Jin, Moonsoo

Publications

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selected publications

Low-dose targeted radionuclide therapy synergizes with CAR T cells and enhances tumor response. Frontiers in immunology. 2024 Academic Article GET IT
Times cited: 1
Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance. Cancers. 2023 Academic Article GET IT
Times cited: 2
Inducible expression of interleukin-12 augments the efficacy of affinity-tuned chimeric antigen receptors in murine solid tumor models. Nature communications. 2023 Academic Article GET IT
Times cited: 28
Activation of the JAK/STAT Pathway Leads to BRAF Inhibitor Resistance in BRAFV600E Positive Thyroid Carcinoma. Molecular cancer research : MCR. 2023 Academic Article GET IT
SSTR2 as an anatomical imaging marker and a safety switch to monitor and manage CAR T cell toxicity. Scientific reports. 2022 Academic Article GET IT
Yeast Surface Display for In Vitro Biosynthetic Pathway Reconstruction. ACS synthetic biology. 2021 Academic Article GET IT
Times cited: 11
Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability. Frontiers in pharmacology. 2021 Academic Article GET IT
Times cited: 8
Bispecific CAR T Cells against EpCAM and Inducible ICAM-1 Overcome Antigen Heterogeneity and Generate Superior Antitumor Responses. Cancer immunology research. 2021 Academic Article GET IT
CSPG4 Is a Potential Therapeutic Target in Anaplastic Thyroid Cancer. Thyroid : official journal of the American Thyroid Association. 2021 Academic Article GET IT
Times cited: 11
PD1 Blockade Enhances ICAM1-Directed CAR T Therapeutic Efficacy in Advanced Thyroid Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 28
Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer. Molecular therapy oncolytics. 2020 Academic Article GET IT
Times cited: 43
Validation of MRI quantitative susceptibility mapping of superparamagnetic iron oxide nanoparticles for hyperthermia applications in live subjects. Scientific reports. 2020 Academic Article GET IT
Times cited: 17
Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy. Scientific reports. 2019 Academic Article GET IT
Times cited: 61
A Fluorescent, [¹⁸F]-Positron-Emitting Agent for Imaging Prostate-Specific Membrane Antigen Allows Genetic Reporting in Adoptively Transferred, Genetically Modified Cells. ACS chemical biology. 2019 Academic Article GET IT
Times cited: 13
[¹⁸F]Fluoroethyltriazolyl Monocyclam Derivatives as Imaging Probes for the Chemokine Receptor CXCR4. Molecules (Basel, Switzerland). 2019 Academic Article GET IT
Times cited: 9
¹⁸F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management. Journal of medicinal chemistry. 2018 Academic Article GET IT
Times cited: 43
[¹⁸F]RPS-544: A PET tracer for imaging the chemokine receptor CXCR4. Nuclear medicine and biology. 2018 Academic Article GET IT
Times cited: 9
Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity. Scientific reports. 2017 Academic Article GET IT
Times cited: 125
CAR T Therapy Targeting ICAM-1 Eliminates Advanced Human Thyroid Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Academic Article GET IT
Times cited: 78
Longitudinal PET imaging demonstrates biphasic CAR T cell responses in survivors. JCI insight. 2016 Academic Article GET IT
Times cited: 77
Side-by-Side Comparison of Commonly Used Biomolecules That Differ in Size and Affinity on Tumor Uptake and Internalization. PloS one. 2015 Academic Article GET IT
Times cited: 20
Multiple sclerosis lesion geometry in quantitative susceptibility mapping (QSM) and phase imaging. Journal of magnetic resonance imaging : JMRI. 2014 Academic Article GET IT
Times cited: 53
Discovering aptamers by cell-SELEX against human soluble growth factors ectopically expressed on yeast cell surface. PloS one. 2014 Academic Article GET IT
Times cited: 2
Sol-gel SELEX circumventing chemical conjugation of low molecular weight metabolites discovers aptamers selective to xanthine. Nucleic acid therapeutics. 2013 Academic Article GET IT
Times cited: 40
Optoporation and genetic manipulation of cells using femtosecond laser pulses. Biophysical journal. 2013 Academic Article GET IT
Times cited: 55
Virus-mimetic polyplex particles for systemic and inflammation-specific targeted delivery of large genetic contents. Gene therapy. 2013 Academic Article GET IT
Times cited: 11
A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell stem cell. 2013 Academic Article GET IT
Times cited: 323
Development of temperature-sensitive mutants of the Drosophila melanogaster P-TEFb (Cyclin T/CDK9) heterodimer using yeast two-hybrid screening. Biochemical and biophysical research communications. 2013 Academic Article GET IT
Tumor suppression via paclitaxel-loaded drug carriers that target inflammation marker upregulated in tumor vasculature and macrophages. Biomaterials. 2012 Academic Article GET IT
Times cited: 46
Thyroid stimulating hormone increases iodine uptake by thyroid cancer cells during BRAF silencing. The Journal of surgical research. 2012 Academic Article GET IT
Times cited: 23
Complex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1. PloS one. 2012 Academic Article GET IT
Times cited: 3
Cell surface assembly of HIV gp41 six-helix bundles for facile, quantitative measurements of hetero-oligomeric interactions. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 14
Synthesis of magnetite/amphiphilic polymer composite nanoparticles as potential theragnostic agents. Journal of nanoscience and nanotechnology. 2012 Academic Article GET IT
Times cited: 13
Novel strategy for selection of monoclonal antibodies against highly conserved antigens: phage library panning against ephrin-B2 displayed on yeast. PloS one. 2012 Academic Article GET IT
Times cited: 4
Reducing the object orientation dependence of susceptibility effects in gradient echo MRI through quantitative susceptibility mapping. Magnetic resonance in medicine. 2012 Academic Article GET IT
Times cited: 99
Visualizing and quantifying acute inflammation using ICAM-1 specific nanoparticles and MRI quantitative susceptibility mapping. Annals of biomedical engineering. 2011 Academic Article GET IT
Times cited: 23
Intercellular adhesion molecule-1 (ICAM-1) is upregulated in aggressive papillary thyroid carcinoma. Annals of surgical oncology. 2011 Academic Article GET IT
Times cited: 30
Inflamed leukocyte-mimetic nanoparticles for molecular imaging of inflammation. Biomaterials. 2011 Academic Article GET IT
Times cited: 53
Tunable physiologic interactions of adhesion molecules for inflamed cell-selective drug delivery. Biomaterials. 2011 Academic Article GET IT
Times cited: 34
Interleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune molecules. Protein engineering, design & selection : PEDS. 2010 Academic Article GET IT
Times cited: 9
Cubic mesoporous graphitic carbon(IV) nitride: an all-in-one chemosensor for selective optical sensing of metal ions. Angewandte Chemie (International ed. in English). 2010 Academic Article GET IT
Times cited: 269
Self-assembled nanoplatform for targeted delivery of chemotherapy agents via affinity-regulated molecular interactions. Biomaterials. 2010 Academic Article GET IT
Times cited: 34
Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases. Toxicon : official journal of the International Society on Toxinology. 2010 Academic Article GET IT
Times cited: 72
Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 22
Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 11
Transposition into replicating DNA occurs through interaction with the processivity factor. Cell. 2009 Academic Article GET IT
Times cited: 58
A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. The EMBO journal. 2009 Academic Article GET IT
Times cited: 89
Yeast surface two-hybrid for quantitative in vivo detection of protein-protein interactions via the secretory pathway. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 24
Real-time quantitation of viral replication and inhibitor potency using a label-free optical biosensor. Journal of receptor and signal transduction research. 2009 Academic Article GET IT
Times cited: 16
An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5. Molecular cell. 2008 Academic Article GET IT
Times cited: 31
Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 83
Inducing rigid local structure around the zinc-binding region by hydrophobic interactions enhances the homotrimerization and apoptotic activity of zinc-free TRAIL. Biochemical and biophysical research communications. 2007 Academic Article GET IT
Times cited: 8
Chip-based detection of hepatitis C virus using RNA aptamers that specifically bind to HCV core antigen. Biochemical and biophysical research communications. 2007 Academic Article GET IT
Times cited: 84
Shear and compression differentially regulate clusters of functionally related temporal transcription patterns in cartilage tissue. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 93
Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 69
Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics. Structure (London, England : 1993). 2004 Academic Article GET IT
Times cited: 90
Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. Journal of biomechanics. 2004 Academic Article GET IT
Times cited: 219
Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 216
Tissue engineering of articular cartilage under the influence of collagen I/III membranes and low oxygen tension. Tissue engineering. 2004 Academic Article GET IT
Times cited: 47
A statistical model of diurnal variation in human growth hormone. American journal of physiology. Endocrinology and metabolism. 2003 Academic Article GET IT
Times cited: 16
Combined effects of dynamic tissue shear deformation and insulin-like growth factor I on chondrocyte biosynthesis in cartilage explants. Archives of biochemistry and biophysics. 2003 Academic Article GET IT
Times cited: 60
Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 985
Biosynthetic response and mechanical properties of articular cartilage after injurious compression. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2001 Academic Article GET IT
Times cited: 179
Tissue shear deformation stimulates proteoglycan and protein biosynthesis in bovine cartilage explants. Archives of biochemistry and biophysics. 2001 Academic Article GET IT
Times cited: 174
A versatile shear and compression apparatus for mechanical stimulation of tissue culture explants. Journal of biomechanics. 2000 Academic Article GET IT
Times cited: 146
Cartilage tissue remodeling in response to mechanical forces. Annual review of biomedical engineering. 2000 Review GET IT
Times cited: 546

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Research

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Funding awarded

New PET/CT System for Human and Non-human Primate Imaging awarded by National Institutes of Health, Office of the Director Key Personnel 2023 - 2025

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Background

education and training

Ph.D., Massachusetts Institute of Technology 2002
M.S., Massachusetts Institute of Technology 1999
B.S., Seoul National University (Korea) 1997

Contact

full name

Moonsoo Jin

primary email

moj2005@med.cornell.edu

External Relationships

externalRelationships

Relationships and collaborations with for-profit and not-for-profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.
Ownership refers to any financial stake an individual owns in any company (e.g., stock options, equity interest)Ownership:
AffyImmune Therapeutics Inc.

VIVO Weill Cornell Medical College

Moonsoo Jin Professor of Biomedical Engineering in Radiology Professor of Biomedical Engineering in Surgery

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

External Relationships

externalRelationships