Gu, Jinghua

Publications

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selected publications

Single-cell RNA profiling of blood CD4⁺ T cells identifies distinct helper and dysfunctional regulatory clusters in children with SLE. Nature immunology. 2025 Academic Article GET IT
Times cited: 1
Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures. 2025 GET IT
Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2. Cell. 2025 Academic Article GET IT
Times cited: 16
Type I IFN drives unconventional IL-1β secretion in lupus monocytes. Immunity. 2024 Academic Article GET IT
Times cited: 18
Optimization of ultracentrifugation-based method to enhance the purity and proteomic profiling depth of plasma-derived extracellular vesicles and particles. Journal of extracellular biology. 2024 Academic Article GET IT
Times cited: 2
Ragas: integration and enhanced visualization for single cell subcluster analysis. Bioinformatics (Oxford, England). 2024 Academic Article GET IT
Times cited: 1
Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner. 2024 GET IT
An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes. 2023 GET IT
Association of Juvenile Dermatomyositis Disease Activity With the Expansion of Blood Memory B and T Cell Subsets Lacking Follicular Markers. Arthritis & rheumatology (Hoboken, N.J.). 2023 Academic Article GET IT
Times cited: 7
Transcriptomic analyses of patient peripheral blood with hemoglobin depletion reveal glioblastoma biomarkers. NPJ genomic medicine. 2023 Academic Article GET IT
Times cited: 8
Dietary long-chain omega 3 fatty acids modify sphingolipid metabolism to facilitate airway hyperreactivity. Scientific reports. 2022 Academic Article GET IT
Dysregulated DNA methylation in the pathogenesis of Fabry disease. Molecular genetics and metabolism reports. 2022 Academic Article GET IT
Times cited: 3
A human Barrett's esophagus organoid system reveals epithelial-mesenchymal plasticity induced by acid and bile salts. American journal of physiology. Gastrointestinal and liver physiology. 2022 Academic Article GET IT
Times cited: 13
Human Rhinovirus Infection of the Respiratory Tract Affects Sphingolipid Synthesis. American journal of respiratory cell and molecular biology. 2021 Academic Article GET IT
Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE. Cell. 2021 Academic Article GET IT
Times cited: 160
Screening for SARS-CoV-2 via PCR and serological testing in asymptomatic healthcare workers. Proceedings (Baylor University. Medical Center). 2021 Academic Article GET IT
In Esophageal Squamous Cells From Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion Through Effects on Intracellular Calcium and a Non-Gastric Proton Pump. Gastroenterology. 2021 Academic Article GET IT
Times cited: 27
Identifying intracellular signaling modules and exploring pathways associated with breast cancer recurrence. Scientific reports. 2021 Academic Article GET IT
Times cited: 9
Cerina: systematic circRNA functional annotation based on integrative analysis of ceRNA interactions. Scientific reports. 2020 Academic Article GET IT
Times cited: 19
Lower esophageal sphincter muscle of patients with achalasia exhibits profound mast cell degranulation. Neurogastroenterology and motility. 2020 Academic Article GET IT
Times cited: 19
Author Correction: BICORN: An R package for integrative inference of de novo cis-regulatory modules. 2020 GET IT
A Human Lung Challenge Model to Evaluate the Safety and Immunogenicity of PPD and Live Bacillus Calmette-Guérin. American journal of respiratory and critical care medicine. 2020 Academic Article GET IT
Times cited: 35
BICORN: An R package for integrative inference of de novo cis-regulatory modules. Scientific reports. 2020 Academic Article GET IT
Times cited: 4
Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells. PloS one. 2020 Academic Article GET IT
Times cited: 9
Profiling Gene Programs in the Blood During Liver Regeneration in Living Liver Donors. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2019 Academic Article GET IT
Times cited: 6
Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing. Bioinformatics (Oxford, England). 2019 Academic Article GET IT
Times cited: 32
Differential expression and release of exosomal miRNAs by human islets under inflammatory and hypoxic stress. Diabetologia. 2019 Academic Article GET IT
Times cited: 44
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus. Nature communications. 2019 Academic Article GET IT
Times cited: 96
Cancer stem cell-associated miRNAs serve as prognostic biomarkers in colorectal cancer. JCI insight. 2019 Academic Article GET IT
Times cited: 27
A combination of curcumin and oligomeric proanthocyanidins offer superior anti-tumorigenic properties in colorectal cancer. Scientific reports. 2018 Academic Article GET IT
Times cited: 65
Mechanistic insights into anticancer properties of oligomeric proanthocyanidins from grape seeds in colorectal cancer. Carcinogenesis. 2018 Academic Article GET IT
Times cited: 49
CRNET: an efficient sampling approach to infer functional regulatory networks by integrating large-scale ChIP-seq and time-course RNA-seq data. Bioinformatics (Oxford, England). 2018 Academic Article GET IT
Times cited: 11
Oligomeric proanthocyanidins (OPCs) target cancer stem-like cells and suppress tumor organoid formation in colorectal cancer. Scientific reports. 2018 Academic Article GET IT
Times cited: 77
A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis. The Journal of experimental medicine. 2017 Academic Article GET IT
Times cited: 46
Phantom: investigating heterogeneous gene sets in time-course data. Bioinformatics (Oxford, England). 2017 Academic Article GET IT
Times cited: 1
DM-BLD: differential methylation detection using a hierarchical Bayesian model exploiting local dependency. Bioinformatics (Oxford, England). 2016 Academic Article GET IT
Times cited: 4
Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 Academic Article GET IT
Times cited: 50
BADGE: a novel Bayesian model for accurate abundance quantification and differential analysis of RNA-Seq data. BMC bioinformatics. 2014 Academic Article GET IT
Times cited: 13
mAPC-GibbsOS: an integrated approach for robust identification of gene regulatory networks. BMC systems biology. 2013 Academic Article GET IT
Times cited: 3
Robust identification of transcriptional regulatory networks using a Gibbs sampler on outlier sum statistic. Bioinformatics (Oxford, England). 2012 Academic Article GET IT
Times cited: 8
Integrative network analysis to identify aberrant pathway networks in ovarian cancer. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2012 Academic Article GET IT
Times cited: 10
GIST: a Gibbs sampler to identify intracellular signal transduction pathways. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2011 Academic Article GET IT
Times cited: 1
Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis. American journal of obstetrics and gynecology. 2010 Academic Article GET IT
Times cited: 50

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Research

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Funding awarded

Early life respiratory viral infections shape immune development trajectories- Project 2 awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2023 - 2027
Center for Lupus Research awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Key Personnel 2022 - 2027
Mechanisms of intracellular iron dysregulation in kidney fibrosis and reno-protective strategies awarded by National Institute of Diabetes & Digestive & Kidney Diseases Key Personnel 2024 - 2026

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Background

education and training

Ph.D., Virginia Polytechnic Institute 2013
M.S., Chinese Academy of Sciences, Shanghai (China) 2009
B.S., Zhejiang University (China) 2006

Contact

full name

Jinghua Gu

primary email

jig4003@med.cornell.edu

VIVO Weill Cornell Medical College

Jinghua Gu Assistant Professor of Research in Pediatrics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email