Young, James W.

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Geriatric syndromes in 2-year, progression-free survivors among older recipients of allogeneic hematopoietic cell transplantation. Bone marrow transplantation. 2020 Letter GET IT
Times cited: 4
Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 176
Favorable long-term outcomes of hematopoietic stem cell transplantation for CMML with myeloablative conditioning, anti-thymocyte globulin, and CD34⁺ selected graft. Bone marrow transplantation. 2019 Letter GET IT
Ex Vivo T Cell-Depleted Hematopoietic Stem Cell Transplantation for Adult Patients with Acute Myelogenous Leukemia in First and Second Remission: Long-Term Disease-Free Survival with a Significantly Reduced Risk of Graft-versus-Host Disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2019 Academic Article GET IT
Times cited: 21
Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant. Science translational medicine. 2018 Academic Article GET IT
Times cited: 257
A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity. Science translational medicine. 2018 Academic Article GET IT
Times cited: 47
Primary T Cells from Cutaneous T-cell Lymphoma Skin Explants Display an Exhausted Immune Checkpoint Profile. Cancer immunology research. 2018 Academic Article GET IT
Times cited: 74
Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome: Comparison of Outcomes between CD34⁺ Selected and Unmodified Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2018 Academic Article GET IT
Times cited: 19
T Cell Depletion as an Alternative Approach for Patients 55 Years or Older Undergoing Allogeneic Stem Cell Transplantation as Curative Therapy for Hematologic Malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2017 Academic Article GET IT
Times cited: 8
A Chemotherapy-Only Regimen of Busulfan, Melphalan, and Fludarabine, and Rabbit Antithymocyte Globulin Followed by Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplantations for the Treatment of Myeloid Malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2017 Academic Article GET IT
Times cited: 6
Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant. Leukemia & lymphoma. 2017 Academic Article GET IT
Times cited: 50
Ex Vivo CD34⁺-Selected T Cell-Depleted Peripheral Blood Stem Cell Grafts for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia and Myelodysplastic Syndrome Is Associated with Low Incidence of Acute and Chronic Graft-versus-Host Disease and High Treatment Response. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Academic Article GET IT
Times cited: 33
Human Dendritic Cells Mitigate NK-Cell Dysfunction Mediated by Nonselective JAK1/2 Blockade. Cancer immunology research. 2016 Academic Article GET IT
Times cited: 30
Hematopoietic Cell Transplantation Comorbidity Index Predicts Outcomes in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes Receiving CD34⁺ Selected Grafts for Allogeneic Hematopoietic Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Academic Article GET IT
Times cited: 22
Second Allogeneic Stem Cell Transplantation for Acute Leukemia Using a Chemotherapy-Only Cytoreduction with Clofarabine, Melphalan, and Thiotepa. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Academic Article GET IT
Times cited: 10
Phase II Study of Haploidentical Natural Killer Cell Infusion for Treatment of Relapsed or Persistent Myeloid Malignancies Following Allogeneic Hematopoietic Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Academic Article GET IT
Times cited: 114
T-cell Exhaustion in Multiple Myeloma Relapse after Autotransplant: Optimal Timing of Immunotherapy. Cancer immunology research. 2015 Academic Article GET IT
Times cited: 155
Robust Vaccine Responses in Adult and Pediatric Cord Blood Transplantation Recipients Treated for Hematologic Malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 31
High Disease-Free Survival with Enhanced Protection against Relapse after Double-Unit Cord Blood Transplantation When Compared with T Cell-Depleted Unrelated Donor Transplantation in Patients with Acute Leukemia and Chronic Myelogenous Leukemia. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 37
Association between Nondominant Unit Total Nucleated Cell Dose and Engraftment in Myeloablative Double-Unit Cord Blood Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 8
CD34-Selected Hematopoietic Stem Cell Transplants Conditioned with Myeloablative Regimens and Antithymocyte Globulin for Advanced Myelodysplastic Syndrome: Limited Graft-versus-Host Disease without Increased Relapse. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 44
Intensified Mycophenolate Mofetil Dosing and Higher Mycophenolic Acid Trough Levels Reduce Severe Acute Graft-versus-Host Disease after Double-Unit Cord Blood Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 32
Phenotypic and functional activation of hyporesponsive KIRnegNKG2Aneg human NK-cell precursors requires IL12p70 provided by Poly(I:C)-matured monocyte-derived dendritic cells. Cancer immunology research. 2014 Academic Article GET IT
Times cited: 5
Frequent human herpesvirus-6 viremia but low incidence of encephalitis in double-unit cord blood recipients transplanted without antithymocyte globulin. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2014 Academic Article GET IT
Times cited: 42
Langerhans-type and monocyte-derived human dendritic cells have different susceptibilities to mRNA electroporation with distinct effects on maturation and activation: implications for immunogenicity in dendritic cell-based immunotherapy. Journal of translational medicine. 2013 Academic Article GET IT
Times cited: 16
A novel reduced-intensity conditioning regimen induces a high incidence of sustained donor-derived neutrophil and platelet engraftment after double-unit cord blood transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013 Academic Article GET IT
Times cited: 56
Graft-versus-host disease after double-unit cord blood transplantation has unique features and an association with engrafting unit-to-recipient HLA match. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013 Academic Article GET IT
Times cited: 58
Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation. Blood. 2012 Academic Article GET IT
Times cited: 141
T cell-depleted stem cell transplantation for adults with high-risk acute lymphoblastic leukemia: long-term survival for patients in first complete remission with a decreased risk of graft-versus-host disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2012 Academic Article GET IT
Times cited: 37
Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain. PloS one. 2012 Academic Article GET IT
Times cited: 27
Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1. Blood. 2012 Academic Article GET IT
Times cited: 44
Long-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant. Leukemia & lymphoma. 2012 Academic Article GET IT
Times cited: 35
Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation. Blood. 2011 Academic Article GET IT
Times cited: 351
Effect of educational components and strategies associated with insulin pump therapy: a systematic review. International journal of evidence-based healthcare. 2011 Information Resource GET IT
Times cited: 12
Anti-IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses. Blood. 2011 Academic Article GET IT
Times cited: 34
Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen. Blood. 2011 Academic Article GET IT
Times cited: 78
Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 Academic Article GET IT
Times cited: 67
Reduced late mortality risk contributes to similar survival after double-unit cord blood transplantation compared with related and unrelated donor hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011 Academic Article GET IT
Times cited: 66
T cell-depleted unrelated donor stem cell transplantation provides favorable disease-free survival for adults with hematologic malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011 Academic Article GET IT
Times cited: 67
Tregs served sunny-side up. Blood. 2010 Article GET IT
Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minorities. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2010 Academic Article GET IT
Times cited: 131
NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2010 Information Resource GET IT
Times cited: 45
Chronic kidney disease, thrombotic microangiopathy, and hypertension following T cell-depleted hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2010 Academic Article GET IT
Times cited: 69
Second-line age-adjusted International Prognostic Index in patients with advanced non-Hodgkin lymphoma after T-cell depleted allogeneic hematopoietic SCT. Bone marrow transplantation. 2010 Academic Article GET IT
Times cited: 21
Fourth complete remission with immunosuppression withdrawal and irinotecan after both autologous and allogeneic transplants for diffuse large B cell lymphoma. Leukemia & lymphoma. 2009 Letter GET IT
Times cited: 3
Cord blood units with low CD34+ cell viability have a low probability of engraftment after double unit transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2009 Academic Article GET IT
Times cited: 101
Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus-host disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2009 Academic Article GET IT
Times cited: 49
Distinct responses of human monocyte subsets to Aspergillus fumigatus conidia. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 64
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. The Journal of experimental medicine. 2009 Academic Article GET IT
Times cited: 248
Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells. Blood. 2009 Academic Article GET IT
Times cited: 228
Human liver dendritic cells promote T cell hyporesponsiveness. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 186
Response to pneumococcal (PNCRM7) and haemophilus influenzae conjugate vaccines (HIB) in pediatric and adult recipients of an allogeneic hematopoietic cell transplantation (alloHCT). Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2008 Academic Article GET IT
Times cited: 60
Sirolimus (rapamycin) induced proteinuria in a patient undergoing allogeneic hematopoietic stem cell transplant. Transplantation. 2008 Article GET IT
Times cited: 3
Transplantation in remission improves the disease-free survival of patients with advanced myelodysplastic syndromes treated with myeloablative T cell-depleted stem cell transplants from HLA-identical siblings. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2008 Academic Article GET IT
Times cited: 59
CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody-based therapy. Blood. 2008 Academic Article GET IT
Times cited: 38
Fludarabine-based conditioning secures engraftment of second hematopoietic stem cell allografts (HSCT) in the treatment of initial graft failure. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2007 Academic Article GET IT
Times cited: 38
Scalable expansion of potent genetically modified human langerhans cells in a closed system for clinical applications. Journal of immunotherapy (Hagerstown, Md. : 1997). 2007 Academic Article GET IT
Times cited: 6
T cell depleted stem-cell transplantation for adults with hematologic malignancies: sustained engraftment of HLA-matched related donor grafts without the use of antithymocyte globulin. Blood. 2007 Academic Article GET IT
Times cited: 103
Colonization, bloodstream infection, and mortality caused by vancomycin-resistant enterococcus early after allogeneic hematopoietic stem cell transplant. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2007 Academic Article GET IT
Times cited: 153
Intravenous busulfan and melphalan, tacrolimus, and short-course methotrexate followed by unmodified HLA-matched related or unrelated hematopoietic stem cell transplantation for the treatment of advanced hematologic malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2007 Academic Article GET IT
Times cited: 24
Immunogenicity of recombinant hepatitis B vaccine (rHBV) in recipients of unrelated or related allogeneic hematopoietic cell (HC) transplants. Blood. 2006 Academic Article GET IT
Times cited: 61
Langerhans-type dendritic cells genetically modified to express full-length antigen optimally stimulate CTLs in a CD4-dependent manner. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 6
In vitro expansion of Ag-specific T cells by HLA-A*0201-transfected K562 cells for immune monitoring. Cytotherapy. 2006 Academic Article GET IT
Times cited: 10
Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions. The Journal of clinical investigation. 2005 Academic Article GET IT
Times cited: 310
Langerhans cells derived from genetically modified human CD34+ hemopoietic progenitors are more potent than peptide-pulsed Langerhans cells for inducing antigen-specific CD8+ cytolytic T lymphocyte responses. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 17
Mature myeloid dendritic cell subsets have distinct roles for activation and viability of circulating human natural killer cells. Blood. 2004 Academic Article GET IT
Times cited: 97
Mature human Langerhans cells derived from CD34+ hematopoietic progenitors stimulate greater cytolytic T lymphocyte activity in the absence of bioactive IL-12p70, by either single peptide presentation or cross-priming, than do dermal-interstitial or monocyte-derived dendritic cells. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 140
Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83. Blood. 2004 Academic Article GET IT
Times cited: 131
Predominant autoantibody production by early human B cell precursors. Science (New York, N.Y.). 2003 Academic Article GET IT
Times cited: 1373
Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation. Blood. 2002 Academic Article GET IT
Times cited: 104
Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations. Blood. 2002 Academic Article GET IT
Times cited: 148
Expression of a functional eotaxin (CC chemokine ligand 11) receptor CCR3 by human dendritic cells. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 53
Identification of poor prognostic features among patients requiring mechanical ventilation after hematopoietic stem cell transplantation. Blood. 2001 Academic Article GET IT
Times cited: 91
Dendritic cells as immunologic adjuvants for the treatment of cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2000 Editorial Article GET IT
Paucity of functional T-cell memory to melanoma antigens in healthy donors and melanoma patients. Clinical cancer research : an official journal of the American Association for Cancer Research. 2000 Academic Article GET IT
Times cited: 33
Circulating human B cells that express surrogate light chains and edited receptors. Nature immunology. 2000 Academic Article GET IT
Times cited: 99
Retrovirally transduced mouse dendritic cells require CD4+ T cell help to elicit antitumor immunity: implications for the clinical use of dendritic cells. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 58
Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions. Blood. 1999 Academic Article GET IT
Times cited: 387
T-cell-depleted allogeneic bone marrow transplantation as postremission therapy for acute myelogenous leukemia: freedom from relapse in the absence of graft-versus-host disease. Blood. 1998 Academic Article GET IT
Times cited: 180
Retrovirally transduced human dendritic cells express a normal phenotype and potent T-cell stimulatory capacity. Blood. 1997 Academic Article GET IT
Times cited: 70
Risk of extramedullary relapse following allogeneic bone marrow transplantation for acute myelogenous leukemia with leukemia cutis. Bone marrow transplantation. 1997 Academic Article GET IT
Times cited: 39
The hematopoietic development of dendritic cells: a distinct pathway for myeloid differentiation. Stem cells (Dayton, Ohio). 1996 Information Resource GET IT
Times cited: 77
Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate. Blood. 1996 Academic Article GET IT
Times cited: 200
Dendritic cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity. The Journal of experimental medicine. 1996 Article GET IT
Times cited: 289
Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha. The Journal of experimental medicine. 1995 Academic Article GET IT
Times cited: 272
Telomerase activity in normal and malignant hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 728
Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease. Blood. 1995 Academic Article GET IT
Times cited: 675
Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha. Journal of immunology (Baltimore, Md. : 1950). 1995 Academic Article GET IT
Times cited: 320
Hyperfractionated total lymphoid irradiation and cyclophosphamide for preparation of previously transfused patients undergoing HLA-identical marrow transplantation for severe aplastic anemia. International journal of radiation oncology, biology, physics. 1994 Academic Article GET IT
Times cited: 13
Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses. The Journal of experimental medicine. 1993 Academic Article GET IT
Times cited: 132
High-dose UV-B radiation alters human dendritic cell costimulatory activity but does not allow dendritic cells to tolerize T lymphocytes to alloantigen in vitro. Blood. 1993 Academic Article GET IT
Times cited: 41
The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro. The Journal of clinical investigation. 1992 Academic Article GET IT
Times cited: 280
New technology for the depletion of T cells from soybean lectin agglutinated, HLA-matched bone marrow grafts for leukemia: initial laboratory and clinical results. Progress in clinical and biological research. 1992 Academic Article GET IT
Times cited: 8
Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells. The Journal of experimental medicine. 1990 Academic Article GET IT
Times cited: 198
Accessory cell requirements for the mixed-leukocyte reaction and polyclonal mitogens, as studied with a new technique for enriching blood dendritic cells. Cellular immunology. 1988 Academic Article GET IT
Times cited: 107
Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells. The Journal of experimental medicine. 1987 Academic Article GET IT
Times cited: 218
Mononuclear phagocytes as targets for cytolytic T lymphocytes. Journal of immunological methods. 1987 Academic Article GET IT
Times cited: 5

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Background

education and training

M.D., Vanderbilt University School of Medicine 79
B.S., Duke University 1975

Contact

full name

James W. Young

primary email

jwy2001@med.cornell.edu

VIVO Weill Cornell Medical College

James W. Young Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email