Boudker, Olga

Publications

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selected publications

Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters. Nature structural & molecular biology. 2025 Academic Article GET IT
Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer. 2025 GET IT
Structural basis of excitatory amino acid transporter 3 substrate recognition. Proceedings of the National Academy of Sciences of the United States of America. 2025 Academic Article GET IT
Free fatty acids inhibit an ion-coupled membrane transporter by dissipating the ion gradient. The Journal of biological chemistry. 2024 Academic Article GET IT
Structural basis of the excitatory amino acid transporter 3 substrate recognition. 2024 GET IT
Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters. 2024 GET IT
HS-AFM single-molecule structural biology uncovers basis of transporter wanderlust kinetics. Nature structural & molecular biology. 2024 Academic Article GET IT
Times cited: 7
Author Correction: Structural basis of pH-dependent activation in a CLC transporter. 2024 GET IT
Ion and lipid orchestration of secondary active transport. Nature. 2024 Review GET IT
Times cited: 22
Structural basis of pH-dependent activation in a CLC transporter. Nature structural & molecular biology. 2024 Academic Article GET IT
Times cited: 9
Symport and antiport mechanisms of human glutamate transporters. Nature communications. 2023 Academic Article GET IT
Times cited: 19
Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by ¹⁹F NMR and Cryo-EM. Journal of the American Chemical Society. 2023 Academic Article GET IT
The archaeal glutamate transporter homologue GltPh shows heterogeneous substrate binding. The Journal of general physiology. 2022 Academic Article GET IT
Times cited: 8
Linking function to global and local dynamics in an elevator-type transporter. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 9
FRET-based Microscopy Assay to Measure Activity of Membrane Amino Acid Transporters with Single-transporter Resolution. Bio-protocol. 2021 Academic Article GET IT
Times cited: 3
Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Science advances. 2021 Academic Article GET IT
Times cited: 37
The high-energy transition state of the glutamate transporter homologue GltPh. The EMBO journal. 2020 Academic Article GET IT
Times cited: 22
Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters. eLife. 2020 Academic Article GET IT
Times cited: 40
Millisecond dynamics of an unlabeled amino acid transporter. Nature communications. 2020 Academic Article GET IT
Times cited: 35
Use of paramagnetic ¹⁹F NMR to monitor domain movement in a glutamate transporter homolog. Nature chemical biology. 2020 Academic Article GET IT
Times cited: 44
Single-molecule transport kinetics of a glutamate transporter homolog shows static disorder. Science advances. 2020 Academic Article GET IT
Times cited: 25
Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh. eLife. 2018 Academic Article GET IT
Times cited: 32
A facile approach for the in vitro assembly of multimeric membrane transport proteins. eLife. 2018 Academic Article GET IT
Times cited: 18
Structural basis of sterol binding and transport by a yeast StARkin domain. The Journal of biological chemistry. 2018 Academic Article GET IT
Times cited: 47
Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5. Nature communications. 2018 Academic Article GET IT
Times cited: 69
Direct visualization of glutamate transporter elevator mechanism by high-speed AFM. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 103
Shared Molecular Mechanisms of Membrane Transporters. Annual review of biochemistry. 2016 Review GET IT
Times cited: 353
The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters. PloS one. 2015 Academic Article GET IT
Times cited: 13
Isothermal titration calorimetry of ion-coupled membrane transporters. Methods (San Diego, Calif.). 2015 Academic Article GET IT
Times cited: 25
Transport domain unlocking sets the uptake rate of an aspartate transporter. Nature. 2015 Academic Article GET IT
Times cited: 136
Coupled ion binding and structural transitions along the transport cycle of glutamate transporters. eLife. 2014 Academic Article GET IT
Times cited: 93
Transport dynamics in a glutamate transporter homologue. Nature. 2013 Academic Article GET IT
Times cited: 147
Chemical catalysis by the translocator protein (18 kDa). Biochemistry. 2013 Academic Article GET IT
Times cited: 30
Binding thermodynamics of a glutamate transporter homolog. Nature structural & molecular biology. 2013 Academic Article GET IT
Times cited: 78
Conformational ensemble of the sodium-coupled aspartate transporter. Nature structural & molecular biology. 2013 Academic Article GET IT
Times cited: 112
Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog. Nature structural & molecular biology. 2012 Academic Article GET IT
Times cited: 137
Structural perspectives on secondary active transporters. Trends in pharmacological sciences. 2010 Review GET IT
Times cited: 126
Transport mechanism of a bacterial homologue of glutamate transporters. Nature. 2009 Academic Article GET IT
Times cited: 369
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature. 2007 Academic Article GET IT
Times cited: 417
Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature. 2004 Academic Article GET IT
Times cited: 699
Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus. Biochemistry. 2003 Academic Article GET IT
Times cited: 84
Isolation and characterization of IIAChb, a soluble protein of the enzyme II complex required for the transport/phosphorylation of N, N'-diacetylchitobiose in Escherichia coli. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 20
The structural stability of the co-chaperonin GroES. Journal of molecular biology. 1997 Academic Article GET IT
Times cited: 71
Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 74

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Research

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Funding awarded

Investigating the Biological Mechanisms and Therapeutic Relevance of the SLC1A1 Amino Acid Transporter in Kidney Cancer awarded by United States Department of Defense Principal Investigator 2025 - 2029
Ion coupling, permeation, and regulation in glutamate transporters awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2024 - 2027

missing activity Co-Investigator 2019 - 2025

Molecular Biophysics Training Program awarded by National Institute of General Medical Sciences Co-Principal Investigator 2025 - 2030
Molecular Biophysics Training Program awarded by National Institute of General Medical Sciences Co-Principal Investigator 2020 - 2025

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Background

education and training

Ph.D., The Johns Hopkins University School of Medicine 1999
M.Sc., Weizmann Institute of Science (Israel) 1993
B.Sc., Novosibirsk State University (Russia) 1990

Contact

full name

Olga Boudker

primary email

olb2003@med.cornell.edu

VIVO Weill Cornell Medical College

Olga Boudker Professor of Biochemistry and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email