selected publications
- MEK inhibitors lead to PDGFR pathway upregulation and sensitize tumors to RAF dimer inhibitors in NF1-deficient malignant peripheral nerve sheath tumor (MPNST). Clinical cancer research : an official journal of the American Association for Cancer Research. 2024 Academic Article GET IT
- The INSIGHT study: a randomized, Phase III study of ripretinib versus sunitinib for advanced gastrointestinal stromal tumor with KIT exon 11 + 17/18 mutations. Future oncology (London, England). 2024 Academic Article GET IT
- Interpretable artificial intelligence to optimise use of imatinib after resection in patients with localised gastrointestinal stromal tumours: an observational cohort study. The Lancet. Oncology. 2024 Academic Article GET IT
- TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer. 2024 GET IT
- Clinicopathologic and molecular correlates to neoadjuvant chemotherapy-induced pathologic response in breast angiosarcoma. Genes, chromosomes & cancer. 2024 Academic Article GET IT
- NF1-Driven Rhabdomyosarcoma Phenotypes: A Comparative Clinical and Molecular Study of NF1-Mutant Rhabdomyosarcoma and NF1-Associated Malignant Triton Tumor. JCO precision oncology. 2024 Academic Article GET IT
- BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer. 2024 GET IT
- Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial. Nature medicine. 2024 Academic Article GET IT
- Activating neutrophils by co-administration of immunogenic recombinant modified vaccinia virus Ankara and granulocyte colony-stimulating factor for the treatment of malignant peripheral nerve sheath tumor. 2023 GET IT
- Immune-related adverse events after immune checkpoint blockade-based therapy are associated with improved survival in advanced sarcomas. Cancer research communications. 2023 Academic Article GET IT
- Novel Genomic Risk Stratification Model for Primary Gastrointestinal Stromal Tumors (GIST) in the Adjuvant Therapy Era. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Academic Article GET IT
- Therapy-induced senescence contributes to the efficacy of abemaciclib in patients with dedifferentiated liposarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Academic Article GET IT
- An interpretable AI model for recurrence prediction after surgery in gastrointestinal stromal tumour: an observational cohort study. EClinicalMedicine. 2023 Academic Article GET IT
- Patient-reported outcomes and tolerability in patients receiving ripretinib versus sunitinib after treatment with imatinib in INTRIGUE, a phase 3, open-label study. European journal of cancer. 2023 Academic Article GET IT
- Distinct genomic landscapes in radiation-associated angiosarcoma compared with other radiation-associated sarcoma histologies. The Journal of pathology. 2023 Academic Article GET IT
- A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Academic Article GET IT
- ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer. Science advances. 2023 Academic Article GET IT
- Charles David Allis (1951-2023). Nature genetics. 2023 Editorial Article GET IT
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Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterations.
NPJ precision oncology.
2023
Academic Article
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Times cited: 8 -
Patient-reported outcomes in individuals with advanced gastrointestinal stromal tumor treated with ripretinib in the fourth-line setting: analysis from the phase 3 INVICTUS trial.
BMC cancer.
2022
Academic Article
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Times cited: 6 - Malignant peripheral nerve sheath tumor in children: A clinicopathologic and molecular study with parallels to the adult counterpart. Genes, chromosomes & cancer. 2022 Academic Article GET IT
- Histology-Specific Prognostication for Radiation-Associated Soft Tissue Sarcoma. JCO precision oncology. 2022 Academic Article GET IT
- The genetic landscape of SMARCB1 alterations in SMARCB1-deficient spectrum of mesenchymal neoplasms. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2022 Academic Article GET IT
- Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses. The Journal of clinical investigation. 2022 Academic Article GET IT
- PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry. Cancer discovery. 2022 Academic Article GET IT
- Efficacy and safety of ripretinib in patients with KIT-altered metastatic melanoma. ESMO open. 2022 Academic Article GET IT
- Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma. Nature communications. 2022 Academic Article GET IT
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Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.
Nature communications.
2022
Academic Article
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Times cited: 74 - Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets. Nature communications. 2022 Academic Article GET IT
- Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets. Science (New York, N.Y.). 2022 Academic Article GET IT
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A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2022
Academic Article
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Times cited: 23 - Clinical, genomic, and transcriptomic correlates of response to immune checkpoint blockade-based therapy in a cohort of patients with angiosarcoma treated at a single center. Journal for immunotherapy of cancer. 2022 Academic Article GET IT
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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer.
Nature communications.
2022
Academic Article
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Times cited: 100 - Long-term Follow-up and Patterns of Response, Progression, and Hyperprogression in Patients after PD-1 Blockade in Advanced Sarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
- Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. Cell. 2022 Academic Article GET IT
- Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors (GIST). Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
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Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2021
Academic Article
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Times cited: 32 -
Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls.
Genes, chromosomes & cancer.
2021
Academic Article
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Times cited: 13 -
Clinical Benefit of Ripretinib Dose Escalation After Disease Progression in Advanced Gastrointestinal Stromal Tumor: An Analysis of the INVICTUS Study.
The oncologist.
2021
Academic Article
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Times cited: 22 -
Ripretinib intrapatient dose escalation after disease progression provides clinically meaningful outcomes in advanced gastrointestinal stromal tumour.
European journal of cancer.
2021
Academic Article
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Times cited: 20 -
Melanoma models for the next generation of therapies.
Cancer cell.
2021
Information Resource
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Times cited: 104 -
The management of metastatic GIST: current standard and investigational therapeutics.
Journal of hematology & oncology.
2021
Review
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Times cited: 140 -
SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies.
Cancer discovery.
2020
Academic Article
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Times cited: 62 -
Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.
The Journal of biological chemistry.
2020
Academic Article
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Times cited: 20 -
ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming.
The Journal of clinical investigation.
2020
Academic Article
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Times cited: 30 -
Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2020
Academic Article
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Times cited: 66 -
HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020
Academic Article
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Times cited: 13 -
Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS): a double-blind, randomised, placebo-controlled, phase 3 trial.
The Lancet. Oncology.
2020
Academic Article
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Times cited: 50 -
Objective Response Rate Among Patients With Locally Advanced or Metastatic Sarcoma Treated With Talimogene Laherparepvec in Combination With Pembrolizumab: A Phase 2 Clinical Trial.
JAMA oncology.
2020
Academic Article
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Times cited: 130 -
Spindle Cell Tumors With RET Gene Fusions Exhibit a Morphologic Spectrum Akin to Tumors With NTRK Gene Fusions.
The American journal of surgical pathology.
2019
Academic Article
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Times cited: 85 -
A Phase I Study of Binimetinib (MEK162) Combined with Pexidartinib (PLX3397) in Patients with Advanced Gastrointestinal Stromal Tumor.
The oncologist.
2019
Academic Article
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Times cited: 32 -
Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes.
Cell systems.
2019
Academic Article
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Times cited: 50 -
Expanding the Molecular Characterization of Thoracic Inflammatory Myofibroblastic Tumors beyond ALK Gene Rearrangements.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2018
Academic Article
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Times cited: 66 -
A phase Ib study of BGJ398, a pan-FGFR kinase inhibitor in combination with imatinib in patients with advanced gastrointestinal stromal tumor.
Investigational new drugs.
2018
Academic Article
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Times cited: 33 -
COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.
The Journal of clinical investigation.
2018
Academic Article
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Times cited: 34 -
GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.
Cell reports.
2018
Academic Article
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Times cited: 56 -
FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor.
Cancer discovery.
2017
Academic Article
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Times cited: 50 -
Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance.
Cancer cell.
2017
Academic Article
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Times cited: 56 -
A Clinicopathologic Study of Head and Neck Malignant Peripheral Nerve Sheath Tumors.
Head and neck pathology.
2017
Academic Article
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Times cited: 17 -
Clinical and Morphologic Characteristics of MEK Inhibitor-Associated Retinopathy: Differences from Central Serous Chorioretinopathy.
Ophthalmology.
2017
Academic Article
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Times cited: 101 -
ETV1-Positive Cells Give Rise to BRAFV600E -Mutant Gastrointestinal Stromal Tumors.
Cancer research.
2017
Academic Article
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Times cited: 13 -
OncoKB: A Precision Oncology Knowledge Base.
JCO precision oncology.
2017
Academic Article
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Times cited: 1655 -
Patient perspectives on ipilimumab across the melanoma treatment trajectory.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2017
Academic Article
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Times cited: 19 -
Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2016
Academic Article
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Times cited: 107 -
Squamous cell carcinoma associated with chronic graft versus host disease-like/lichen planus-like lesion of the oral cavity in a patient managed for metastatic melanoma with a PD-1 inhibitor pembrolizumab.
Oral oncology.
2016
Letter
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Times cited: 7 -
A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon.
PloS one.
2016
Academic Article
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Times cited: 19 -
Overall Survival and Response to Systemic Therapy in Metastatic Extrauterine Leiomyosarcoma.
Sarcoma.
2016
Academic Article
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Times cited: 10 -
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.
Science (New York, N.Y.).
2016
Academic Article
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Times cited: 296 -
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma.
Nature genetics.
2016
Academic Article
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Times cited: 224 -
Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST.
The American journal of surgical pathology.
2016
Academic Article
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Times cited: 229 -
A Phase Ib/II Study of Gemcitabine and Docetaxel in Combination With Pazopanib for the Neoadjuvant Treatment of Soft Tissue Sarcomas.
The oncologist.
2015
Academic Article
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Times cited: 23 -
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.
Nature.
2015
Academic Article
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Times cited: 186 -
Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth.
Cancer discovery.
2015
Academic Article
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Times cited: 113 -
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.
Nature genetics.
2014
Academic Article
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Times cited: 451 -
Organoid cultures derived from patients with advanced prostate cancer.
Cell.
2014
Academic Article
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Times cited: 1144 -
High-risk features in radiation-associated breast angiosarcomas.
British journal of cancer.
2013
Academic Article
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Times cited: 58 -
ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.
Nature medicine.
2013
Academic Article
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Times cited: 237 -
Visualization of the interstitial cells of cajal (ICC) network in mice.
Journal of visualized experiments : JoVE.
2011
Academic Article
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Times cited: 13 -
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours.
Nature.
2010
Academic Article
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Times cited: 268 -
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers.
Nature reviews. Cancer.
2010
Information Resource
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Times cited: 922 -
Chromatin remodeling and cancer, Part I: Covalent histone modifications.
Trends in molecular medicine.
2007
Information Resource
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Times cited: 311 -
Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling.
Trends in molecular medicine.
2007
Information Resource
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Times cited: 193 -
Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies.
Neuron.
2003
Academic Article
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Times cited: 250 -
Regulation of neurotransmitter release by synapsin III.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002
Academic Article
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Times cited: 130 -
Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons.
The Journal of physiology.
2002
Academic Article
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Times cited: 97 -
Synapsin dispersion and reclustering during synaptic activity.
Nature neuroscience.
2001
Academic Article
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Times cited: 272