selected publications
- ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis. 2024 GET IT
- Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment. Nature communications. 2024 Academic Article GET IT
- ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis. Cancer cell. 2024 Academic Article GET IT
- SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions. Cancer cell. 2024 Academic Article GET IT
- BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science (New York, N.Y.). 2023 Academic Article GET IT
- BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL. Cancer discovery. 2022 Academic Article GET IT
- SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis. Cancer discovery. 2022 Academic Article GET IT
- Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival. Blood cancer discovery. 2021 Academic Article GET IT
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Identification of MALT1 feedback mechanisms enables rational design of potent antilymphoma regimens for ABC-DLBCL.
Blood.
2021
Academic Article
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Times cited: 25 -
Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence.
Cancer discovery.
2021
Academic Article
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Times cited: 136 -
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology.
2021
Academic Article
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Times cited: 25 -
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
Nature.
2020
Academic Article
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Times cited: 150 -
Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage.
Molecular cell.
2020
Academic Article
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Times cited: 24 -
Combined EZH2 and Bcl-2 inhibitors as precision therapy for genetically defined DLBCL subtypes.
Blood advances.
2020
Academic Article
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Times cited: 28 -
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.
Cell.
2020
Academic Article
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Times cited: 67 - The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. Nature cancer. 2020 Academic Article GET IT
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Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response.
Cancer cell.
2020
Academic Article
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Times cited: 92 -
Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma.
Cancer discovery.
2020
Academic Article
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Times cited: 106 -
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.
Cancer cell.
2019
Academic Article
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Times cited: 84 -
Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.
Cancer discovery.
2019
Academic Article
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Times cited: 34 -
Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition.
Cancer discovery.
2019
Academic Article
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Times cited: 88 -
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
Cancer discovery.
2018
Academic Article
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Times cited: 119 -
Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.
The Journal of clinical investigation.
2018
Academic Article
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Times cited: 43 -
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
Nature communications.
2018
Academic Article
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Times cited: 54 -
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
Nature communications.
2017
Academic Article
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Times cited: 124 -
The new frontier of epigenetic heterogeneity in B-cell neoplasms.
Current opinion in hematology.
2017
Review
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Times cited: 10 -
Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.
Science translational medicine.
2017
Academic Article
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Times cited: 48 -
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
Cancer discovery.
2016
Academic Article
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Times cited: 204 -
Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region.
Immunity.
2016
Academic Article
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Times cited: 103 -
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.
Cancer cell.
2016
Academic Article
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Times cited: 178 -
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.
The Journal of clinical investigation.
2016
Academic Article
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Times cited: 130 -
Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status".
Nature medicine.
2016
Article
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Times cited: 7 -
Loss of BAP1 function leads to EZH2-dependent transformation.
Nature medicine.
2015
Academic Article
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Times cited: 283 -
DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.
Cell reports.
2015
Academic Article
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Times cited: 85 -
The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.
Cell reports.
2014
Academic Article
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Times cited: 67 -
CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.
Cell reports.
2014
Academic Article
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Times cited: 145 -
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
Cancer cell.
2013
Academic Article
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Times cited: 662 -
Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo.
Cellular and molecular life sciences : CMLS.
2010
Academic Article
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Times cited: 171 -
Quality control in microarray assessment of gene expression in human airway epithelium.
BMC genomics.
2009
Academic Article
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Times cited: 73 -
Trachea epithelium as a "canary" for cigarette smoking-induced biologic phenotype of the small airway epithelium.
Clinical and translational science.
2009
Academic Article
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Times cited: 14