Xiang, Jenny Zhaoying

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selected publications

Detection of rare and novel gene fusions in patients with diffuse glioma: An institutional retrospective study. Journal of neuropathology and experimental neurology. 2024 Academic Article GET IT
Blockade of store-operated calcium entry by BTP2 preserves anti-inflammatory gene expression in human peripheral blood mononuclear cells. Human immunology. 2024 Academic Article GET IT
An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study- Identified Diabetes Genes and Drug Discovery. 2024 GET IT
Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis. Cancer letters. 2024 Academic Article GET IT
Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection. Cell stem cell. 2024 Academic Article GET IT
Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection. 2024 GET IT
Author Correction: Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. 2024 GET IT
RNA-sequencing of Human Kidney Allografts and Delineation of T-Cell Genes, Gene Sets, and Pathways Associated With Acute T Cell-mediated Rejection. Transplantation. 2024 Academic Article GET IT
A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells. Journal of molecular cell biology. 2023 Academic Article GET IT
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS. Nature communications. 2023 Academic Article GET IT
Times cited: 10
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs. The Journal of experimental medicine. 2023 Academic Article GET IT
Times cited: 4
Multicenter phase 2 study of oral azacitidine (CC-486) plus CHOP as initial treatment for PTCL. Blood. 2023 Academic Article GET IT
Times cited: 26
Molecular profiling of the stroke-induced alterations in the cerebral microvasculature reveals promising therapeutic candidates. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Nature cell biology. 2023 Academic Article GET IT
Times cited: 9
Epsilon toxin-producing Clostridium perfringens colonize the MS gut and epsilon toxin overcomes immune privilege. The Journal of clinical investigation. 2023 Academic Article GET IT
Activation of the JAK/STAT Pathway Leads to BRAF Inhibitor Resistance in BRAFV600E Positive Thyroid Carcinoma. Molecular cancer research : MCR. 2023 Academic Article GET IT
Molecular evolution of classic Hodgkin lymphoma revealed through whole genome sequencing of Hodgkin and Reed Sternberg cells. Blood cancer discovery. 2023 Academic Article GET IT
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell stem cell. 2022 Academic Article GET IT
Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis. Nature cardiovascular research. 2022 Academic Article GET IT
GLI1-Rearranged Enteric Tumor: Expanding the Spectrum of Gastrointestinal Neoplasms with GLI1 gene fusions. The American journal of surgical pathology. 2022 Academic Article GET IT
Low-dose carbon monoxide suppresses metastatic progression of disseminated cancer cells. Cancer letters. 2022 Academic Article GET IT
Allele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay. NAR cancer. 2022 Academic Article GET IT
Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nature communications. 2022 Academic Article GET IT
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell stem cell. 2022 Academic Article GET IT
A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells. iScience. 2022 Academic Article GET IT
Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability. Nature cell biology. 2021 Academic Article GET IT
Times cited: 20
An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Cell reports. 2021 Academic Article GET IT
Performance assessment of DNA sequencing platforms in the ABRF Next-Generation Sequencing Study. Nature biotechnology. 2021 Academic Article GET IT
Functional comparison of exome capture-based methods for transcriptomic profiling of formalin-fixed paraffin-embedded tumors. NPJ genomic medicine. 2021 Academic Article GET IT
Methylation of dual-specificity phosphatase 4 controls cell differentiation. Cell reports. 2021 Academic Article GET IT
Times cited: 1
Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2. Stem cell reports. 2021 Academic Article GET IT
Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia. NPJ precision oncology. 2021 Academic Article GET IT
Times cited: 21
SARS-CoV-2 infection induces beta cell transdifferentiation. Cell metabolism. 2021 Academic Article GET IT
Times cited: 131
An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circulation research. 2021 Academic Article GET IT
Times cited: 43
Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice. Communications biology. 2021 Academic Article GET IT
Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions. Nature communications. 2021 Academic Article GET IT
Times cited: 89
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 125
Common germline-somatic variant interactions in advanced urothelial cancer. Nature communications. 2020 Academic Article GET IT
Times cited: 22
Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology. Translational oncology. 2020 Academic Article GET IT
Times cited: 9
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2020 Academic Article GET IT
Times cited: 366
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis. Nature. 2020 Academic Article GET IT
Times cited: 149
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell stem cell. 2020 Academic Article GET IT
Times cited: 493
DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. Nature communications. 2020 Academic Article GET IT
Times cited: 14
ABEMUS: platform-specific and data-informed detection of somatic SNVs in cfDNA. Bioinformatics (Oxford, England). 2020 Academic Article GET IT
Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 118
Urinary cell transcriptomics and acute rejection in human kidney allografts. JCI insight. 2020 Academic Article GET IT
Times cited: 26
miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor. The American journal of pathology. 2020 Academic Article GET IT
Times cited: 14
Molecular determinants of nephron vascular specialization in the kidney. Nature communications. 2019 Academic Article GET IT
Times cited: 81
A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. eLife. 2019 Academic Article GET IT
Times cited: 33
Landscape of innate immune system transcriptome and acute T cell-mediated rejection of human kidney allografts. JCI insight. 2019 Academic Article GET IT
Times cited: 33
A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection. Journal of the American Society of Nephrology : JASN. 2019 Academic Article GET IT
Times cited: 70
Altered Cervical Mucosal Gene Expression and Lower Interleukin 15 Levels in Women With Schistosoma haematobium Infection but Not in Women With Schistosoma mansoni Infection. The Journal of infectious diseases. 2019 Academic Article GET IT
Times cited: 13
Gene Expression Differences in Host Response to Schistosoma haematobium Infection. Infection and immunity. 2018 Academic Article GET IT
Times cited: 11
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival. Nature communications. 2018 Academic Article GET IT
Times cited: 27
Genome encode analyses reveal the basis of convergent evolution of fleshy fruit ripening. Nature plants. 2018 Academic Article GET IT
Times cited: 89
Somatic Mutations in Renal Cyst Epithelium in Autosomal Dominant Polycystic Kidney Disease. Journal of the American Society of Nephrology : JASN. 2018 Academic Article GET IT
Times cited: 47
Discovery of a drug candidate for GLIS3-associated diabetes. Nature communications. 2018 Academic Article GET IT
Times cited: 48
Derivation and characterization of a UCP1 reporter human ES cell line. Stem cell research. 2018 Academic Article GET IT
Times cited: 5
Dried Blood Spot RNA Transcriptomes Correlate with Transcriptomes Derived from Whole Blood RNA. The American journal of tropical medicine and hygiene. 2018 Academic Article GET IT
Times cited: 15
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells. Nature communications. 2017 Academic Article GET IT
Times cited: 65
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nature medicine. 2017 Academic Article GET IT
Times cited: 289
Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E. Cell reports. 2017 Academic Article GET IT
Times cited: 18
Conversion of adult endothelium to immunocompetent haematopoietic stem cells. Nature. 2017 Academic Article GET IT
Times cited: 165
A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 31
Exome Sequencing and Prediction of Long-Term Kidney Allograft Function. PLoS computational biology. 2016 Academic Article GET IT
Times cited: 44
Ferroptosis is an autophagic cell death process. Cell research. 2016 Academic Article GET IT
Times cited: 1222
An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery. Cell stem cell. 2016 Academic Article GET IT
Times cited: 94
Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care. NPJ genomic medicine. 2016 Academic Article GET IT
Times cited: 66
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. Oncotarget. 2016 Academic Article GET IT
Times cited: 17
RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis. Journal of immunology (Baltimore, Md. : 1950). 2016 Academic Article GET IT
Times cited: 61
Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response. JAMA oncology. 2015 Academic Article GET IT
Times cited: 229
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature cell biology. 2015 Academic Article GET IT
Times cited: 2041
Dynamics of gene expression patterns during early development of the European seabass (Dicentrarchus labrax). Physiological genomics. 2015 Academic Article GET IT
Times cited: 11
Nonuniform gene expression pattern detected along the longitudinal axis in the matured rice leaf. Scientific reports. 2015 Academic Article GET IT
Times cited: 8
The sex-specific transcriptome of the hermaphrodite sparid sharpsnout seabream (Diplodus puntazzo). BMC genomics. 2014 Academic Article GET IT
Times cited: 57
Histone variant H3.3 is an essential maternal factor for oocyte reprogramming. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 75
Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell research. 2014 Article GET IT
Times cited: 1302
Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach. Investigational new drugs. 2014 Academic Article GET IT
Times cited: 12
Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration. Developmental cell. 2013 Academic Article GET IT
Times cited: 484
The transcriptome of the baculovirus Autographa californica multiple nucleopolyhedrovirus in Trichoplusia ni cells. Journal of virology. 2013 Academic Article GET IT
Times cited: 149
Overcoming the response plateau in multiple myeloma: a novel bortezomib-based strategy for secondary induction and high-yield CD34+ stem cell mobilization. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Academic Article GET IT
Times cited: 20
Single-base resolution methylomes of tomato fruit development reveal epigenome modifications associated with ripening. Nature biotechnology. 2013 Academic Article GET IT
Times cited: 417
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition. Blood. 2012 Academic Article GET IT
Times cited: 65
Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression. Cell. 2012 Academic Article GET IT
Times cited: 191
High-throughput illumina strand-specific RNA sequencing library preparation. Cold Spring Harbor protocols. 2011 Academic Article GET IT
Times cited: 290
Changes in matrix protein gene expression associated with mineralization in the differentiating chick limb-bud micromass culture system. Journal of cellular biochemistry. 2011 Academic Article GET IT
Times cited: 7
Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. American journal of human genetics. 2010 Academic Article GET IT
Times cited: 83
Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies. Journal of the neurological sciences. 2009 Academic Article GET IT
Times cited: 20
Human sex hormone-binding globulin gene expression- multiple promoters and complex alternative splicing. BMC molecular biology. 2009 Academic Article GET IT
Times cited: 16
Oviduct-specific glycoprotein is a molecular marker for invasion in endometrial tumorigenesis identified using a relevant mouse model. International journal of cancer. 2009 Academic Article GET IT
Times cited: 7
WNT/beta-catenin signaling is involved in regulation of osteoclast differentiation by human immunodeficiency virus protease inhibitor ritonavir: relationship to human immunodeficiency virus-linked bone mineral loss. The American journal of pathology. 2008 Academic Article GET IT
Times cited: 46
Up-regulation of apoptosis and regeneration genes in the dorsal root ganglia during cisplatin treatment. Experimental neurology. 2007 Academic Article GET IT
Times cited: 22
A spatial bias for the origins of interneuron subgroups within the medial ganglionic eminence. Developmental biology. 2007 Academic Article GET IT
Times cited: 181
Inflammatory pathway gene expression in chronic rhinosinusitis. American journal of rhinology. 2006 Academic Article GET IT
Times cited: 26
Responses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthase. The American journal of tropical medicine and hygiene. 2006 Academic Article GET IT
Times cited: 29
Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures. The Journal of dermatology. 2006 Academic Article GET IT
Times cited: 29
Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: genetic evidence for TLR4-dependent responses to endogenous, nonmicrobial stimuli. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 3
Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples. Endocrinology. 2005 Academic Article GET IT
Times cited: 116
Gene expression profiling in chronic inflammatory demyelinating polyneuropathy. Journal of neuroimmunology. 2004 Academic Article GET IT
Times cited: 39
Global gene expression profiling in interleukin-12-induced activation of CD8(+) cytotoxic T lymphocytes against mouse mammary Carcinoma. Cellular & molecular immunology. 2004 Academic Article GET IT
Times cited: 6
Role of IFN regulatory factor-1 and IL-12 in immunological resistance to pathogenesis of N-methyl-N-nitrosourea-induced T lymphoma. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 26
Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma. International journal of cancer. 2004 Academic Article GET IT
Times cited: 18
Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-gamma-independent mechanisms. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 26
Microarray expression profiling: analysis and applications. Current opinion in drug discovery & development. 2003 Information Resource GET IT
Times cited: 39

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Background

education and training

B.M., First Military Medical University (China) 83
M.Med., The Second Military Medical University (China) 1989

Contact

full name

Jenny Zhaoying Xiang

primary email

jzx2002@med.cornell.edu

VIVO Weill Cornell Medical College

Jenny Zhaoying Xiang Professor of Research in Microbiology and Immunology

Publications

selected publications

Background

education and training

Contact

full name

primary email