Leyre, Louise

Publications

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selected publications

Rapid and profound decay of inducible and intact HIV genomes in early treated Thai children. The Journal of clinical investigation. 2026 Academic Article GET IT
Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones. Nature. 2026 Academic Article GET IT
Dynamic Antigen Expression and Intrinsic CTL Resistance in HIV Reservoir Clones. 2026 GET IT
Q4ddPCR: a flexible, 4-target assay for high-resolution HIV reservoir profiling. Nature communications. 2026 Academic Article GET IT
HIV Nef amplifies mechanical heterogeneity to promote immune evasion. 2025 GET IT
EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8⁺ T cells toward less-exhausted phenotypes. Cell reports. 2025 Academic Article GET IT
Times cited: 2
Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4 ⁺ T-cells. 2024 GET IT
Gastrointestinal germinal center B cell depletion and reduction in IgA⁺ plasma cells in HIV-1 infection. Science immunology. 2024 Academic Article GET IT
Times cited: 3
Gastrointestinal germinal center B cell depletion and reduction in IgA ⁺ plasma cells in HIV-1 infection. 2024 GET IT
An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8⁺ T cell magnitude and short-lived differentiation status. Cell host & microbe. 2023 Academic Article GET IT
Times cited: 29
SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8⁺ T-cells. Nature communications. 2022 Academic Article GET IT
Times cited: 28
Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity. The Journal of clinical investigation. 2022 Comment GET IT
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity. Nature medicine. 2022 Academic Article GET IT
Times cited: 169
Continuous Prophylactic Antiretrovirals/Antiretroviral Therapy Since Birth Reduces Seeding and Persistence of the Viral Reservoir in Children Vertically Infected With Human Immunodeficiency Virus. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 Comment GET IT
Times cited: 22
Selective BCL-X_L Antagonists Eliminate Infected Cells from a Primary-Cell Model of HIV Latency but Not from Ex Vivo Reservoirs. Journal of virology. 2021 Academic Article GET IT
Times cited: 13
The V2 loop of HIV gp120 delivers costimulatory signals to CD4⁺ T cells through Integrin α₄β₇ and promotes cellular activation and infection. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 19
Integrated Assessment of Viral Transcription, Antigen Presentation, and CD8⁺ T Cell Function Reveals Multiple Limitations of Class I-Selective Histone Deacetylase Inhibitors during HIV-1 Latency Reversal. Journal of virology. 2020 Academic Article GET IT
Times cited: 21
Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection. Science translational medicine. 2020 Academic Article GET IT
Times cited: 90
Upregulation of IL-32 Isoforms in Virologically Suppressed HIV-Infected Individuals: Potential Role in Persistent Inflammation and Transcription From Stable HIV-1 Reservoirs. Journal of acquired immune deficiency syndromes (1999). 2019 Academic Article GET IT
Times cited: 27
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection. PLoS pathogens. 2019 Academic Article GET IT
Times cited: 195
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals. Science translational medicine. 2018 Academic Article GET IT
Times cited: 70
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection. Nature medicine. 2018 Academic Article GET IT
Times cited: 281
Distinct biomarker signatures in HIV acute infection associate with viral dynamics and reservoir size. JCI insight. 2018 Academic Article GET IT
Times cited: 32
Acute Retroviral Syndrome Is Associated With High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2018 Academic Article GET IT
Times cited: 51

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Background

education and training

Ph.D., Weill Cornell Medical College, Cornell University 25
M.S., University of Montreal (Canada) 2018
B.Sc., University of Lausanne (Switzerland) 2015

Contact

full name

Louise Noelie Josephine Leyre

primary email

lol4001@med.cornell.edu

VIVO Weill Cornell Medical College

Louise Noelie Josephine Leyre Postdoctoral Associate in Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email