selected publications
- Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Stenberg cells reveals escape from NK cell recognition and an unfolded protein response. 2025 GET IT
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EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function.
Cancer cell.
2024
Academic Article
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Times cited: 26 -
ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.
2024
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Times cited: 3 -
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
Nature communications.
2024
Academic Article
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Times cited: 17 -
ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.
Cancer cell.
2024
Academic Article
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Times cited: 26 -
SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions.
Cancer cell.
2024
Academic Article
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Times cited: 24 - Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas. 2023 GET IT
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BTG1 mutation yields supercompetitive B cells primed for malignant transformation.
Science (New York, N.Y.).
2023
Academic Article
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Times cited: 27 -
An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas.
Cancer discovery.
2023
Editorial Article
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Times cited: 13 -
BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer discovery.
2022
Academic Article
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Times cited: 24 -
SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.
Cancer discovery.
2022
Academic Article
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Times cited: 22 -
Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival.
Blood cancer discovery.
2021
Academic Article
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Times cited: 20 -
Identification of MALT1 feedback mechanisms enables rational design of potent antilymphoma regimens for ABC-DLBCL.
Blood.
2021
Academic Article
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Times cited: 30 -
Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence.
Cancer discovery.
2021
Academic Article
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Times cited: 180 -
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology.
2021
Academic Article
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Times cited: 28 -
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
Nature.
2020
Academic Article
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Times cited: 185 -
Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage.
Molecular cell.
2020
Academic Article
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Times cited: 28 -
Combined EZH2 and Bcl-2 inhibitors as precision therapy for genetically defined DLBCL subtypes.
Blood advances.
2020
Academic Article
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Times cited: 39 -
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.
Cell.
2020
Academic Article
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Times cited: 84 -
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.
Nature cancer.
2020
Academic Article
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Times cited: 52 -
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response.
Cancer cell.
2020
Academic Article
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Times cited: 117 -
Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma.
Cancer discovery.
2020
Academic Article
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Times cited: 132 -
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.
Cancer cell.
2019
Academic Article
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Times cited: 97 -
Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.
Cancer discovery.
2019
Academic Article
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Times cited: 39 -
Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition.
Cancer discovery.
2019
Academic Article
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Times cited: 250 -
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
Cancer discovery.
2018
Academic Article
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Times cited: 147 -
Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.
The Journal of clinical investigation.
2018
Academic Article
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Times cited: 48 -
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
Nature communications.
2018
Academic Article
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Times cited: 61 -
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
Nature communications.
2017
Academic Article
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Times cited: 146 -
Untangling the Web of Lymphoma Somatic Mutations.
Cell.
2017
Comment
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Times cited: 1 -
The new frontier of epigenetic heterogeneity in B-cell neoplasms.
Current opinion in hematology.
2017
Review
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Times cited: 10 -
Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.
Science translational medicine.
2017
Academic Article
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Times cited: 52 -
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
Cancer discovery.
2016
Academic Article
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Times cited: 227 -
Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region.
Immunity.
2016
Academic Article
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Times cited: 114 -
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.
Cancer cell.
2016
Academic Article
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Times cited: 201 -
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.
The Journal of clinical investigation.
2016
Academic Article
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Times cited: 146 -
Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status".
Nature medicine.
2016
Letter
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Times cited: 7 -
Loss of BAP1 function leads to EZH2-dependent transformation.
Nature medicine.
2015
Academic Article
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Times cited: 310 -
DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.
Cell reports.
2015
Academic Article
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Times cited: 92 -
The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.
Cell reports.
2014
Academic Article
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Times cited: 76 -
CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.
Cell reports.
2014
Academic Article
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Times cited: 151 -
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
Cancer cell.
2013
Academic Article
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Times cited: 719 -
Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo.
Cellular and molecular life sciences : CMLS.
2010
Academic Article
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Times cited: 179 -
Quality control in microarray assessment of gene expression in human airway epithelium.
BMC genomics.
2009
Academic Article
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Times cited: 76 -
Trachea epithelium as a "canary" for cigarette smoking-induced biologic phenotype of the small airway epithelium.
Clinical and translational science.
2009
Academic Article
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Times cited: 14