Martin, M. Laura

Publications

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selected publications

Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade. 2023 GET IT
Acid Sphingomyelinase-Ceramide Induced Vascular Injury Determines Colorectal Cancer Stem Cell Fate. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2022 Academic Article GET IT
Next generation patient derived tumor organoids. Translational research : the journal of laboratory and clinical medicine. 2022 Review GET IT
The regulation of CD73 in non-small cell lung cancer. European journal of cancer. 2022 Academic Article GET IT
The lactate-NAD⁺ axis activates cancer-associated fibroblasts by downregulating p62. Cell reports. 2022 Academic Article GET IT
Colorectal cancer develops inherent radiosensitivity that can be predicted using patient-derived organoids. Cancer research. 2022 Academic Article GET IT
Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells. JCI insight. 2022 Academic Article GET IT
Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection. Gut microbes. 2022 Academic Article GET IT
Extracellular Matrix in Synthetic Hydrogel-based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 inhibitors. Advanced materials (Deerfield Beach, Fla.). 2021 Academic Article GET IT
Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis. Cancer discovery. 2021 Academic Article GET IT
Times cited: 171
T cell-derived interferon-γ programs stem cell death in immune-mediated intestinal damage. Science immunology. 2019 Academic Article GET IT
Times cited: 88
A simple surface biofunctionalization strategy to inhibit the biofilm formation by Staphylococcus aureus on solid substrates. Colloids and surfaces. B, Biointerfaces. 2019 Academic Article GET IT
Times cited: 2
Albumin biofunctionalization to minimize the Staphylococcus aureus adhesion on solid substrates. Colloids and surfaces. B, Biointerfaces. 2018 Academic Article GET IT
Times cited: 7
Logarithmic expansion of LGR5⁺ cells in human colorectal cancer. Cellular signalling. 2017 Academic Article GET IT
Times cited: 38
Role of the C-terminal basic amino acids and the lipid anchor of the Gγ₂ protein in membrane interactions and cell localization. Biochimica et biophysica acta. Biomembranes. 2017 Academic Article GET IT
Times cited: 6
Distinct Levels of Radioresistance in Lgr5⁺ Colonic Epithelial Stem Cells versus Lgr5⁺ Small Intestinal Stem Cells. Cancer research. 2017 Academic Article GET IT
Times cited: 47
Establishing estrogen-responsive mouse mammary organoids from single Lgr5⁺ cells. Cellular signalling. 2016 Academic Article GET IT
Times cited: 36
Optimized Protocol To Analyze Changes in the Lipidome of Xenografts after Treatment with 2-Hydroxyoleic Acid. Analytical chemistry. 2015 Academic Article GET IT
Times cited: 8
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature. 2015 Academic Article GET IT
Times cited: 811
Tumor-infiltrating, interleukin-33-producing effector-memory CD8(+) T cells in resected hepatocellular carcinoma prolong patient survival. Hepatology (Baltimore, Md.). 2015 Academic Article GET IT
Times cited: 70
IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3β. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 20
Deletion of Foxp3+ regulatory T cells in genetically targeted mice supports development of intestinal inflammation. BMC gastroenterology. 2012 Academic Article GET IT
Times cited: 76
2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 93
Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 143

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Research

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Funding awarded

The DARC side of Breast Cancer Disparities - African Ancestry and Cancer- Related Immune Response awarded by National Cancer Institute Co-Investigator 2021 - 2026
Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory awarded by United States Department of Defense Co-Investigator 2021 - 2025
Novel Complex Structural Variants And Epigenetic Alterations Link The Genomes Of Prostate Cancer In African Americans With Outcome Disparity. awarded by United States Department of Defense Co-Investigator 2021 - 2025
Unraveling the landscape of homologous recombination deficiency in patients with breast and prostate cancer across the African diaspora in NYC awarded by National Institute of General Medical Sciences Co-Investigator 2020 - 2024

Research collaboration agreement w/ Eli Lilly and Company awarded by Eli Lilly and Company Key Personnel 2019 - 2025

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Background

education and training

Ph.D., University of the Balearic Islands (Spain) 2011
M.S., University of the Balearic Islands (Spain) 2009
B.A., National University of Mar del Plata (Argentina) 2006

Contact

full name

M. Laura Martin

primary email

mlm4001@med.cornell.edu

VIVO Weill Cornell Medical College

M. Laura Martin Assistant Professor of Research in Physiology and Biophysics (Courtesy)

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email