Our lab is broadly interested in the molecular mechanisms of transmembrane signaling, focusing on how cell surface receptors detect and respond to extracellular ligand cues to regulate cellular homeostasis. We take an integrative approach, combining biochemistry, structural biology, biophysics, proteomics, and protein engineering to study these processes. Our research focusses on ligand-receptor systems critical to human health and disease, including G protein-coupled receptors (GPCRs) and other transmembrane proteins.