Chi, Ping

Publications

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selected publications

MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor. Clinical cancer research : an official journal of the American Association for Cancer Research. 2024 Academic Article GET IT
Times cited: 3
The INSIGHT study: a randomized, Phase III study of ripretinib versus sunitinib for advanced gastrointestinal stromal tumor with KIT exon 11 + 17/18 mutations. Future oncology (London, England). 2024 Academic Article GET IT
Times cited: 11
Interpretable artificial intelligence to optimise use of imatinib after resection in patients with localised gastrointestinal stromal tumours: an observational cohort study. The Lancet. Oncology. 2024 Academic Article GET IT
Times cited: 14
TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer. 2024 GET IT
Clinicopathologic and molecular correlates to neoadjuvant chemotherapy-induced pathologic response in breast angiosarcoma. Genes, chromosomes & cancer. 2024 Academic Article GET IT
Times cited: 3
NF1-Driven Rhabdomyosarcoma Phenotypes: A Comparative Clinical and Molecular Study of NF1-Mutant Rhabdomyosarcoma and NF1-Associated Malignant Triton Tumor. JCO precision oncology. 2024 Academic Article GET IT
Times cited: 6
BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer. 2024 GET IT
Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2024 Academic Article GET IT
Times cited: 21
Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial. Nature medicine. 2024 Academic Article GET IT
Times cited: 39
Activating neutrophils by co-administration of immunogenic recombinant modified vaccinia virus Ankara and granulocyte colony-stimulating factor for the treatment of malignant peripheral nerve sheath tumor. 2023 GET IT
Immune-related Adverse Events after Immune Checkpoint Blockade-based Therapy Are Associated with Improved Survival in Advanced Sarcomas. Cancer research communications. 2023 Academic Article GET IT
Times cited: 8
Novel Genomic Risk Stratification Model for Primary Gastrointestinal Stromal Tumors (GIST) in the Adjuvant Therapy Era. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Academic Article GET IT
Times cited: 15
An interpretable AI model for recurrence prediction after surgery in gastrointestinal stromal tumour: an observational cohort study. EClinicalMedicine. 2023 Academic Article GET IT
Times cited: 18
Patient-reported outcomes and tolerability in patients receiving ripretinib versus sunitinib after treatment with imatinib in INTRIGUE, a phase 3, open-label study. European journal of cancer. 2023 Academic Article GET IT
Times cited: 9
Distinct genomic landscapes in radiation-associated angiosarcoma compared with other radiation-associated sarcoma histologies. The Journal of pathology. 2023 Academic Article GET IT
Times cited: 14
A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Academic Article GET IT
Times cited: 39
ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer. Science advances. 2023 Academic Article GET IT
Times cited: 11
Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterations. NPJ precision oncology. 2023 Academic Article GET IT
Times cited: 15
Patient-reported outcomes in individuals with advanced gastrointestinal stromal tumor treated with ripretinib in the fourth-line setting: analysis from the phase 3 INVICTUS trial. BMC cancer. 2022 Academic Article GET IT
Times cited: 8
Malignant peripheral nerve sheath tumor in children: A clinicopathologic and molecular study with parallels to the adult counterpart. Genes, chromosomes & cancer. 2022 Academic Article GET IT
Times cited: 7
Histology-Specific Prognostication for Radiation-Associated Soft Tissue Sarcoma. JCO precision oncology. 2022 Academic Article GET IT
The genetic landscape of SMARCB1 alterations in SMARCB1-deficient spectrum of mesenchymal neoplasms. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2022 Academic Article GET IT
Times cited: 20
PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry. Cancer discovery. 2022 Academic Article GET IT
Times cited: 24
Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses. The Journal of clinical investigation. 2022 Academic Article GET IT
Times cited: 15
DICER1-Associated Anaplastic Sarcoma of the Kidney With Coexisting Activating PDGFRA D842V Mutations and Response to Targeted Kinase Inhibitors in One Patient. 2022 GET IT
Efficacy and safety of ripretinib in patients with KIT-altered metastatic melanoma. ESMO open. 2022 Academic Article GET IT
Times cited: 12
Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma. Nature communications. 2022 Academic Article GET IT
Times cited: 43
Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma. Nature communications. 2022 Academic Article GET IT
Times cited: 129
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets. Nature communications. 2022 Academic Article GET IT
Times cited: 144
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets. Science (New York, N.Y.). 2022 Academic Article GET IT
Times cited: 157
A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Times cited: 34
Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Times cited: 9
Clinical, genomic, and transcriptomic correlates of response to immune checkpoint blockade-based therapy in a cohort of patients with angiosarcoma treated at a single center. Journal for immunotherapy of cancer. 2022 Academic Article GET IT
Times cited: 41
Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. Nature communications. 2022 Academic Article GET IT
Times cited: 155
Long-term Follow-up and Patterns of Response, Progression, and Hyperprogression in Patients after PD-1 Blockade in Advanced Sarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Times cited: 15
FGFR2::TACC2 fusion as a novel KIT-independent mechanism of targeted therapy failure in a multidrug-resistant gastrointestinal stromal tumor. 2022 GET IT
Times cited: 8
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. Cell. 2022 Academic Article GET IT
Times cited: 410
Phase II Trial of Imatinib Plus Binimetinib in Patients With Treatment-Naive Advanced Gastrointestinal Stromal Tumor. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2022 Academic Article GET IT
Times cited: 24
Low-grade endometrial stromal sarcoma-like tumors in male with JAZF1 gene fusions. 2021 GET IT
Times cited: 5
Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Academic Article GET IT
Times cited: 39
Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls. Genes, chromosomes & cancer. 2021 Academic Article GET IT
Times cited: 17
Clinical Benefit of Ripretinib Dose Escalation After Disease Progression in Advanced Gastrointestinal Stromal Tumor: An Analysis of the INVICTUS Study. The oncologist. 2021 Academic Article GET IT
Times cited: 29
Ripretinib intrapatient dose escalation after disease progression provides clinically meaningful outcomes in advanced gastrointestinal stromal tumour. European journal of cancer. 2021 Academic Article GET IT
Times cited: 23
Melanoma models for the next generation of therapies. Cancer cell. 2021 Review GET IT
Times cited: 140
The management of metastatic GIST: current standard and investigational therapeutics. Journal of hematology & oncology. 2021 Review GET IT
Times cited: 189
SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies. Cancer discovery. 2020 Academic Article GET IT
Times cited: 80
Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. The Journal of biological chemistry. 2020 Academic Article GET IT
Times cited: 28
Combined Inhibition of Gα_q and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Comment GET IT
Times cited: 39
Clinical Outcome of Leiomyosarcomas With Somatic Alteration in Homologous Recombination Pathway Genes. JCO precision oncology. 2020 Academic Article GET IT
Times cited: 34
ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 39
GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma. 2020 GET IT
Times cited: 1
Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2020 Academic Article GET IT
Times cited: 83
HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 17
Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS): a double-blind, randomised, placebo-controlled, phase 3 trial. The Lancet. Oncology. 2020 Academic Article GET IT
Times cited: 330
Objective Response Rate Among Patients With Locally Advanced or Metastatic Sarcoma Treated With Talimogene Laherparepvec in Combination With Pembrolizumab: A Phase 2 Clinical Trial. JAMA oncology. 2020 Academic Article GET IT
Times cited: 160
MEK Inhibitor-Associated Central Retinal Vein Occlusion Associated with Hyperhomocysteinemia and MTHFR Variants. 2019 GET IT
Times cited: 13
Spindle Cell Tumors With RET Gene Fusions Exhibit a Morphologic Spectrum Akin to Tumors With NTRK Gene Fusions. The American journal of surgical pathology. 2019 Academic Article GET IT
Times cited: 94
A Phase I Study of Binimetinib (MEK162) Combined with Pexidartinib (PLX3397) in Patients with Advanced Gastrointestinal Stromal Tumor. The oncologist. 2019 Academic Article GET IT
Times cited: 40
Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes. Cell systems. 2019 Academic Article GET IT
Times cited: 52
Expanding the Molecular Characterization of Thoracic Inflammatory Myofibroblastic Tumors beyond ALK Gene Rearrangements. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2018 Academic Article GET IT
Times cited: 75
A phase Ib study of BGJ398, a pan-FGFR kinase inhibitor in combination with imatinib in patients with advanced gastrointestinal stromal tumor. Investigational new drugs. 2018 Academic Article GET IT
Times cited: 37
Basket trial of TRK inhibitors demonstrates efficacy in TRK fusion-positive cancers. Journal of hematology & oncology. 2018 Review GET IT
Times cited: 47
COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 39
GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma. Cell reports. 2018 Academic Article GET IT
Times cited: 65
FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor. Cancer discovery. 2017 Academic Article GET IT
Times cited: 51
Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer cell. 2017 Academic Article GET IT
Times cited: 63
A Clinicopathologic Study of Head and Neck Malignant Peripheral Nerve Sheath Tumors. Head and neck pathology. 2017 Academic Article GET IT
Times cited: 21
Clinical and Morphologic Characteristics of MEK Inhibitor-Associated Retinopathy: Differences from Central Serous Chorioretinopathy. Ophthalmology. 2017 Academic Article GET IT
Times cited: 119
ETV1-Positive Cells Give Rise to BRAF^V600E -Mutant Gastrointestinal Stromal Tumors. Cancer research. 2017 Academic Article GET IT
Times cited: 14
OncoKB: A Precision Oncology Knowledge Base. JCO precision oncology. 2017 Academic Article GET IT
Times cited: 2040
Patient perspectives on ipilimumab across the melanoma treatment trajectory. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2017 Academic Article GET IT
Times cited: 23
Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Academic Article GET IT
Times cited: 116
Squamous cell carcinoma associated with chronic graft versus host disease-like/lichen planus-like lesion of the oral cavity in a patient managed for metastatic melanoma with a PD-1 inhibitor pembrolizumab. Oral oncology. 2016 Letter GET IT
Times cited: 8
A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon. PloS one. 2016 Academic Article GET IT
Times cited: 25
Progression-Free Survival Among Patients With Well-Differentiated or Dedifferentiated Liposarcoma Treated With CDK4 Inhibitor Palbociclib: A Phase 2 Clinical Trial. JAMA oncology. 2016 Academic Article GET IT
Times cited: 281
Overall Survival and Response to Systemic Therapy in Metastatic Extrauterine Leiomyosarcoma. Sarcoma. 2016 Academic Article GET IT
Times cited: 10
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 317
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. Nature genetics. 2016 Academic Article GET IT
Times cited: 247
Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST. The American journal of surgical pathology. 2016 Academic Article GET IT
Times cited: 248
A Phase Ib/II Study of Gemcitabine and Docetaxel in Combination With Pazopanib for the Neoadjuvant Treatment of Soft Tissue Sarcomas. The oncologist. 2015 Academic Article GET IT
Times cited: 24
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer. Nature. 2015 Academic Article GET IT
Times cited: 203
Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Cancer discovery. 2015 Academic Article GET IT
Times cited: 117
Additional Primary Malignancies in Patients with Gastrointestinal Stromal Tumor (GIST): A Clinicopathologic Study of 260 Patients with Molecular Analysis and Review of the Literature. Annals of surgical oncology. 2015 Review GET IT
Times cited: 46
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nature genetics. 2014 Academic Article GET IT
Times cited: 502
Organoid cultures derived from patients with advanced prostate cancer. Cell. 2014 Academic Article GET IT
Times cited: 1272
High-risk features in radiation-associated breast angiosarcomas. British journal of cancer. 2013 Academic Article GET IT
Times cited: 64
ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nature medicine. 2013 Academic Article GET IT
Times cited: 246
Visualization of the interstitial cells of cajal (ICC) network in mice. Journal of visualized experiments : JoVE. 2011 Academic Article GET IT
Times cited: 13
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature. 2010 Academic Article GET IT
Times cited: 280
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nature reviews. Cancer. 2010 Review GET IT
Times cited: 968
Chromatin remodeling and cancer, Part I: Covalent histone modifications. Trends in molecular medicine. 2007 Review GET IT
Times cited: 311
Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling. Trends in molecular medicine. 2007 Review GET IT
Times cited: 200
Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies. Neuron. 2003 Academic Article GET IT
Times cited: 250
Regulation of neurotransmitter release by synapsin III. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Academic Article GET IT
Times cited: 134
Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons. The Journal of physiology. 2002 Academic Article GET IT
Times cited: 101
Synapsin dispersion and reclustering during synaptic activity. Nature neuroscience. 2001 Academic Article GET IT
Times cited: 272

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Background

education and training

B.A., Mount Holyoke College 96
M.D., Cornell University Medical College 2003
Ph.D., The Rockefeller University 2002

Contact

full name

Ping Chi

primary email

chip@mskcc.org

VIVO Weill Cornell Medical College

Ping Chi Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email