selected publications
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EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer.
Cancer discovery.
2020
Academic Article
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Times cited: 267 -
Systemic Chemotherapy for Metastatic Colitis-Associated Cancer Has a Worse Outcome Than Sporadic Colorectal Cancer: Matched Case Cohort Analysis.
Clinical colorectal cancer.
2020
Academic Article
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Times cited: 1 -
A rectal cancer organoid platform to study individual responses to chemoradiation.
Nature medicine.
2019
Academic Article
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Times cited: 338 -
Assessment of a Watch-and-Wait Strategy for Rectal Cancer in Patients With a Complete Response After Neoadjuvant Therapy.
JAMA oncology.
2019
Academic Article
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Times cited: 393 -
Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions.
Cancer research.
2019
Academic Article
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Times cited: 114 -
RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling.
Nature medicine.
2018
Academic Article
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Times cited: 132 -
Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2018
Academic Article
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Times cited: 405 -
Association of Preoperative and Postoperative Serum Carcinoembryonic Antigen and Colon Cancer Outcome.
JAMA oncology.
2018
Academic Article
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Times cited: 159 -
Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAFV600E-Mutant Colorectal Cancer.
Cancer discovery.
2018
Academic Article
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Times cited: 429 -
Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.
Cancer cell.
2018
Academic Article
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Times cited: 560 -
Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition.
Cancer research.
2017
Academic Article
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Times cited: 66 -
Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
2017
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Times cited: 23 -
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.
Nature.
2017
Academic Article
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Times cited: 391 -
Clinical and Morphologic Characteristics of MEK Inhibitor-Associated Retinopathy: Differences from Central Serous Chorioretinopathy.
Ophthalmology.
2017
Academic Article
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Times cited: 101 -
OncoKB: A Precision Oncology Knowledge Base.
JCO precision oncology.
2017
Academic Article
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Times cited: 1655 -
PI3K pathway mutations are associated with longer time to local progression after radioembolization of colorectal liver metastases.
Oncotarget.
2017
Academic Article
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Times cited: 29 -
Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival.
Molecular cancer research : MCR.
2017
Academic Article
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Times cited: 22 -
Clinical and genetic determinants of ovarian metastases from colorectal cancer.
Cancer.
2016
Academic Article
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Times cited: 51 -
Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma.
Oncotarget.
2016
Academic Article
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Times cited: 23 -
Faster FOLFOX: Oxaliplatin Can Be Safely Infused at a Rate of 1 mg/m2/min.
Journal of oncology practice.
2016
Academic Article
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Times cited: 6 -
Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease.
Gastroenterology.
2016
Academic Article
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Times cited: 140 -
Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2016
Academic Article
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Times cited: 190 -
Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF.
Molecular cancer research : MCR.
2015
Academic Article
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Times cited: 42 -
Impact of somatic mutations on patterns of metastasis in colorectal cancer.
Journal of gastrointestinal oncology.
2015
Information Resource
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Times cited: 85 -
RAF plus EGFR Inhibition for BRAF-Mutant Metastatic Colorectal Cancer-Response.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2015
Article
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Times cited: 1 -
AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H Status: A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants.
Molecular cancer research : MCR.
2015
Academic Article
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Times cited: 22 -
Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2015
Academic Article
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Times cited: 235 -
RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer.
Cancer.
2014
Academic Article
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Times cited: 148 -
Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions.
Genome biology.
2014
Academic Article
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Times cited: 285 -
False-positive elevations of carcinoembryonic antigen in patients with a history of resected colorectal cancer.
Journal of the National Comprehensive Cancer Network : JNCCN.
2014
Academic Article
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Times cited: 80 -
BRAF mutation predicts for poor outcomes after metastasectomy in patients with metastatic colorectal cancer.
Cancer.
2014
Academic Article
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Times cited: 159 -
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer research.
2014
Academic Article
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Times cited: 247 -
BRAF mutations in colorectal cancer: clinical relevance and role in targeted therapy.
Journal of the National Comprehensive Cancer Network : JNCCN.
2012
Article
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Times cited: 12 -
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.
Nature.
2012
Academic Article
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Times cited: 1537 -
Comparing genetic ancestry and self-described race in african americans born in the United States and in Africa.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2008
Academic Article
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Times cited: 104 -
17HSD 2 may be higher in African-American breast cancer and is associated with estrogen receptor-negative tumors.
Cancer genomics & proteomics.
2007
Academic Article
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Times cited: 4