancer. 2011 Article GET IT
Times cited: 8
Five-year survival is similar in thyroid cancer patients with distant metastases prepared for radioactive iodine therapy with either thyroid hormone withdrawal or recombinant human TSH. The Journal of clinical endocrinology and metabolism. 2011 Academic Article GET IT
Times cited: 74
Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling. Oncogene. 2011 Academic Article GET IT
Times cited: 152
Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 180
The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells. Endocrine-related cancer. 2010 Academic Article GET IT
Times cited: 52
Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system. Thyroid : official journal of the American Thyroid Association. 2010 Academic Article GET IT
Times cited: 724
Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension. Thyroid : official journal of the American Thyroid Association. 2010 Academic Article GET IT
Times cited: 81
Genomic and biological characterization of exon 4 KRAS mutations in human cancer. Cancer research. 2010 Academic Article GET IT
Times cited: 241
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2010 Academic Article GET IT
Times cited: 315
Harvesting the low-hanging fruit: kinase inhibitors for therapy of advanced medullary and nonmedullary thyroid cancer. The Journal of clinical endocrinology and metabolism. 2010 Editorial Article GET IT
Times cited: 20
Encapsulated thyroid tumors of follicular cell origin with high grade features (high mitotic rate/tumor necrosis): a clinicopathologic and molecular study. Human pathology. 2009 Academic Article GET IT
Times cited: 65
Can risk-adapted treatment recommendations replace the 'one size fits all' approach for early-stage thyroid cancer patients?. Oncology (Williston Park, N.Y.). 2009 Article GET IT
Times cited: 8
Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. Cancer research. 2009 Academic Article GET IT
Times cited: 468
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 229
Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 107
Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules. The Journal of clinical endocrinology and metabolism. 2009 Academic Article GET IT
Times cited: 546
Role of MAPK pathway oncoproteins in thyroid cancer pathogenesis and as drug targets. Current opinion in cell biology. 2009 Information Resource GET IT
Times cited: 94
Molecular pathology of thyroid cancer: diagnostic and clinical implications. Best practice & research. Clinical endocrinology & metabolism. 2008 Information Resource GET IT
Times cited: 155
Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer. Endocrine-related cancer. 2008 Academic Article GET IT
Times cited: 359
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. The Journal of clinical endocrinology and metabolism. 2008 Academic Article GET IT
Times cited: 504
Refractory thyroid cancer: a paradigm shift in treatment is not far off. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2008 Editorial Article GET IT
Times cited: 52
RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: evidence for molecular and functional interactions between RET and EGFR. Cancer research. 2008 Academic Article GET IT
Times cited: 84
BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines. The Journal of clinical endocrinology and metabolism. 2008 Academic Article GET IT
Times cited: 111
Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth. American journal of physiology. Gastrointestinal and liver physiology. 2007 Academic Article GET IT
Times cited: 23
The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells. Cancer research. 2007 Academic Article GET IT
Times cited: 98
[Thyroid cancer: past, present and future]. Arquivos brasileiros de endocrinologia e metabologia. 2007 Academic Article GET IT
The Jeremiah Metzger Lecture: intelligent design of cancer therapy: trials and tribulations. Transactions of the American Clinical and Climatological Association. 2007 Conference Paper GET IT
Times cited: 8
Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling. Cancer research. 2006 Academic Article GET IT
Times cited: 113
Significance of BRAF mutations in papillary thyroid carcinoma: prognostic and therapeutic implications. Nature clinical practice. Endocrinology & metabolism. 2006 Article GET IT
Times cited: 25
Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Academic Article GET IT
Times cited: 127
Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 71
BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis. Endocrinology. 2005 Academic Article GET IT
Times cited: 94
RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response. Endocrine-related cancer. 2005 Academic Article GET IT
Times cited: 80
Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer research. 2005 Academic Article GET IT
Times cited: 312
Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells. Cancer research. 2005 Academic Article GET IT
Times cited: 171
Characterization of novel non-clonal intrachromosomal rearrangements between the H4 and PTEN genes (H4/PTEN) in human thyroid cell lines and papillary thyroid cancer specimens. Mutation research. 2005 Academic Article GET IT
Times cited: 29
Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Gut. 2005 Academic Article GET IT
Times cited: 105
Genetics of papillary thyroid cancer initiation: implications for therapy. Transactions of the American Clinical and Climatological Association. 2005 Academic Article GET IT
Times cited: 51
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer. The Journal of clinical investigation. 2005 Academic Article GET IT
Times cited: 379
How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy. The Journal of endocrinology. 2004 Information Resource GET IT
Times cited: 119
Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma. The Journal of clinical endocrinology and metabolism. 2004 Academic Article GET IT
Times cited: 231
Challenging dogma in thyroid cancer molecular genetics--role of RET/PTC and BRAF in tumor initiation. The Journal of clinical endocrinology and metabolism. 2004 Editorial Article GET IT
Times cited: 75
Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. Cancer letters. 2004 Academic Article GET IT
Times cited: 127
Smooth muscle overexpression of IGF-I induces a novel adaptive response to small bowel resection. American journal of physiology. Gastrointestinal and liver physiology. 2004 Academic Article GET IT
Times cited: 29
Autonomously functioning thyroid nodules are not associated with BRAF mutations. Clinical endocrinology. 2004 Article GET IT
Times cited: 5
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. The Journal of clinical endocrinology and metabolism. 2003 Academic Article GET IT
Times cited: 801
Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 24
Acute expression of RET/PTC induces isozyme-specific activation and subsequent downregulation of PKCepsilon in PCCL3 thyroid cells. Oncogene. 2003 Academic Article GET IT
Times cited: 15
RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase. Oncogene. 2003 Academic Article GET IT
Times cited: 119
Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels. Molecular endocrinology (Baltimore, Md.). 2003 Academic Article GET IT
Times cited: 57
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer research. 2003 Academic Article GET IT
Times cited: 1252
Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes. Oncogene. 2003 Academic Article GET IT
Times cited: 37
Mesenchymal IGF-I overexpression: paracrine effects in the intestine, distinct from endocrine actions. American journal of physiology. Gastrointestinal and liver physiology. 2002 Academic Article GET IT
Times cited: 45
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon. The Journal of clinical endocrinology and metabolism. 2002 Academic Article GET IT
Times cited: 29
Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophy. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 48
Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1. Clinical endocrinology. 2002 Academic Article GET IT
Times cited: 51
IGF-binding protein-4 expression and IGF-binding protein-4 protease activity are regulated coordinately in smooth muscle during postnatal development and after vascular injury. Endocrinology. 2001 Academic Article GET IT
Times cited: 15
Targeted overexpression of IGF-I in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injury. Endocrinology. 2001 Academic Article GET IT
Times cited: 67
Smooth muscle-targeted overexpression of insulin-like growth factor I results in enhanced vascular contractility. Endocrinology. 2001 Academic Article GET IT
Times cited: 29
Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis. Advances in enzyme regulation. 2001 Academic Article GET IT
Times cited: 3
Conditional apoptosis induced by oncogenic ras in thyroid cells. Molecular endocrinology (Baltimore, Md.). 2000 Academic Article GET IT
Times cited: 46
Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells. Science (New York, N.Y.). 2000 Academic Article GET IT
Times cited: 362
The highly malignant phenotype of anaplastic thyroid carcinoma cell lines is recessive. European journal of endocrinology. 2000 Academic Article GET IT
Times cited: 13
The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway. Oncogene. 2000 Academic Article GET IT
Times cited: 149
Parathyroid hormone-related protein induces G1 phase growth arrest of vascular smooth muscle cells. American journal of physiology. Endocrinology and metabolism. 2000 Academic Article GET IT
Times cited: 20
Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation. Endocrinology. 2000 Academic Article GET IT
Times cited: 296
Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas. Oncogene. 1999 Academic Article GET IT
Times cited: 88
Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 69
Frequent loss of heterozygosity at chromosome 3p14.2-3p21 in human pancreatic islet cell tumours. Clinical endocrinology. 1999 Academic Article GET IT
Times cited: 29
Reduced blood pressure and increased sensitivity of the vasculature to parathyroid hormone-related protein (PTHrP) in transgenic mice overexpressing the PTH/PTHrP receptor in vascular smooth muscle. Endocrinology. 1999 Academic Article GET IT
Times cited: 58
Targeted overexpression of parathyroid hormone-related protein (PTHrP) to vascular smooth muscle in transgenic mice lowers blood pressure and alters vascular contractility. Endocrinology. 1999 Academic Article GET IT
Times cited: 65
Chapter 8 Mechanisms of radiation-induced carcinogenesis: The thyroid model. Advances in Molecular and Cellular Endocrinology. 1998 Article GET IT
Growth hormone-insulin-like growth factor-I axis in adult insulin-dependent diabetic patients: evidence for central hypersensitivity to growth hormone-releasing hormone and peripheral resistance to growth hormone. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1998 Academic Article GET IT
Times cited: 18
Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas. Cancer. 1998 Academic Article GET IT
Times cited: 66
Prevalence of minisatellite and microsatellite instability in radiation-induced post-Chernobyl pediatric thyroid carcinomas. Oncogene. 1998 Academic Article GET IT
Times cited: 28
Parathyroid hormone-related protein expression in vascular smooth muscle of spontaneously hypertensive rats: evidence for lack of response to angiotensin II. Journal of hypertension. 1998 Academic Article GET IT
Times cited: 8
From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization. American journal of human genetics. 1998 Academic Article GET IT
ret rearrangements in Japanese pediatric and adult papillary thyroid cancers. Thyroid : official journal of the American Thyroid Association. 1998 Academic Article GET IT
Times cited: 63
Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology. 1998 Academic Article GET IT
Times cited: 88
Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells. The American journal of physiology. 1998 Academic Article GET IT
Times cited: 82
Studies of allelic loss in thyroid tumors reveal major differences in chromosomal instability between papillary and follicular carcinomas. The Journal of clinical endocrinology and metabolism. 1998 Academic Article GET IT
Times cited: 101
Aortic smooth muscle cells interact with tenascin-C through its fibrinogen-like domain. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 39
Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. Nucleic acids research. 1997 Academic Article GET IT
Times cited: 34
Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice. The Journal of clinical investigation. 1997 Academic Article GET IT
Times cited: 172
Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer research. 1997 Academic Article GET IT
Times cited: 528
Direct effects of somatostatin analog octreotide on insulin-like growth factor-I in the arterial wall. Laboratory investigation; a journal of technical methods and pathology. 1997 Academic Article GET IT
Times cited: 29
Familial nonmedullary thyroid carcinoma--the case for genetic susceptibility. The Journal of clinical endocrinology and metabolism. 1997 Editorial Article GET IT
Times cited: 39
Risk factors for thyroid cancer. Trends in endocrinology and metabolism: TEM. 1997 Academic Article GET IT
Expression of the Ets-1 proto-oncogene in human gastric carcinoma: correlation with tumor invasion. The American journal of pathology. 1996 Academic Article GET IT
Times cited: 102
Prevalence of mutations of ras and p53 in benign and malignant thyroid tumors from children exposed to radiation after the Chernobyl nuclear accident. Oncogene. 1996 Academic Article GET IT
Times cited: 117
Cell-specific signal transduction of parathyroid hormone (PTH)-related protein through stably expressed recombinant PTH/PTHrP receptors in vascular smooth muscle cells. Endocrinology. 1996 Academic Article GET IT
Times cited: 62
Regulated expression of the ets-1 transcription factor in vascular smooth muscle cells in vivo and in vitro. Circulation research. 1996 Academic Article GET IT
Times cited: 84
Reexpression of thyroid peroxidase in a derivative of an undifferentiated thyroid carcinoma cell line by introduction of wild-type p53. Cancer research. 1996 Academic Article GET IT
Times cited: 87
Block of c-myc expression by antisense oligonucleotides inhibits proliferation of human thyroid carcinoma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research. 1996 Academic Article GET IT
Times cited: 61
Thyroid lesions in children and adolescents after the Chernobyl disaster: implications for the study of radiation tumorigenesis. The Journal of clinical endocrinology and metabolism. 1996 Academic Article GET IT
Times cited: 101
A mutated p53 gene alters thyroid cell differentiation. Oncogene. 1995 Academic Article GET IT
Times cited: 36
Characteristics of follicular tumors and nonneoplastic thyroid lesions in children and adolescents exposed to radiation as a result of the Chernobyl disaster. Cancer. 1995 Academic Article GET IT
Times cited: 41
Involvement of cell cycle and mitogen-activated pathways in induction of parathyroid hormone-related protein gene expression in rat aortic smooth muscle cells. Endocrinology. 1995 Academic Article GET IT
Times cited: 35
Mutations of the adenomatous polyposis coli gene in sporadic thyroid neoplasms. The Journal of clinical endocrinology and metabolism. 1994 Academic Article GET IT
Times cited: 51
Stimulation of rat vascular smooth muscle cell glycosaminoglycan production by angiotensin II. Atherosclerosis. 1994 Academic Article GET IT
Times cited: 20
Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor and its messenger ribonucleic acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells: cell-specific regulation by angiotensin-II and PTHrP. Endocrinology. 1994 Academic Article GET IT
Times cited: 82
Cloning and characterization of alternatively spliced isoforms of rat tenascin. Platelet-derived growth factor-BB markedly stimulates expression of spliced variants of tenascin mRNA in arterial smooth muscle cells. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 59
Mechanical stimuli induce vascular parathyroid hormone-related protein gene expression in vivo and in vitro. Endocrinology. 1994 Academic Article GET IT
Times cited: 73
Expression and insulin-like growth factor-dependent proteolysis of insulin-like growth factor-binding protein-4 are regulated by cell confluence in vascular smooth muscle cells. Circulation research. 1994 Academic Article GET IT
Times cited: 50
Molecular genetics of human thyroid neoplasms. Annual review of medicine. 1994 Information Resource GET IT
Times cited: 60
Effects of N-terminal, midregion, and C-terminal parathyroid hormone-related peptides on adenosine 3',5'-monophosphate and cytoplasmic free calcium in rat aortic smooth muscle cells and UMR-106 osteoblast-like cells. Endocrinology. 1993 Academic Article GET IT
Times cited: 54
Aberrant deoxyribonucleic acid methylation in human thyroid tumors. The Journal of clinical endocrinology and metabolism. 1993 Academic Article GET IT
Times cited: 23
Growth factor production by human thyroid carcinoma cells: abundant expression of a platelet-derived growth factor-B-like protein by a human papillary carcinoma cell line. The Journal of clinical endocrinology and metabolism. 1993 Academic Article GET IT
Times cited: 24
The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms. The Journal of clinical endocrinology and metabolism. 1993 Academic Article GET IT
Times cited: 77
Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 126
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. The Journal of clinical investigation. 1993 Academic Article GET IT
Times cited: 625
Angiotensin II regulates tenascin gene expression in vascular smooth muscle cells. The Journal of biological chemistry. 1992 Academic Article GET IT
Times cited: 76
Regulation of insulin-like growth factor-I and its receptor in rat aorta after balloon denudation. Evidence for local bioactivity. The Journal of clinical investigation. 1992 Academic Article GET IT
Times cited: 96
Platelet-derived growth factor isoforms decrease insulin-like growth factor I gene expression in rat vascular smooth muscle cells and selectively stimulate the biosynthesis of insulin-like growth factor binding protein 4. Circulation research. 1992 Academic Article GET IT
Times cited: 59
Growth factors, cytokines, and vascular injury. Trends in cardiovascular medicine. 1992 Article GET IT
Times cited: 18
Effects of hypophysectomy on vascular insulin-like growth factor-I gene expression after balloon denudation in rats. Atherosclerosis. 1992 Academic Article GET IT
Times cited: 29
Abundant expression of parathyroid hormone-related protein in primary rat aortic smooth muscle cells accompanies serum-induced proliferation. The Journal of clinical investigation. 1991 Academic Article GET IT
Times cited: 120
Allelotype of human thyroid tumors: loss of chromosome 11q13 sequences in follicular neoplasms. Molecular endocrinology (Baltimore, Md.). 1991 Academic Article GET IT
Times cited: 87
Transforming DNA sequences present in human prolactin-secreting pituitary tumors. Molecular endocrinology (Baltimore, Md.). 1991 Academic Article GET IT
Times cited: 62
A paradigm for restenosis based on cell biology: clues for the development of new preventive therapies. Journal of the American College of Cardiology. 1991 Information Resource GET IT
Times cited: 459
Clonal origin of pituitary adenomas. The Journal of clinical endocrinology and metabolism. 1990 Academic Article GET IT
Times cited: 462
Point mutations of ras oncogenes are an early event in thyroid tumorigenesis. Molecular endocrinology (Baltimore, Md.). 1990 Academic Article GET IT
Times cited: 295
Clonal composition of benign and malignant human thyroid tumors. The Journal of clinical investigation. 1990 Academic Article GET IT
Times cited: 130
H-ras protooncogene mutations in human thyroid neoplasms. The Journal of clinical endocrinology and metabolism. 1990 Academic Article GET IT
Times cited: 110
Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation. Circulation research. 1990 Academic Article GET IT
Times cited: 166
Pituitary insulin-like growth factor-I gene expression: regulation by triiodothyronine and growth hormone. Endocrinology. 1989 Academic Article GET IT
Times cited: 62
Coordinate decrease of tissue insulinlike growth factor I posttranscriptional alternative mRNA transcripts in diabetes mellitus. Diabetes. 1989 Academic Article GET IT
Times cited: 65
Regulation of pituitary insulin-like growth factor-I messenger ribonucleic acid levels in rats harboring somatomammotropic tumors: implications for growth hormone autoregulation. Endocrinology. 1988 Academic Article GET IT
Times cited: 48
Insulinotropic effects of vanadate. Diabetes. 1987 Academic Article GET IT
Times cited: 32
Insulin-like growth factor I gene expression in GH3 rat pituitary cells: messenger ribonucleic acid content, immunocytochemistry, and secretion. Endocrinology. 1987 Academic Article GET IT
Times cited: 60
Acromegaly update--etiology, diagnosis and management. The Western journal of medicine. 1987 Information Resource GET IT
Times cited: 7
Relative increase in insulin-like growth factor I messenger ribonucleic acid levels in compensatory renal hypertrophy. Endocrinology. 1987 Academic Article GET IT
Times cited: 116
Expression of the myc cellular proto-oncogene in human thyroid tissue. The Journal of clinical endocrinology and metabolism. 1986 Academic Article GET IT
Times cited: 45
Bromocriptine inhibits incorporation of [3H]thymidine into rat pituitary tumor cells. Brain research. 1986 Academic Article GET IT
Times cited: 4
Optimizing glycemic control: can insulin dependent diabetic patients rely on their perception of blood glucose fluctuations in order to make therapeutic decisions?. Diabetes research (Edinburgh, Scotland). 1986 Academic Article GET IT
Times cited: 5
Isolation and characterization of rat-mouse somatic cell hybrids secreting growth hormone and prolactin. Experimental cell research. 1986 Academic Article GET IT
Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features. Gastroenterology. 1986 Academic Article GET IT
Times cited: 35
[Insulin portable pump vs. intensified conventional injections in diabetes]. Medicina. 1985 Academic Article GET IT
Times cited: 2

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Background

education and training

M.D., University of Buenos Aires Faculty of Medicine (Argentina) 73

Contact

full name

James Alexander Fagin

primary email

faginj@mskcc.org

VIVO Weill Cornell Medical College

James Alexander Fagin Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email