Heerdt, Paul M

Publications

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selected publications

Method for generating right ventricular pressure-volume loops in routine practice. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2025 Academic Article GET IT
"Right Ventricular Function and Echocardiographic Pressure-volume Loops": There Is More to the Story. Journal of cardiothoracic and vascular anesthesia. 2025 Letter GET IT
Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. 2025 GET IT
Early detection of lung injury and matrix metalloproteinase activation in ARDS could improve diagnostic and therapeutic strategies?. Expert review of respiratory medicine. 2025 Editorial Article GET IT
Preoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications. BJA open. 2025 Academic Article GET IT
Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study. JMIR perioperative medicine. 2025 Academic Article GET IT
Times cited: 1
Biventricular Response to Positive End-expiratory Pressure in Swine: Assessment Based on Beat-to-beat Pressure Waveform Analysis. Anesthesiology. 2025 Academic Article GET IT
Exercise Limitation in Pulmonary Hypertension - Physiological Insights into the 6-Minute Walk Test. American journal of respiratory and critical care medicine. 2024 Letter GET IT
Times cited: 1
The metabolic and physiologic impairments underlying long COVID associated exercise intolerance. Pulmonary circulation. 2024 Academic Article GET IT
Right Ventricular Pressure Waveform Analysis-Clinical Relevance and Future Directions. Journal of cardiothoracic and vascular anesthesia. 2024 Review GET IT
Times cited: 3
Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period. Perioperative medicine (London, England). 2024 Review GET IT
Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ open research. 2024 Academic Article GET IT
Times cited: 6
Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal of intensive care medicine. 2023 Review GET IT
Times cited: 5
Integrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical Application. Journal of cardiothoracic and vascular anesthesia. 2023 Academic Article GET IT
Times cited: 5
Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload. International journal of molecular sciences. 2023 Academic Article GET IT
Times cited: 1
Response to letter to the editor "noninvasive determinants of pulmonary hypertension in interstitial lung disease". Pulmonary circulation. 2023 Academic Article GET IT
Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS-CoV-2 infection (PASC) syndrome. Pulmonary circulation. 2023 Academic Article GET IT
Times cited: 7
Noninvasive determinants of pulmonary hypertension in interstitial lung disease. Pulmonary circulation. 2023 Academic Article GET IT
Times cited: 16
Corrigendum to 'Impaired systemic oxygen extraction long after mild COVID-19: potential perioperative implications' (Br J Anaesth 2022; 128: e246-9). 2022 GET IT
ISHLT consensus statement: Perioperative management of patients with pulmonary hypertension and right heart failure undergoing surgery. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2022 Editorial Article GET IT
Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience. Anesthesia and analgesia. 2022 Academic Article GET IT
Times cited: 6
Pressure-based estimation of right ventricular ejection fraction. ESC heart failure. 2022 Academic Article GET IT
Times cited: 10
Reply to Grignola and Trujillo. Journal of applied physiology (Bethesda, Md. : 1985). 2022 Letter GET IT
Invasive Right Ventricular Pressure-Volume Analysis: Basic Principles, Clinical Applications, and Practical Recommendations. Circulation. Heart failure. 2021 Academic Article GET IT
Times cited: 95
Impaired systemic oxygen extraction long after mild COVID-19: potential perioperative implications. British journal of anaesthesia. 2021 Letter GET IT
Times cited: 10
Visualizing the Immediate Hemodynamic Impact of Successful Transcatheter Edge-to-Edge Repair of the Mitral Valve. Journal of cardiothoracic and vascular anesthesia. 2021 Letter GET IT
Times cited: 1
Defining end-systolic pressure for single-beat estimation of right ventricle-pulmonary artery coupling: simple… but not really. ERJ open research. 2021 Academic Article GET IT
Times cited: 9
Persistent Exertional Intolerance After COVID-19: Insights From Invasive Cardiopulmonary Exercise Testing. Chest. 2021 Academic Article GET IT
Times cited: 245
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension. Journal of pharmacological and toxicological methods. 2021 Academic Article GET IT
Times cited: 4
Arterial load and right ventricular-vascular coupling in pulmonary hypertension. Journal of applied physiology (Bethesda, Md. : 1985). 2021 Academic Article GET IT
Times cited: 22
Preoperative Assessment and Perioperative Management of the Patient with Pulmonary Vascular Disease. Clinics in chest medicine. 2021 Review GET IT
Times cited: 6
Sex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection Fraction. Chest. 2021 Academic Article GET IT
Times cited: 22
Diagnostic utility of sub-maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction. Pulmonary circulation. 2020 Academic Article GET IT
Times cited: 12
The glymphatic system and its role in cerebral homeostasis. Journal of applied physiology (Bethesda, Md. : 1985). 2020 Academic Article GET IT
Times cited: 27
A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept. The European respiratory journal. 2020 Letter GET IT
Times cited: 31
Heart rate variability measures for prediction of severity of illness and poor outcome in ED patients with sepsis. The American journal of emergency medicine. 2020 Academic Article GET IT
Times cited: 15
Response to letter by Drs. Bottinger and van der Hoorn. Intensive care medicine experimental. 2019 Article GET IT
Glymphatic System Function in Relation to Anesthesia and Sleep States. Anesthesia and analgesia. 2019 Review GET IT
Times cited: 121
Automated expiratory ventilation assistance through a small endotracheal tube can improve venous return and cardiac output. Intensive care medicine experimental. 2019 Academic Article GET IT
Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine. Anesthesiology. 2018 Academic Article GET IT
Times cited: 1
Blood Pressure Targets in Perioperative Care. Hypertension (Dallas, Tex. : 1979). 2018 Review GET IT
Times cited: 149
Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers. Anesthesiology. 2018 Academic Article GET IT
Perioperative pulmonary thromboembolism: current concepts and treatment options. Current opinion in anaesthesiology. 2018 Information Resource GET IT
Times cited: 3
Accuracy of a Simulation Algorithm for Modelling LV Contractility, Diastolic Capacitance, and Energetics Using Data Available From Common Hemodynamic Monitors and Echocardiography. Journal of cardiothoracic and vascular anesthesia. 2017 Academic Article GET IT
Times cited: 1
Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases. The Journal of experimental medicine. 2017 Academic Article GET IT
Times cited: 35
Bridging the Educational Gap in Thoracic Anesthesia. Journal of cardiothoracic and vascular anesthesia. 2017 Editorial Article GET IT
Times cited: 1
Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution During Hemorrhagic Shock and Resuscitation in Adult Swine. Critical care medicine. 2017 Academic Article GET IT
Times cited: 4
Anesthesia for nonintubated video-assisted thoracic surgery. Current opinion in anaesthesiology. 2017 Review GET IT
Times cited: 23
Single-lung ventilation and oxidative stress: a different perspective on a common practice. Current opinion in anaesthesiology. 2017 Review GET IT
Times cited: 17
Dose-response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man. Anesthesiology. 2016 Academic Article GET IT
Times cited: 9
Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine-Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat. Anesthesiology. 2016 Academic Article GET IT
Novel neuromuscular blocking drugs and antagonists. Current opinion in anaesthesiology. 2015 Information Resource GET IT
Times cited: 9
Effect of gantacurium on evoked laryngospasm and duration of apnea in anesthetized healthy cats. American journal of veterinary research. 2015 Academic Article GET IT
Times cited: 3
Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 4
Comparative pharmacodynamics of pancuronium, cisatracurium, and CW002 in rabbits. Journal of the American Association for Laboratory Animal Science : JAALAS. 2014 Academic Article GET IT
Times cited: 12
NHE isoform switching and KChIP2 upregulation in aging porcine atria. PloS one. 2013 Academic Article GET IT
Times cited: 4
Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy. Journal of molecular and cellular cardiology. 2012 Academic Article GET IT
Times cited: 12
Anesthesia and pulmonary hypertension. Progress in cardiovascular diseases. 2012 Review GET IT
Times cited: 30
Letter to the editor: response to Ballestero et al. Pediatric cardiology. 2011 Article GET IT
Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles. Journal of pharmacological and toxicological methods. 2011 Academic Article GET IT
Times cited: 21
Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011. Anesthesiology. 2010 Academic Article GET IT
Times cited: 25
Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology. Anesthesiology. 2010 Academic Article GET IT
Times cited: 13
Pharmacodynamics and cardiopulmonary side effects of CW002, a cysteine-reversible neuromuscular blocking drug in dogs. Anesthesiology. 2010 Academic Article GET IT
Times cited: 14
Minimally invasive surgical techniques in the treatment of lung cancer. Minerva chirurgica. 2009 Information Resource GET IT
Times cited: 8
Postoperative care after pulmonary resection: postanesthesia care unit versus intensive care unit. Current opinion in anaesthesiology. 2009 Information Resource GET IT
Times cited: 13
Re: Undersizing left double-lumen tubes. Anesthesia and analgesia. 2008 Article GET IT
The emerging role of minimally invasive surgical techniques for the treatment of lung malignancy in the elderly. Anesthesiology clinics. 2008 Information Resource GET IT
Times cited: 7
Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma. Journal of neurochemistry. 2008 Academic Article GET IT
Times cited: 7
Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation. Metabolic brain disease. 2008 Academic Article GET IT
Times cited: 2
Nitrosative stress and myocardial sarcoplasmic endoreticular calcium adenosine triphosphatase subtype 2a activity after lung resection in swine. Anesthesiology. 2007 Academic Article GET IT
Inflammation and outcome after general thoracic surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2007 Academic Article GET IT
Times cited: 40
Differential regulation of protein phosphatase-1(I) by neurabin. Biochemical and biophysical research communications. 2007 Academic Article GET IT
Pulmonary resection in the elderly. Current opinion in anaesthesiology. 2007 Information Resource GET IT
Times cited: 14
Systemic oxidative stress associated with lung resection during single lung ventilation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2006 Article GET IT
Times cited: 5
Cardiomyopathic etiology and SERCA2a reverse remodeling during mechanical support of the failing human heart. Anesthesia and analgesia. 2006 Academic Article GET IT
Times cited: 15
Hemodynamic effects of di-sec-butyl phenol, an anesthetic substituted phenol. Pharmacology. 2005 Academic Article GET IT
Times cited: 1
Statin use is associated with a reduction in atrial fibrillation after noncardiac thoracic surgery independent of C-reactive protein. Chest. 2005 Academic Article GET IT
Times cited: 158
Anesthetic-induced alteration in expression of myocardial calcium cycling proteins. Journal of cardiothoracic and vascular anesthesia. 2005 Academic Article GET IT
Times cited: 2
Ectonucleoside triphosphate diphosphohydrolase 1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis. The Journal of pharmacology and experimental therapeutics. 2005 Academic Article GET IT
Times cited: 28
Autonomic mechanisms in the age-related hypotensive effect of propofol. Anesthesia and analgesia. 2005 Academic Article GET IT
Times cited: 10
Anesthesia and multiorgan protein remodeling. Anesthesiology. 2004 Article GET IT
Tobacco smoke induces CYP1B1 in the aerodigestive tract. Carcinogenesis. 2004 Academic Article GET IT
Times cited: 69
Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs. Anesthesiology. 2004 Academic Article GET IT
Times cited: 17
Phospholipid abnormalities in children with Barth syndrome. Journal of the American College of Cardiology. 2003 Academic Article GET IT
Times cited: 144
Increased severity of reperfusion arrhythmias in mouse hearts lacking histamine H3-receptors. Biochemical and biophysical research communications. 2003 Academic Article GET IT
Times cited: 18
Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome. Annals of neurology. 2002 Academic Article GET IT
Times cited: 200
The effects of advanced age on the incidence of supraventricular arrhythmias after pneumonectomy in dogs. Anesthesia and analgesia. 2002 Academic Article GET IT
Times cited: 6
Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device. The Annals of thoracic surgery. 2002 Academic Article GET IT
Times cited: 45
Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure: a primary role of mechanical unloading underlying reverse remodeling. Circulation. 2001 Academic Article GET IT
Times cited: 156
Flow dependency of error in thermodilution measurement of cardiac output during acute tricuspid regurgitation. Journal of cardiothoracic and vascular anesthesia. 2001 Academic Article GET IT
Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure. Circulation. 2000 Academic Article GET IT
Times cited: 246
Isoflurane pretreatment ameliorates postischemic neurologic dysfunction and preserves hippocampal Ca2+/calmodulin-dependent protein kinase in a canine cardiac arrest model. Anesthesiology. 2000 Academic Article GET IT
Disparity of isoflurane effects on left and right ventricular afterload and hydraulic power generation in swine. Anesthesia and analgesia. 1998 Academic Article GET IT
Times cited: 28
Intrapulmonary shunt fraction and prostaglandin E1. Anesthesia and analgesia. 1998 Article GET IT
Effects of vasoactive medications on the blood flow of island musculocutaneous flaps in swine. Annals of plastic surgery. 1997 Academic Article GET IT
Times cited: 53
Glutathione metabolism in patients with non-small cell lung cancers. Cancer research. 1997 Academic Article GET IT
Times cited: 67
Nitric oxide synthesis inhibition and right ventricular systolic function in swine. Journal of cardiothoracic and vascular anesthesia. 1996 Academic Article GET IT
Times cited: 4
The dose-dependent effects of halothane on right ventricular contraction pattern and regional inotropy in swine. Anesthesia and analgesia. 1996 Academic Article GET IT
Times cited: 26
Effect of halothane on in vivo and in vitro cardiotoxicity of an aminocardenolide. Journal of cardiovascular pharmacology. 1994 Academic Article GET IT
Times cited: 2
Comparison of cardiac output measured by intrapulmonary artery Doppler, thermodilution, and electromagnetometry. The Annals of thoracic surgery. 1992 Academic Article GET IT
Times cited: 16
Intrapulmonary Doppler for continuous measurement of cardiac output. Journal of cardiothoracic and vascular anesthesia. 1992 Article GET IT
The Washington University-Barnes Hospital experience with lung transplantation. Washington University Lung Transplantation Group. JAMA. 1991 Academic Article GET IT
Times cited: 52
The cardiovascular response to digoxin in conscious dogs with left atrial obstruction. Journal of cardiothoracic anesthesia. 1990 Academic Article GET IT
Times cited: 2
Prostaglandin E1 and intrapulmonary shunt in cardiac surgical patients with pulmonary hypertension. The Annals of thoracic surgery. 1990 Academic Article GET IT
Times cited: 21
The mechanism of nitrous oxide-induced changes in pulmonary vascular resistance in a dog model of left atrial outflow obstruction. Journal of cardiothoracic anesthesia. 1989 Academic Article GET IT
Times cited: 7
Life-threatening ECG artifact during extracorporeal shock wave lithotripsy. Anesthesiology. 1988 Article GET IT
Times cited: 6
PGI2 synthesis and excretion in dog kidney: evidence for renal PG compartmentalization. The American journal of physiology. 1986 Academic Article GET IT
Times cited: 16

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Background

education and training

B.S., Memphis State University 78
Ph.D., University of Tennessee 1985
M.D., University of Tennessee College of Medicine 1982

Contact

full name

Paul M Heerdt

primary email

pmheerd@med.cornell.edu

VIVO Weill Cornell Medical College

Paul M Heerdt Adjunct Clinical Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email