Butler, Jason M

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Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response. Nature communications. 2023 Academic Article GET IT
Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics. Nature communications. 2022 Academic Article GET IT
Times cited: 21
Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and Aging. Current stem cell reports. 2021 Review GET IT
Times cited: 12
Inhibition of Oxidative Phosphorylation Reverses Bone Marrow Hypoxia Visualized in Imageable Syngeneic B-ALL Mouse Model. Frontiers in oncology. 2020 Academic Article GET IT
Times cited: 11
Endothelial mTOR maintains hematopoiesis during aging. The Journal of experimental medicine. 2020 Academic Article GET IT
Times cited: 20
Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF. Nature communications. 2020 Academic Article GET IT
Times cited: 49
Blood making: learning what to put into the dish. F1000Research. 2020 Review GET IT
Times cited: 6
The bone marrow microenvironment at single-cell resolution. Nature. 2019 Academic Article GET IT
Times cited: 617
The Instructive Role of the Bone Marrow Niche in Aging and Leukemia. Current stem cell reports. 2018 Review GET IT
Times cited: 15
Targeting skeletal endothelium to ameliorate bone loss. Nature medicine. 2018 Academic Article GET IT
Times cited: 253
Derivation and characterization of a UCP1 reporter human ES cell line. Stem cell research. 2018 Academic Article GET IT
Times cited: 5
The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem cell reports. 2018 Academic Article GET IT
Times cited: 27
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Science immunology. 2018 Academic Article GET IT
Times cited: 99
Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 56
Endothelial transplantation rejuvenates aged hematopoietic stem cell function. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 109
Regulation of the hematopoietic stem cell lifecycle by the endothelial niche. Current opinion in hematology. 2017 Review GET IT
Times cited: 37
Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function. Development (Cambridge, England). 2017 Academic Article GET IT
Times cited: 36
Conversion of adult endothelium to immunocompetent haematopoietic stem cells. Nature. 2017 Academic Article GET IT
Times cited: 165
A Common Origin for B-1a and B-2 Lymphocytes in Clonal Pre- Hematopoietic Stem Cells. Stem cell reports. 2017 Academic Article GET IT
Times cited: 39
Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis. Nature communications. 2016 Academic Article GET IT
Times cited: 41
Sinusoidal ephrin receptor EPHB4 controls hematopoietic progenitor cell mobilization from bone marrow. The Journal of clinical investigation. 2016 Academic Article GET IT
Times cited: 36
Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates. Stem cells translational medicine. 2016 Academic Article GET IT
Times cited: 26
Transplantation of Endothelial Cells to Mitigate Acute and Chronic Radiation Injury to Vital Organs. Radiation research. 2016 Review GET IT
Times cited: 19
Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature. 2016 Academic Article GET IT
Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme. Journal of anatomy. 2016 Academic Article GET IT
Times cited: 9
Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature. 2016 Academic Article GET IT
Times cited: 543
Angiocrine functions of organ-specific endothelial cells. Nature. 2016 Review GET IT
Times cited: 679
Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis. Stem cell reports. 2015 Academic Article GET IT
Times cited: 45
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. The Journal of clinical investigation. 2015 Academic Article GET IT
Times cited: 65
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. The Journal of clinical investigation. 2015 Academic Article GET IT
Times cited: 90
Activation of the vascular niche supports leukemic progression and resistance to chemotherapy. Experimental hematology. 2014 Academic Article GET IT
Times cited: 48
Inducible nitric oxide synthase in neutrophils and endothelium contributes to ischemic brain injury in mice. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 109
Reprogramming human endothelial cells to haematopoietic cells requires vascular induction. Nature. 2014 Academic Article GET IT
Times cited: 185
Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer cell. 2014 Academic Article GET IT
Times cited: 192
Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell reports. 2013 Academic Article GET IT
Times cited: 203
Endothelial cells provide a niche for placental hematopoietic stem/progenitor cell expansion through broad transcriptomic modification. Stem cell research. 2013 Academic Article GET IT
Times cited: 20
Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration. Developmental cell. 2013 Academic Article GET IT
Times cited: 488
Prominin 1/CD133 endothelium sustains growth of proneural glioma. PloS one. 2013 Academic Article GET IT
Times cited: 19
Stem cells: Painkillers caught in blood-cell trafficking. Nature. 2013 Comment GET IT
Times cited: 1
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition. Blood. 2012 Academic Article GET IT
Times cited: 65
Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression. Cell. 2012 Academic Article GET IT
Times cited: 196
Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells. Blood. 2012 Academic Article GET IT
Times cited: 83
Serial monitoring of human systemic and xenograft models of leukemia using a novel vascular disrupting agent. Leukemia. 2012 Academic Article GET IT
Times cited: 13
Generation of a vascular niche for studying stem cell homeostasis. Methods in molecular biology (Clifton, N.J.). 2012 Academic Article GET IT
Times cited: 11
c-Kit-mediated functional positioning of stem cells to their niches is essential for maintenance and regeneration of adult hematopoiesis. PloS one. 2011 Academic Article GET IT
Times cited: 64
Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment. Molecular cell. 2011 Academic Article GET IT
Times cited: 240
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature. 2010 Academic Article GET IT
Times cited: 664
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Nature cell biology. 2010 Academic Article GET IT
Times cited: 319
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell stem cell. 2010 Academic Article GET IT
Times cited: 528
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nature reviews. Cancer. 2010 Review GET IT
Times cited: 480
Generation of stable co-cultures of vascular cells in a honeycomb alginate scaffold. Tissue engineering. Part A. 2010 Academic Article GET IT
Times cited: 34
Bone marrow stem and progenitor cell contribution to neovasculogenesis is dependent on model system with SDF-1 as a permissive trigger. Blood. 2009 Academic Article GET IT
Times cited: 52
Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell stem cell. 2009 Academic Article GET IT
Times cited: 519
Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 118
The role of progenitor cells in the development of intimal hyperplasia. Journal of vascular surgery. 2008 Review GET IT
Times cited: 45
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. The Journal of clinical investigation. 2008 Academic Article GET IT
Times cited: 817
A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization. Cancer cell. 2008 Comment GET IT
Times cited: 73
Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells. Arteriosclerosis, thrombosis, and vascular biology. 2007 Review GET IT
Times cited: 53
The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death. Blood. 2007 Academic Article GET IT
Times cited: 66
Does N-cadherin regulate interaction of hematopoietic stem cells with their niches?. Cell stem cell. 2007 Comment GET IT
Times cited: 9
The role of the donor in the repair of the marrow vascular niche following hematopoietic stem cell transplant. Stem cells (Dayton, Ohio). 2007 Academic Article GET IT
Times cited: 48
Genomic profiling of acquired resistance to apoptosis in cells derived from human atherosclerotic lesions: potential role of STATs, cyclinD1, BAD, and Bcl-XL. Journal of molecular and cellular cardiology. 2005 Academic Article GET IT
Times cited: 28
SDF-1 is both necessary and sufficient to promote proliferative retinopathy. The Journal of clinical investigation. 2005 Academic Article GET IT
Times cited: 246
The role of adult bone marrow-derived stem cells in choroidal neovascularization. Investigative ophthalmology & visual science. 2003 Academic Article GET IT
Times cited: 139
Induction of Fas ligand-mediated apoptosis by interferon-alpha. Clinical immunology (Orlando, Fla.). 2000 Academic Article GET IT
Times cited: 57

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Background

education and training

Ph.D., University of Florida 2006
M.S., University of Florida 2002
B.S., University of Florida 2001

Contact

full name

Jason M Butler

primary email

jmb2009@med.cornell.edu

VIVO Weill Cornell Medical College

Jason M Butler Adjunct Assistant Professor of Regenerative Medicine in Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email