Raphael Lis Assistant Professor of Reproductive Medicine in Medicine

Assistant Professor of Reproductive Medicine in Medicine, Medicine , Weill Cornell Medical College 2019 -
Assistant Professor of Reproductive Medicine, Reproductive Medicine , Weill Cornell Medical College 2019 -
Instructor of Reproductive Medicine in Medicine, Medicine , Weill Cornell Medical College 2015 - 2019
Instructor in Reproductive Medicine, Reproductive Medicine , Weill Cornell Medical College 2015 - 2019
Research Associate in Medicine, Medicine , Weill Cornell Medical College 2014 - 2015
Research Associate in Reproductive Medicine, Reproductive Medicine , Weill Cornell Medical College 2014 - 2015
Research Associate in Genetic Medicine, Genetic Medicine , Weill Cornell Medical College 2014 - 2014
Postdoctoral Associate in Genetic Medicine, Genetic Medicine , Weill Cornell Medical College 2012 - 2014

Publications

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selected publications

Mice with Lymphatic Dysfunction Develop Pathogenic Lung Tertiary Lymphoid Organs that Model an Autoimmune Emphysema Phenotype of COPD. American journal of physiology. Lung cellular and molecular physiology. 2024 Academic Article GET IT
Lung lymphatic endothelial cells undergo inflammatory and prothrombotic changes in a model of chronic obstructive pulmonary disease. Frontiers in cell and developmental biology. 2024 Academic Article GET IT
Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids. Translational psychiatry. 2024 Academic Article GET IT
Lymphatic Dysfunction Models an Autoimmune Emphysema Phenotype of Chronic Obstructive Pulmonary Disease. 2023 GET IT
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell stem cell. 2022 Academic Article GET IT
Times cited: 40
Angiocrine ANGPTL2 executes HSC functions in endothelial niche. Blood. 2022 Editorial Article GET IT
Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability. Nature cell biology. 2021 Academic Article GET IT
Times cited: 26
Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. Genes & development. 2021 Academic Article GET IT
Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells: Current Controversies. Frontiers in physiology. 2021 Academic Article GET IT
Times cited: 31
Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice. Communications biology. 2021 Academic Article GET IT
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 136
Molecular determinants of nephron vascular specialization in the kidney. Nature communications. 2019 Academic Article GET IT
Times cited: 85
Haematopoietic stem cell reprogramming and the hope for a universal blood product. FEBS letters. 2019 Information Resource GET IT
Times cited: 2
Akt-activated endothelium promotes ovarian cancer proliferation through notch activation. Journal of translational medicine. 2019 Academic Article GET IT
Times cited: 16
In vitro conversion of adult murine endothelial cells to hematopoietic stem cells. Nature protocols. 2018 Academic Article GET IT
Times cited: 6
Discovery of a drug candidate for GLIS3-associated diabetes. Nature communications. 2018 Academic Article GET IT
Times cited: 49
CCL2/CCL5 secreted by the stroma induce IL-6/PYK2 dependent chemoresistance in ovarian cancer. Molecular cancer. 2018 Academic Article GET IT
Times cited: 64
Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 56
Activated ovarian endothelial cells promote early follicular development and survival. Journal of ovarian research. 2017 Academic Article GET IT
Times cited: 7
Post-translational control of T cell development by the ESCRT protein CHMP5. Nature immunology. 2017 Academic Article GET IT
Times cited: 23
Conversion of adult endothelium to immunocompetent haematopoietic stem cells. Nature. 2017 Academic Article GET IT
Times cited: 167
Sox17 drives functional engraftment of endothelium converted from non-vascular cells. Nature communications. 2017 Academic Article GET IT
Times cited: 18
Notch hyper-activation drives trans-differentiation of hESC-derived endothelium. Stem cell research. 2016 Academic Article GET IT
Times cited: 8
Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis. Nature medicine. 2016 Academic Article GET IT
Times cited: 217
The transcription factor XBP1 is selectively required for eosinophil differentiation. Nature immunology. 2015 Academic Article GET IT
Times cited: 143
Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration. Nature cell biology. 2015 Academic Article GET IT
Times cited: 124
Predictive markers of chemoresistance in advanced stages epithelial ovarian carcinoma. Gynecologic oncology. 2014 Academic Article GET IT
Times cited: 45
Akt-activated endothelium constitutes the niche for residual disease and resistance to bevacizumab in ovarian cancer. Molecular cancer therapeutics. 2014 Academic Article GET IT
Times cited: 18
Role of mesenchymal cells in the natural history of ovarian cancer: a review. Journal of translational medicine. 2014 Review GET IT
Times cited: 28
Reprogramming human endothelial cells to haematopoietic cells requires vascular induction. Nature. 2014 Academic Article GET IT
Times cited: 186
Mesenchymal cell interaction with ovarian cancer cells induces a background dependent pro-metastatic transcriptomic profile. Journal of translational medicine. 2014 Academic Article GET IT
Times cited: 29
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature. 2013 Academic Article GET IT
Times cited: 515
Lymphatic and nerve distribution throughout the parametrium. Gynecologic oncology. 2013 Academic Article GET IT
Times cited: 15
Wading through the waves of human embryonic hemogenesis. Cell cycle (Georgetown, Tex.). 2013 Editorial Article GET IT
Times cited: 2
Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model. Journal of translational medicine. 2013 Academic Article GET IT
Times cited: 67
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition. Blood. 2012 Academic Article GET IT
Times cited: 65
Comprehensive characterization of mesenchymal stem cells from human placenta and fetal membrane and their response to osteoactivin stimulation. Stem cells international. 2012 Academic Article GET IT
Times cited: 68
Mesenchymal cell interaction with ovarian cancer cells triggers pro-metastatic properties. PloS one. 2012 Academic Article GET IT
Times cited: 43
Copy number variation analysis of matched ovarian primary tumors and peritoneal metastasis. PloS one. 2011 Academic Article GET IT
Times cited: 43
Tumor associated mesenchymal stem cells protects ovarian cancer cells from hyperthermia through CXCL12. International journal of cancer. 2011 Academic Article GET IT
Times cited: 79
Oncologic trogocytosis with Hospicells induces the expression of N-cadherin by breast cancer cells. International journal of oncology. 2010 Academic Article GET IT
Times cited: 18
Oncologic trogocytosis of an original stromal cells induces chemoresistance of ovarian tumours. PloS one. 2008 Academic Article GET IT
Times cited: 92

Research

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Co-investigator Network

Funding awarded

missing activity Co-Investigator 2020 - 2027

missing activity Co-Principal Investigator 2021 - 2025

missing activity Principal Investigator Subaward 2021 - 2026

Background

education and training

Ph.D., Universite Paris SUD XI (France) 2011
M.S., University Paul Sabatier, Toulouse (France) 2008
B.S., University Paul Sabatier, Toulouse (France) 2006

Contact

full name

Raphael Lis

primary email

ral2020@med.cornell.edu