selected publications
- Overactive Glutamatergic Basal Forebrain: Compensatory or Causal Mechanism in Cognitive Disorders. Anesthesia and analgesia. 2025 Academic Article GET IT
- Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature. 2024 Academic Article GET IT
- An epigenetic barrier sets the timing of human neuronal maturation. Nature. 2024 Academic Article GET IT
- An anchor-tether 'hindered' HCN1 inhibitor is antihyperalgesic in a rat spared nerve injury neuropathic pain model. British journal of anaesthesia. 2023 Academic Article GET IT
- Probucol is anti-hyperalgesic in a mouse peripheral nerve injury model of neuropathic pain. Neurobiology of pain (Cambridge, Mass.). 2023 Academic Article GET IT
- Ethical considerations for theatre teams in organ donation after circulatory determination of death. British journal of anaesthesia. 2023 Editorial Article GET IT
- Editorial: CNS pain circuits in health and disease. Frontiers in neural circuits. 2022 Editorial Article GET IT
- Mitigation of perioperative neurocognitive disorders: A holistic approach. Frontiers in aging neuroscience. 2022 Review GET IT
- Predictive Value of Emergency Designation on Outcomes of Moribund Patients. Cureus. 2022 Academic Article GET IT
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Patient care in rapid-expansion intensive care units during the COVID-19 pandemic crisis.
BMC anesthesiology.
2022
Academic Article
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Times cited: 6 - Targeting Affective Mood Disorders With Ketamine to Prevent Chronic Postsurgical Pain. Frontiers in pain research (Lausanne, Switzerland). 2022 Review GET IT
- The ethics of quality improvement studies: do the needs of the many outweigh the needs of the few?. British journal of anaesthesia. 2021 Editorial Article GET IT
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Reducing Perioperative Neurocognitive Disorders (PND) Through Depth of Anesthesia Monitoring: A Critical Review.
International journal of general medicine.
2021
Information Resource
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Times cited: 24 -
Obesity as a risk factor for poor outcome in COVID-19-induced lung injury: the potential role of undiagnosed obstructive sleep apnoea.
British journal of anaesthesia.
2020
Letter
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Times cited: 52 -
Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.
Trends in pharmacological sciences.
2019
Information Resource
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Times cited: 157 - Brief Report -The Current State of Biomedical Ethics Education Among Anesthesiology Training Programs: A Call to Arms. The journal of education in perioperative medicine : JEPM. 2019 Academic Article GET IT
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NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells.
Nature biotechnology.
2019
Academic Article
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Times cited: 136 -
Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency.
Biochemical pharmacology.
2019
Academic Article
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Times cited: 6 -
The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment.
Frontiers in psychiatry.
2019
Information Resource
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Times cited: 207 -
Neuromonitoring in the ambulatory anesthesia setting: a pro-con discussion.
Current opinion in anaesthesiology.
2018
Information Resource
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Times cited: 1 -
A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Acetaminophen on Hospital Length of Stay in Obese Individuals Undergoing Sleeve Gastrectomy.
Obesity surgery.
2018
Academic Article
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Times cited: 7 -
Optimizing Patient Access During an Emergency While Using Intraoperative Computed Tomography.
World neurosurgery.
2018
Academic Article
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Times cited: 3 -
HCN and K2P Channels in Anesthetic Mechanisms Research.
Methods in enzymology.
2018
Article
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Times cited: 7 - Relevance of Clinical Relevance. Anesthesiology. 2016 Article GET IT
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Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain?.
Trends in pharmacological sciences.
2016
Information Resource
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Times cited: 61 -
Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability.
Neurobiology of disease.
2016
Academic Article
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Times cited: 51 -
Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease.
Cell stem cell.
2015
Academic Article
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Times cited: 92 -
Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.
Neurobiology of disease.
2015
Academic Article
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Times cited: 36 -
HCN1 Channels as Targets for Volatile Anesthetics: Coming to the Fore.
Anesthesia and analgesia.
2015
Editorial Article
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Times cited: 5 -
Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015
Academic Article
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Times cited: 26 -
Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments.
Anesthesiology.
2015
Academic Article
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Times cited: 10 -
Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.
Frontiers in cellular neuroscience.
2015
Academic Article
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Times cited: 11 -
Facilitating the initiation of the physician's professional identity: Cornell's urban semester program.
Perspectives on medical education.
2014
Academic Article
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Times cited: 7 -
cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.
PloS one.
2014
Academic Article
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Times cited: 3 -
Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.
Cell stem cell.
2013
Academic Article
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Times cited: 468 -
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.
The Journal of pharmacology and experimental therapeutics.
2013
Academic Article
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Times cited: 62 -
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells.
Nature.
2012
Academic Article
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Times cited: 284 -
Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.
PloS one.
2012
Academic Article
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Times cited: 23 -
PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011
Academic Article
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Times cited: 35 - All results count. Anesthesia and analgesia. 2009 Editorial Article GET IT
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The modulation of synaptic GABA(A) receptors in the thalamus by eszopiclone and zolpidem.
The Journal of pharmacology and experimental therapeutics.
2008
Academic Article
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Times cited: 44 -
Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.
Neuropharmacology.
2008
Academic Article
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Times cited: 24 -
Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2008
Academic Article
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Times cited: 100 -
Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008
Academic Article
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Times cited: 148 -
Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus.
The Journal of pharmacology and experimental therapeutics.
2007
Academic Article
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Times cited: 50 -
Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007
Academic Article
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Times cited: 46 -
Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons.
Neuroscience.
2006
Academic Article
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Times cited: 39 -
Supplemental oxygen and risk of surgical wound infection.
JAMA.
2006
Letter
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Times cited: 8 -
Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons.
The European journal of neuroscience.
2006
Academic Article
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Times cited: 62 -
Emerging molecular mechanisms of general anesthetic action.
Trends in pharmacological sciences.
2005
Information Resource
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Times cited: 377 -
An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.
Journal of neurophysiology.
2005
Academic Article
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Times cited: 205 -
Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.
The Journal of pharmacology and experimental therapeutics.
2005
Academic Article
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Times cited: 45 -
A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse.
Genes, brain, and behavior.
2005
Academic Article
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Times cited: 30 -
Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
Molecular pain.
2005
Academic Article
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Times cited: 44 -
Propofol-block of SK channels in reticular thalamic neurons enhances GABAergic inhibition in relay neurons.
Journal of neurophysiology.
2004
Academic Article
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Times cited: 38 -
Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: a randomized controlled trial.
JAMA.
2004
Academic Article
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Times cited: 275 -
Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit.
Journal of neurophysiology.
2002
Academic Article
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Times cited: 76 -
Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury.
The Journal of physiology.
2001
Academic Article
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Times cited: 74 -
Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord (part 2): effects on somatodendritic sites of GABAergic neurons.
Anesthesiology.
2000
Academic Article
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Times cited: 92 -
Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn.
The Journal of physiology.
1998
Academic Article
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Times cited: 104 -
ATP P2X receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1997
Academic Article
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Times cited: 248 -
Calcium entry through a subpopulation of AMPA receptors desensitized neighbouring NMDA receptors in rat dorsal horn neurons.
The Journal of physiology.
1995
Academic Article
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Times cited: 66 -
Variable distributions of Ca(2+)-permeable and Ca(2+)-impermeable AMPA receptors on embryonic rat dorsal horn neurons.
Journal of neurophysiology.
1995
Academic Article
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Times cited: 21 -
A meta-analysis of randomized control trials of progestational agents in pregnancy.
British journal of obstetrics and gynaecology.
1989
Academic Article
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Times cited: 145