McIntire, Laura Beth J

Publications

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selected publications

A perspective: PLA2G4A as drug target for vascular inflammation in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026 Information Resource GET IT
The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts. Biological psychiatry. 2026 Information Resource GET IT
STING-IFN-CH25H lipid axis links innate immune activation to tau pathology. bioRxiv : the preprint server for biology. 2025 Article GET IT
Detection, imaging and quantification of phosphoinositides using ion chromatography suppressed conductivity and mass spectrometry imaging. Methods in enzymology. 2025 Academic Article GET IT
Diagnostic utility of plasma p-tau217 differs by Alzheimer's disease tau-based subtypes. Alzheimer's & dementia (Amsterdam, Netherlands). 2025 Academic Article GET IT
Metabolomic signatures of hypocaloric dietary interventions associate with breast cancer risk in the Nurses' Health Study II. medRxiv : the preprint server for health sciences. 2025 Article GET IT
Sex-Associated Cerebellar and Hippocampal Volume Reduction in Alzheimer's Disease: Insights from the Clinical ADNI Cohort and STZ Animal Model. International journal of molecular sciences. 2025 Academic Article GET IT
Divergent neurodegeneration associations with choroid plexus volume and degree of calcification in cognitively normal APOE ε4 carriers and non-carriers. Scientific reports. 2025 Academic Article GET IT
Times cited: 4
Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 Information Resource GET IT
Times cited: 29
APOE ε4-associated heterogeneity of neuroimaging biomarkers across the Alzheimer's disease continuum. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 Academic Article GET IT
Times cited: 6
Corrigendum: Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment. Frontiers in aging neuroscience. 2024 Article GET IT
A phosphorylation-controlled switch confers cell cycle-dependent protein relocalization. Nature cell biology. 2024 Academic Article GET IT
Times cited: 3
Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment. Frontiers in aging neuroscience. 2024 Academic Article GET IT
Times cited: 4
A phosphorylation-controlled switch confers cell cycle-dependent protein relocalization. bioRxiv : the preprint server for biology. 2024 Article GET IT
Evidence of Pericyte Damage in a Cognitively Normal Cohort: Association With CSF and PET Biomarkers of Alzheimer Disease. Alzheimer disease and associated disorders. 2024 Academic Article GET IT
Times cited: 6
Depression and cognition are associated with lipid dysregulation in both a multigenerational study of depression and the National Health and Nutrition Examination Survey. Translational psychiatry. 2024 Academic Article GET IT
Times cited: 49
Prognostic Power? Do the Plasma Biomarkers, Neurofilament Light and Phospho-Tau 181, Improve Prediction of Progression to Alzheimer's Disease Using a Machine Learning Approach in the ADNI Cohort?. Journal of Alzheimer's disease : JAD. 2024 Academic Article GET IT
Times cited: 1
Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma. Cancer letters. 2023 Academic Article GET IT
Times cited: 46
mTORC2-NDRG1-CDC42 axis couples fasting to mitochondrial fission. Nature cell biology. 2023 Academic Article GET IT
Times cited: 42
Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline. Scientific reports. 2023 Academic Article GET IT
Times cited: 28
Associations of ApoE4 status and DHA supplementation on plasma and CSF lipid profiles and entorhinal cortex thickness. Journal of lipid research. 2023 Academic Article GET IT
Times cited: 10
Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice. Translational psychiatry. 2022 Academic Article GET IT
Times cited: 40
Fundamental Clock of Biological Aging: Convergence of Molecular, Neurodegenerative, Cognitive and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology. International journal of molecular sciences. 2021 Information Resource GET IT
Times cited: 9
Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures. Frontiers in pharmacology. 2021 Academic Article GET IT
Times cited: 96
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells. Developmental cell. 2017 Academic Article GET IT
Times cited: 60
Threonine 576 residue of amyloid-β precursor protein regulates its trafficking and processing. Biochemical and biophysical research communications. 2015 Academic Article GET IT
Times cited: 10
Screening assay for small-molecule inhibitors of synaptojanin 1, a synaptic phosphoinositide phosphatase. Journal of biomolecular screening. 2013 Academic Article GET IT
Times cited: 7
Phenotypic assays for β-amyloid in mouse embryonic stem cell-derived neurons. Chemistry & biology. 2013 Academic Article GET IT
Times cited: 7
Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 64
Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism. Nature neuroscience. 2008 Academic Article GET IT
Times cited: 181

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Research

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Funding awarded

Spatial dysregulation of the lipidome in Alzheimers disease human and mouse brain awarded by National Institute on Aging Principal Investigator 2022 - 2027
Acyl chain remodeling and regional lipid dysregulation in Alzheimer''s disease awarded by National Institute on Aging Principal Investigator 2022 - 2027

Brain fluid clearance and misfolded protein dynamics following traumatic brain injury awarded by National Institute on Aging Co-Investigator 2023 - 2028
Quantitative MRI-based cerebral oxygen metabolism in Alzheimer''s disease awarded by National Institute on Aging Co-Investigator 2023 - 2028

Uncovering Dementia-Related Lipid Alterations and Mechanisms in Astrocytes awarded by National Institute on Aging Co-Principal Investigator 2024 - 2026

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Background

education and training

Ph.D., University of Washington 2006
B.S., University of Washington 1998

Contact

full name

Laura Beth J McIntire

primary email

lbm7002@med.cornell.edu

VIVO Weill Cornell Medical College

Laura Beth J McIntire Assistant Professor of Pharmacology in Radiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email