Choi, Mary E

Publications

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selected publications

Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort. JCI insight. 2024 Letter GET IT
Retinoic acid receptor α activity in proximal tubules prevents kidney injury and fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
Autophagy and mitophagy: physiological implications in kidney inflammation and diseases. American journal of physiology. Renal physiology. 2023 Review GET IT
Plasma extracellular vesicles and cell-free mitochondrial DNA are associated with cognitive dysfunction in treated older adults with HIV. Journal of neurovirology. 2023 Academic Article GET IT
Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS. Molecular medicine (Cambridge, Mass.). 2023 Academic Article GET IT
Times cited: 14
Iron therapy mitigates chronic kidney disease progression by regulating intracellular iron status of kidney macrophages. JCI insight. 2023 Academic Article GET IT
Times cited: 26
Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS. PLoS pathogens. 2022 Academic Article GET IT
Times cited: 19
Plasma Cell-Free Mitochondrial DNA as a Marker of Geriatric Syndromes in Older Adults With HIV. Journal of acquired immune deficiency syndromes (1999). 2022 Academic Article GET IT
Times cited: 4
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19. iScience. 2022 Academic Article GET IT
Times cited: 8
Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome. The American journal of pathology. 2022 Academic Article GET IT
Times cited: 19
Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis. Kidney international. 2022 Academic Article GET IT
Times cited: 28
Urine Cell-Free Mitochondrial DNA as a Marker of Weight Loss and Body Composition in Older Adults With HIV. Journal of acquired immune deficiency syndromes (1999). 2021 Academic Article GET IT
Times cited: 7
Autophagy in major human diseases. The EMBO journal. 2021 Review GET IT
Times cited: 1074
Novel Roles of Necroptosis Mediator Receptor-Interacting Protein Kinase 3 in Kidney Injury. Nephron. 2021 Review GET IT
Times cited: 6
Cytokine signatures of end organ injury in COVID-19. Scientific reports. 2021 Academic Article GET IT
Times cited: 36
Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort. Respiratory research. 2021 Academic Article GET IT
Times cited: 20
Effect of Neutropenic Critical Illness on Development and Prognosis of Acute Respiratory Distress Syndrome. American journal of respiratory and critical care medicine. 2021 Letter GET IT
Times cited: 10
COVID-19 in Patients with CKD in New York City. Kidney360. 2021 Academic Article GET IT
Times cited: 21
Mitochondrial dysfunction in kidney injury, inflammation, and disease: Potential therapeutic approaches. Kidney research and clinical practice. 2020 Review GET IT
Times cited: 116
Characteristics of Acute Kidney Injury in Hospitalized COVID-19 Patients in an Urban Academic Medical Center. Clinical journal of the American Society of Nephrology : CJASN. 2020 Letter GET IT
Times cited: 34
Cigarette smoke-initiated autoimmunity facilitates sensitisation to elastin-induced COPD-like pathologies in mice. The European respiratory journal. 2020 Academic Article GET IT
Times cited: 57
Carbonyl iron and iron dextran therapies cause adverse effects on bone health in juveniles with chronic kidney disease. Kidney international. 2020 Academic Article GET IT
Times cited: 13
HIV protease inhibitor ritonavir induces renal fibrosis and dysfunction: role of platelet-derived TGF-β1 and intervention via antioxidant pathways. AIDS (London, England). 2020 Academic Article GET IT
Times cited: 6
Elevated cardiac risk score by Atherosclerotic Cardiovascular Disease calculation is associated with albuminuria in older people living with HIV. AIDS (London, England). 2020 Academic Article GET IT
Autophagy in chronic lung disease. Progress in molecular biology and translational science. 2020 Review GET IT
Times cited: 26
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort. JCI insight. 2020 Academic Article GET IT
Times cited: 33
Autophagy in kidney disease: Advances and therapeutic potential. Progress in molecular biology and translational science. 2020 Review GET IT
Times cited: 23
Molecular determinants of nephron vascular specialization in the kidney. Nature communications. 2019 Academic Article GET IT
Times cited: 91
Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis. JCI insight. 2019 Academic Article GET IT
Times cited: 131
The Emerging Role of Mitophagy in Kidney Diseases. Journal of life sciences (Westlake Village, Calif.). 2019 Academic Article GET IT
Times cited: 49
Autophagy in Kidney Disease. Annual review of physiology. 2019 Review GET IT
Times cited: 117
Necroptosis: a crucial pathogenic mediator of human disease. JCI insight. 2019 Review GET IT
Times cited: 338
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Nature communications. 2019 Academic Article GET IT
Times cited: 133
Interleukin-6 Contributes to the Development of Anemia in Juvenile CKD. Kidney international reports. 2018 Academic Article GET IT
Times cited: 45
Mitochondrial Dysfunction as a Pathogenic Mediator of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Annals of the American Thoracic Society. 2018 Review GET IT
Times cited: 82
Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease. JCI insight. 2018 Academic Article GET IT
Times cited: 19
Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor β2 Agonist. The Journal of pharmacology and experimental therapeutics. 2018 Academic Article GET IT
Times cited: 20
RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction. JCI insight. 2018 Academic Article GET IT
Times cited: 151
Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease. Antioxidants & redox signaling. 2018 Review GET IT
Times cited: 83
RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase. JCI insight. 2018 Academic Article GET IT
Times cited: 91
HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-β1 and can be suppressed by exogenous carbon monoxide. PloS one. 2017 Academic Article GET IT
Times cited: 31
A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine. 2017 Academic Article GET IT
Times cited: 69
Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease. American journal of physiology. Renal physiology. 2016 Academic Article GET IT
Times cited: 47
Autophagy: Friend or Foe in Lung Disease?. Annals of the American Thoracic Society. 2016 Review GET IT
Times cited: 82
Transforming growth factor-β1-mediated cardiac fibrosis: potential role in HIV and HIV/antiretroviral therapy-linked cardiovascular disease. AIDS (London, England). 2016 Review GET IT
Times cited: 19
TGF-β signaling in the kidney: profibrotic and protective effects. American journal of physiology. Renal physiology. 2016 Review GET IT
Times cited: 227
Impaired oxidative phosphorylation regulates necroptosis in human lung epithelial cells. Biochemical and biophysical research communications. 2015 Academic Article GET IT
Times cited: 29
Oxidative stress and autophagy: crucial modulators of kidney injury. Redox biology. 2015 Review GET IT
Times cited: 298
Autophagy in diabetic nephropathy. The Journal of endocrinology. 2014 Review GET IT
Times cited: 275
Therapeutic targets for treating fibrotic kidney diseases. Translational research : the journal of laboratory and clinical medicine. 2014 Review GET IT
Times cited: 165
Urinary biomarkers for early diabetic nephropathy: beyond albuminuria. Pediatric nephrology (Berlin, Germany). 2014 Review GET IT
Times cited: 82
Autophagy regulates TGF-β expression and suppresses kidney fibrosis induced by unilateral ureteral obstruction. Journal of the American Society of Nephrology : JASN. 2014 Academic Article GET IT
Times cited: 236
TGF-β-activated kinase 1 is crucial in podocyte differentiation and glomerular capillary formation. Journal of the American Society of Nephrology : JASN. 2014 Academic Article GET IT
Times cited: 22
Cecal ligation and puncture-induced sepsis as a model to study autophagy in mice. Journal of visualized experiments : JoVE. 2014 Review GET IT
Times cited: 58
Regulation of autophagy by TGF-β: emerging role in kidney fibrosis. Seminars in nephrology. 2013 Review GET IT
Times cited: 128
Autophagy in kidney health and disease. Antioxidants & redox signaling. 2013 Review GET IT
Times cited: 95
TGF-β signaling via TAK1 pathway: role in kidney fibrosis. Seminars in nephrology. 2012 Review GET IT
Times cited: 121
TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney disease. Kidney research and clinical practice. 2012 Review GET IT
Times cited: 74
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Guideline GET IT
Times cited: 2963
Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-β1. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 204
Lyme disease-associated glomerulonephritis. 2011 GET IT
Times cited: 18
REIN on obesity, proteinuria and CKD. Journal of the American Society of Nephrology : JASN. 2011 Editorial Article GET IT
Times cited: 3
TGF-{beta}1 protects against mesangial cell apoptosis via induction of autophagy. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 130
Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 72
The not-so-sweet side of fructose. Journal of the American Society of Nephrology : JASN. 2009 Editorial Article GET IT
Times cited: 9
BAT3 interacts with transforming growth factor-beta (TGF-beta) receptors and enhances TGF-beta1-induced type I collagen expression in mesangial cells. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 22
Protein phosphatase 2A is a negative regulator of transforming growth factor-beta1-induced TAK1 activation in mesangial cells. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 48
Protective effects of low-dose carbon monoxide against renal fibrosis induced by unilateral ureteral obstruction. American journal of physiology. Renal physiology. 2007 Academic Article GET IT
Times cited: 36
TGF-beta-activated kinase 1 and TAK1-binding protein 1 cooperate to mediate TGF-beta1-induced MKK3-p38 MAPK activation and stimulation of type I collagen. American journal of physiology. Renal physiology. 2007 Academic Article GET IT
Times cited: 113
Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer research. 2006 Academic Article GET IT
Times cited: 84
Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 112
Transforming growth factor-beta1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cells. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 62
TGF-beta1 stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells. American journal of physiology. Lung cellular and molecular physiology. 2002 Academic Article GET IT
Times cited: 100
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 89
Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 427
Stimulation of pro-alpha(1)(I) collagen by TGF-beta(1) in mesangial cells: role of the p38 MAPK pathway. American journal of physiology. Renal physiology. 2001 Academic Article GET IT
Times cited: 142
Mechanism of transforming growth factor-beta1 signaling:. Kidney international. Supplement. 2000 Review GET IT
Times cited: 68
Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. The American journal of physiology. 1999 Academic Article GET IT
Times cited: 116
TGF-beta receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain. Kidney international. 1999 Academic Article GET IT
Times cited: 68
Transforming growth factor beta1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 95
Cloning and characterization of a naturally occurring soluble form of TGF-beta type I receptor. The American journal of physiology. 1999 Academic Article GET IT
Times cited: 19
Induction of apoptosis by particulate matter: role of TNF-alpha and MAPK. The American journal of physiology. 1998 Academic Article GET IT
Times cited: 91
Differential expression of transforming growth factor-beta receptors in rat kidney development. The American journal of physiology. 1997 Academic Article GET IT
Times cited: 32
Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-beta receptors. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 133
Spatially restricted expression of set mRNA in developing rat kidney. The American journal of physiology. 1994 Academic Article GET IT
Times cited: 17
Rat mesangial cell hypertrophy in response to transforming growth factor-beta 1. Kidney international. 1993 Academic Article GET IT
Times cited: 87

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Research

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Funding awarded

Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers awarded by National Heart, Lung, & Blood Institute Principal Investigator 2021 - 2026

QSM for detection of hemorrhaging cysts and risk stratification in ADPKD awarded by National Institute of Diabetes & Digestive & Kidney Diseases Co-Investigator 2025 - 2029
Gene Nutrient Interactions in Kidney Function awarded by National Institute of Diabetes & Digestive & Kidney Diseases Co-Investigator 2022 - 2026
A Phase 1b Study of Inhaled CO for the Treatment of Sepsis-Induced ARDS awarded by National Heart, Lung, & Blood Institute Co-Investigator 2020 - 2025
A Phase II Study of Inhaled CO for the Treatment of ARDS awarded by United States Department of Defense Co-Investigator 2018 - 2025

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Background

education and training

M.D., University of Kansas School of Medicine 1984
B.A., University of Kansas 1980

Contact

full name

Mary E Choi

primary email

mec2025@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Mary E Choi Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage