Dahmane, Nadia

Publications

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selected publications

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling. Nature biotechnology. 2024 Academic Article GET IT
The Genetics of Chiari 1 Malformation. Journal of clinical medicine. 2024 Review GET IT
Influence of focused ultrasound on locoregional drug delivery to the brain: Potential implications for brain tumor therapy. Journal of controlled release : official journal of the Controlled Release Society. 2023 Academic Article GET IT
Preclinical validation of a novel therapeutic strategy for choroid plexus carcinoma. Journal of controlled release : official journal of the Controlled Release Society. 2023 Academic Article GET IT
Leptomeningeal dissemination in pediatric brain tumors. Neoplasia (New York, N.Y.). 2023 Academic Article GET IT
Times cited: 8
RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons. Molecular and cellular biology. 2021 Academic Article GET IT
PET, image-guided HDAC inhibition of pediatric diffuse midline glioma improves survival in murine models. Science advances. 2020 Academic Article GET IT
Times cited: 23
Missing diversity in brain tumor trials. Neuro-oncology advances. 2020 Academic Article GET IT
B7-H3 as a Prognostic Biomarker and Therapeutic Target in Pediatric central nervous system Tumors. Translational oncology. 2019 Academic Article GET IT
Times cited: 33
Multivariate Analysis of Preoperative Magnetic Resonance Imaging Reveals Transcriptomic Classification of de novo Glioblastoma Patients. Frontiers in computational neuroscience. 2019 Academic Article GET IT
Immune landscapes associated with different glioblastoma molecular subtypes. Acta neuropathologica communications. 2019 Academic Article GET IT
Times cited: 115
Transcriptome signatures associated with meningioma progression. Acta neuropathologica communications. 2019 Academic Article GET IT
Times cited: 29
Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas. Molecular therapy oncolytics. 2018 Academic Article GET IT
Times cited: 135
In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature. Neuro-oncology. 2018 Academic Article GET IT
Times cited: 91
Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1. Scientific reports. 2018 Academic Article GET IT
Times cited: 128
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. Nature communications. 2018 Academic Article GET IT
Times cited: 189
Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons. Cell reports. 2017 Academic Article GET IT
Times cited: 95
SHP2 regulates proliferation and tumorigenicity of glioma stem cells. Journal of neuro-oncology. 2017 Academic Article GET IT
Times cited: 20
In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ-Index. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Academic Article GET IT
Times cited: 82
c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. The Journal of clinical investigation. 2016 Academic Article GET IT
Times cited: 98
Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 82
Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques. Neuro-oncology. 2015 Academic Article GET IT
Times cited: 246
NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. Cancer research. 2014 Academic Article GET IT
Times cited: 27
Pyrvinium attenuates Hedgehog signaling downstream of smoothened. Cancer research. 2014 Academic Article GET IT
Times cited: 71
Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. Journal of cell science. 2012 Academic Article GET IT
Times cited: 62
Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development. Development (Cambridge, England). 2012 Academic Article GET IT
Times cited: 17
Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors. Tetrahedron. 2011 Academic Article GET IT
RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion. Cell death and differentiation. 2011 Academic Article GET IT
Times cited: 66
Direct reprogramming of melanocytes to neural crest stem-like cells by one defined factor. Stem cells (Dayton, Ohio). 2011 Academic Article GET IT
Times cited: 51
Studies directed toward the elucidation of the pharmacophore of steroid-based Sonic Hedgehog signaling inhibitors. Organic letters. 2011 Academic Article GET IT
Times cited: 9
Stereoselective synthesis of F-ring saturated estrone-derived inhibitors of Hedgehog signaling based on cyclopamine. Organic letters. 2011 Academic Article GET IT
Times cited: 15
Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development. Genome research. 2011 Academic Article GET IT
Times cited: 155
Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia. Blood. 2011 Academic Article GET IT
Times cited: 38
Differential modulation of Sonic-hedgehog-induced cerebellar granule cell precursor proliferation by the IGF signaling network. Developmental neuroscience. 2010 Academic Article GET IT
Times cited: 51
ZNF238 is expressed in postmitotic brain cells and inhibits brain tumor growth. Cancer research. 2010 Academic Article GET IT
Times cited: 33
The full-length unprocessed hedgehog protein is an active signaling molecule. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 44
Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine. Organic letters. 2009 Academic Article GET IT
Times cited: 41
Sonic hedgehog mutations identified in holoprosencephaly patients can act in a dominant negative manner. Human genetics. 2008 Academic Article GET IT
Times cited: 23
Neuronal distribution of spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17. Experimental cell research. 2007 Academic Article GET IT
Times cited: 9
Sonic hedgehog signaling in forebrain development and its interactions with pathways that modify its effects. Trends in cell biology. 2006 Information Resource GET IT
Times cited: 53
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development (Cambridge, England). 2004 Academic Article GET IT
Times cited: 525
A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002 Academic Article GET IT
Times cited: 96
Gli and hedgehog in cancer: tumours, embryos and stem cells. Nature reviews. Cancer. 2002 Information Resource GET IT
Times cited: 626
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development (Cambridge, England). 2001 Academic Article GET IT
Times cited: 400
Embryonic regionalization of the neocortex. Mechanisms of development. 2001 Information Resource GET IT
Times cited: 15
Wnt signals are targets and mediators of Gli function. Current biology : CB. 2001 Academic Article GET IT
Times cited: 125
Sonic hedgehog regulates the growth and patterning of the cerebellum. Development (Cambridge, England). 1999 Academic Article GET IT
Times cited: 689
Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. Genomics. 1998 Academic Article GET IT
Times cited: 35
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature. 1997 Academic Article GET IT
Times cited: 518
Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 84
3.6-Mb genomic and YAC physical map of the Down syndrome chromosome region on chromosome 21. Genomics. 1994 Academic Article GET IT

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Research

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Funding awarded

A Mass Spectrometry Approach to the Genetic and Epigenetic Mechanisms Controlling Neuronal Identity awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2020 - 2025
Deciphering the 3D genome of pediatric brain tumors awarded by National Institutes of Health, Office of the Director Principal Investigator 2022 - 2024
Therapeutical reprogramming of DIPG cells awarded by Andrew McDonough B+ Foundation Principal Investigator 2021 - 2024

An IGF-1R targeted peptide drug conjugate for targeted treatment of atypical teratoid/rhabdoid tumors awarded by National Cancer Institute Principal Investigator Subaward 2023 - 2025

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Contact

full name

Nadia Dahmane

primary email

nad2639@med.cornell.edu

VIVO Weill Cornell Medical College

Nadia Dahmane Associate Professor of Developmental Biology in Neurological Surgery

Publications

selected publications

Research

Funding awarded

Contact

full name

primary email