Ishii, Makoto

Publications

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selected publications

A Novel Neurovascular Liaison Governing the Blood-Brain Barrier. Neuron. 2020 Academic Article GET IT
Risk factor for Alzheimer's disease breaks the blood-brain barrier. Nature. 2020 Comment GET IT
Times cited: 4
Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 Academic Article GET IT
Times cited: 4
Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). 2019 Academic Article GET IT
Times cited: 2
Apolipoprotein B as a New Link Between Cholesterol and Alzheimer Disease. JAMA neurology. 2019 Editorial Article GET IT
McLeod syndrome: Five new pedigrees with novel mutations. Parkinsonism & related disorders. 2019 Academic Article GET IT
Times cited: 1
Retinol Binding Protein 4 Levels Are Not Altered in Preclinical Alzheimer's Disease and Not Associated with Cognitive Decline or Incident Dementia. Journal of Alzheimer's disease : JAD. 2019 Academic Article GET IT
Times cited: 1
Disorders of Body Weight, Sleep and Circadian Rhythm as Manifestations of Hypothalamic Dysfunction in Alzheimer's Disease. Frontiers in cellular neuroscience. 2018 Article GET IT
Times cited: 8
Endocrine Emergencies With Neurologic Manifestations. Continuum (Minneapolis, Minn.). 2017 Review GET IT
Times cited: 7
Leptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies. Cellular and molecular neurobiology. 2016 Review GET IT
Times cited: 42
The Role of the Adipocyte Hormone Leptin in Alzheimer's Disease. The Keio journal of medicine. 2016 Academic Article GET IT
Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology. Biochimica et biophysica acta. 2015 Review GET IT
Times cited: 16
Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology. Cell metabolism. 2015 Review GET IT
Times cited: 65
Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 42
Neurologic complications of nondiabetic endocrine disorders. Continuum (Minneapolis, Minn.). 2014 Review GET IT
Times cited: 6
Amyloid β-Related Central Nervous System Angiitis Presenting With an Isolated Seizure. The Neurohospitalist. 2014 Academic Article GET IT
Times cited: 6
Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory. PloS one. 2011 Academic Article GET IT
Times cited: 20
Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell metabolism. 2009 Academic Article GET IT
Times cited: 57
Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities. Regulatory peptides. 2008 Academic Article GET IT
Times cited: 6
The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion. Results and problems in cell differentiation. 2008 Academic Article GET IT
Times cited: 30
Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain. Brain research. 2006 Academic Article GET IT
Times cited: 38
Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 92
Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticity. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 44
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Comment GET IT
Times cited: 1466
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Academic Article GET IT
Times cited: 2722

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Research

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Co-investigator Network

Funding awarded

Hypothalamic and metabolic dysfunction in Alzheimer''s disease awarded by National Institute on Aging Principal Investigator 2021 - 2025
Circulating immunometabolic factors in Alzheimer''s disease awarded by BrightFocus Foundation Principal Investigator 2020 - 2023
Calcium dysregulation and hypothalamic dysfunction in Alzheimer''s disease awarded by Alzheimer''s Association National Office Principal Investigator 2020 - 2023

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Background

education and training

M.D., Weill Cornell Medical College, Cornell University 2008
Ph.D., The Rockefeller University 2004
B.S.E., Princeton University 1998

Contact

full name

Makoto Ishii

primary email

mishii@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Makoto Ishii Assistant Professor of Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage