Hegde, Muralidhar

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RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability. bioRxiv : the preprint server for biology. 2025 Article GET IT
F2,6BP restores mitochondrial genome integrity in Huntington's Disease. bioRxiv : the preprint server for biology. 2025 Article GET IT
Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson's disease and parkinsonism-dementia of Guam. Cell death & disease. 2024 Academic Article GET IT
Times cited: 15
A Commentary on Mitochondrial Dysfunction and Compromised DNA Repair in Neurodegeneration: The Emerging Role of FUS in ALS. Neuroscience insights. 2024 Academic Article GET IT
Times cited: 1
Selective Inhibition of Cytosolic PARylation via PARG99: A Targeted Approach for Mitigating FUS-associated Neurodegeneration. bioRxiv : the preprint server for biology. 2024 Article GET IT
The role of carotenoids from red mamey fruit (Pouteria sapota) against amyloid-β monomers in Alzheimer's disease: Computational analysis and ADMET prediction. Journal of Alzheimer's disease : JAD. 2024 Academic Article GET IT
Oxidized Carbon Nanoparticles Enhance Cellular Energetics With Application to Injured Brain. Advanced healthcare materials. 2024 Academic Article GET IT
Times cited: 9
Hemin-Induced Transient Senescence Via DNA Damage Response: A Neuroprotective Mechanism Against Ferroptosis in Intracerebral Hemorrhage. Research square. 2024 Article GET IT
Regulation of DNA damage response by RNA/DNA-binding proteins: Implications for neurological disorders and aging. Ageing research reviews. 2024 Information Resource GET IT
Times cited: 10
TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner. Molecular brain. 2024 Academic Article GET IT
Times cited: 5
TDP43 Interacts with MLH1 and MSH6 Proteins in A DNA Damage-Inducible Manner. Research square. 2024 Article GET IT
Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence. Research square. 2024 Article GET IT
FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease. Nature communications. 2024 Academic Article GET IT
Times cited: 23
Mitochondria-Targeted Oligomeric α-Synuclein Induces TOM40 Degradation and Mitochondrial Dysfunction in Parkinson's Disease and Parkinsonism-Dementia of Guam. Research square. 2024 Article GET IT
Correction: The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis. PLoS genetics. 2024 Article GET IT
lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons. Cells. 2023 Academic Article GET IT
Times cited: 7
FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration. Research square. 2023 Article GET IT
lncRNA Sequencing Reveals Neurodegeneration-associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists In Motor Neurons. Research square. 2023 Article GET IT
DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders. International journal of molecular sciences. 2022 Information Resource GET IT
Times cited: 29
Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 23
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells. NAR cancer. 2020 Academic Article GET IT
Times cited: 43
Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective. Cells. 2020 Information Resource GET IT
Times cited: 69
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 32
Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle. ACS nano. 2020 Academic Article GET IT
Times cited: 78
RT² PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease. Molecular brain. 2019 Academic Article GET IT
Times cited: 18
Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis. International journal of molecular sciences. 2019 Information Resource GET IT
Times cited: 93
A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis. Journal of experimental neuroscience. 2019 Article GET IT
Times cited: 16
Hexahydropyrrolo[2,3-b]indole Compounds as Potential Therapeutics for Alzheimer's Disease. ACS chemical neuroscience. 2019 Academic Article GET IT
Times cited: 16
Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients. Molecular brain. 2019 Academic Article GET IT
Times cited: 22
New Mechanisms of DNA Repair Defects in Fused in Sarcoma-Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?. Journal of experimental neuroscience. 2019 Article GET IT
Times cited: 1
New mechanisms of dna repair defects in fused in sarcoma–associated neurodegeneration: Stage set for dna repair-based therapeutics?. Journal of Experimental Neuroscience. 2019 Article GET IT
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis. Nature communications. 2018 Academic Article GET IT
Times cited: 166
HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial. JAMA oncology. 2017 Academic Article GET IT
Times cited: 776
Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 170
Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential. Neurological research and therapy. 2014 Academic Article GET IT
DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease. Frontiers in bioscience (Landmark edition). 2010 Information Resource GET IT
Times cited: 47

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Background

education and training

Ph.D., Mysore University (India) 2006
M.S., Karnataka University (India) 2000
B.S., Karnataka University (India) 1998

Contact

full name

Muralidhar Hegde

primary email

mlh2004@med.cornell.edu

VIVO Weill Cornell Medical College

Muralidhar Hegde Assistant Professor of Neuroscience in Neurological Surgery

Publications

selected publications

Background

education and training

Contact

full name

primary email