selected publications
- Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. Cell. 2024 Academic Article GET IT
- Disease-linked mutations in Munc18-1 deplete synaptic Doc2. Brain : a journal of neurology. 2024 Academic Article GET IT
- Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. 2023 GET IT
- α-Synuclein in synaptic function and dysfunction. Trends in neurosciences. 2022 Review GET IT
- Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models. Nature communications. 2022 Academic Article GET IT
- Cellular And Small Animal Models Of Neurodegenerative Diseases. Journal of visualized experiments : JoVE. 2022 Editorial Article GET IT
- Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins. Cell reports. 2022 Academic Article GET IT
- Targeted stabilization of Munc18-1 function via pharmacological chaperones. EMBO molecular medicine. 2020 Academic Article GET IT
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Autosomal dominant neuronal ceroid lipofuscinosis: Clinical features and molecular basis.
Clinical genetics.
2020
Information Resource
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Times cited: 18 -
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators.
Nature structural & molecular biology.
2020
Academic Article
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Times cited: 12 -
The complexity of tau in Alzheimer's disease.
Neuroscience letters.
2019
Information Resource
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Times cited: 199 -
Definition of a molecular pathway mediating α-synuclein neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015
Academic Article
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Times cited: 151 -
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 348 -
Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity.
Neuron.
2014
Academic Article
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Times cited: 47 -
Synaptic function of nicastrin in hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 26 -
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 90 - Acoustic echoes reveal room shape. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
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Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.
eLife.
2013
Academic Article
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Times cited: 253 -
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012
Academic Article
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Times cited: 133 -
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
Science translational medicine.
2012
Academic Article
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Times cited: 42 -
CSPα knockout causes neurodegeneration by impairing SNAP-25 function.
The EMBO journal.
2011
Academic Article
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Times cited: 117 -
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.
Proceedings of the National Academy of Sciences of the United States of America.
2011
Academic Article
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Times cited: 273 -
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
The EMBO journal.
2011
Academic Article
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Times cited: 119 -
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Nature cell biology.
2010
Academic Article
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Times cited: 162 -
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
Science (New York, N.Y.).
2010
Academic Article
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Times cited: 1334 -
Evolution of CASK into a Mg2+-sensitive kinase.
Science signaling.
2010
Academic Article
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Times cited: 43 -
CASK Functions as a Mg2+-independent neurexin kinase.
Cell.
2008
Academic Article
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Times cited: 224 -
The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.
Nature structural & molecular biology.
2004
Academic Article
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Times cited: 256 -
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.
The Journal of cell biology.
2004
Academic Article
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Times cited: 289 -
The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia.
The Journal of biological chemistry.
2003
Academic Article
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Times cited: 62 -
CFTR folding and maturation in cells.
Methods in molecular medicine.
2002
Academic Article
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Times cited: 11