Sharma, Manu

Publications

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selected publications

Some brain disorders are "chaperonopathies". Science (New York, N.Y.). 2024 Comment GET IT
Disease-linked mutations in Munc18-1 deplete synaptic Doc2. Brain : a journal of neurology. 2024 Academic Article GET IT
Times cited: 1
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins. 2024 GET IT
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. Cell. 2024 Academic Article GET IT
Times cited: 3
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. 2023 GET IT
α-Synuclein in synaptic function and dysfunction. Trends in neurosciences. 2022 Review GET IT
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models. Nature communications. 2022 Academic Article GET IT
Cellular And Small Animal Models Of Neurodegenerative Diseases. Journal of visualized experiments : JoVE. 2022 Editorial Article GET IT
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins. Cell reports. 2022 Academic Article GET IT
Times cited: 30
Targeted stabilization of Munc18-1 function via pharmacological chaperones. EMBO molecular medicine. 2020 Academic Article GET IT
Times cited: 10
Autosomal dominant neuronal ceroid lipofuscinosis: Clinical features and molecular basis. Clinical genetics. 2020 Review GET IT
Times cited: 22
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators. Nature structural & molecular biology. 2020 Academic Article GET IT
Times cited: 12
The complexity of tau in Alzheimer's disease. Neuroscience letters. 2019 Review GET IT
Times cited: 232
Cell Biology and Pathophysiology of α-Synuclein. Cold Spring Harbor perspectives in medicine. 2018 Review GET IT
Times cited: 374
Definition of a molecular pathway mediating α-synuclein neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Academic Article GET IT
Times cited: 159
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 368
Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity. Neuron. 2014 Academic Article GET IT
Times cited: 47
Synaptic function of nicastrin in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 27
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 90
Acoustic echoes reveal room shape. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 174
Properties of native brain α-synuclein. Nature. 2013 Comment GET IT
Times cited: 272
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2. eLife. 2013 Academic Article GET IT
Times cited: 265
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 137
Proteasome inhibition alleviates SNARE-dependent neurodegeneration. Science translational medicine. 2012 Academic Article GET IT
Times cited: 42
CSPα knockout causes neurodegeneration by impairing SNAP-25 function. The EMBO journal. 2011 Academic Article GET IT
Times cited: 119
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 284
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. The EMBO journal. 2011 Academic Article GET IT
Times cited: 123
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nature cell biology. 2010 Academic Article GET IT
Times cited: 162
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 1394
Evolution of CASK into a Mg2+-sensitive kinase. Science signaling. 2010 Academic Article GET IT
Times cited: 44
CASK Functions as a Mg2+-independent neurexin kinase. Cell. 2008 Academic Article GET IT
Times cited: 229
The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR. Nature structural & molecular biology. 2004 Academic Article GET IT
Times cited: 256
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. The Journal of cell biology. 2004 Academic Article GET IT
Times cited: 293
The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 62
CFTR folding and maturation in cells. Methods in molecular medicine. 2002 Academic Article GET IT
Times cited: 11

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Research

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Co-investigator Network

Funding awarded

Tau proteostasis by chaperone-complexes in tauopathies including Alzheimer''s disease awarded by National Institute on Aging Principal Investigator 2024 - 2029
Cellular Mechanism of Adult Onset Neuronal Ceroid Lipofuscinosis (ANCL) Caused by Mutations in Cysteine String Protein-Alpha (CSPalpha) awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2017 - 2025
missing activity Principal Investigator 2016 - 2024

Small molecule inhibitors of CAPON-induced tau aggregation awarded by National Institute on Aging Co-Investigator 2024 - 2027

The impact of beta- and gamma-synucleins on alpha-synuclein''s synaptic function awarded by National Institute of Neurological Disorders & Stroke Co-Principal Investigator 2022 - 2025

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Background

education and training

Ph.D., University of Toronto (Canada) 2005
B.Sc., University of Toronto (Canada) 1998

Contact

full name

Manu Sharma

primary email

mas2189@med.cornell.edu

VIVO Weill Cornell Medical College

Manu Sharma Associate Professor of Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email