selected publications
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Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.
Cancer discovery.
2019
Academic Article
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Times cited: 34 -
Loss of plasmacytoid dendritic cell differentiation is highly predictive for post-induction measurable residual disease and inferior outcomes in acute myeloid leukemia.
Haematologica.
2018
Academic Article
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Times cited: 11 -
Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis.
Blood.
2018
Academic Article
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Times cited: 30 -
Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.
Nature genetics.
2017
Academic Article
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Times cited: 67 -
Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.
Cancer discovery.
2017
Academic Article
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Times cited: 89 -
Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.
Cancer discovery.
2017
Academic Article
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Times cited: 87 - LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation. Cell. 2016 Editorial Article GET IT
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Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
Leukemia.
2015
Academic Article
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Times cited: 56 -
Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome.
Genome research.
2011
Academic Article
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Times cited: 30 -
LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation.
Cell.
2010
Academic Article
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Times cited: 219 -
CG dinucleotide periodicities recognized by the Dnmt3a-Dnmt3L complex are distinctive at retroelements and imprinted domains.
Mammalian genome : official journal of the International Mammalian Genome Society.
2009
Academic Article
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Times cited: 28 -
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers.
Nucleic acids research.
2009
Academic Article
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Times cited: 134 -
Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features.
Blood.
2009
Academic Article
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Times cited: 80 -
CG dinucleotide clustering is a species-specific property of the genome.
Nucleic acids research.
2007
Academic Article
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Times cited: 70 -
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.
Nature.
2007
Academic Article
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Times cited: 518 -
Comparative isoschizomer profiling of cytosine methylation: the HELP assay.
Genome research.
2006
Academic Article
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Times cited: 343