Hajjar, Katherine Amberson

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selected publications

Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice. Nature communications. 2024 Academic Article GET IT
Blockade of Annexin A2 Prevents Early Microvasculopathy in Murine Models of Diabetic Retinopathy. Investigative ophthalmology & visual science. 2023 Academic Article GET IT
Times cited: 3
Annexin A2 Loss After Cardiopulmonary Bypass and Development of Acute Postoperative Respiratory Dysfunction in Children. Critical care explorations. 2023 Academic Article GET IT
Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Annexin A2 in Fibrinolysis, Inflammation and Fibrosis. International journal of molecular sciences. 2021 Review GET IT
Times cited: 42
Reduced expression of annexin A2 is associated with impaired cell surface fibrinolysis and venous thromboembolism. Blood. 2021 Academic Article GET IT
Times cited: 16
Annexin A2 in Inflammation and Host Defense. Cells. 2020 Review GET IT
Times cited: 83
Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2. American journal of obstetrics and gynecology. 2019 Academic Article GET IT
Times cited: 53
Annexin A2 is a Robo4 ligand that modulates ARF6 activation-associated cerebral trans-endothelial permeability. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2018 Academic Article GET IT
Times cited: 29
Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases. The Journal of experimental medicine. 2017 Academic Article GET IT
Times cited: 32
Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting. Scientific reports. 2017 Academic Article GET IT
Times cited: 41
Central venous catheter thrombosis and the fibrin sleeve: unraveling the mystery. European journal of haematology. 2017 Editorial Article GET IT
The annexin A2 system and angiogenesis. Biological chemistry. 2016 Review GET IT
Times cited: 50
Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue. JCI insight. 2016 Academic Article GET IT
Times cited: 56
The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection. Journal of immunology (Baltimore, Md. : 1950). 2016 Academic Article GET IT
Times cited: 36
Alterations of Cholesterol Metabolism in Inflammation-Induced Atherogenesis. Journal of enzymology and metabolism. 2016 Academic Article GET IT
Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer. Science signaling. 2015 Academic Article GET IT
Times cited: 94
Aaron J. Marcus: in pursuit of perfection. The Journal of clinical investigation. 2015 Academic Article GET IT
Annexin A2 promotes phagophore assembly by enhancing Atg16L⁺ vesicle biogenesis and homotypic fusion. Nature communications. 2015 Academic Article GET IT
Times cited: 38
The Biology of Annexin A2: From Vascular Fibrinolysis to Innate Immunity. Transactions of the American Clinical and Climatological Association. 2015 Review GET IT
Times cited: 64
Fibrinolysis and the control of blood coagulation. Blood reviews. 2014 Review GET IT
Times cited: 622
Epidermal growth factor-like domain 7 is a marker of the endothelial lineage and active angiogenesis. Genesis (New York, N.Y. : 2000). 2014 Academic Article GET IT
Times cited: 17
Annexin A2 mediates secretion of collagen VI, pulmonary elasticity and apoptosis of bronchial epithelial cells. Journal of cell science. 2013 Academic Article GET IT
Times cited: 44
The perivascular niche regulates breast tumour dormancy. Nature cell biology. 2013 Academic Article GET IT
Times cited: 903
Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes. Blood. 2013 Academic Article GET IT
Times cited: 77
Dysfunction of annexin A2 contributes to hyperglycaemia-induced loss of human endothelial cell surface fibrinolytic activity. Thrombosis and haemostasis. 2013 Academic Article GET IT
Times cited: 22
Annexin A2 system in human biology: cell surface and beyond. Seminars in thrombosis and hemostasis. 2013 Review GET IT
Times cited: 86
The annexin A2/S100A10 system in health and disease: emerging paradigms. Journal of biomedicine & biotechnology. 2012 Information Resource GET IT
Times cited: 86
Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PloS one. 2012 Academic Article GET IT
Times cited: 106
Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris. Nature communications. 2012 Academic Article GET IT
Times cited: 50
Annexin A2 promotes glioma cell invasion and tumor progression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 107
Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice. Blood. 2011 Academic Article GET IT
Times cited: 60
Inducible nitric oxide synthase provides protection against injury-induced thrombosis in female mice. American journal of physiology. Heart and circulatory physiology. 2011 Academic Article GET IT
Times cited: 12
The annexin A2 system and vascular homeostasis. Vascular pharmacology. 2011 Review GET IT
Times cited: 94
Autoantibodies against the fibrinolytic receptor, annexin A2, in cerebral venous thrombosis. Stroke. 2010 Academic Article GET IT
Times cited: 32
Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 55
Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy. Stroke. 2010 Academic Article GET IT
Times cited: 26
Annexin A2 mediates up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells. Gastroenterology. 2010 Academic Article GET IT
Times cited: 54
Durable responses with the metronomic rituximab and thalidomide plus prednisone, etoposide, procarbazine, and cyclophosphamide regimen in elderly patients with recurrent mantle cell lymphoma. Cancer. 2010 Academic Article GET IT
Times cited: 56
Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2010 Academic Article GET IT
Times cited: 74
Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis. The Journal of clinical investigation. 2009 Academic Article GET IT
Times cited: 64
Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo. Blood. 2009 Academic Article GET IT
Times cited: 128
Annexin A2 regulates phagocytosis of photoreceptor outer segments in the mouse retina. Molecular biology of the cell. 2009 Academic Article GET IT
Times cited: 64
The endothelial cell annexin A2 system and vascular fibrinolysis. General physiology and biophysics. 2009 Review GET IT
Times cited: 44
Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma. Annals of oncology : official journal of the European Society for Medical Oncology. 2008 Review GET IT
Times cited: 94
Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 117
Efficacy of recombinant annexin 2 for fibrinolytic therapy in a rat embolic stroke model: a magnetic resonance imaging study. Brain research. 2007 Academic Article GET IT
Times cited: 24
Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome. Blood. 2006 Academic Article GET IT
Times cited: 160
Vascular tenascin-C regulates cardiac endothelial phenotype and neovascularization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Academic Article GET IT
Times cited: 66
Molecular mechanisms of fibrinolysis. British journal of haematology. 2005 Review GET IT
Times cited: 582
An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 205
Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. The Journal of clinical investigation. 2004 Academic Article GET IT
Times cited: 339
Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart. Developmental biology. 2004 Academic Article GET IT
Times cited: 18
Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: enhanced expression by macrophages. Blood. 2003 Academic Article GET IT
Times cited: 93
Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells. Journal of cellular biochemistry. 2003 Academic Article GET IT
Times cited: 44
Annexin II: a plasminogen-plasminogen activator co-receptor. Frontiers in bioscience : a journal and virtual library. 2002 Review GET IT
Times cited: 154
Frequent LOH at hMLH1, a highly variable SNP in hMSH3, and negligible coding instability in ovarian cancer. Anticancer research. 2002 Academic Article GET IT
Times cited: 9
Recombinant annexin II modulates impaired fibrinolytic activity in vitro and in rat carotid artery. Circulation research. 2001 Academic Article GET IT
Times cited: 46
Potential role of recombinant annexin II in diabetic vascular injury. Annals of the New York Academy of Sciences. 2001 Academic Article GET IT
Times cited: 8
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature medicine. 2001 Academic Article GET IT
Times cited: 1638
Neuritogenesis and the nerve growth factor-induced differentiation of PC-12 cells requires annexin II-mediated plasmin generation. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 100
Recombinant angiostatin prevents retinal neovascularization in a murine proliferative retinopathy model. Gene therapy. 2001 Academic Article GET IT
Times cited: 35
Homocysteine: a sulph'rous fire. The Journal of clinical investigation. 2001 Comment GET IT
Times cited: 57
Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II. Blood. 2001 Academic Article GET IT
Times cited: 89
New concepts in fibrinolysis and angiogenesis. Current atherosclerosis reports. 2000 Review GET IT
Times cited: 13
High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 213
Annexin II and regulation of cell surface fibrinolysis. Annals of the New York Academy of Sciences. 2000 Review GET IT
Times cited: 70
Construction of recombinant adenoviral vector of annexin II. Annals of the New York Academy of Sciences. 2000 Academic Article GET IT
Times cited: 2
Inhibition of endothelial cell thromboresistance by homocysteine. The Journal of nutrition. 2000 Review GET IT
Times cited: 33
Simplified production of a recombinant human angiostatin derivative that suppresses intracerebral glial tumor growth. Clinical cancer research : an official journal of the American Association for Cancer Research. 1999 Academic Article GET IT
Times cited: 16
Annexin II: a mediator of the plasmin/plasminogen activator system. Trends in cardiovascular medicine. 1999 Review GET IT
Times cited: 148
Annexin II and bleeding in acute promyelocytic leukemia. The New England journal of medicine. 1999 Academic Article GET IT
Times cited: 352
Modulation of annexin II by homocysteine: implications for atherothrombosis. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 1998 Review GET IT
Times cited: 38
Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 26
Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 217
Profibrinolytic properties characterize a stably transformed human endothelial cell line. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 1998 Academic Article GET IT
Times cited: 4
Annexin II: a novel mediator of cell surface plasmin generation. Annals of the New York Academy of Sciences. 1997 Review GET IT
Times cited: 56
The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. The Journal of clinical investigation. 1997 Academic Article GET IT
Times cited: 387
Thrombotic thrombocytopenic purpura and sporadic hemolytic-uremic syndrome plasmas induce apoptosis in restricted lineages of human microvascular endothelial cells. Blood. 1997 Academic Article GET IT
Times cited: 160
Interaction of the fibrinolytic receptor, annexin II, with the endothelial cell surface. Essential role of endonexin repeat 2. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 110
The role of lipoprotein(a) in atherogenesis and thrombosis. Annual review of medicine. 1996 Review GET IT
Times cited: 99
Changing concepts in fibrinolysis. Current opinion in hematology. 1995 Review GET IT
Times cited: 12
Cellular receptors in the regulation of plasmin generation. Thrombosis and haemostasis. 1995 Review GET IT
Times cited: 97
Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions. Thrombosis and haemostasis. 1995 Review GET IT
Times cited: 75
Principles of thromboregulation: control of platelet reactivity in vascular disease. Advances in prostaglandin, thromboxane, and leukotriene research. 1995 Review GET IT
Times cited: 9
Factor V Leiden--an unselfish gene?. The New England journal of medicine. 1994 Editorial Article GET IT
Times cited: 43
An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 318
An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 467
alpha-Fucose-mediated binding and degradation of tissue-type plasminogen activator by HepG2 cells. The Journal of clinical investigation. 1994 Academic Article GET IT
Times cited: 44
Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. The Journal of clinical investigation. 1993 Academic Article GET IT
Times cited: 314
What are current approaches to studying lipoprotein metabolism as it relates to thrombosis?. The American journal of clinical nutrition. 1992 Academic Article GET IT
Times cited: 1
Assembly of plasmin-generating proteins on the surface of human endothelial cells. Annals of epidemiology. 1992 Review GET IT
Times cited: 1
Exercise and atherosclerotic heart disease in women. Medicine and science in sports and exercise. 1992 Academic Article GET IT
Times cited: 20
The endothelial cell tissue plasminogen activator receptor. Specific interaction with plasminogen. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 120
Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells. The Journal of clinical investigation. 1991 Academic Article GET IT
Times cited: 161
Lipoprotein (a) regulates plasminogen activator inhibitor-1 expression in endothelial cells. A potential mechanism in thrombogenesis. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 268
Endothelial cell fibrinolytic assembly. Annals of the New York Academy of Sciences. 1991 Review GET IT
Times cited: 24
Identification and characterization of human endothelial cell membrane binding sites for tissue plasminogen activator and urokinase. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 132
Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis. Nature. 1989 Academic Article GET IT
Times cited: 634
Decreased messenger RNA translation in herpesvirus-infected arterial cells: effects on cholesteryl ester hydrolase. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 18
Endothelial cell-mediated conversion of Glu-plasminogen to Lys-plasminogen. Further evidence for assembly of the fibrinolytic system on the endothelial cell surface. The Journal of clinical investigation. 1988 Academic Article GET IT
Times cited: 96
Interactions of arterial cells: III. Stathmokinetic analyses of smooth muscle cells cocultured with endothelial cells. Journal of cellular physiology. 1988 Academic Article GET IT
Times cited: 4
Arterial cell interactions: mechanistic studies related to eicosanoid and growth factor-induced alterations in cholesterol metabolism. Advances in experimental medicine and biology. 1988 Information Resource GET IT
Binding of tissue plasminogen activator to cultured human endothelial cells. The Journal of clinical investigation. 1987 Academic Article GET IT
Times cited: 173
Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells. The Journal of experimental medicine. 1987 Academic Article GET IT
Times cited: 158
Interactions of arterial cells. Studies on the mechanisms of endothelial cell modulation of cholesterol metabolism in co-cultured smooth muscle cells. The Journal of biological chemistry. 1987 Academic Article GET IT
Times cited: 30
Binding of plasminogen to cultured human endothelial cells. The Journal of biological chemistry. 1986 Academic Article GET IT
Times cited: 262
Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. The Journal of experimental medicine. 1986 Academic Article GET IT
Times cited: 260
Philadelphia chromosome-positive chronic myelogenous leukemia following apparent acute lymphoblastic leukemia. 1985 GET IT
Times cited: 1
Structural and functional analysis of spectrin from neonatal erythrocytes. Biochimica et biophysica acta. 1985 Academic Article GET IT

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Background

education and training

M.D., The Johns Hopkins University School of Medicine 1978
A.B., Smith College 1974

Contact

full name

Katherine Amberson Hajjar

primary email

khajjar@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Katherine Amberson Hajjar Senior Associate Dean for Faculty

Publications

selected publications

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email

webpage