Glodzik, Lidia

Publications

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selected publications

Brain glymphatic fluid mapping in Alzheimer's disease: a human MRI and PET study. Brain communications. 2025 Academic Article GET IT
Cardiac Biomarkers, Subclinical Brain Vascular Changes, and Cognitive Decline: Post Hoc Analysis of the SPRINT Trial. The journals of gerontology. Series A, Biological sciences and medical sciences. 2025 Academic Article GET IT
Divergent neurodegeneration associations with choroid plexus volume and degree of calcification in cognitively normal APOE ε4 carriers and non-carriers. Scientific reports. 2025 Academic Article GET IT
Concordance between Centiloid quantification and visual interpretation of amyloid PET scans across the Alzheimer's disease continuum. AJNR. American journal of neuroradiology. 2025 Academic Article GET IT
Effect Modifiers of the Association of Blood Pressure With Brain Amyloid and Tau Pathology. Neurology. 2025 Academic Article GET IT
Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts. GeroScience. 2025 Academic Article GET IT
Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis. Alzheimer's & Dementia. 2024 Review GET IT
Utilizing structural MRI and unsupervised clustering to differentiate schizophrenia and Alzheimer's disease in late-onset psychosis. Behavioural brain research. 2024 Academic Article GET IT
Retrospective analysis of Braak stage- and APOE4 allele-dependent associations between MR spectroscopy and markers of tau and neurodegeneration in cognitively unimpaired elderly. NeuroImage. 2024 Academic Article GET IT
Periodontal Inflammation and Dysbiosis Relate to Microbial Changes in the Gut. Microorganisms. 2024 Academic Article GET IT
Times cited: 6
Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects. Alzheimer's & Dementia. 2024 Academic Article GET IT
Times cited: 3
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people. Immunity & ageing : I & A. 2024 Academic Article GET IT
Times cited: 7
Evidence of Pericyte Damage in a Cognitively Normal Cohort: Association With CSF and PET Biomarkers of Alzheimer Disease. Alzheimer disease and associated disorders. 2024 Academic Article GET IT
Times cited: 3
Brain Fluid Clearance After Traumatic Brain Injury Measured Using Dynamic Positron Emission Tomography. Neurotrauma reports. 2024 Academic Article GET IT
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people. 2024 GET IT
Reduction in Constitutively Activated Auditory Brainstem Microglia in Aging and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024 Academic Article GET IT
Multimodal assessment of brain fluid clearance is associated with amyloid-beta deposition in humans. Journal of neuroradiology = Journal de neuroradiologie. 2023 Academic Article GET IT
Times cited: 13
Lower mortality risk in APOE4 carriers with normal cognitive ageing. Scientific reports. 2023 Academic Article GET IT
Times cited: 7
Time in Target Blood Pressure Range and Dementia. Hypertension (Dallas, Tex. : 1979). 2023 Editorial Article GET IT
Times cited: 1
Choroid Plexus Calcification Correlates with Cortical Microglial Activation in Humans: A Multimodal PET, CT, MRI Study. AJNR. American journal of neuroradiology. 2023 Academic Article GET IT
Times cited: 7
Tau PET following acute TBI: Off-target binding to blood products, tauopathy, or both?. Frontiers in neuroimaging. 2022 Academic Article GET IT
Times cited: 3
Quadratic relationship between systolic blood pressure and white matter lesions in individuals with hypertension. Journal of hypertension. 2022 Academic Article GET IT
Times cited: 1
Higher body mass index is associated with worse hippocampal vasoreactivity to carbon dioxide. Frontiers in aging neuroscience. 2022 Academic Article GET IT
Times cited: 1
Obstructive Sleep Apnea and Hypertension with Longitudinal Amyloid-β Burden and Cognitive Changes. American journal of respiratory and critical care medicine. 2022 Letter GET IT
Times cited: 13
Positron Emission Tomography reveals age-associated hypothalamic microglial activation in women. Scientific reports. 2022 Academic Article GET IT
Times cited: 7
Incomplete circle of Willis variants and stroke outcome. European journal of radiology. 2022 Academic Article GET IT
Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease. Neurobiology of disease. 2022 Review GET IT
Times cited: 34
Statistical Parametric Mapping in Amyloid Positron Emission Tomography. Frontiers in aging neuroscience. 2022 Academic Article GET IT
Times cited: 5
Decreased CSF clearance and increased brain amyloid in Alzheimer's disease. Fluids and barriers of the CNS. 2022 Academic Article GET IT
Times cited: 59
Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load. Clinical interventions in aging. 2021 Academic Article GET IT
Times cited: 10
Blood-Brain Barrier Crossing Renin-Angiotensin System Drugs: Considerations for Dementia and Cognitive Decline. Hypertension (Dallas, Tex. : 1979). 2021 Editorial Article GET IT
Times cited: 14
Rationale, study design and implementation of the LUCINDA Trial: Leuprolide plus Cholinesterase Inhibition to reduce Neurologic Decline in Alzheimer's. Contemporary clinical trials. 2021 Academic Article GET IT
Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly. Alzheimer's & dementia (Amsterdam, Netherlands). 2021 Academic Article GET IT
Times cited: 39
Global brain volume and N-acetyl-aspartate decline over seven decades of normal aging. Neurobiology of aging. 2020 Academic Article GET IT
Times cited: 14
Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau. Molecular neurodegeneration. 2019 Academic Article GET IT
Times cited: 71
Precisely-Measured Hydration Status Correlates with Hippocampal Volume in Healthy Older Adults. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2019 Letter GET IT
Times cited: 5
Different Relationship Between Systolic Blood Pressure and Cerebral Perfusion in Subjects With and Without Hypertension. Hypertension (Dallas, Tex. : 1979). 2019 Academic Article GET IT
Times cited: 50
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference. Nature communications. 2018 Academic Article GET IT
Times cited: 359
Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study. American journal of respiratory and critical care medicine. 2018 Academic Article GET IT
Times cited: 199
The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease. PloS one. 2018 Academic Article GET IT
Times cited: 46
Basal forebrain septal nuclei are enlarged in healthy subjects prior to the development of Alzheimer's disease. Neurobiology of aging. 2018 Academic Article GET IT
Times cited: 28
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2017 Review GET IT
Times cited: 217
Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2017 Academic Article GET IT
Times cited: 188
Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid Aβ42 Levels in Cognitively Normal Elderly. Sleep. 2016 Academic Article GET IT
Times cited: 152
Transient and chronic seizure-induced inflammation in human focal epilepsy. 2016 GET IT
Times cited: 39
Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis. Nature communications. 2016 Academic Article GET IT
Times cited: 868
Orexin-A is Associated with Increases in Cerebrospinal Fluid Phosphorylated-Tau in Cognitively Normal Elderly Subjects. Sleep. 2016 Academic Article GET IT
Times cited: 48
Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects. Alzheimer's & dementia (Amsterdam, Netherlands). 2016 Academic Article GET IT
Times cited: 29
Clearance systems in the brain--implications for Alzheimer diseaser. 2016 GET IT
Times cited: 40
Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). 2016 Review GET IT
Times cited: 40
Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2016 Academic Article GET IT
Times cited: 38
Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a journal of neurology. 2015 Academic Article GET IT
Times cited: 111
Clearance systems in the brain-implications for Alzheimer disease. Nature reviews. Neurology. 2015 Review GET IT
Times cited: 1243
Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. Nature communications. 2015 Academic Article GET IT
Times cited: 274
Sleep-disordered breathing advances cognitive decline in the elderly. Neurology. 2015 Academic Article GET IT
Times cited: 361
Global N-acetylaspartate in normal subjects, mild cognitive impairment and Alzheimer's disease patients. Journal of Alzheimer's disease : JAD. 2015 Academic Article GET IT
Times cited: 28
Periodontal disease associates with higher brain amyloid load in normal elderly. Neurobiology of aging. 2014 Academic Article GET IT
Times cited: 210
Reduced retention of Pittsburgh compound B in white matter lesions. European journal of nuclear medicine and molecular imaging. 2014 Academic Article GET IT
Times cited: 28
Reduced glucose uptake and Aβ in brain regions with hyperintensities in connected white matter. NeuroImage. 2014 Academic Article GET IT
Times cited: 22
Nutrient intake and brain biomarkers of Alzheimer's disease in at-risk cognitively normal individuals: a cross-sectional neuroimaging pilot study. BMJ open. 2014 Academic Article GET IT
Times cited: 75
Mediterranean Diet and Magnetic Resonance Imaging-Assessed Brain Atrophy in Cognitively Normal Individuals at Risk for Alzheimer's Disease. The journal of prevention of Alzheimer's disease. 2014 Academic Article GET IT
Comparison of human septal nuclei MRI measurements using automated segmentation and a new manual protocol based on histology. NeuroImage. 2014 Academic Article GET IT
Times cited: 26
FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer's Disease. Advances in molecular imaging. 2014 Academic Article GET IT
Times cited: 83
Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD. Neurology. 2014 Academic Article GET IT
Times cited: 51
Interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals. Neurobiology of aging. 2013 Academic Article GET IT
Times cited: 112
Imaging and cerebrospinal fluid biomarkers in the search for Alzheimer's disease mechanisms. Neuro-degenerative diseases. 2013 Academic Article GET IT
Times cited: 12
Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly. Neurobiology of aging. 2013 Academic Article GET IT
Times cited: 65
Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2013 Review GET IT
Times cited: 109
The whole-brain N-acetylaspartate correlates with education in normal adults. Psychiatry research. 2012 Academic Article GET IT
Times cited: 8
Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents. Neurobiology of aging. 2012 Academic Article GET IT
Times cited: 53
Ordering of Alzheimer disease biomarkers. Archives of neurology. 2012 Letter GET IT
Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 47
Whole brain N-acetylaspartate concentration is conserved throughout normal aging. Neurobiology of aging. 2012 Academic Article GET IT
Times cited: 23
Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 62
Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 9
Greater risk of Alzheimer's disease in older adults with insomnia. Journal of the American Geriatrics Society. 2011 Letter GET IT
Times cited: 162
Structural brain changes in normal individuals with a maternal history of Alzheimer's. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 52
Hippocampal blood flow in normal aging measured with arterial spin labeling at 3T. Magnetic resonance in medicine. 2011 Academic Article GET IT
Times cited: 30
Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's. Biological psychiatry. 2010 Academic Article GET IT
Times cited: 44
Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2010 Academic Article GET IT
Times cited: 64
Evaluation of Early Dementia (Mild Cognitive Impairment). PET clinics. 2010 Review GET IT
Times cited: 4
Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 125
Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders. Neurobiology of aging. 2010 Academic Article GET IT
Times cited: 41
Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging. Journal of Alzheimer's disease : JAD. 2010 Information Resource GET IT
Times cited: 240
TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects. Journal of neuroimmunology. 2009 Academic Article GET IT
Times cited: 246
An entorhinal cortex sulcal pattern is associated with Alzheimer's disease. Human brain mapping. 2009 Academic Article GET IT
Times cited: 13
FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2009 Academic Article GET IT
Times cited: 400
Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology. Journal of Alzheimer's disease : JAD. 2009 Academic Article GET IT
Times cited: 7
Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2009 Academic Article GET IT
Times cited: 55
Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease. Neurology. 2008 Academic Article GET IT
Times cited: 162
Anteroposterior hippocampal metabolic heterogeneity: three-dimensional multivoxel proton 1H MR spectroscopic imaging--initial findings. Radiology. 2008 Academic Article GET IT
Times cited: 22
Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline. Neuropsychology. 2008 Academic Article GET IT
Times cited: 69
Memantine decreases hippocampal glutamate levels: a magnetic resonance spectroscopy study. Progress in neuro-psychopharmacology & biological psychiatry. 2008 Academic Article GET IT
Times cited: 24
Longitudinal CSF isoprostane and MRI atrophy in the progression to AD. Journal of neurology. 2007 Academic Article GET IT
Times cited: 73
Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 213

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Research

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Funding awarded

Anatomy of the circle of Willis, cerebral blood flow, and Alzheimer''s disease biomarkers in hypertension awarded by National Heart, Lung, & Blood Institute Principal Investigator 2022 - 2026
Hypertension, brain clearance and markers of neurodegeneration awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2019 - 2025

Brain fluid clearance and misfolded protein dynamics following traumatic brain injury awarded by National Institute on Aging Co-Investigator 2023 - 2028
The LUCINDA Trial awarded by National Institute on Aging Co-Investigator 2019 - 2026
CSF Clearance in Sporadic Alzheimer''s Disease Co-Investigator 2019 - 2025

New PET/CT System for Human and Non-human Primate Imaging awarded by National Institutes of Health, Office of the Director Key Personnel 2023 - 2026
7T Magnetic Resonance Imaging System for Basic, Translational and Clinical Research awarded by National Institutes of Health, Office of the Director Key Personnel 2021 - 2025

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Background

education and training

M.D., Medical Academy of Lublin (Poland) 96
Ph.D., Jagiellonian University (Poland) 2003

Contact

full name

Lidia Glodzik

primary email

lig4005@med.cornell.edu

VIVO Weill Cornell Medical College

Lidia Glodzik Associate Professor of Neuroscience in Radiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email