selected publications
- High-throughput fragment screening identifies a new small molecule scaffold that modulates TREM2 Signaling. Bioorganic & medicinal chemistry. 2026 Academic Article GET IT
- Using biophysical techniques to enhance early-stage drug discovery: the impact and challenges. Expert opinion on drug discovery. 2025 Editorial Article GET IT
- HTS-Oracle: Experimentally validated AI-enabled prioritization for generalizable small molecule hit discovery. bioRxiv : the preprint server for biology. 2025 Article GET IT
- High-Throughput Fragment Screening Identifies a New Small Molecule Scaffold that Modulates TREM2 Signaling. bioRxiv : the preprint server for biology. 2025 Article GET IT
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TREM2 hit discovery using temperature-related intensity change (TRIC) technology: A proof-of-concept high-throughput screening approach.
SLAS discovery : advancing life sciences R & D.
2025
Academic Article
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Times cited: 1 -
TREM2 and LAG-3 in cancer and Alzheimer's disease immunotherapy.
Trends in pharmacological sciences.
2025
Information Resource
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Times cited: 3 - TREM2 Hit Discovery Using TRIC Technology: A Proof-of-Concept High-Throughput Screening Approach. bioRxiv : the preprint server for biology. 2025 Article GET IT
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From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3.
ACS medicinal chemistry letters.
2024
Academic Article
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Times cited: 7 -
Structural Modifications of Covalent Cathepsin S Inhibitors: Impact on Affinity, Selectivity, and Permeability.
ACS medicinal chemistry letters.
2024
Academic Article
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Times cited: 2 -
Dual Strategy to Design New Agents Targeting Schistosoma mansoni: Advancing Phenotypic and SmCB1 Inhibitors for Improved Efficacy.
ACS infectious diseases.
2024
Academic Article
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Times cited: 3 -
Inhibitors of Immune Checkpoints: Small Molecule- and Peptide-Based Approaches.
Journal of personalized medicine.
2024
Information Resource
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Times cited: 20 -
Next Generation of Fluorometric Protease Assays: 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-amides (NBD-Amides) as Class-Spanning Protease Substrates.
Chemistry (Weinheim an der Bergstrasse, Germany).
2023
Academic Article
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Times cited: 3 -
Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible α-Fluorovinylsulfones and α-Sulfonates as Potential Immunomodulators in Cancer.
ChemMedChem.
2023
Academic Article
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Times cited: 5 -
New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins.
European journal of medicinal chemistry.
2022
Academic Article
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Times cited: 11 -
Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues.
ACS chemical biology.
2022
Academic Article
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Times cited: 7 -
Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.
Journal of medicinal chemistry.
2021
Academic Article
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Times cited: 38 -
Applicability of a single-use bioreactor compared to a glass bioreactor for the fermentation of filamentous fungi and evaluation of the reproducibility of growth in pellet form.
Engineering in life sciences.
2021
Academic Article
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Times cited: 7 -
Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery.
Cells.
2020
Information Resource
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Times cited: 43