Karajannis, Matthias

Publications

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selected publications

Sustained imaging response and hearing preservation with low-dose bevacizumab in sporadic vestibular schwannoma. 2019 GET IT
Times cited: 11
Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival. The Journal of biological chemistry. 2019 Academic Article GET IT
Times cited: 10
Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma. Science advances. 2018 Academic Article GET IT
Times cited: 117
Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma. Neuro-oncology. 2018 Academic Article GET IT
Times cited: 94
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma. Nature communications. 2018 Academic Article GET IT
Times cited: 53
Heterogeneity within the PF-EPN-B ependymoma subgroup. Acta neuropathologica. 2018 Academic Article GET IT
Times cited: 100
Effect of lapatinib on meningioma growth in adults with neurofibromatosis type 2. Journal of neuro-oncology. 2018 Academic Article GET IT
Times cited: 33
2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. American journal of medical genetics. Part A. 2018 Letter GET IT
Times cited: 14
DNA methylation-based classification of central nervous system tumours. Nature. 2018 Academic Article GET IT
Times cited: 2114
Patterns of relapse for children with localized intracranial ependymoma. Journal of neuro-oncology. 2018 Academic Article GET IT
Times cited: 19
Programmed death ligand 1 expression and tumor infiltrating lymphocytes in neurofibromatosis type 1 and 2 associated tumors. Journal of neuro-oncology. 2018 Academic Article GET IT
Times cited: 66
Pre-treatment lymphopenia and indication of tumor-induced systemic immunosuppression in medulloblastoma. Journal of neuro-oncology. 2017 Academic Article GET IT
Times cited: 18
Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2. Cell reports. 2017 Academic Article GET IT
Times cited: 87
DNA Methylation-Based Classifier for Accurate Molecular Diagnosis of Bone Sarcomas. JCO precision oncology. 2017 Academic Article GET IT
Times cited: 40
Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome. Acta neuropathologica. 2017 Academic Article GET IT
Times cited: 193
Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017 Academic Article GET IT
Times cited: 273
Endothelium-Independent Primitive Myxoid Vascularization Creates Invertebrate-Like Channels to Maintain Blood Supply in Optic Gliomas. The American journal of pathology. 2017 Academic Article GET IT
Times cited: 4
Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis. Molecular cancer therapeutics. 2017 Academic Article GET IT
Times cited: 35
The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis. American journal of medical genetics. Part A. 2017 Conference Paper GET IT
Times cited: 7
Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis. Journal of neuro-oncology. 2017 Academic Article GET IT
Times cited: 36
A novel, potentially targetable TMEM106B-BRAF fusion in pleomorphic xanthoastrocytoma. 2017 GET IT
Pediatric high-grade glioma: biologically and clinically in need of new thinking. Neuro-oncology. 2017 Review GET IT
Times cited: 295
Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway. Acta neuropathologica. 2016 Academic Article GET IT
Times cited: 212
Mutant IDH1 and thrombosis in gliomas. Acta neuropathologica. 2016 Academic Article GET IT
Times cited: 140
Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation. Acta neuropathologica communications. 2016 Letter GET IT
Times cited: 82
Utility of MRI versus tumor markers for post-treatment surveillance of marker-positive CNS germ cell tumors. Journal of neuro-oncology. 2016 Academic Article GET IT
Times cited: 8
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Academic Article GET IT
Times cited: 178
Pediatric Brain Tumors: An Update. Current problems in pediatric and adolescent health care. 2016 Review GET IT
Times cited: 36
Noncarboplatin-induced Sensorineural Hearing Loss in a Patient With an Intracranial Nongerminomatous Germ Cell Tumor. 2016 GET IT
The promise of molecular profiling of choroid plexus tumors for diagnostic and prognostic stratification: where to go from here?. Neuro-oncology. 2016 Editorial Article GET IT
Times cited: 1
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. Cell. 2016 Academic Article GET IT
Times cited: 738
Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 Review GET IT
Times cited: 186
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. Cancer cell. 2015 Academic Article GET IT
Times cited: 936
Neurofibromatosis-related tumors: emerging biology and therapies. Current opinion in pediatrics. 2015 Review GET IT
Times cited: 57
Recurrent ascites in a patient with low-grade astrocytoma and ventriculo-peritoneal shunt treated with the multikinase inhibitor sorafenib. 2014 GET IT
Times cited: 7
Clinical response to bevacizumab in schwannomatosis. 2014 GET IT
Times cited: 29
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer cell. 2014 Academic Article GET IT
Times cited: 192
Glioblastoma multiforme: State of the art and future therapeutics. Surgical neurology international. 2014 Review GET IT
Times cited: 231
Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas. Neuro-oncology. 2014 Academic Article GET IT
Times cited: 189
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nature genetics. 2014 Academic Article GET IT
Times cited: 511
Phase II study of everolimus in children and adults with neurofibromatosis type 2 and progressive vestibular schwannomas. Neuro-oncology. 2013 Academic Article GET IT
Times cited: 101
Recommendations for imaging tumor response in neurofibromatosis clinical trials. Neurology. 2013 Academic Article GET IT
Times cited: 122
Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target. Neuro-oncology. 2013 Academic Article GET IT
Times cited: 65
Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis. The Lancet. Oncology. 2013 Academic Article GET IT
Times cited: 314
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nature genetics. 2013 Academic Article GET IT
Times cited: 655
MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. Neuro-oncology. 2012 Academic Article GET IT
Times cited: 54
Phase II trial of lapatinib in adult and pediatric patients with neurofibromatosis type 2 and progressive vestibular schwannomas. Neuro-oncology. 2012 Academic Article GET IT
Times cited: 148
Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus. EMBO reports. 2012 Review GET IT
Times cited: 112
BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants. Journal of neuropathology and experimental neurology. 2012 Academic Article GET IT
Times cited: 142
Consensus recommendations for current treatments and accelerating clinical trials for patients with neurofibromatosis type 2. American journal of medical genetics. Part A. 2011 Academic Article GET IT
Times cited: 110
R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma. Acta neuropathologica. 2010 Letter GET IT
Times cited: 64
Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma. Journal of neuro-oncology. 2010 Academic Article GET IT
Times cited: 49
Bevacizumab in recurrent high-grade pediatric gliomas. Neuro-oncology. 2010 Academic Article GET IT
Times cited: 71
Overexpression and activation of epidermal growth factor receptor in hemangioblastomas. Journal of neuro-oncology. 2010 Academic Article GET IT
Times cited: 15
ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma. Neuro-oncology. 2010 Academic Article GET IT
Times cited: 81
Consensus recommendations to accelerate clinical trials for neurofibromatosis type 2. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Conference Paper GET IT
Times cited: 66
Synchronous mixed germ cell tumor of the pineal gland and suprasellar region with a predominant angiomatous component: a diagnostic challenge. 2008 GET IT
Times cited: 11
Treatment of pediatric brain tumors. Journal of cellular physiology. 2008 Review GET IT
Times cited: 55
The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death. Blood. 2007 Academic Article GET IT
Times cited: 67
Treatment-related myelodysplastic syndrome after chemotherapy for childhood low-grade astrocytoma. Journal of pediatric hematology/oncology. 2006 Article GET IT
Times cited: 1
Activation of FGFR1beta signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells. Leukemia. 2006 Academic Article GET IT
Times cited: 38
Fetal stromal-dependent paracrine and intracrine vascular endothelial growth factor-a/vascular endothelial growth factor receptor-1 signaling promotes proliferation and motility of human primary myeloma cells. Cancer research. 2005 Academic Article GET IT
Times cited: 55
Epstein-Barr virus infection in Western European pediatric non-Hodgkin lymphomas. Blood. 2003 Letter GET IT
Times cited: 19
Strict lymphotropism of Epstein-Barr virus during acute infectious mononucleosis in nonimmunocompromised individuals. Blood. 1997 Academic Article GET IT
Times cited: 73

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Background

education and training

M.S., New York University School of Medicine 2009
M.D., Free University of Berlin (Germany) 1997

Contact

full name

Matthias Karajannis

webpage

https://www.mskcc.org/cancer-care/doctors/matthias-karajannis

VIVO Weill Cornell Medical College

Matthias Karajannis Professor of Pediatrics

Publications

selected publications

Background

education and training

Contact

full name

webpage