Hegde, Muralidhar

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selected publications

Oxidized Carbon Nanoparticles Enhance Cellular Energetics With Application to Injured Brain. Advanced healthcare materials. 2024 Academic Article GET IT
Hemin-Induced Transient Senescence Via DNA Damage Response: A Neuroprotective Mechanism Against Ferroptosis in Intracerebral Hemorrhage. 2024 GET IT
Regulation of DNA damage response by RNA/DNA-binding proteins: Implications for neurological disorders and aging. Ageing research reviews. 2024 Review GET IT
TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner. Molecular brain. 2024 Academic Article GET IT
TDP43 Interacts with MLH1 and MSH6 Proteins in A DNA Damage-Inducible Manner. 2024 GET IT
RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability. 2024 GET IT
FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease. Nature communications. 2024 Academic Article GET IT
Mitochondria-Targeted Oligomeric α-Synuclein Induces TOM40 Degradation and Mitochondrial Dysfunction in Parkinson's Disease and Parkinsonism-Dementia of Guam. 2024 GET IT
Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, in ammation, and neuronal senescence. 2024 GET IT
Correction: The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis. 2024 GET IT
lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons. Cells. 2023 Academic Article GET IT
FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration. 2023 GET IT
lncRNA Sequencing Reveals Neurodegeneration-associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists In Motor Neurons. 2023 GET IT
1. Parkinson's disease - Perspectives from Alpha-synuclein related pathogenesis and current research. Journal of stem cells & regenerative medicine. 2023 Academic Article GET IT
Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks. The Journal of biological chemistry. 2023 Academic Article GET IT
Times cited: 11
Characterizing the Repair of DNA Double-Strand Breaks: A Review of Surrogate Plasmid-Based Reporter Methods. Methods in molecular biology (Clifton, N.J.). 2023 Review GET IT
Introduction to The Special Issue: Novel Molecular Pathways and Therapeutic Challenges in Neurodegenerative Diseases. Journal of Alzheimer's disease : JAD. 2023 Article GET IT
Editorial: The self-renewal and reprogramming of cancer stem cells and their crosstalk with the immune microenvironment. Frontiers in cell and developmental biology. 2022 Editorial Article GET IT
CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Academic Article GET IT
Times cited: 16
SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations. Ageing research reviews. 2022 Review GET IT
Times cited: 13
DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders. International journal of molecular sciences. 2022 Review GET IT
Times cited: 15
Pouteria sapota (Red Mamey Fruit): Chemistry and Biological Activity of Carotenoids. Combinatorial chemistry & high throughput screening. 2022 Academic Article GET IT
Times cited: 1
DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication. Frontiers in molecular neuroscience. 2021 Review GET IT
Times cited: 15
A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage. Annals of clinical and translational neurology. 2021 Review GET IT
Times cited: 5
RETRACTED: Biopsychosocial intersections of social/affective touch and psychiatry: Implications of 'touch hunger' during COVID-19. The International journal of social psychiatry. 2021 Academic Article GET IT
Times cited: 8
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin. Nucleic acids research. 2021 Academic Article GET IT
Times cited: 20
Computational Evaluation of Interaction Between Curcumin Derivatives and Amyloid-β Monomers and Fibrils: Relevance to Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2021 Academic Article GET IT
Times cited: 7
Polyphenols as Potential Metal Chelation Compounds Against Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2021 Information Resource GET IT
Times cited: 94
The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis. Frontiers in cellular neuroscience. 2020 Academic Article GET IT
Times cited: 22
Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 16
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells. NAR cancer. 2020 Academic Article GET IT
Times cited: 35
Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective. Cells. 2020 Information Resource GET IT
Times cited: 53
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 29
Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle. ACS nano. 2020 Academic Article GET IT
Times cited: 61
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challenges. Progress in neurobiology. 2019 Information Resource GET IT
Times cited: 25
RT² PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease. Molecular brain. 2019 Academic Article GET IT
Times cited: 13
A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis. Journal of experimental neuroscience. 2019 Comment GET IT
Times cited: 14
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. Progress in neurobiology. 2019 Review GET IT
Times cited: 106
Hexahydropyrrolo[2,3-b]indole Compounds as Potential Therapeutics for Alzheimer's Disease. ACS chemical neuroscience. 2019 Academic Article GET IT
Times cited: 13
Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis. 2019 GET IT
Times cited: 2
Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients. Molecular brain. 2019 Academic Article GET IT
Times cited: 18
New Mechanisms of DNA Repair Defects in Fused in Sarcoma-Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?. Journal of experimental neuroscience. 2019 Comment GET IT
Times cited: 1
Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis. Human molecular genetics. 2019 Academic Article GET IT
Times cited: 45
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 189
New mechanisms of dna repair defects in fused in sarcoma–associated neurodegeneration: Stage set for dna repair-based therapeutics?. Journal of Experimental Neuroscience. 2019 Article GET IT
Cannabinoid exposure during pregnancy and its impact on immune function. Cellular and molecular life sciences : CMLS. 2018 Review GET IT
Times cited: 51
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis. Nature communications. 2018 Academic Article GET IT
Times cited: 132
Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response. Oncology reports. 2018 Academic Article GET IT
Times cited: 15
Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs. Molecular nutrition & food research. 2018 Academic Article GET IT
Times cited: 48
Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress. DNA repair. 2018 Academic Article GET IT
Times cited: 19
An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1. Journal of Alzheimer's disease : JAD. 2018 Academic Article GET IT
Times cited: 10
HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial. JAMA oncology. 2017 Academic Article GET IT
Times cited: 633
Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis. Oncotarget. 2017 Academic Article GET IT
Times cited: 11
Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex. Nucleic acids research. 2017 Academic Article GET IT
Times cited: 73
Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity. Molecular and cellular biology. 2017 Academic Article GET IT
Times cited: 36
An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?. Journal of Alzheimer's disease : JAD. 2017 Information Resource GET IT
Times cited: 9
Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease. Journal of Alzheimer's disease : JAD. 2017 Academic Article GET IT
Times cited: 62
DNA damage responses in central nervous system and age-associated neurodegeneration. Mechanisms of ageing and development. 2017 Editorial Article GET IT
Times cited: 9
Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A. Nucleic acids research. 2016 Academic Article GET IT
Times cited: 14
Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 148
TDP-43/FUS in motor neuron disease: Complexity and challenges. Progress in neurobiology. 2016 Information Resource GET IT
Times cited: 89
Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?. Mechanisms of ageing and development. 2016 Information Resource GET IT
Times cited: 27
Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions. Oncotarget. 2016 Academic Article GET IT
Times cited: 14
8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging. Mechanisms of ageing and development. 2016 Academic Article GET IT
Times cited: 11
Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling. Free radical biology & medicine. 2015 Academic Article GET IT
Times cited: 32
The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: DOMINANT NEGATIVE FUNCTION OF THE CTD. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 40
The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis. PLoS genetics. 2015 Academic Article GET IT
Times cited: 84
New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins. Cellular and molecular life sciences : CMLS. 2015 Information Resource GET IT
Times cited: 45
Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells. Journal of bioanalysis & biomedicine. 2015 Academic Article GET IT
The role of 8-oxoguanine DNA glycosylase-1 in inflammation. International journal of molecular sciences. 2014 Information Resource GET IT
Times cited: 99
New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases. Biomolecules. 2014 Information Resource GET IT
Times cited: 29
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice. Cell reports. 2014 Academic Article GET IT
Times cited: 56
Molecular characterization of neuroprotective activities of plant based products could revive their utilization and lead discovery of new drug candidates for brain diseases. Journal of pharmacy & bioallied sciences. 2014 Academic Article GET IT
8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization. Free radical biology & medicine. 2014 Academic Article GET IT
Times cited: 53
A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells. Jacobs journal of radiation oncology. 2014 Academic Article GET IT
Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential. Neurological research and therapy. 2014 Academic Article GET IT
Identification and characterization of a basic thaumatin-like protein (TLP 2) as an allergen in sapodilla plum (Manilkara zapota). Molecular nutrition & food research. 2013 Academic Article GET IT
Times cited: 9
Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 86
Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair. DNA repair. 2013 Academic Article GET IT
Times cited: 60
8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1. Free radical biology & medicine. 2013 Academic Article GET IT
Times cited: 73
The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions. Journal of molecular biology. 2013 Academic Article GET IT
Times cited: 41
Human DNA Glycosylase NEIL1's Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival. Biomolecules. 2012 Academic Article GET IT
Times cited: 33
The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 26
Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease. Molecular neurobiology. 2012 Information Resource GET IT
Times cited: 59
Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 50
Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 108
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2. DNA repair. 2012 Academic Article GET IT
Times cited: 39
New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders. Journal of pharmacy & bioallied sciences. 2012 Academic Article GET IT
Times cited: 45
Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes. Progress in molecular biology and translational science. 2012 Article GET IT
Times cited: 46
Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 81
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer. Cell research. 2011 Academic Article GET IT
Times cited: 35
Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword. Journal of Alzheimer's disease : JAD. 2011 Information Resource GET IT
Times cited: 59
Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 123
Functions of disordered regions in mammalian early base excision repair proteins. Cellular and molecular life sciences : CMLS. 2010 Information Resource GET IT
Times cited: 58
Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 64
Evidence of altered DNA integrity in the brain regions of suicidal victims of Bipolar Depression. Indian journal of psychiatry. 2010 Academic Article GET IT
Times cited: 26
RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures. DNA repair. 2010 Academic Article GET IT
Times cited: 51
DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease. Frontiers in bioscience (Landmark edition). 2010 Review GET IT
Times cited: 38
Challenges associated with metal chelation therapy in Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2009 Information Resource GET IT
Times cited: 143
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 92
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell research. 2008 Information Resource GET IT
Times cited: 530
Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 117
Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways. Journal of molecular biology. 2007 Academic Article GET IT
Times cited: 27
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 89
DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes. Archives of biochemistry and biophysics. 2007 Academic Article GET IT
Times cited: 50
A new evidence for DNA nicking property of amyloid beta-peptide (1-42): relevance to Alzheimer's disease. Archives of biochemistry and biophysics. 2007 Academic Article GET IT
Times cited: 24
Role of protein conformational dynamics and DNA integrity in relevance to neuronal cell death in neurodegeneration. Current Alzheimer research. 2006 Information Resource GET IT
Times cited: 18
Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference. Progress in neurobiology. 2006 Information Resource GET IT
Times cited: 30
Studies on genomic DNA topology and stability in brain regions of Parkinson's disease. Archives of biochemistry and biophysics. 2006 Academic Article GET IT
Times cited: 45
Aluminium in Alzheimer's disease: are we still at a crossroad?. Cellular and molecular life sciences : CMLS. 2005 Information Resource GET IT
Times cited: 245
Serum trace element levels and the complexity of inter-element relations in patients with Parkinson's disease. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2004 Academic Article GET IT
Times cited: 103

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Background

education and training

Ph.D., Mysore University (India) 2006
M.S., Karnataka University (India) 2000
B.S., Karnataka University (India) 1998

Contact

full name

Muralidhar Hegde

primary email

mlh2004@med.cornell.edu

VIVO Weill Cornell Medical College

Muralidhar Hegde Assistant Professor of Neuroscience in Neurological Surgery

Publications

selected publications

Background

education and training

Contact

full name

primary email