Magrane, Jordi

Publications

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selected publications

Imaging neuronal activity in the central and peripheral nervous systems using new Thy1.2-GCaMP6 transgenic mouse lines. Journal of neuroscience methods. 2020 Academic Article GET IT
Times cited: 22
Mitochondrial dysfunction in neurons in Friedreich's ataxia. Molecular and cellular neurosciences. 2019 Review GET IT
Times cited: 15
Early VGLUT1-specific parallel fiber synaptic deficits and dysregulated cerebellar circuit in the KIKO mouse model of Friedreich ataxia. Disease models & mechanisms. 2017 Academic Article GET IT
Times cited: 21
Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia. Disease models & mechanisms. 2017 Academic Article GET IT
Times cited: 50
Distinct intracellular sAC-cAMP domains regulate ER Ca²⁺ signaling and OXPHOS function. Journal of cell science. 2017 Academic Article GET IT
Times cited: 23
Diisopropylfluorophosphate Impairs the Transport of Membrane-Bound Organelles in Rat Cortical Axons. The Journal of pharmacology and experimental therapeutics. 2015 Academic Article GET IT
Times cited: 33
Imaging of mitochondrial dynamics in motor and sensory axons of living mice. Methods in enzymology. 2014 Article GET IT
Times cited: 12
α-Synuclein is localized to mitochondria-associated ER membranes. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 397
Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production. Journal of neurochemistry. 2013 Academic Article GET IT
Times cited: 31
Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models. Human molecular genetics. 2013 Academic Article GET IT
Times cited: 257
The mitochondrial calcium regulator cyclophilin D is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis. Brain : a journal of neurology. 2012 Academic Article GET IT
Times cited: 57
Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 114
In vivo pathogenic role of mutant SOD1 localized in the mitochondrial intermembrane space. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 59
A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo. Molecular neurodegeneration. 2011 Academic Article GET IT
Times cited: 31
Adiponectin is a negative regulator of antigen-activated T cells. European journal of immunology. 2011 Academic Article GET IT
Times cited: 82
adPEO mutations in ANT1 impair ADP-ATP translocation in muscle mitochondria. Human molecular genetics. 2011 Academic Article GET IT
Times cited: 32
Isolation and culture of neurons and astrocytes from the mouse brain cortex. Methods in molecular biology (Clifton, N.J.). 2011 Academic Article GET IT
Times cited: 43
SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse. Brain : a journal of neurology. 2010 Academic Article GET IT
Times cited: 96
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 1334
Novel role of ATPase subunit C targeting peptides beyond mitochondrial protein import. Molecular biology of the cell. 2009 Academic Article GET IT
Times cited: 25
Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities. Human molecular genetics. 2009 Academic Article GET IT
Times cited: 128
Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis. Antioxidants & redox signaling. 2009 Information Resource GET IT
Times cited: 101
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. PloS one. 2009 Academic Article GET IT
Times cited: 119
Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 38
The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 135
Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 102
Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Academic Article GET IT
Times cited: 34
Dissociation of ERK and Akt signaling in endothelial cell angiogenic responses to beta-amyloid. Experimental cell research. 2006 Academic Article GET IT
Times cited: 17
Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 114
Stress proteins in Alzheimer's disease. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 2005 Review GET IT
Times cited: 26
Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 202
Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism. Neurobiology of aging. 2003 Academic Article GET IT
Times cited: 61
The role of O-linked sugars in determining the very low density lipoprotein receptor stability or release from the cell. FEBS letters. 1999 Academic Article GET IT
Times cited: 62
Bovine aortic endothelial cells express a variant of the very low density lipoprotein receptor that lacks the O-linked sugar domain. Journal of lipid research. 1998 Academic Article GET IT
Times cited: 27

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Research

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Funding awarded

Selective frataxin deficiency in glial cells in vivo in novel mouse models of Friedreich''s ataxia awarded by National Ataxia Foundation Principal Investigator 2024 - 2025
Assessment of early somatosensory impairment in the KIKO mouse model of Friedreich''s ataxia awarded by Friedreich''s Ataxia Research Alliance Principal Investigator 2021 - 2024
Cell & non-cell autonomous effects of frataxin deficiency in FA pathophysiology awarded by Muscular Dystrophy Associations of America, Inc. Principal Investigator 2019 - 2024

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Background

education and training

Ph.D., University of Barcelona, Faculty of Biology (Spain) 2000
B.S., University of Barcelona (Spain) 1994

Contact

full name

Jordi Magrane

primary email

jom2025@med.cornell.edu

VIVO Weill Cornell Medical College

Jordi Magrane Associate Professor of Research in Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email