Zhou, Ping

Publications

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selected publications

A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury. Nature neuroscience. 2024 Academic Article GET IT
Correction: Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress. 2024 GET IT
tPA supplementation preserves neurovascular and cognitive function in Tg2576 mice. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 Academic Article GET IT
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress. Molecular neurodegeneration. 2023 Academic Article GET IT
Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation. Nature communications. 2023 Academic Article GET IT
Novel method of isolating nuclei of human oligodendrocyte precursor cells reveals substantial developmental changes in gene expression and H3K27ac histone modification. Glia. 2023 Academic Article GET IT
Role of microglial and endothelial CD36 in post-ischemic inflammasome activation and interleukin-1β-induced endothelial activation. Brain, behavior, and immunity. 2021 Academic Article GET IT
Times cited: 14
Sexual Dimorphism in Differentiating Osteoclast Precursors Demonstrates Enhanced Inflammatory Pathway Activation in Female Cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021 Academic Article GET IT
tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020 Academic Article GET IT
Times cited: 35
Elevated post-ischemic ubiquitination results from suppression of deubiquitinase activity and not proteasome inhibition. Cellular and molecular life sciences : CMLS. 2020 Academic Article GET IT
Times cited: 8
Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration. Nature neuroscience. 2020 Academic Article GET IT
Times cited: 72
Prohibitin S-Nitrosylation Is Required for the Neuroprotective Effect of Nitric Oxide in Neuronal Cultures. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020 Academic Article GET IT
Prohibitin levels regulate OMA1 activity and turnover in neurons. Cell death and differentiation. 2019 Academic Article GET IT
Times cited: 38
Alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference. Communications biology. 2019 Academic Article GET IT
Times cited: 7
AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke. Cell reports. 2019 Academic Article GET IT
Times cited: 18
Prohibitin is a positive modulator of mitochondrial function in PC12 cells under oxidative stress. Journal of neurochemistry. 2018 Academic Article GET IT
Times cited: 36
Critical Role of Flavin and Glutathione in Complex I-Mediated Bioenergetic Failure in Brain Ischemia/Reperfusion Injury. Stroke. 2018 Academic Article GET IT
Times cited: 67
Estrogen receptor beta modulates permeability transition in brain mitochondria. Biochimica et biophysica acta. Bioenergetics. 2018 Academic Article GET IT
Times cited: 41
Neuronal expression of the mitochondrial protein prohibitin confers profound neuroprotection in a mouse model of focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2017 Academic Article GET IT
Times cited: 15
Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides. Circulation research. 2017 Academic Article GET IT
Times cited: 167
Obligatory Role of EP1 Receptors in the Increase in Cerebral Blood Flow Produced by Hypercapnia in the Mice. PloS one. 2016 Academic Article GET IT
Times cited: 6
Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Academic Article GET IT
Times cited: 132
The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction. Nature communications. 2014 Academic Article GET IT
Times cited: 108
Inducible nitric oxide synthase in neutrophils and endothelium contributes to ischemic brain injury in mice. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 109
Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy. Stroke. 2014 Academic Article GET IT
Times cited: 93
Dichotomous effects of chronic intermittent hypoxia on focal cerebral ischemic injury. Stroke. 2014 Academic Article GET IT
Times cited: 41
Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia and ameliorates postischemic hippocampal dysfunction. Stroke. 2014 Academic Article GET IT
Times cited: 30
Progranulin deficiency promotes post-ischemic blood-brain barrier disruption. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Academic Article GET IT
Times cited: 77
COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organ. American journal of physiology. Heart and circulatory physiology. 2013 Academic Article GET IT
Times cited: 30
Lipoprotein receptor-related protein-6 protects the brain from ischemic injury. Stroke. 2013 Academic Article GET IT
Times cited: 20
Prostaglandin E2 type 1 receptors contribute to neuronal apoptosis after transient forebrain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013 Academic Article GET IT
Times cited: 31
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 108
Genetic deletion of CD36 enhances injury after acute neonatal stroke. Annals of neurology. 2012 Academic Article GET IT
Times cited: 71
Brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain. Stroke. 2012 Academic Article GET IT
Times cited: 50
Angiotensin II type 2 receptor-coupled nitric oxide production modulates free radical availability and voltage-gated Ca2+ currents in NTS neurons. American journal of physiology. Regulatory, integrative and comparative physiology. 2012 Academic Article GET IT
Times cited: 24
Prohibitin reduces mitochondrial free radical production and protects brain cells from different injury modalities. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 77
Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. PloS one. 2011 Academic Article GET IT
Times cited: 30
Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 128
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 137
The scavenger receptor CD36 contributes to the neurotoxicity of bone marrow-derived monocytes through peroxynitrite production. Neurobiology of disease. 2011 Academic Article GET IT
Times cited: 11
Enhanced dendritic availability of μ-opioid receptors in inhibitory neurons of the extended amygdala in mice deficient in the corticotropin-releasing factor-1 receptor. Synapse (New York, N.Y.). 2011 Academic Article GET IT
Times cited: 6
Distribution of estrogen receptor β containing cells in the brains of bacterial artificial chromosome transgenic mice. Brain research. 2010 Academic Article GET IT
Times cited: 61
Gender differences in cardiovascular risks of obese adolescents in the Bronx. Journal of clinical research in pediatric endocrinology. 2010 Academic Article GET IT
Times cited: 6
Key role of CD36 in Toll-like receptor 2 signaling in cerebral ischemia. Stroke. 2010 Academic Article GET IT
Times cited: 110
Cyclooxygenase 1-derived prostaglandin E2 and EP1 receptors are required for the cerebrovascular dysfunction induced by angiotensin II. Hypertension (Dallas, Tex. : 1979). 2010 Academic Article GET IT
Times cited: 57
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. The Journal of experimental medicine. 2009 Academic Article GET IT
Times cited: 398
Spatial and intracellular relationships between the alpha7 nicotinic acetylcholine receptor and the vesicular acetylcholine transporter in the prefrontal cortex of rat and mouse. Neuroscience. 2009 Academic Article GET IT
Times cited: 41
Normal responses to restraint stress in mice lacking the gene for neuronal nitric oxide synthase. Journal of andrology. 2009 Academic Article GET IT
Times cited: 9
NMDA receptor activation increases free radical production through nitric oxide and NOX2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Times cited: 213
Electron microscopic localization of corticotropin-releasing factor (CRF) and CRF receptor in rat and mouse central nucleus of the amygdala. The Journal of comparative neurology. 2009 Academic Article GET IT
Times cited: 30
The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2008 Academic Article GET IT
Times cited: 73
Insulin receptor autoimmunity and insulin resistance. Journal of pediatric endocrinology & metabolism : JPEM. 2008 Academic Article GET IT
Times cited: 2
Nuclear factor-kappaB activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 100
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 280
Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway. Neurobiology of disease. 2007 Academic Article GET IT
Times cited: 51
Lipopolysaccharide induces early tolerance to excitotoxicity via nitric oxide and cGMP. Stroke. 2007 Academic Article GET IT
Times cited: 34
MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 176
Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Academic Article GET IT
Times cited: 125
N-terminal truncation of antiapoptotic MCL1, but not G2/M-induced phosphorylation, is associated with stabilization and abundant expression in tumor cells. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 37
Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2007 Academic Article GET IT
Times cited: 195
iNOS-derived NO and nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2007 Academic Article GET IT
Times cited: 39
Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. Arteriosclerosis, thrombosis, and vascular biology. 2006 Academic Article GET IT
Times cited: 106
Testosterone production in mice lacking inducible nitric oxide synthase expression is sensitive to restraint stress. American journal of physiology. Endocrinology and metabolism. 2006 Academic Article GET IT
Times cited: 16
Nox2, Ca2+, and protein kinase C play a role in angiotensin II-induced free radical production in nucleus tractus solitarius. Hypertension (Dallas, Tex. : 1979). 2006 Academic Article GET IT
Times cited: 92
Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006 Academic Article GET IT
Times cited: 70
Evidence that estrogen directly and indirectly modulates C1 adrenergic bulbospinal neurons in the rostral ventrolateral medulla. Brain research. 2006 Academic Article GET IT
Times cited: 46
Inducible nitric oxide synthase contributes to gender differences in ischemic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006 Academic Article GET IT
Times cited: 102
Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals. Arteriosclerosis, thrombosis, and vascular biology. 2006 Academic Article GET IT
Times cited: 118
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nature medicine. 2006 Academic Article GET IT
Times cited: 313
Mitochondria are involved in the neurogenic neuroprotection conferred by stimulation of cerebellar fastigial nucleus. Journal of neurochemistry. 2005 Academic Article GET IT
Times cited: 27
Obligatory role of inducible nitric oxide synthase in ischemic preconditioning. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2005 Academic Article GET IT
Times cited: 100
Nitric oxide inhibits caspase activation and apoptotic morphology but does not rescue neuronal death. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2005 Academic Article GET IT
Times cited: 42
NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 221
Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury. Stroke. 2004 Academic Article GET IT
Times cited: 65
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circulation research. 2004 Academic Article GET IT
Times cited: 187
Exogenous NADPH increases cerebral blood flow through NADPH oxidase-dependent and -independent mechanisms. Arteriosclerosis, thrombosis, and vascular biology. 2004 Academic Article GET IT
Times cited: 50
Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity. Annals of neurology. 2004 Academic Article GET IT
Times cited: 127
Neurogenic neuroprotection. Cellular and molecular neurobiology. 2003 Information Resource GET IT
Times cited: 30
Electrical stimulation of cerebellar fastigial nucleus protects rat brain, in vitro, from staurosporine-induced apoptosis. Journal of neurochemistry. 2001 Academic Article GET IT
Times cited: 28
Specific actions of cyanide on membrane potential and voltage-gated ion currents in rostral ventrolateral medulla neurons in rat brainstem slices. Neuroscience letters. 2001 Academic Article GET IT
Times cited: 21
MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes. Blood. 2001 Academic Article GET IT
Times cited: 158
Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 152
Protection from cell death by mcl-1 is mediated by membrane hyperpolarization induced by K(+) channel activation. The Journal of membrane biology. 1999 Academic Article GET IT
Times cited: 37
Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 114
Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage. Blood. 1998 Academic Article GET IT
Times cited: 148
Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms. The American journal of pathology. 1997 Academic Article GET IT
Times cited: 176
Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions. Blood. 1997 Academic Article GET IT
Times cited: 301
Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells. Cancer research. 1994 Academic Article GET IT
Times cited: 250
Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease. Genomics. 1994 Academic Article GET IT
Times cited: 43

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Research

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Funding awarded

Role of prohibitin nitrosylation in its neuroprotective functions awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2027

ApoE4, neurovascular injury and cognitive impairment awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2022 - 2027
Dietary sodium, neurovascular dysfunction and cerebrovascular risk awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2021 - 2026

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Background

education and training

Ph.D., University of Illinois at Urbana-Champaign 91
B.S., Nanjing University (China) 1982

Contact

full name

Ping Zhou

primary email

piz2001@med.cornell.edu

VIVO Weill Cornell Medical College

Ping Zhou Associate Professor of Research in Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email