Zhou, Joe

Publications

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selected publications

Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation. 2024 GET IT
Clonal evolution during metastatic spread in high-risk neuroblastoma. Nature genetics. 2023 Academic Article GET IT
Times cited: 542
Stomach-derived human insulin-secreting organoids restore glucose homeostasis. Nature cell biology. 2023 Academic Article GET IT
Times cited: 1347
Matrix viscoelasticity controls spatiotemporal tissue organization. Nature materials. 2022 Academic Article GET IT
In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system. Cell chemical biology. 2022 Academic Article GET IT
Rapid establishment of human colonic organoid knockout lines. STAR protocols. 2022 Academic Article GET IT
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell stem cell. 2021 Academic Article GET IT
Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas. Nature metabolism. 2021 Academic Article GET IT
Times cited: 1
PDX1^LOW MAFA^LOW β-cells contribute to islet function and insulin release. Nature communications. 2021 Academic Article GET IT
Times cited: 45
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis. Nature. 2020 Academic Article GET IT
Times cited: 130
Pancreas regeneration. Nature. 2018 Information Resource GET IT
Times cited: 242
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1. Stem cell reports. 2017 Academic Article GET IT
Times cited: 86
Reprogramming of Pancreatic Acinar Cells to Functional Beta Cells by In Vivo Transduction of a Polycistronic Construct Containing Pdx1, Ngn3, MafA in Mice. Current protocols in stem cell biology. 2017 Academic Article GET IT
Times cited: 11
How to make insulin-producing pancreatic β cells for diabetes treatment. Science China. Life sciences. 2016 Information Resource GET IT
Times cited: 11
Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation. Cell stem cell. 2016 Academic Article GET IT
Times cited: 105
Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice. Diabetologia. 2015 Academic Article GET IT
Times cited: 25
Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells. Endocrinology. 2015 Academic Article GET IT
Times cited: 25
Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes. Current pathobiology reports. 2015 Academic Article GET IT
Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells. Nature biotechnology. 2014 Academic Article GET IT
Times cited: 66
De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts. Cell reports. 2014 Academic Article GET IT
Times cited: 131
Direct lineage conversion of pancreatic exocrine to endocrine Beta cells in vivo with defined factors. Methods in molecular biology (Clifton, N.J.). 2014 Academic Article GET IT
Times cited: 11
In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. eLife. 2014 Academic Article GET IT
Times cited: 91
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (Cambridge, England). 2009 Academic Article GET IT
Times cited: 234
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008 Academic Article GET IT
Times cited: 1532
Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell. 2008 Academic Article GET IT
Times cited: 260
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (Cambridge, England). 2008 Academic Article GET IT
Times cited: 129
Genetic targeting of the endoderm with claudin-6CreER. Developmental dynamics : an official publication of the American Association of Anatomists. 2008 Academic Article GET IT
Times cited: 48
A multipotent progenitor domain guides pancreatic organogenesis. Developmental cell. 2007 Academic Article GET IT
Times cited: 379
The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell. 2002 Academic Article GET IT
Times cited: 780
The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron. 2001 Academic Article GET IT
Times cited: 446
Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron. 2000 Academic Article GET IT
Times cited: 601

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Research

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Co-investigator Network

Funding awarded

Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapy awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2022 - 2026
Derivation of pancreatic islet-like organoids from human gastric stem cells awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2022 - 2026
Investigating a master regulator of large intestine stem cells awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2021 - 2025
Developing a novel cell therapy to treat Type 1 diabetes awarded by Daedalus Fund for Innovation (Weill Cornell) Principal Investigator 2022 - 2024

Adaptable tissue-specific endothelial cells for organ regeneration awarded by National Heart, Lung, & Blood Institute Co-Investigator 2020 - 2027
Subcutaneous Transplantation of Pre-Vascularized Human Islets and SC-β cells to Treat Type I Diabetes Co-Investigator 2022 - 2024

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Background

education and training

Ph.D., California Institute of Technology 2003
M.S., Boston University 1997
B.S., Qingdao University 1993

Contact

full name

Joe Zhou

primary email

jqz4001@med.cornell.edu

VIVO Weill Cornell Medical College

Joe Zhou Associate Professor of Regenerative Medicine in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email